Deep convolutional networks for automated detection of posterior-element fractures on spine CT

Injuries of the spine, and its posterior elements in particular, are a common occurrence in trauma patients, with potentially devastating consequences. Computer-aided detection (CADe) could assist in the detection and classification of spine fractures. Furthermore, CAD could help assess the stability and chronicity of fractures, as well as facilitate research into optimization of treatment paradigms. In this work, we apply deep convolutional networks (ConvNets) for the automated detection of posterior element fractures of the spine. First, the vertebra bodies of the spine with its posterior elements are segmented in spine CT using multi-atlas label fusion. Then, edge maps of the posterior elements are computed. These edge maps serve as candidate regions for predicting a set of probabilities for fractures along the image edges using ConvNets in a 2.5D fashion (three orthogonal patches in axial, coronal and sagittal planes). We explore three different methods for training the ConvNet using 2.5D patches along the edge maps of 'positive', i.e. fractured posterior-elements and 'negative', i.e. non-fractured elements. An experienced radiologist retrospectively marked the location of 55 displaced posterior-element fractures in 18 trauma patients. We randomly split the data into training and testing cases. In testing, we achieve an area-under-the-curve of 0.857. This corresponds to 71% or 81% sensitivities at 5 or 10 false-positives per patient, respectively. Analysis of our set of trauma patients demonstrates the feasibility of detecting posterior-element fractures in spine CT images using computer vision techniques such as deep convolutional networks.Comment: To be presented at SPIE Medical Imaging, 2016, San Dieg

Involving your librarian in instruction : or ... how I learned to stop worrying and love my librarian

Presented at 2015 FaCET Conference at UMKC, January 15, 2015Title from PDF, viewed on March 13, 201

A review of coxiellosis (Q fever) and brucellosis in goats and humans: implications for disease control in smallholder farming systems in Southeast Asia

Coxiella burnetii and Brucella spp. are pathogenic bacteria that can cause large-scale outbreaks in livestock. Furthermore, these infectious agents are capable of causing zoonotic infections and therefore pose a risk to the close relationship between farm households and their livestock, especially goats. A review of seroprevalence studies of Coxiella burnetii and Brucella spp. in domestic goats demonstrated large differences in the total number of samples tested in different regions and countries. This review aims to provide information on coxiellosis (Q fever in humans) and brucellosis in goats concerning the characteristics of the causative agent, surveillance, and available prevention and control measures at a global level. Implications for Coxiella burnetii and Brucella spp. infections in domesticated goats in Southeast Asia are discussed

Parent-child interaction in Nigerian families: conversation analysis, context and culture

This paper uses a conversation analysis (CA) approach to explore parent child interaction (PCI) within Nigerian families. We illustrate how speech and language therapists (SLTs), by using CA, can tailor recommendations according to the interactional style of each individual family that are consonant with the family’s cultural beliefs. Three parent-child dyads were videoed playing and talking together in their home environments. The analysis uncovered a preference for instructional talk similar to that used in the classroom. Closer examination revealed that this was not inappropriate when considering the context of the activities and their perceived discourse role. Furthermore, this was not necessarily at the expense of responsivity or semantic contingency. The preference for instructional talk appeared to reflect deeply held cultural beliefs about the role of adults and children within the family and it is argued that the cultural paradigm is vitally important to consider when evaluating PCI. Given a potential risk that such young children may be vulnerable in terms of language difficulties, we offer an example of how PCI can be enhanced to encourage language development without disrupting the naturally occurring talk or the underlying purpose of the interaction

Angular momentum coefficients for meson strong decay and unquenched quark models

In most meson strong decay and unquenched (coupled-channel) quark models, the pair-creation operator is a scalar product of vectors in the spin and spatial degrees of freedom. While differing in the spatial part, most models have the same spin part, which creates a qq* pair coupled to spin triplet, with the spins of the initial quarks as spectators. This is a basic assumption of the 3P0 model, and is well-known to arise also in the flux tube model, starting from the strong coupling expansion of lattice QCD. In this article the same structure is shown to emerge in the Cornell model, in the dominant contributions of a more general microscopic decay model, and in the pseudoscalar-meson emission model. A solution is obtained for arbitrary matrix elements in these ``non-flip, triplet'' models, expressed as a weighted sum over spatial matrix elements. The coefficients in the expansion, which involve the spin degrees of freedom and the associated angular momentum algebra, are model-independent. Tables of the angular momentum coefficients are presented which can be used in future calculations, avoiding tedious Clebsch-Gordan sums. The symmetry and orthogonality properties of the coefficients are discussed, as well as their application to transitions involving hybrid mesons and states of mixed spin. New selection rules are derived, and existing ones generalised. The coefficients lead to model-independent relations among decay amplitudes and widths which can be tested in experiment and lattice QCD. They can also be used to explain how mass shifts in the unquenched quark model do not spoil successful predictions of the ordinary (quenched) quark model.Comment: 45 pages, 4 figures, 16 table

Doppler-free spectroscopy of the 1S0-3P0 optical clock transition in laser-cooled fermionic isotopes of neutral mercury

We have performed for the first time direct laser spectroscopy of the 1S0-3P0 optical clock transition at 265.6 nm in fermionic isotopes of neutral mercury laser-cooled in a magneto-optical trap. Spectroscopy is performed by measuring the depletion of the magneto-optical trap induced by the excitation of the long-lived 3P0 state by a probe at 265.6 nm. Measurements resolve the Doppler-free recoil doublet allowing for a determination of the transition frequency to an uncer- tainty well below the Doppler-broadened linewidth. We have performed absolute measurement of the frequency with respect to an ultra-stable reference monitored by LNE-SYRTE fountain pri- mary frequency standards using a femtosecond laser frequency comb. The measured frequency is 1128575290808 +/- 5.6 kHz in 199Hg and 1128569561140 +/- 5.3 kHz in 201Hg, more than 4 orders of magnitude better than previous indirect determinations. Owing to a low sensitivity to blackbody radiation, mercury is a promising candidate for reaching the ultimate performance of optical lattice clocks

Heterogeneous Timed Machines

International audienceWe present an algebra of discrete timed input/output au- tomata that execute in the context of different clock granularities -- timed machines -- as models of systems that can be dynamically inter- connected at run time in a heterogeneous context. We show how timed machines can be refined to a lower granularity of time and how timed machines with different clock granularities can be composed. We propose techniques for checking whether timed machines are consistent or feasi- ble. Finally, we investigate how consistency and feasibility of composition can be proved at run-time without computing products of automata

Numerical Simulations of Internal Wave Generation by Convection in Water

Water's density maximum at 4C makes it well suited to study internal gravity wave excitation by convection: an increasing temperature profile is unstable to convection below 4C, but stably stratified above 4C. We present numerical simulations of a water-like fluid near its density maximum in a two dimensional domain. We successfully model the damping of waves in the simulations using linear theory, provided we do not take the weak damping limit typically used in the literature. In order to isolate the physical mechanism exciting internal waves, we use the novel spectral code Dedalus to run several simplified model simulations of our more detailed simulation. We use data from the full simulation as source terms in two simplified models of internal wave excitation by convection: bulk excitation by convective Reynolds stresses, and interface forcing via the mechanical oscillator effect. We find excellent agreement between the waves generated in the full simulation and the simplified simulation implementing the bulk excitation mechanism. The interface forcing simulations over excite high frequency waves because they assume the excitation is by the "impulsive" penetration of plumes, which spreads energy to high frequencies. However, we find the real excitation is instead by the "sweeping" motion of plumes parallel to the interface. Our results imply that the bulk excitation mechanism is a very accurate heuristic for internal wave generation by convection.Comment: Accepted to PR

Patient Outcomes in Palliative Care - NSW and ACT, January - June 2019

The Australian palliative care sector is a world leader in using routine clinical assessment information to guide patient centred care and measure patient and family outcomes. Providers of palliative care are commended for their commitment to excellence in delivering evidence-based, patient-centred care by using the routine Palliative Care Outcomes Collaboration (PCOC) assessment framework and contributing patient data toward national outcome measurement and benchmarking. PCOC acknowledges the dedication and willingness of clinicians to improve the care of patients, their families and caregivers. The information collected is not just data - it represents the real-life outcomes of over 40,000 Australians who die an expected death every year. While the focus of this report is on the most recent information relating to January to June 2019, results over the last three years are also presented to highlight achievements and improvement in outcomes. The most recent information corresponds to 24,562 patients, having 31,826 episodes of care and 73,209 palliative care phases from 138 services who provide palliative care in hospital / hospice or in the person\u27s home

Transplanted enteric neural stem cells integrate within the developing chick spinal cord: implications for spinal cord repair

Spinal cord injury (SCI) causes paralysis, multisystem impairment and reduced life expectancy, as yet with no cure. Stem cell therapy can potentially replace lost neurons, promote axonal regeneration and limit scar formation, but an optimal stem cell source has yet to be found. Enteric neural stem cells (ENSC) isolated from the enteric nervous system (ENS) of the gastrointestinal (GI) tract are an attractive source. Here, we used the chick embryo to assess the potential of ENSC to integrate within the developing spinal cord. In vitro, isolated ENSC formed extensive cell connections when co-cultured with spinal cord (SC)-derived cells. Further, qRT-PCR analysis revealed the presence of TuJ1+ neurons, S100+ glia and Sox10+ stem cells within ENSC neurospheres, as well as expression of key neuronal subtype genes, at levels comparable to SC tissue. Following ENSC transplantation to an ablated region of chick embryo SC, donor neurons were found up to 12\xc2\xa0days later. These neurons formed bridging connections within the SC injury zone, aligned along the anterior/posterior axis, and were immunopositive for TuJ1. These data provide early proof of principle support for the use of ENSCs for SCI, and encourage further research into their potential for repair