65 research outputs found

    Percepción de la personalidad de marca en artículos deportivos en estudiantes universitarios españoles

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    his research analyzes the work that sports brands do to be present in the consumer mind, measuring the perception of the Brand Personality of some of the most important ones. Using the adapted version to the Spanish market of Brand Personality Scale created by Aaker in 1997, there were measured the perceptions of four of the most important current brands of sports material on the world market and particularly in the Spanish - Adidas, Nike, Puma and Decathlon-. his study realized with a sample of 424 survey respondents that mostly practiced sports. he study measured the existing diferences according to whether the respondent usually practiced sport, age, gender or if they had federative license. To do these, the Diferences were analyzed using Student’s t-test for independent samples between two groups or analysis of variance (ANOVA) with Schefé’s posthoc test for comparisons with more than two groups. A perfectly deined Brand Personality facilitates the consumer choice in an environment of overabundance of information. he results of study conirm that Adidas and Nike are those who obtain better punctuations in all the Dimensions of Brand Personality, primarily among young people, which are exactly the group of age who is their principal target. Moreover, Decathlon, stands out for its high valuation in Peacefulness, an aspect that can turn out to be an attraction to the increasing group of people who joins to the sports practice.Esta investigación analiza el trabajo que realizan las marcas deportivas para estar presentes en la mente del consumidor, midiendo la percepción de la Personalidad de Marca de algunas de las más importantes. Utilizando la versión adaptada al mercado español de la escala de Personalidad de Marca creada por Aaker en 1997, fueron medidas las percepciones de cuatro de las más importantes marcas de material deportivo presentes en el mercado mundial y particularmente en el español – Adidas, Nike, Puma y Decathlon-. El estudio se realizó con una muestra de 424 individuos que mayoritariamente eran practicantes de actividad física y deporte. Se midieron las diferencias existentes en función de si el encuestado practicaba habitualmente deporte, de la edad, del género o de si tenía licencia federativa. Para hacerlo se analizaron las diferencias por medio de la t de Student para muestras independientes entre dos grupos o el análisis de varianza (ANOVA) con prueba post-hoc de Schefé para comparaciones con más de dos grupos. Tener una Personalidad de Marca perfectamente deinida facilita la elección del consumidor, ayudando a la toma de decisiones en un entorno de sobreabundancia de información. Los resultados de nuestro estudio conirman que Adidas y Nike son las que obtienen mejores puntuaciones en todas las Dimensiones de Personalidad de Marca, principalmente entre los más jóvenes, que son justamente el grupo de edad al que suelen dirigir sus acciones de promoción. Por su parte, Decathlon, destaca por su buena valoración en la dimensión de Tranquilidad, un aspecto que puede resultar atractivo al creciente grupo de nuevos practicantes de actividad física

    Cerâmica romana importada na Foz do Douro : uma escavação arqueológica no Castelo de Gaia (V. N. Gaia, Norte de Portugal)

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    A colina do Castelo de Gaia é um dos locais mais emblemáticos da ocupação humanana foz do rio Douro. Numa das intervenções arqueológicas ali realizadas, em 2008, motivada pelanecessidade de avaliação prévia de um projeto imobiliário, encontraram-se restos de estruturasda época romana e signicativo espólio cerâmico.Observaram-se as cerâmicas de importação procedentes desta intervenção a m de analisar acirculação e consumo de recipientes em diferentes momentos da ocupação romana na região. Nasproduções mais antigas destacam-se formas do séc. I a.C., como ânforas vinárias provenientes dazona campana. Muito signicativas são também as produções tardo-antigas, representadas porânforas orientais, a par de sigillata e cerâmicas comuns.The hill known as Castelo de Gaia is one of the main places of ancient human occupationat Douros river mouth. An archaeological excavation that occurred there in 2008, due toa previous archaeological evaluation of a building project, led to the discovery of Roman ruinsand relevant ceramic nds.is paper focuses the imported wares set, providing data to further analyse on certain vesselscirculation and consumption in dierent moments of Roman presence in the region. Amongstthe most ancient wares there are types of the 1st century BC, like Campanian amphorae used forwine trade. Several Late-Antique productions were also identied, like Oriental amphorae, as wellas LRC ne wares and other imported table ceramic

    Epidermolysis bullosa (EB): Pathogenesis, clinical, diagnostic and genetic aspects, molecular basis, epidemiological aspects, management of patients with EB and translational implications of mutation analysis

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    Dismorfología, Citogenética y Clínica: Resultados de estudios sobre los datos del ECEMCUnder the term "Epidermolysis Bullosa" (EB), there is a heterogeneous group of vesicular disorders that are generally congenital and of genetic origin, and affect skin and often mucosas. It is remarkable the extreme fragility of these epithelia; the vesicles arise spontaneously as well as induced by even slight trauma or the influence of high temperatures. Their content is sero-hemorrhagic and in the scarring can be very difficult. As a consecuence of the scarring processes, joint contractures and fusion of digits (pseudo-syndactyly) can occur. Pathogenetically, EB is caused by abnormal blistering at the basement membrane zone in the dermal-epidermal attachment zone and its surroundings. This is due to alterations in the attachment complexes, and some mutations have been identified in a total of 10 genes expressed in such level. Four main types of EB can be distinguished (simple, junctional, dystrophic and hemidesmosomal), depending on the level at which the cleavage that forms the bulla takes place, although about 30 subtypes have been described. The clinical characteristics or optic microscopy are not adequate for diagnosis, and it is mandatory to perform electron microscopy, immunofluorescent and immunohistochemical studies, as well as mutation analysis if available. Regarding the epidemiological aspects, in the Spanish Collaborative Study of Congenital Malformations (ECEMC), since 1976 up to December 2004, a total of 2,204,264 liveborn infants were controlled and, among them 27 cases have been identified, for a minimum frequency of 0.12 per 10,000 (95% confidence interval:0.08-0.18). It seems generally accepted that the determination of the frequency of EB is subject to multiple biases and registration of cases is always incomplete. We have also reviewed the issues related to management of EB patients by clinicians.N

    Complex I-Associated Hydrogen Peroxide Production Is Decreased and Electron Transport Chain Enzyme Activities Are Altered in n-3 Enriched fat-1 Mice

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    The polyunsaturated nature of n-3 fatty acids makes them prone to oxidative damage. However, it is not clear if n-3 fatty acids are simply a passive site for oxidative attack or if they also modulate mitochondrial reactive oxygen species (ROS) production. The present study used fat-1 transgenic mice, that are capable of synthesizing n-3 fatty acids, to investigate the influence of increases in n-3 fatty acids and resultant decreases in the n-6∶n-3 ratio on liver mitochondrial H2O2 production and electron transport chain (ETC) activity. There was an increase in n-3 fatty acids and a decrease in the n-6∶n-3 ratio in liver mitochondria from the fat-1 compared to control mice. This change was largely due to alterations in the fatty acid composition of phosphatidylcholine and phosphatidylethanolamine, with only a small percentage of fatty acids in cardiolipin being altered in the fat-1 animals. The lipid changes in the fat-1 mice were associated with a decrease (p<0.05) in the activity of ETC complex I and increases (p<0.05) in the activities of complexes III and IV. Mitochondrial H2O2 production with either succinate or succinate/glutamate/malate substrates was also decreased (p<0.05) in the fat-1 mice. This change in H2O2 production was due to a decrease in ROS production from ETC complex I in the fat-1 animals. These results indicate that the fatty acid changes in fat-1 liver mitochondria may at least partially oppose oxidative stress by limiting ROS production from ETC complex I

    Differential requirements for Tousled-like kinases 1 and 2 in mammalian development

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    The regulation of chromatin structure is critical for a wide range of essential cellular processes. The Tousled-like kinases, TLK1 and TLK2, regulate ASF1, a histone H3/H4 chaperone, and likely other substrates, and their activity has been implicated in transcription, DNA replication, DNA repair, RNA interference, cell cycle progression, viral latency, chromosome segregation and mitosis. However, little is known about the functions of TLK activity in vivo or the relative functions of the highly similar TLK1 and TLK2 in any cell type. To begin to address this, we have generated Tlk1- and Tlk2-deficient mice. We found that while TLK1 was dispensable for murine viability, TLK2 loss led to late embryonic lethality because of placental failure. TLK2 was required for normal trophoblast differentiation and the phosphorylation of ASF1 was reduced in placentas lacking TLK2. Conditional bypass of the placental phenotype allowed the generation of apparently healthy Tlk2-deficient mice, while only the depletion of both TLK1 and TLK2 led to extensive genomic instability, indicating that both activities contribute to genome maintenance. Our data identifies a specific role for TLK2 in placental function during mammalian development and suggests that TLK1 and TLK2 have largely redundant roles in genome maintenance

    Very low frequency Syndromes

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    Dismorfología, Citogenética y Clínica: Resultados de estudios sobre los datos del ECEMCThe aim of this chapter is to summarize updated knowledge about the clinical characteristics, etiology, genetic and molecular aspects, as well as mechanisms involved in syndromes having very low frequency, in order to promote their better recognition. During the last five years, a total of 30 syndromes have been published in this chapter of the Boletín del ECEMC. This issue includes the following selected syndromes: Crouzon, Pfeiffer, Apert, Saethre-Chotzen, Carpenter and Muenke. All share craniosynostosis as the main clinical feature but also present with other birth defects, the most important being limb malformations, specially syndactyly and polydactyly. Over 100 syndromes with craniosynostosis have been described, usually involving multiple sutures, and several of them are associated with limb malformations. The clinical overlapping between those syndromes makes difficult to perform a neonatal diagnosis, based on their clinical findings. However, molecular genetic testing, specifically of the FRGR1-3 and TWIST1 genes, could help to establish the diagnosis of some of them. Early diagnosis is important for establishing the most suitable treatment for each patient, as well as to offer an accurate genetic counselling and the possibility of preimplantational and/or prenatal diagnosis.N
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