Opioid-related deaths investigated by the Dublin City and County Coroners in 1999: background, analysis and prevention initiatives.

This report outlines the findings of the second in a series of surveys on the inquest files of the Dublin City and County Coroners. The majority of the decedents were young (mean age, 29.73), male (male: female ratio; 8.55: 1), single (75.6%) and unemployed (70.9%). Benzodiazepines were implicated in the highest number of deaths (73.3%). There was a 9.17% increase and an 11.55% decrease in the number of cases proving positive for heroin and methadone respectively. However 90.71% of cases had two or more drugs (mean 3.38) implicated per death. The increased risk of overdose among those recently released from prison was highlighted and the heightened risk of suicide among opiate users was also discussed

Bottom Pressure Tides Along a Line in the Southeast Atlantic Ocean and Comparisons with Satellite Altimetry

Seafloor pressure records, collected at 11 stations aligned along a single ground track of the Topex/Poseidon and Jason satellites, are analyzed for their tidal content. With very low background noise levels and approximately 27 months of high-quality records, tidal constituents can be estimated with unusually high precision. This includes many high-frequency lines up through the seventh-diurnal band. The station deployment provides a unique opportunity to compare with tides estimated from satellite altimetry, point by point along the satellite track, in a region of moderately high mesoscale variability. That variability can significantly corrupt altimeter-based tide estimates, even with 17 years of data. A method to improve the along-track altimeter estimates by correcting the data for nontidal variability is found to yield much better agreement with the bottom-pressure data. The technique should prove useful in certain demanding applications, such as altimetric studies of internal tides

Cannabis and benzodiazepines as determinants of methadone trough plasma concentration variability in maintenance treatment: a transnational study

Purpose: To assess tobacco, alcohol, cannabis and benzodiazepine use in methadone maintenance treatment (MMT) as potential sources of variability in methadone pharmacokinetics. Methods: Trough plasma (R)- and (S)-methadone concentrations were measured on 77 Australian and 74 Swiss MMT patients with no additional medications other than benzodiazepines. Simple and multiple regression analyses were performed for the primary metric, plasma methadone concentration/dose. Results: Cannabis and methadone dose were significantly associated with lower 24-h plasma (R)- and (S)-methadone concentrations/dose. The models containing these variables explained 14-16% and 17-25% of the variation in (R)- and (S)-methadone concentration/dose, respectively. Analysis of 61 patients using only CYP3A4 metabolised benzodiazepines showed this class to be associated with higher (R)-concentration/dose, which is consistent with a potential competitive inhibition of CYP3A4. Conclusion: Cannabis use and higher methadone doses in MMT could in part be a response to—or a cause of—more rapid methadone clearance. The effects of cannabis and benzodiazepines should be controlled for in future studies on methadone pharmacokinetics in MM

Effects of dredging-related pressures on critical ecological processes for organisms other than fish or coral. Report of Theme 9 - Project 9.1 prepared for the Dredging Science Node

In November 2013 a workshop was held at CSIRO Floreat, which brought together national and international marine scientists. The workshop addressed two primary objectives: • identify the timing of critical ecological processes in tropical and temperate ecosystems with a focus on non-coral and non-fish biota (seagrass, seaweed, sponges, ascidians, bryozoans, molluscs, echinoderms, crustaceans and non-coral cnidarians); and • identify environmental windows for critical ecological processes identified in Objective 1. This will be achieved by compiling information on the timing of reproduction, release of propagules and recruitment for these organisms, as well as the temporal and spatial scales of reproduction and recruitment events. During Workshop 1 a conceptual diagram was developed to illustrate and guide the decision process behind the selection of environmental windows (EWs) (see Figure 1). The life histories of the biota investigated were then identified and listed in detailed tables with specific reference to potential effects of dredging at each life history stage..

Close encounters: Analyzing how social similarity and propinquity contribute to strong network connections.

Models of network formation emphasize the importance of social similarity and propinquity in producing strong interpersonal connections. The positive effect each factor can have on tie strength has been documented across a number of studies, and yet we know surprisingly very little about how the two factors combine to produce strong ties. Being in close proximity could either amplify or dampen the positive effect that social similarity can have on tie strength. Data on tie strength among teachers working in five public schools were analyzed to shed light on this theoretical question. The empirical results indicate that teachers who were similar in age were more likely to be connected by a strong tie, especially teachers for whom age similarity was more likely to be salient. Moreover, teachers who took breaks at the same time or who had classrooms on the same floor communicated more frequently and felt more emotionally attached. Among the public school teachers, propinquity amplified the positive effect that age similarity had on tie strength. The strongest network connections occurred among age-similar teachers who had classrooms on the same floor. The empirical results illustrate the value of considering how social similarity and propinquity contribute to strong ties independently and when combined with each other

Research priorities in hypertrophic cardiomyopathy: report of a Working Group of the National Heart, Lung, and Blood Institute.

Hypertrophic cardiomyopathy (HCM) is a myocardial disorder characterized by left ventricular (LV) hypertrophy without dilatation and without apparent cause (ie, it occurs in the absence of severe hypertension, aortic stenosis, or other cardiac or systemic diseases that might cause LV hypertrophy). Numerous excellent reviews and consensus documents provide a wealth of additional background.1–8 HCM is the leading cause of sudden death in young people and leads to significant disability in survivors. It is caused by mutations in genes that encode components of the sarcomere. Cardiomyocyte and cardiac hypertrophy, myocyte disarray, interstitial and replacement fibrosis, and dysplastic intramyocardial arterioles characterize the pathology of HCM. Clinical manifestations include impaired diastolic function, heart failure, tachyarrhythmia (both atrial and ventricular), and sudden death. At present, there is a lack of understanding of how the mutations in genes encoding sarcomere proteins lead to the phenotypes described above. Current therapeutic approaches have focused on the prevention of sudden death, with implantable cardioverter defibrillator placement in high-risk patients. But medical therapies have largely focused on alleviating symptoms of the disease, not on altering its natural history. The present Working Group of the National Heart, Lung, and Blood Institute brought together clinical, translational, and basic scientists with the overarching goal of identifying novel strategies to prevent the phenotypic expression of disease. Herein, we identify research initiatives that we hope will lead to novel therapeutic approaches for patients with HCM

Adaptation of the Basic Empathy Scale among a Portuguese sample of incarcerated juvenile offenders

The main aim of the present study was to examine the psychometric properties of the Basic Empathy Scale (BES) and of its adapted short version among a forensic sample of incarcerated male juvenile offenders (N = 221). The Portuguese validations of the BES and its adapted short version demonstrated good psychometric properties, namely in terms of the two-factor structure, internal consistency, convergent validity, discriminant validity, and concurrent validity that generally justifies its use among this population. Statistically significant associations were found with callous– unemotional traits and social anxiety. Findings are discussed in terms of the use of the BES and its adapted short version with juvenile offenders.This research was supported by the Portuguese Foundation for Science and Technology (FCT) with co-financing of the European Social Fund – POPH/FSE [grant number SFRH/BPD/86666/2012]