Strain rate and oxidation effects on crack initiation at 600 and 650 °C in a nickel-based superalloy

Nickel-based superalloys are sensitive to an oxidation-assisted intergranular crack (OAIC) growth mechanism. Crack initiation during slow strain rate tensile tests is investigated at 600 and 650 °C, at different strain rates, with or without oxidation on a direct-aged material. A V-shaped sample geometry is used to promote damage initiation for a specific stress triaxiality. The critical mechanical loading paths inducing intergranular crack initiation as well as the effect of oxidation are discussed

Mechanisms of leukemogenesis induced by bovine leukemia virus: prospects for novel anti-retroviral therapies in human

In 1871, the observation of yellowish nodules in the enlarged spleen of a cow was considered to be the first reported case of bovine leukemia. The etiological agent of this lymphoproliferative disease, bovine leukemia virus (BLV), belongs to the deltaretrovirus genus which also includes the related human T-lymphotropic virus type 1 (HTLV-1). This review summarizes current knowledge of this viral system, which is important as a model for leukemogenesis. Recently, the BLV model has also cast light onto novel prospects for therapies of HTLV induced diseases, for which no satisfactory treatment exists so far

Open Celled Porous Titanium

Among the porous metals, those made of titanium attract particular attention due to the interesting properties of this element. This review examines the state of research understanding and technological development of these materials, in terms of processing capability, resultant structure and properties, and the most advanced applications under development. The impact of the rise of additive manufacturing techniques on these materials is discussed, along with the likely future directions required for these materials to find practical applications on a large scale

Stabilisation du récepteur biochimique dans une électrode enzymatique

Doctorat en sciences chimiques -- UCL, 199

Sulfénylation ou alkylation à partir de sulfoxydes : β-trifluoroacétoxysulfénylations intramoléculaires par cyclisation de tert-butylsulfoxydes, étude des vinylsulfoxydes, précurseurs des α, β-dications

Doctorat en sciences chimiques -- UCL, 199

Peptidomimétisme des coudes β et γ

dissertn: Diss. Doct. Ann

Les chémokines et leurs récepteurs : rôle dans les infections virales et dans les pathologies cancéreuses

The chemokines and their receptors: the main functions of chemokines are cell activation and stimulation of leukocyte migration. By interacting with G protein-coupled receptors, these proteins regulate many biological processes like apoptosis, proliferation, angiogenesis, hematopoiesis or organogenesis. They maintain the homeostasis of the lymphocyte compartment and ensure correct functioning of the immune system. Interestingly, the chemokines and their receptors are ideal targets for viruses. Furthermore, most cancers are characterized by a default of their expression or their activity