Trois nouvelles espagnoles de Balzac.

Sin resume

As Metamorfoses da Universidade

Conferência proferida na USP, em 1984, por ocasião das comemorações do Cinqüentenári

La novela como búsqueda

La novela es una forma particular del relato. Este es un fenómeno que rebasa considerablemente el terreno de la literatura; es uno de los elementos esenciales de nuestra aprehensión de la realidad. Hasta nuestra muerte, y desde. que comprendernos las palabras, nos hallarnos perpetuamente rodeados de relatos, primero en nuestra familia, luego en la escuela, y luego a través de los encuentros y las lecturas

Stèle pour Claude Simon

pour Rhéa Une enfance dans les vignesauprès d’une forteressede l’autre côté des montsle vacarme de la guerreon veut y participerce n’est que pour assisterà l’écrasement du droit Mais c’est loin d’être finireprend la guerre la guerreici et là un brandonqui rallume en incendieles souvenirs d’autres guerrescelles du début du sièclecelles des siècles passés Les vieilles femmes en parlenttandis que les rescapéss’efforcent d’exorciserles images effroyablesqui reviennent les hantercherchent à cicatr..

Stèle pour Claude Simon

pour Rhéa Une enfance dans les vignesauprès d’une forteressede l’autre côté des montsle vacarme de la guerreon veut y participerce n’est que pour assisterà l’écrasement du droit Mais c’est loin d’être finireprend la guerre la guerreici et là un brandonqui rallume en incendieles souvenirs d’autres guerrescelles du début du sièclecelles des siècles passés Les vieilles femmes en parlenttandis que les rescapéss’efforcent d’exorciserles images effroyablesqui reviennent les hantercherchent à cicatr..

Pre-B-cell development in the absence of λ5 in transgenic mice expressing a heavy-chain disease protein

AbstractBackground: Heavy-chain diseases (HCDs) are human lymphoproliferative neoplasias that are characterized by the secretion of truncated immunoglobulin heavy chains devoid of light chains. We have previously proposed — by analogy to the process by which mutated growth factor receptors can be oncogenic — that because the genetic defects in HCDs result in the production of abnormal membrane-associated heavy chains lacking an antigen-binding domain, these abnormal B-cell antigen receptors might engage in ligand-independent signalling. Normal pre-B-cell development requires the presence of the pre-B-cell receptor, formed by the association of μ heavy chains with two polypeptides — so-called surrogate light chains, Vpre-B and λ5 — that are homologous to the variable and constant portions of immunoglobulin light chains, respectively. To assess whether amino-terminal truncation of membrane-associated heavy chains results in their constitutive activation, we have examined the ability of a HCD-associated μ protein to promote pre-B-cell development in transgenic mice.Results When the μ HCD transgene is introduced into SCID mice, CD43− pre-B cells develop normally. To determine whether this pre-B-cell development requires surrogate light chains, we backcrossed mice expressing full-length or truncated μ transgenes with λ5-deficient mice. Our results show that the truncated heavy chain, but not the normal chain, is able to promote pre-B-cell development in the absence of λ5. We also show that truncated μ chains spontaneously aggregate at the surface of bone marrow cells.Conclusion Expression of the truncated μ heavy chain overrides a tightly controlled step of pre-B-cell development, which strongly suggests that a constitutive signal is delivered by the truncated μ chain disease protein. The self-aggregation of μ chain disease proteins might account for this constitutive activation. We conclude that amino-terminal truncation of heavy chains could play a role in the genesis of HCD neoplasia if it occurs at an appropriate stage of B-cell differentiation, namely in a mature B cell

Biogenic amines content in the fermented Asian food in the Czech Republic

The aim of this work was to study the typical fermented Asian food (miso paste, soy sauce, rice vinegar, kimchi and tempeh) to monitor their microbial quality and presence of biogenic amines in relation to time and temperature of storage. This study is focused on microbiological research in order to determinate presence of selected indicator groups of microorganisms during storage of individual products at three different temperatures, 8 °C, 23 °C, 30 °C. It was found that the highest increase of total viable counts was observed in products stored in 23 °C and 30 °C, especially in tempeh and miso paste. In soy sauce and rice vinegar were observed only very low amounts of microorganisms through the storage period. In the second part of the experiment, the biogenic amines were analyzed using high performance liquid chromatography. It was found that the levels of biogenic amines in tested products were low and does not affect human health. © 2018 Potravinarstvo Slovak Journal of Food Sciences