El papel del voluntariado universitario en la creación de una comunidad de aprendizaje.

La comunicación que presentamos describe el proceso de participación del voluntariado universitario en la comunidad de aprendizaje CEIP Albolafia de Córdoba. Dado que el papel del voluntariado en este tipo de experiencias es clave para la puesta en práctica de las actuaciones transformadoras, nuestra tarea ha estado centrada en articular la presencia de un grupo de alumnos y alumnas en el centro educativo. Por ello consideramos de interés valorar sus conocimientos previos sobre el tema, sus deseos de transformación social y sus motivaciones para participar en este proyecto. La información obtenida ha permitido reformular las actuaciones en relación a la formación, el compromiso y la participación en la comunidad de aprendizaje

The cyanobacterial ribosomal-associated protein LrtA from Synechocystis sp. PCC 6803 is an oligomeric protein in solution with chameleonic sequence properties

The LrtA protein of Synechocystis sp. PCC 6803 intervenes in cyanobacterial post-stress survival and in stabilizing 70S ribosomal particles. It belongs to the hibernating promoting factor (HPF) family of proteins, involved in protein synthesis. In this work, we studied the conformational preferences and stability of isolated LrtA in solution. At physiological conditions, as shown by hydrodynamic techniques, LrtA was involved in a self-association equilibrium. As indicated by Nuclear Magnetic Resonance (NMR), circular dichroism (CD) and fluorescence, the protein acquired a folded, native-like conformation between pH 6.0 and 9.0. However, that conformation was not very stable, as suggested by thermal and chemical denaturations followed by CD and fluorescence. Theoretical studies of its highly-charged sequence suggest that LrtA had a Janus sequence, with a context-dependent fold. Our modelling and molecular dynamics (MD) simulations indicate that the protein adopted the same fold observed in other members of the HPF family ( - - - - - ) at its N-terminal region (residues 1–100), whereas the C terminus (residues 100–197) appeared disordered and collapsed, supporting the overall percentage of overall secondary structure obtained by CD deconvolution. Then, LrtA has a chameleonic sequence and it is the first member of the HPF family involved in a self-association equilibrium, when isolated in solution.Ministerio de Economía y Competitividad CTQ2015-64445-RMinisterio de Economía y Competitividad BIO2016-78020-RMinisterio de Economía y Competitividad FIS2014-52212-RMinisterio de Economía y Competitividad BIO2016-75634-PFundación Séneca 19353/PI/1

Assessment of nutritional and biological activity of wild bulbs of Allium ampeloprasum L.

Allium ampeloprasum L. posee un gran potencial nutricional con presencia de compuestos antioxidantes de interés para la salud. Diversos estudios epidemiológicos han demostrado los efectos beneficiosos del consumo de diversas especies pertenecientes al género Allium, destacando sus efectos anticancerígenos. En el presente trabajo se estudia el contenido de nutrientes (hidratos de carbono, proteínas, grasa y minerales), compuestos bioactivos (ácidos orgánicos, vitamina C, tocoferoles, perfil de ácidos grasos) y actividad antioxidante (DPPH, poder reductor, inhibición de la decoloración del β-caroteno y TBARS) la parte comestible del ajo porro (A. ampeloprasum). Para ello, se recolectaron muestras de los puerros (bulbos y parte basal de las hojas) de dicha especie silvestre en dos localidades diferentes del centro peninsular durante dos años consecutivos (2007-2008), sobre los cuales se llevaron a cabo los análisis mencionados. Los resultados del análisis de los compuestos anteriormente mencionado indican que, a pesar de la amplia variabilidad natural detectada, esta planta destacó por ser una buena fuente de fibra (3,5 – 4,7 g/100 g), hierro (0,20 – 0,92 mg/100 g) y cinc (0,03 – 1,67 mg/100 g) en comparación con otras especies del mismo género, así como por su bajo valor calórico (59-97 Kcal/100 g). Asimismo, presentó un alto porcentaje de ácidos grasos poliinsaturados, siendo el ácido linoleico el principal ácido graso (53% del total de ácidos grasos). Se obtuvieron valores equilibrados en cuanto a la presencia de compuestos bioactivos hidrófilos y lipófilos en esta planta. La bioactividad de este bulbo se caracterizó por su actividad antioxidante medida como poder reductor (correlacionado con los tocoferoles) y TBARS (correlacionado con los compuestos fenólicos totales).Allium ampeloprasum L. has a great nutritional value as it presents antioxidant compounds with potentially beneficial effects on human. Different epidemiological studies have shown the healthy effects of the consumption of various species of the genus Allium, highlighting its anticancer effects. In the present work, the nutritional composition (carbohydrates, proteins, fat and minerals), bioactive compounds (organic acids, vitamin C, tocopherols and fatty acids) and antioxidant activity (DPPH, reducing power, inhibition of β-carotene bleaching and TBARS methods) of the edible part of the wild leek (A. Ampeloprasum) were studied. Samples of wild leek were collected from two different wild populations located in the center of the Iberian Peninsula for three consecutive years (2007-2008), on which the aforementioned analysis were conducted. Despite the large natural variability detected, this plant stood out as a good source of fiber (3.5 to 4.7 g/100 g), iron (0.20 to 0.92 mg/100 g) and zinc (0.03 to 1.67 mg/100 g), compared to other species of the same genus. Wild leeks also showed a high proportion of polyunsaturated fatty acids, being linoleic acid the major one (53% of total fatty acids). Values were balanced in terms of the presence of hydrophilic and lipophilic bioactive compounds in this plant. The bioactivity of this species was better characterized by antioxidant activity measured as reducing power assay (correlated with tocopherols) and TBARS (correlated with total phenolic compounds).ERDF and the Spanish Ministry of Education and Science (CGL2006-09546/BOS). The authors are also grateful to Fundação para a Ciência e a Tecnologia (FCT, Portugal) and COMPETE/QREN/EU for financial support to CIMO (strategic project PEst- OE/AGR/UI0690/2011). P. García-Herrera thanks to the Spanish Ministry of Education and Science (CGL2006-09546/BOS) for her UCM predoctoral fellowship

Nutrients, phytochemicals and antioxidant activity in wild populations of Allium ampeloprasum, a valuable underutilized vegetable

Wild Allium species with a long tradition of use, such as Allium ampeloprasum L. could provide interesting bioactive compounds to current diet. The nutrient and bioactive compound content of this wild vegetable has been scarcely known. Therefore, the aim of this work is to provide a detailed chemical quantification of nutrients, hydrophilic and lipophilic bioactive compounds and the antioxidant capacity of the edible parts of wild leek, as well as data about plant production and availability of the species in their natural habitats. Wild leek can be considered as a low energy food, being a good source of fiber and zinc, compared to its cultivated relatives, and has revealed a predominance of polyunsaturated fatty acids, linoleic acid being the main fatty acid. Additionally, the natural yield of this species, although lower than other cultivated Allium species, was found to be stable and well-adapted to human-disturbed environments. For these reasons, this non-conventional wild bulb should be revalorized as a good alternative to increase the diversity of vegetables consumed and enhance the quality of current occidental diets.ERDF and the Spanish Ministry of Education and Science (CGL2006-09546/BOS). The authors are also grateful to Fundação para a Ciência e a Tecnologa (FCT, Portugal) and COMPETE/QREN/EU for financial support to CIMO (strategic project PEst-OE/AGR/UI0690/2011). P. García-Herrera thanks to the Spanish Ministry of Education and Science for her UCM predoctoral fellowship. We also thank to Ramón Morales, Laura Aceituno, and Susana González for their collaboration in the gathering and preparation of the samples, and also to Carmen Díez for her support in mineral analysis

Electrochemical Treatment of C.I. Reactive Black 5 Solutions on Stabilized Doped Ti/SnO2 Electrodes

The electrochemical treatment of wastewaters from the textile industry is a promising technique for substances which are resistant to biodegradation. This paper deals with the electrochemical decolourisation and degradation of synthetic solutions containing a bifunctional reactive dye with a high molecular complexity: C.I. Reactive Black 5. The electrolysis was carried out under galvanostatic conditions employing a filter press reactor with two different configurations. A divided filter press reactor (D-FPR) to study only the oxidation process and an undivided filter press reactor (UD-FPR) to study the oxido-reduction process. All the processes were evaluated using Ti/SnO2-Sb-Pt and stainless steel electrodes as anode and cathode, respectively. The decolourisation and degradation of the dye were tracked by means of total organic carbon (TOC), chemical oxygen demand (COD) measurements, UV-Visible spectroscopy, as well as high performance liquid chromatography (HPLC). The kinetics of decolourisation was of pseudo-first order for both processes. Average Oxidation State (AOS), Carbon Oxidation State (COS) and Average Current Efficiency (ACE) were also determined. © 2013 by ESG.Del Río García, AI.; Benimeli Camara, MJ.; Molina Puerto, J.; Bonastre Cano, JA.; Cases Iborra, FJ. (2012). Electrochemical Treatment of C.I. Reactive Black 5 Solutions on Stabilized Doped Ti/SnO2 Electrodes. International Journal of Electrochemical Science. 7(12):13074-13092. http://hdl.handle.net/10251/58001S130741309271

Evaluación nutricional y de la actividad biológica de los bulbos silvestres de Allium ampeloprasum L.

Las plantas silvestres comestibles representan una interesante alternativa en alimentación, por ser fuentes de colores y sabores inusuales, así como por su composición química y nutricional. En concreto, Allium ampeloprasum L. posee un gran potencial nutricional con presencia de compuestos antioxidantes de interés para la salud. Diversos estudios epidemiológicos han demostrado los efectos beneficiosos del consumo de diversas especies pertenecientes al género Allium, destacando sus efectos anticancerígenos. En el presente trabajo se estudia el contenido de nutrientes (hidratos de carbono, proteínas, grasa y minerales), compuestos bioactivos (ácidos orgánicos, vitamina C, tocoferoles, perfil de ácidos grasos) y actividad antioxidante (DPPH, poder reductor, inhibición de la decoloración del β-caroteno y TBARS) de los bulbos de A. ampeloprasum (ajoporro o puerro). Para ello, se recolectaron muestras de bulbos silvestres de A. ampeloprasum en dos localidades diferentes del centro peninsular durante tres años consecutivos (2007-2009), sobre los cuales se llevaron a cabo los análisis mencionados. A pesar de la amplia variabilidad natural detectada, esta planta destacó por ser una buena fuente de fibra (3,5 – 4,7 g/100 g), hierro (0,20 – 0,92 mg/100 g) y cinc (0,03 – 1,67 mg/100 g) en comparación con otras especies del mismo género, así como por su bajo valor calórico (59-97 Kcal/100 g). Asimismo, presentó un alto porcentaje de ácidos grasos poliinsaturados, siendo el ácido linoleico el principal ácido graso (53% del total de ácidos grasos). Se obtuvieron valores equilibrados en cuanto a la presencia de compuestos bioactivos hidrófilos y lipófilos en esta planta. La bioactividad de este bulbo se caracterizó mejor por los métodos de poder reductor (correlacionado con los tocoferoles) y TBARS (correlacionado con los compuestos fenólicos totales).Wild edible plants represent an interesting alternative for food uses, as sources of unusual colors and flavors, as well as due to its chemical and nutritional composition. Specifically, Allium ampeloprasum L. has a great nutritional potential as it presents antioxidant compounds with health interest. Different epidemiological studies have shown the beneficial effects of the consumption of various species of the genus Allium, highlighting its anticancer effects. In the present work, the nutritional composition (carbohydrates, proteins, fat and minerals), bioactive compounds (organic acids, vitamin C, tocopherols and fatty acids) and antioxidant activity (DPPH, reducing power, inhibition of β-carotene bleaching and TBARS methods) of wild leek bulbs (A. Ampeloprasum) were studied. Samples were collected in two different locations in the center of the Iberian Peninsula for three consecutive years (2007-2009), on which the aforementioned analyzes were conducted. Despite the large natural variability detected, this plant stood out as a good source of fiber (3.5 to 4.7 g/100 g), iron (0.20 to 0.92 mg/100 g) and zinc (0.03 to 1.67 mg/100 g), compared to other species of the same genus, as well as due to its low energy value (59- 97 Kcal/100 g). Also wild leek bulbs showed a high proportion of polyunsaturated fatty acids, being linoleic acid the major one (53% of total fatty acids). Values were balanced in terms of the presence of hydrophilic and lipophilic bioactive compounds in this plant. The bioactivity of this bulb was better characterized by reducing power assay (correlated with tocopherols) and TBARS (correlated with total phenolic compounds)

Arte Rupestre en el Karst de Ojo Guareña (Merindad de Sotoscueva-Burgos) : trabajos de documentación y estudio en «La Sala de La Fuente»

La amplia nómina de autores que firman el presente artículo dan forma al equipo multidisciplinar que en 1995 inició un ambicioso proyecto, subvencionado por la Junta de Castilla y León, denominado «Trabajos de Documentación y Estudio del Arte Rupestre en el Karst de Ojo Guareña». El avance de sus primeros trabajos está recogido en el siguiente texto y fue presentado al Primer Congreso de Arqueología Burgalesa (1998), mas, al no haberse publicado éste, sigue aún inédito. Su interés, y de forma especial la continuidad de la investigación, aconseja a los autores su edición en Espacio, Tiempo y Forma con vistas a una mayor difusión del proyecto y, con ello, a un mejor conocimiento de la grafía rupestre de las galerías subterráneas del norte de la provincia de Burgos.The wide number of researchers who sign the present añide joined in the multi-discipline team that started an ambitious project, which was sponsored by the regional authority: Junta de Castilla y León, called «Records and Research on Cave Art at the karst in Ojo Guareña». The deveiopment of thelr first researches Is shown in the present Ítem and it was also presented in the First Burgos Archaeology Congress (1998), although it is still unavailable since it has never been published. Both, the Importance of its contents and specially the continuity of the research led its authors to publish this article in Espacio, Tiempo y Forma so that the project could be widely known and, at the same time, provide a better knowledge of rock graphics in the underground galleries which can be found in the north of Burgos province

Prodromal symptoms and the duration of untreated psychosis in first episode of psychosis patients: what differences are there between early vs. adult onset and between schizophrenia vs. bipolar disorder?

To assess the role of age (early onset psychosis-EOP < 18 years vs. adult onset psychosis-AOP) and diagnosis (schizophrenia spectrum disorders-SSD vs. bipolar disorders-BD) on the duration of untreated psychosis (DUP) and prodromal symptoms in a sample of patients with a first episode of psychosis. 331 patients with a first episode of psychosis (7–35 years old) were recruited and 174 (52.6%) diagnosed with SSD or BD at one-year follow-up through a multicenter longitudinal study. The Symptom Onset in Schizophrenia (SOS) inventory, the Positive and Negative Syndrome Scale and the structured clinical interviews for DSM-IV diagnoses were administered. Generalized linear models compared the main effects and group interaction. 273 AOP (25.2 ± 5.1 years; 66.5% male) and 58 EOP patients (15.5 ± 1.8 years; 70.7% male) were included. EOP patients had significantly more prodromal symptoms with a higher frequency of trouble with thinking, avolition and hallucinations than AOP patients, and significantly different median DUP (91 [33–177] vs. 58 [21–140] days; Z = − 2.006, p = 0.045). This was also significantly longer in SSD vs. BD patients (90 [31–155] vs. 30 [7–66] days; Z = − 2.916, p = 0.004) who, moreover had different profiles of prodromal symptoms. When assessing the interaction between age at onset (EOP/AOP) and type of diagnosis (SSD/BD), avolition was significantly higher (Wald statistic = 3.945; p = 0.047), in AOP patients with SSD compared to AOP BD patients (p = 0.004). Awareness of differences in length of DUP and prodromal symptoms in EOP vs. AOP and SSD vs. BD patients could help improve the early detection of psychosis among minors

Técnicas y métodos de evaluación en la UPC. Incidencia en los procesos

En el presente proyecto, en primer lugar se ha estructurado y organizado el contenido del espacio virtual propio del Grupo de evaluación, GRAPA, dentro de la plataforma RIMA. Dicho entorno incluye desde aportaciones propias de los miembros del grupo, principalmente profesorado UPC, sobre sus experiencias en técnicas de evaluación, hasta bibliografía general y específica del ámbito. Además se ha traducido el contenido del entorno virtual a los dos idiomas oficiales de Cataluña para posibilitar su difusión al resto de España y así poder convertirse también en un referente nacional. Se ha ido actualizando el contenido para mantener al día toda la información de interés en el ámbito de la docencia y en especial de la evaluación. Con esta actuación se ha conseguido el principal resultado esperado del proyecto que era el de “Crear un espacio virtual propio en el ámbito de la evaluación de la práctica académica, que permita a toda la comunidad docente de la UPC, encontrar sistemas de evaluación sistematizados útiles para sus asignaturas, que aseguren la calidad del proceso de enseñanza-aprendizaje”. En segundo lugar y no por ello menos importante, la ayuda económica concedida en este proyecto ha permitido difundir y dar visibilidad a las iniciativas y los resultados obtenidos por el grupo GRAPA, a toda la comunidad universitaria, por un lado mediante la participación y asistencia a varios congresos nacionales del ámbito docente y por otro mediante la realización de reuniones y contactos con otros grupos de innovación nacionales. Uno de los resultados más importantes fruto de estos contactos ha sido la organización de varios talleres o cursos de formación en el ámbito de la evaluación, ofertados a toda la comunidad universitaria a través del ICE-UPC. Las diferentes actuaciones han favorecido la divulgación del grupo, posibilitando el aumento del número de miembros UPC de los 18 iniciales a los 36 actuales, todos ellos en mayor o menor medida activos en el grupo.Peer Reviewe

Electroconvulsive Therapy in Super Refractory Status Epilepticus: Case Series with a Defined Protocol

Super-refractory status epilepticus (SRSE) represents a neurological emergency that is characterized by a lack of response to the third line of antiepileptic treatment, including intravenous general anesthetics. It is a medical challenge with high morbidity and mortality. Electroconvulsive therapy (ECT) has been recommended as a nonpharmacologic option of treatment after other alternatives are unsuccessful. Its effect on the cessation of SRSE has been minimally investigated. The objective of this article is to analyze the effect of ECT on SRSE. For this purpose, a multidisciplinary team created a protocol based on clinical guidelines similar to those described previously by Ray et al. (2017). ECT was applied to six patients with SRSE after the failure of antiepileptic treatment and pharmacologic coma.The objective of each ECT session was to elicit a motor seizure for at least 20 s. SRSE was resolved in all patients after several days of treatment, including ECT as a therapy, without relevant adverse effects. Thus, ECT is an effective and feasible option in the treatment of SRSE, and its place in the algorithm in treatment should be studied due to the uncommon adverse effects and the noninvasive character of the therapy