VALIDITY AND RELIABILITY TEST OF NORDIC MUSCULOSCELETAL QUESTIONNAIRE (NMQ) FOR BLUE-COLLAR WORKER

Gangguan muskuloskeletal mempengaruhi produktivitas kerja pekerja industri manufaktur, khususnya garmen. Nordic Musculoskeletal Questionnare (NMQ) dapat berfungsi sebagai instrumen identifikasi atau penilaian risiko yang harus penuh dengan persyaratan validitas dan reliabilitas. Validitas dan reliabilitas pekerja kerah biru versi Nordik Muskuloskeletal Questionnare (NMQ) versi Indonesia merupakan kelanjutan dari validitas sebelumnya di Indonesia. Penelitian ini bertujuan untuk mendapatkan validitas dan reliabilitas Nordic Musculosceletal Questionnare (NMQ) dalam Bahasa Indonesia yang dapat digunakan untuk pekerja kerah biru. Kuesioner terjemahan menyederhanakan kata-kata dalam kalimat dan bahasa melalui panel diskusi ahli. Kuesioner telah diuji untuk mengetahui uji korelasi dan validitas antar butir, kemudian diuji reliabilitasnya dengan teknik pengukuran yaitu dalam waktu 7 hari untuk mendapatkan nilai Alpha Chronbach. Penelitian ini dianalisis dengan menggunakan SPSS 20 untuk hasil akhir. Penelitian menunjukkan bahwa responden yang memiliki latar belakang pendidikan maksimal SMA memberikan nilai validitas angket adalah mayoritas skor kuat (0,600 – 0,777) dan hasil angket uji reliabilitas pada penelitian pertama dan kedua memiliki nilai Alpha Cronbach yang hampir sama tingginya (0,965 – 0,966) dan berarti sangat reliabel.Musculoskeletal disorder affects work productivity of manufacturing industry workers, especially garment. Nordic Musculoskeletal Questionnare (NMQ) can serve as an identification instrument or risk assessment that must be full of validity and reliability requirements. Validity and reliability of the Nordic Musculoskeletal Questionnare (NMQ) Indonesian version of the blue collar worker is a continuation of previous validity in Indonesia. The research is aimed to get the validity and reliability of Nordic Musculosceletal Questionnare (NMQ) in Indonesian Language that can be used for blue collar worker. The translation questionnaire simplified the words in the sentence and language through a panel of expert discussion. The questionnaire has been tested to determine the inter-items correlation and validity test, then tested the reliability with the measuring technique that is within 7 days to get the value of Chronbach's Alpha. The research was analized by using SPSS 20 for final result. The research showed that respondents who have maximum education background of high school give the validity value of the questionnaire is the majority of the strong score (0.600 - 0.777) and the results of the reliability test questionnaire in the first and the second research has Cronbach's Alpha value of almost the same equally high (0.965 - 0.966) and means it is very reliable. The Nordic Musculoskeletal Questionnare (NMQ) in Bahasa Indonesia is valid and reliable to be used among blue collar worker

EFEKTIVITAS BUKU SAKU SEBAGAI MEDIA EDUKASI DALAM MENINGKATKAN PENGETAHUAN DIET DAN KEPATUHAN DIET PASIEN DIABETES MELITUS TIPE 2 DI KECAMATAN SUMBANG BANYUMAS

Latar belakang masalah : Penatalaksanaan khusus untuk diabetes melitus (DM) terdiri dari edukasi, perencanaan makan, latihan jasmani, dan terapi farmakologis. Edukasi adalah kegiatan penyampaian pesan kesehatan kepada kelompok atau individu dengan tujuan agar dapat memperoleh pengetahuan yang lebih baik. Media yang dipilih dalam adalah buku saku, karena sifatnya yang sederhana, ringkas, serta memuat banyak informasi.                                                     Tujuan : Tujuan penelitian ini untuk mengetahui efektifitas penggunaan media edukasi buku saku dalam meningkatkan pengetahuan diet, dan kepatuhan diet pasien diabetes melitus tipe 2 di Kecamatan Sumbang Banyumas. Metode : Quasi Eksperimental dengan pre test - post test design. Intervensi yang diberikan adalah edukasi dengan buku saku yang diberikan ke semua responden, sebelum dan sesudah intervensi dilakukan penilaian pengetahuan dan kepatuhan diet. Pengetahuan Diet DM dinilai dari jawaban responden atas soal yang diberikan dengan skala numerik, kepatuhan diet DM diukur dengan Percieived Dietary Adherence Questionnaire (PDAQ) dengan skala numerik, untuk mengetahui perbedaan variable bebas sebelum dan sesudah intervensi, dilakukan uji paired t-test Hasil : Dari 32 responden didapatkan hasil: untuk variable kepatuhan diet, sebelum intervensi, rata-rata nilai pengetahuan diet 9,75, sesudah intervensi menjadi 11,46, perbedaan sebelum dan sesudah intervensi dengan uji paired t test didapatkan nilai sig 2 tailed 0,029 (< 0,05), sedangkan pada variabel kepatuhan diet, nilai sebelum intervensi 26,68, sesudah intervensi 28,56. Perbedaan antara sesbelum dan sesudah / nilai sig 2 tailed 0,235. Kesimpulan : Terdapat perbedaan yang bermakna pada pengetahuan diet antara sebelum dan sesudah intervensi. Tidak terdapat perbedaan yang bermakna pada kepatuhan diet antara sebelum dan sesudah intervensi. Buku saku sebagai media edukasi efektif untuk meningkatkan pengetahuan diet, buku saku sebagai media edukasi tidak efektif untuk meningkatkan kepatuhan diet.   &nbsp

Concentration-dependent effects of resveratrol and metabolites on the redox status of human erythrocytes in single-dose studies

AbstractDietary trans-resveratrol (RES) is rapidly metabolized into sulfated and glucuronated conjugates in humans. This study focused on the in vitro determination of the antioxidant capacity of RES and its main physiological metabolites and on its relevance in vivo. In vitro, RES, RES-3-O-sulfate (R3S) and 3-O-glucuronide (R3G) showed antioxidant activities at a concentration of 1mM when compared to Trolox using an assay in which the antioxidant inhibits iron-induced linoleic acid oxidation: 0.87±0.08mM Trolox equivalents (TE) for RES, 0.52±0.01mM TE for R3S and 0.36±0.02mM TE for R3G. At a concentration of 1μM, compounds promoted linoleic acid peroxidation (RES −0.30±0.09mM TE, R3S −0.48±0.05mM TE and R3G −0.57±0.07mM TE). To elucidate whether these effects were reflected in vivo, total antioxidant capacity, reactive oxygen species (ROS), conjugated fatty acid dienes (CD), superoxide dismutase (SOD) and catalase (CAT) activities were determined in human plasma and erythrocytes over 24h, after oral intake of either 0.05g RES as piceid or 5g RES. Oral administration of RES did not show an impact on total antioxidant capacity, ROS or CD. However, enzymatic activities of ROS scavenging SOD and CAT were significantly lower after high-dose compared to low-dose administration of RES (P<.03 and P<.01). In conclusion, in healthy subjects, neither 0.05g nor 5g RES changed blood oxidative state, although our in vitro data point to a prooxidative activity of low concentrations of RES and its metabolites, which could be important in vivo for individuals with compromised antioxidant defense capacity

PERAN ORANG TUA DALAM PEMENUHAN GIZI ANAK DI 1000 HARI PERTAMA KEHIDUPAN

1000 hari pertama kehidupan anak, yang dimulai dari masa kehamilan hingga anak berusia dua tahun, merupakan periode kritis dalam perkembangan kognitif, fisik, dan emosional anak. Salah satu aspek yang paling menentukan dalam periode ini adalah pemenuhan gizi yang adekuat. Hasil riset menunjukkan bahwa kekurangan gizi pada periode ini dapat mengakibatkan gangguan perkembangan otak, keterlambatan pertumbuhan, serta penurunan kemampuan belajar di kemudian hari. Peran orang tua, khususnya ibu, sangat besar dalam memastikan terpenuhinya gizi anak selama 1000 hari pertama kehidupan. Kegiatan pengabdian masyarakat ini, menekankan peran strategis orang tua terutama ibu, dalam memastikan pemenuhan gizi yang optimal bagi anak selama 1000 hari pertama kehidupannya. Kegiatan ini dilakukan pada ibu yang memiliki anak balita di Posyandu Mugi Lestari 13, Desa Kedung Bunder, Kabupaten Banyumas. Serangkaian kegiatan dilakukan melalui pengisian kuesioner, penyuluhan, dan diskusi. Hasil dari kegiatan ini menunjukkan bahwa pengetahuan ibu tentang pemenuhan gizi anak meningkat. Dengan demikian, pertumbuhan dan perkembangan anak dapat optimal sehingga stunting dapat dicegah.The first 1000 days of a child's life, starting from pregnancy until the age of two years, is a critical period for cognitive, physical, and emotional development. One of the most determining aspects during this period is the adequacy of nutrition. Research has shown that malnutrition during this period can lead to impaired brain development, growth retardation, and reduced learning abilities later in life. The role of parents, especially mothers, is paramount in ensuring children's nutrition is fulfilled during the first 1000 days of life. This community service activity emphasizes the strategic role of parents, especially mothers, in ensuring optimal nutrition for children during the first 1000 days of their lives. This activity was carried out for mothers with toddlers at the Mugi Lestari 13 Health Post, Kedung Bunder Village, Banyumas Regency. A series of activities were carried out through questionnaires, counseling, and discussions. The results of this activity indicate that mothers' knowledge about fulfilling children's nutrition has increased. Thus, optimal growth and development of children can be achieved so that stunting can be prevented

THE EFFECT OF USING THE VISITING PATIENT APPLICATION ON THE STRESS LEVEL OF INPATIENTS AT MARGONO SOEKARJO HOSPITAL

Latar belakang: Stres adalah perasaan psikologis akibat adanya tekanan mental dan dapat memberi respon negatif terhadap kesehatan. Stres dapat berkurang dengan adanya penambahan pengetahuan melalui suatu informasi dan edukasi yang disampaikan dari media aplikasi. Aplikasi visiting patient adalah aplikasi berbasis android berisi tentang keutamaan orang yang sedang sakit. Penelitian ini bertujuan untuk mengetahui pengaruh penggunaan aplikasi visiting patient terhadap tingkat stres pasien rawat inap RS Margono Soekarjo. Metode: Penelitian ini menggunakan jenis kuantitatif quasi experimental dengan rancangan penelitian pre and post-test with control group design. Teknik pengambilan data secara non random sampling dengan pendekatan consecutive sampling. Jumlah responden 24 kontrol dan 24 intervensi. Pengukuran tingkat stres menggunakan kuesioner Depression and Anxiety Stress Scale (DASS) 21. Hasil: Rerata tingkat stres pre-test pada kelompok kontrol 9.67 dan pada kelompok intervensi 11.92, sedangkan rerata post-test pada kelompok kontrol 10.67 dan pada kelompok intervensi 10.25. Hasil uji Dependent T-Test kelompok intervensi didapatkan p=0.069 (p&gt;0.05) yang berarti tidak ada perbedaan yang bermakna pada kelompok intervensi, sedangkan kelompok kontrol didapatkan p=0.037 (p&lt;0.05) yang berarti ada perbedaan yang bermakna pada kelompok kontrol. Hasil uji Independent T-Test didapatkan p=0.796 (p&gt;0.05) yang berarti tidak ada perbedaan yang bermakna pada kelompok intervensi dan kontrol. Kesimpulan: Penggunaan aplikasi visiting patient tidak mempengaruhi tingkat stres pasien rawat inap di RS Margono Soekarjo, tetapi hanya menambah pengetahuan pasien yang setidaknya mampu merubah sikap dan pola pikir.Background: Stress is a psychological feeling due to mental stress and can give a negative response to health. Stress can be reduced by adding knowledge through information and education delivered from application media. The visiting patient application is an android-based application containing the virtues of people who are sick. This study aims to determine the effect of using the visiting patient application on the stress level of inpatients at Margono Soekarjo Hospital. method: This study used a quasi-experimental quantitative type with a pre- and post-test research design with control group design. Data collection technique by non-random sampling with a consecutive sampling approach. The number of respondents was 24 controls and 24 interventions. Measurement of stress levels using the Depression and Anxiety Stress Scale (DASS) 21 questionnaire. Results: The average pre-test stress level in the control group was 9.67 and in the intervention group was 11.92, while the post-test mean in the control group was 10.67 and in the intervention group was 10.25. The results of the Dependent T-Test test of the intervention group were obtained p=0.069 (p&gt;0.05) which means that there was no meaningful difference in the intervention group, while the control group was obtained p=0.037 (p&lt;0.05) which means that there was a meaningful difference in the control group. Independent T-Test results were obtained p=0.796 (p&gt;0.05) which means that there were no significant differences in the intervention and control groups. Conclusion: The use of the visiting patient application does not affect the stress level of inpatients at Margono Soekarjo Hospital, but only adds to the patient's knowledge that is at least able to change attitudes and mindsets

Pelatihan Manajemen ASI Perah dan Pembuatan MP-ASI Sebagai Pemenuhan Gizi di 1000 Hari Pertama Kehidupan Anak

Gerakan 1000 Hari Pertama Kehidupan (HPK) merupakan inisiatif pemerintah untuk meningkatkan gizi anak-anak pada periode emas ini. ASI eksklusif dan pemberian MP-ASI yang tepat berperan penting dalam memenuhi kebutuhan gizi bayi selama 1000 HPK. Namun, kurangnya pengetahuan ibu tentang manajemen ASI perah dan MP-ASI serta faktor eksternal memengaruhi keberhasilan pelaksanaan. Data RISKESDAS menunjukkan rendahnya cakupan ASI eksklusif di Indonesia. Pelatihan di Posyandu Mugi Lestari berhasil meningkatkan pengetahuan dan keterampilan ibu tentang manajemen ASI perah dan pembuatan MP-ASI. Hal ini dapat meningkatkan asupan gizi bayi selama 1000 HPK, mencegah stunting, dan mendukung pertumbuhan anak. Inisiatif semacam ini perlu dilakukan secara rutin untuk edukasi ibu dan pencegahan stunting di periode emas 1000 HPK anak

Concentration-dependent effects of resveratrol and metabolites on the redox status of human erythrocytes in single-dose studies

AbstractDietary trans-resveratrol (RES) is rapidly metabolized into sulfated and glucuronated conjugates in humans. This study focused on the in vitro determination of the antioxidant capacity of RES and its main physiological metabolites and on its relevance in vivo. In vitro, RES, RES-3-O-sulfate (R3S) and 3-O-glucuronide (R3G) showed antioxidant activities at a concentration of 1mM when compared to Trolox using an assay in which the antioxidant inhibits iron-induced linoleic acid oxidation: 0.87±0.08mM Trolox equivalents (TE) for RES, 0.52±0.01mM TE for R3S and 0.36±0.02mM TE for R3G. At a concentration of 1μM, compounds promoted linoleic acid peroxidation (RES −0.30±0.09mM TE, R3S −0.48±0.05mM TE and R3G −0.57±0.07mM TE). To elucidate whether these effects were reflected in vivo, total antioxidant capacity, reactive oxygen species (ROS), conjugated fatty acid dienes (CD), superoxide dismutase (SOD) and catalase (CAT) activities were determined in human plasma and erythrocytes over 24h, after oral intake of either 0.05g RES as piceid or 5g RES. Oral administration of RES did not show an impact on total antioxidant capacity, ROS or CD. However, enzymatic activities of ROS scavenging SOD and CAT were significantly lower after high-dose compared to low-dose administration of RES (P<.03 and P<.01). In conclusion, in healthy subjects, neither 0.05g nor 5g RES changed blood oxidative state, although our in vitro data point to a prooxidative activity of low concentrations of RES and its metabolites, which could be important in vivo for individuals with compromised antioxidant defense capacity

What Is New for an Old Molecule? Systematic Review and Recommendations on the Use of Resveratrol

Stilbenes are naturally occurring phytoalexins that generally exist as their more stable E isomers. The most well known natural stilbene is resveratrol (Res), firstly isolated in 1939 from roots of Veratrum grandiflorum (white hellebore) (1) and since then found in various edible plants, notably in Vitis vinifera L. (Vitaceae) (2). The therapeutic potential of Res covers a wide range of diseases, and multiple beneficial effects on human health such as antioxidant, anti-inflammatory and anti-cancer activities have been suggested based on several in vitro and animal studies (3). In particular, Res has been reported to be an inhibitor of carcinogenesis at multiple stages via its ability to inhibit cyclooxygenase, and is an anticancer agent with a role in antiangiogenesis (4). Moreover, both in vitro and in vivo studies showed that Res induces cell cycle arrest and apoptosis in tumor cells (4). However, clinical studies in humans evidenced that Res is rapidly absorbed after oral intake, and that the low level observed in the blood stream is caused by a fast conversion into metabolites that are readily excreted from the body (5). Thus, considerable efforts have gone in the design and synthesis of Res analogues with enhanced metabolic stability. Considering that reduced Res (dihydro- resveratrol, D-Res) conjugates may account for as much as 50% of an oral Res dose (5), and that D-Res has a strong proliferative effect on hormone-sensitive cancer cell lines such as breast cancer cell line MCF7 (6), we recently devoted our synthetic efforts to the preparation of trans-restricted analogues of Res in which the E carbon-carbon double bond is embedded into an imidazole nucleus. To keep the trans geometry, the two aryl rings were linked to the heteroaromatic core in a 1,3 fashion. Based on this design, we successfully prepared a variety of 1,4-, 2,4- and 2,5-diaryl substituted imidazoles including Res analogues 1, 2 and 3, respectively, by procedures that involve transition metal-catalyzed Suzuki-Miyaura cross-coupling reactions and highly selective N-H or C-H direct arylation reactions as key synthetic steps. The anticancer activity of compounds 1–3 was evaluated against the 60 human cancer cell lines panel of the National Cancer Institute (NCI, USA). The obtained results, that will be showed and discussed along with the protocols developed for the preparation of imidazoles 1–3, confirmed that a structural optimization of Res may provide analogues with improved potency in inhibiting the growth of human cancer cell lines in vitro when compared to their natural lead. (1) Takaoka,M.J.Chem.Soc.Jpn.1939,60,1090-1100. (2) Langcake, P.; Pryce, R. J. Physiological. Plant Patology 1976, 9, 77-86. (3) Vang, O.; et al. PLoS ONE 2011, 6, e19881. doi:10.1371/journal.pone.0019881 (4) Kraft, T. E.; et al. Critical Reviews in Food Science and Nutrition 2009, 49, 782-799. (5) Walle, T. Ann. N.Y. Acad. Sci. 2011, 1215, 9-15. doi: 10.1111/j.1749-6632.2010.05842.x (6) Gakh,A.A.;etal.Bioorg.Med.Chem.Lett.2010,20,6149-6151