RESPONSE OF WEANED PIGS TO DIFFERENT DIETARY PROTEIN SOURCES AND DIET TYPES

Pig is one of the most consumed meat across the globe. However, its production is limited by high cost of feed ingredients. Hence, the search for alternative cheap feed ingredients without any loss to animal’s performance is on the increase. The influence of different protein sources and feed types (wet or dry) was investigated on the growth performance, haematology and serum biochemistry of weaned pigs. Weight gain and feed conversion ratio were higher for soybean and full-fat soya-based diets. Feed and water intake were not significantly different amongst treatments. Nature of feed did not influence weight gain, feed intake and feed conversion ratio. Groundnut cake meal may compare with soybean meal in pig’s diet, but it may have to be supplemented with lysine, methionine or fish meal.   &nbsp

Determinants of prostate specific antigen screening test uptake in an urban community in North-Central Nigeria

Background: Despite the increasing incidence of Prostate cancer, there has not been any focused screening policy or strategy in sub-Saharan Africa including Nigeria.Objectives: To assess the level of awareness and uptake of PSA screening test and their determinants in a Nigerian community.Methods: A cross-sectional population survey of men with no prior history of prostate cancer was carried out. Logistic re- gression analysis was used to determine the effect of identified variables in predicting awareness and uptake of prostate cancer screening.Results: Mean age was 51.5±9.8 years; a few men (31, 16.9%) had ever heard of the screening test and most got the information from health centers. A low proportion (8, 4.4%) had taken the screening test. Men with incomes above poverty line (OR = 11.7 2.8–50.1, p = .001) or those with health insurance (OR = 2.7 1.2–6.5, p = .023) were significantly more likely to be aware of the test. Only the men with higher incomes (OR = 25.6 5.8–114.2, p = .0001) were significantly more likely to have taken the test.Conclusion: Higher incomes and health insurance status impact screening awareness but only income status determines if men subsequently proceed to take the PSA screening test.Keywords: Prostate cancer; PSA screening; sub-Saharan Africa; Nigeria

A Compact Size and Low Profile Rectangular Slot Monopole Antenna for UWB Body Centric Applications

A compact-size rectangular slot antenna required for ultra-wide band body centric applications is presented. The antenna design is based on etching a rectangular slot on a circular radiator. The antenna geometric design parameters are determined by a state-of-the-art AI-driven antenna design method. Analysis of the proposed antenna was carried out and its performance assessed in terms of bandwidth, gain, efficiency, and radiation pattern. Results investigated show that the rectangular slot antenna maintains its bandwidth when placed in closed contact with the human body phantom. The very close agreement between the simulated and measured results both in free space and on body indicates that the antenna performance is immune to variation in the presence of human body phantom and robust to fabrication tolerances

Alcohol Use and its Associated Factors among Residents of an Urban Community in Plateau State Nigeria

Background:According to the World Health Organization (WHO), alcohol use contributes about 2.3 million deaths globally and accounts for 3.8% of global mortality. Nigeria ranks as the leading country in alcohol consumption in Africa. In view of this, this study was conducted to assess the level of alcohol use and its associated factors among residents of an urban community in Plateau state, Nigeria.Methodology: A cross sectional study carried outnbsp among 212 adult residents of AngwanRukuba community of Jos North Local Government Area of Plateau Statenbsp using quantitative method of data collection.nbsp Epi info statistical software version 7.0 was used for data analysis with adjusted odds ratio and 95% confidence intervalused in the study while a p-value of le 0.05 was considered statistically significant.Result: The average age of the respondents in this study was 28.2plusmn10.4 years with majority being 30 years and below. More of the respondents 142(60.8%) were current consumers of alcoholic drinks with harmful level of alcohol intake found to be 32.0%.Sex, quantity of drinks adjudged as normal in one sitting and age of onset of alcohol use were found to significantly predict harmful intake of alcohol containing drinks in the study.Conclusion: A relatively high level of alcohol use was found in this study with a corresponding level of harmful use. Sex, age of onset of alcohol use and quantity of drinks adjudged as normal in a sitting were significant contributors to harmful alcohol use.nbs

Determinants of prostate specific antigen screening test uptake in an urban community in North-Central Nigeria

Background: Despite the increasing incidence of Prostate cancer, there has not been any focused screening policy or strategy in sub-Saharan Africa including Nigeria. Objectives: To assess the level of awareness and uptake of PSA screening test and their determinants in a Nigerian community. Methods: A cross-sectional population survey of men with no prior history of prostate cancer was carried out. Logistic regression analysis was used to determine the effect of identified variables in predicting awareness and uptake of prostate cancer screening. Results: Mean age was 51.5\ub19.8 years; a few men (31, 16.9%) had ever heard of the screening test and most got the information from health centers. A low proportion (8, 4.4%) had taken the screening test. Men with incomes above poverty line (OR = 11.7 2.8\u201350.1, p = .001) or those with health insurance (OR = 2.7 1.2\u20136.5, p = .023) were significantly more likely to be aware of the test. Only the men with higher incomes (OR = 25.6 5.8\u2013114.2, p = .0001) were significantly more likely to have taken the test. Conclusion: Higher incomes and health insurance status impact screening awareness but only income status determines if men subsequently proceed to take the PSA screening test. DOI: https://dx.doi.org/10.4314/ahs.v19i1.42 Cite as: Bello JO, Buhari T, Mohammed TO, Olanipekun HB, Egbuniwe AM, Fasiku OK, et al. Determinants of prostate specific antigen screening test uptake in an urban community in North-Central Nigeria. Afri Health Sci. 2019;19(1). 1665-1670. https://dx.doi.org/10.4314/ ahs. v19i1.4

Evidence that breast cancer risk at the 2q35 locus is mediated through IGFBP5 regulation.

GWAS have identified a breast cancer susceptibility locus on 2q35. Here we report the fine mapping of this locus using data from 101,943 subjects from 50 case-control studies. We genotype 276 SNPs using the 'iCOGS' genotyping array and impute genotypes for a further 1,284 using 1000 Genomes Project data. All but two, strongly correlated SNPs (rs4442975 G/T and rs6721996 G/A) are excluded as candidate causal variants at odds against >100:1. The best functional candidate, rs4442975, is associated with oestrogen receptor positive (ER+) disease with an odds ratio (OR) in Europeans of 0.85 (95% confidence interval=0.84-0.87; P=1.7 × 10(-43)) per t-allele. This SNP flanks a transcriptional enhancer that physically interacts with the promoter of IGFBP5 (encoding insulin-like growth factor-binding protein 5) and displays allele-specific gene expression, FOXA1 binding and chromatin looping. Evidence suggests that the g-allele confers increased breast cancer susceptibility through relative downregulation of IGFBP5, a gene with known roles in breast cell biology

Functional mechanisms underlying pleiotropic risk alleles at the 19p13.1 breast-ovarian cancer susceptibility locus

A locus at 19p13 is associated with breast cancer (BC) and ovarian cancer (OC) risk. Here we analyse 438 SNPs in this region in 46,451 BC and 15,438 OC cases, 15,252 BRCA1 mutation carriers and 73,444 controls and identify 13 candidate causal SNPs associated with serous OC (P=9.2 × 10-20), ER-negative BC (P=1.1 × 10-13), BRCA1-associated BC (P=7.7 × 10-16) and triple negative BC (P-diff=2 × 10-5). Genotype-gene expression associations are identified for candidate target genes ANKLE1 (P=2 × 10-3) and ABHD8 (P<2 × 10-3). Chromosome conformation capture identifies interactions between four candidate SNPs and ABHD8, and luciferase assays indicate six risk alleles increased transactivation of the ADHD8 promoter. Targeted deletion of a region containing risk SNP rs56069439 in a putative enhancer induces ANKLE1 downregulation; and mRNA stability assays indicate functional effects for an ANKLE1 3′-UTR SNP. Altogether, these data suggest that multiple SNPs at 19p13 regulate ABHD8 and perhaps ANKLE1 expression, and indicate common mechanisms underlying breast and ovarian cancer risk

Meningococcus serogroup C clonal complex ST-10217 outbreak in Zamfara State, Northern Nigeria.

After the successful roll out of MenAfriVac, Nigeria has experienced sequential meningitis outbreaks attributed to meningococcus serogroup C (NmC). Zamfara State in North-western Nigeria recently was at the epicentre of the largest NmC outbreak in the 21st Century with 7,140 suspected meningitis cases and 553 deaths reported between December 2016 and May 2017. The overall attack rate was 155 per 100,000 population and children 5-14 years accounted for 47% (3,369/7,140) of suspected cases. The case fatality rate (CFR) among children 5-9 years was 10%, double that reported among adults ≥ 30 years (5%). NmC and pneumococcus accounted for 94% (172/184) and 5% (9/184) of the laboratory-confirmed cases, respectively. The sequenced NmC belonged to the ST-10217 clonal complex (CC). All serotyped pneumococci were PCV10 serotypes. The emergence of NmC ST-10217 CC outbreaks threatens the public health gains made by MenAfriVac, which calls for an urgent strategic action against meningitis outbreaks