To Be a Man: A Re-Assessment of Black Masculinity in Lorraine Hansberry\u27s A Raisin in the Sun and Les Blancs

The first Black woman to pen a Broadway play, Lorraine Hansberry scripted a majority of male protagonists. Critics tend to see Hansberry’s depiction of Black men as either an unfortunate departure from her feminist concerns, or as damaging representations of Black masculinity. In contrast to such views, this essay maps the trajectory of Hansberry’s career-long project of scripting positive visions of Black masculinity, from the politically progressive, while still patriarchal, structures of masculinity in A Raisin in the Sun, to the heterogeneous performances of revolutionary masculinity in Les Blancs. Further, in her role as public intellectual, Hansberry questioned prevailing assumptions about masculinity during her time. In the pages of The Village Voice, Hansberry challenged a group of white writers she termed the “new paternalists,” including Jean Genet and Norman Mailer, in order to dismantle stereotypes of Black men as violent and hypersexual

Establishing a Pragmatic Framework to Optimise Health Outcomes in Heart Failure and Multimorbidity (ARISE-HF): A Multidisciplinary Position Statement

Background Multimorbidity in heart failure (HF), defined as HF of any aetiology and multiple concurrent conditions that require active management, represents an emerging problem within the ageing HF patient population worldwide. Methods To inform this position paper, we performed: 1) an initial review of the literature identifying the ten most common conditions, other than hypertension and ischaemic heart disease, complicating the management of HF (anaemia, arrhythmias, cognitive dysfunction, depression, diabetes, musculoskeletal disorders, renal dysfunction, respiratory disease, sleep disorders and thyroid disease) and then 2) a review of the published literature describing the association between HF with each of the ten conditions. From these data we describe a clinical framework, comprising five key steps, to potentially improve historically poor health outcomes in this patient population. Results We identified five key steps (ARISE-HF) that could potentially improve clinical outcomes if applied in a systematic manner: 1) Acknowledge multimorbidity as a clinical syndrome that is associated with poor health outcomes, 2) Routinely profile (using a standardised protocol — adapted to the local health care system) all patients hospitalised with HF to determine the extent of concurrent multimorbidity, 3) Identify individualised priorities and person-centred goals based on the extent and nature of multimorbidity, 4) Support individualised, home-based, multidisciplinary, case management to supplement standard HF management, and 5) Evaluate health outcomes well beyond acute hospitalisation and encompass all-cause events and a person-centred perspective in affected individuals. Conclusions We propose ARISE-HF as a framework for improving typically poor health outcomes in those affected by multimorbidity in HF

Reappraising Social Insect Behavior through Aversive Responsiveness and Learning

Background: The success of social insects can be in part attributed to their division of labor, which has been explained by a response threshold model. This model posits that individuals differ in their response thresholds to task-associated stimuli, so that individuals with lower thresholds specialize in this task. This model is at odds with findings on honeybee behavior as nectar and pollen foragers exhibit different responsiveness to sucrose, with nectar foragers having higher response thresholds to sucrose concentration. Moreover, it has been suggested that sucrose responsiveness correlates with responsiveness to most if not all other stimuli. If this is the case, explaining task specialization and the origins of division of labor on the basis of differences in response thresholds is difficult. Methodology: To compare responsiveness to stimuli presenting clear-cut differences in hedonic value and behavioral contexts, we measured appetitive and aversive responsiveness in the same bees in the laboratory. We quantified proboscis extension responses to increasing sucrose concentrations and sting extension responses to electric shocks of increasing voltage. We analyzed the relationship between aversive responsiveness and aversive olfactory conditioning of the sting extension reflex, and determined how this relationship relates to division of labor. Principal Findings: Sucrose and shock responsiveness measured in the same bees did not correlate, thus suggesting that they correspond to independent behavioral syndromes, a foraging and a defensive one. Bees which were more responsiv

Establishing the value of genomics in medicine: the IGNITE Pragmatic Trials Network.

PURPOSE: A critical gap in the adoption of genomic medicine into medical practice is the need for the rigorous evaluation of the utility of genomic medicine interventions. METHODS: The Implementing Genomics in Practice Pragmatic Trials Network (IGNITE PTN) was formed in 2018 to measure the clinical utility and cost-effectiveness of genomic medicine interventions, to assess approaches for real-world application of genomic medicine in diverse clinical settings, and to produce generalizable knowledge on clinical trials using genomic interventions. Five clinical sites and a coordinating center evaluated trial proposals and developed working groups to enable their implementation. RESULTS: Two pragmatic clinical trials (PCTs) have been initiated, one evaluating genetic risk APOL1 variants in African Americans in the management of their hypertension, and the other to evaluate the use of pharmacogenetic testing for medications to manage acute and chronic pain as well as depression. CONCLUSION: IGNITE PTN is a network that carries out PCTs in genomic medicine; it is focused on diversity and inclusion of underrepresented minority trial participants; it uses electronic health records and clinical decision support to deliver the interventions. IGNITE PTN will develop the evidence to support (or oppose) the adoption of genomic medicine interventions by patients, providers, and payers

Finishing the euchromatic sequence of the human genome

The sequence of the human genome encodes the genetic instructions for human physiology, as well as rich information about human evolution. In 2001, the International Human Genome Sequencing Consortium reported a draft sequence of the euchromatic portion of the human genome. Since then, the international collaboration has worked to convert this draft into a genome sequence with high accuracy and nearly complete coverage. Here, we report the result of this finishing process. The current genome sequence (Build 35) contains 2.85 billion nucleotides interrupted by only 341 gaps. It covers ∼99% of the euchromatic genome and is accurate to an error rate of ∼1 event per 100,000 bases. Many of the remaining euchromatic gaps are associated with segmental duplications and will require focused work with new methods. The near-complete sequence, the first for a vertebrate, greatly improves the precision of biological analyses of the human genome including studies of gene number, birth and death. Notably, the human enome seems to encode only 20,000-25,000 protein-coding genes. The genome sequence reported here should serve as a firm foundation for biomedical research in the decades ahead

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

Our story has not been told in any moment : Radical black feminist theatre from the old left to Black Power

This dissertation investigates the radical black feminist theatre of the 1940s through the 1970s, focusing on the work of playwrights Alice Childress, Lorraine Hansberry, and Sonia Sanchez. Each of these artists critically intervened in the discourses of gender, race, and class during the civil rights movement, and, later, the Black Power and Arts movements. Using archival and historical research, I argue that there was a vibrant, radical black feminist theatre movement throughout the twentieth century that sought equal representation for African Americans and a voice for black women. Chapters Two and Three add to the growing body of scholarship that situates Alice Childress as a major figure within the black left and the Communist Party. Through archival research and readings of her work, I demonstrate how Childress scripted dignified, humorous, and realistic portrayals of working class black women. Childress illustrated the theory of triple jeopardy, the idea circulated within black radical circles that working class African American women were triply oppressed due to their class, race, and gender. Through her experimental forms and daring content, Childress revised racist stereotypes of, for instance, the black female domestic worker, into full-fledged characters. The manner in which African Americans were represented—artistically and politically—was her greatest concern. In Chapter Two, I argue that Childress\u27s body of work can be viewed as an alternative feminist chronicle of African American women through its scripting of the working class black woman, specifically in her play Florence (1949) and her experimental novel of monologues, Like One of the Family (1956). Childress wrote, I concentrate on portraying the have-nots in a have society, those seldom singled out by mass media, except as source material for derogatory humor. Her focus on the ordinary is anti-bourgeois in its refusal to participate in racial uplift stories lionizing the successful black middle class. In Chapter Three, I focus on Trouble in Mind. While this play has been hitherto regarded as formally conservative, I argue that, to the contrary, Childress uses innovative Brechtian structures. Childress employs radical formal experimentation to forcefully argue for black self-determination in the arts, well before the artists of the Black Arts Movement would. Chapter Four, The White Problem: White Supremacy and Black Masculinity in the Work of Lorraine Hansberry, focuses on Hansberry\u27s A Raisin in the Sun and Les Blancs and the playwright\u27s critical interventions into the racial discourses of whiteness, black masculinity, and their intersections, in the civil rights era. By focusing on Hansberry\u27s critique of whiteness and patriarchal white supremacy, this essay redresses a gap in scholarship on Hansberry. I argue that Hansberry was one of the central assessors of whiteness and black masculinity in the civil rights-era United States. Hansberry\u27s representation of black men across her career attempts to find common ground for progressive black masculinity and black feminism to work together to defeat the white supremacist patriarchy detrimental to all African Americans. Moving into the Black Power era, my final chapter posits an alternative model to current scholarship on gender ideology within the Black Arts and Power movements. Rather than envisioning a movement led by men who repressed women, or considering women as marginal figures fighting from the periphery to address questions of feminism, gender, women\u27s issues, and sexuality, I ask, what happens if we center such feminist concerns in our narrative of the Black Arts Movement? Using works by Alice Childress and Sonia Sanchez, I demonstrate that black feminists in this time not only critiqued the masculinist rhetoric of much Black Arts writing, but also proposed a community-centered alternative model of black nationalism. This feminist model was grounded in love and support between black women and men, and advanced by black feminists as imperative for the success of the black nation\u27s political goals

Antisaccade errors reveal cognitive control deficits in Parkinson’s disease with freezing of gait

Freezing of gait is a poorly understood symptom of Parkinson's disease (PD) that is commonly accompanied by executive dysfunction. This study employed an antisaccade task to measure deficits in inhibitory control in patients with freezing, and to determine if these are associated with a specific pattern of grey matter loss using voxel-based morphometry. PD patients with (n\ua0=\ua015) and without (n\ua0=\ua011) freezing along with 10 age-matched controls were included. A simple prosaccade task was administered, followed by a second antisaccade task that required subjects to either look towards or away from a peripheral target. Behavioral results from the antisaccade task were entered as covariates in the voxel-based morphometry analysis. Patient and control groups performed equally well on the first task. However, patients with freezing were significantly worse on the second, which was driven by a specific impairment in suppressing their responses toward the target on the antisaccade trials. Impaired antisaccade performance was associated with grey matter loss across bilateral visual and fronto-parietal regions. These results suggest that patients with freezing have a significant deficit of inhibitory control that is associated with volume reductions in regions crucial for orchestrating both complex motor behaviors and cognitive control. These findings highlight the inter-relationship between freezing of gait and cognition and confirm that dysfunction along common neural pathways is likely to mediate the widespread cognitive dysfunction that emerges with this symptom