Cooperation and Cheating

In this article, we extend the variable delivery claim framework (Cross, Buccola, and Thomann, 2006) to examine the option-to-cheat, that is, the option to shift production between contracts ex post. We use this framework to provide a solution to the age-old conflict between enforcement and the cooperative tradition of providing a "home" for member produce. We show that, in contrast to Nourse's competitive yardstick hypothesis, the value of the cooperative-provided option increases as market competition intensifies. When the option-to-cheat is fairly-priced, it is Pareto improving, increasing grower returns, lowering cooperative per-unit costs and reducing contract shortfalls for investor-owned rivals at no additional per-unit cost. Our valuation framework is consistent with replication-based equilibria and is free from parametric specification of individual preference or firm cost structure.Marketing,

Time of flight identification with FAZIA

This contribution reports on the time of flight implementation in the FAZIA Si-Si-CsI(Tl) telescopes, focusing on the basic ideas of the method and on some preliminary results from recent experiments at LNS

Time of flight identification with FAZIA

FAZIA (Forward A and Z identification Array) is an array of threestage Si-Si-CsI(Tl) telescopes. It was designed to operate with beams in the 20– 100MeV/u energy range and it provides charge and mass discrimination over a wide range of nuclei and energies. In the perspective of FAZIA experiments at lower energies (e.g. to be realized at the new ISOL facilities SPES and/or Spiral2), and in general to lower the identification thresholds, the time of flight (ToF) information could be used. Usually, the time of flight can be obtained in two ways: either two detectors (start and stop) are used at a certain well-measured distance, or the start time mark is given by the accelerator RF signal. In order to work also in the absence of pulsed beam, we are studying and implementing a new approach that works for those events where at least one ejectile is properly discriminated in mass. The identified fragments can be used to extract the event start time mark from their energy and mass. This algorithm needs a perfect synchronisation among all the ADC clock signals and a precise tuning of all the possible clock skews. This contribution reports on such recent FAZIA activity, focusing on the basic ideas of the method and on some first results from recent experiments at LNS

New investigations on the 32S(3He,d)33Cl reaction at 9.6 MeV bombarding energy

The 32S(3He,d)33Cl one-proton transfer reaction is a powerful tool to investigate the spectroscopy of low-lying states in the proton-rich 33Cl nucleus. However, the extraction of firm differential cross-section data at various angles to benchmark and constrain theoretical models is made challenging by the presence of competitive reactions on target contaminants. In this paper we report on arecent measurement using a new generation hodoscope of silicon detectors, capable to detect and identify emitted deuterons down to energies of the order of 2 MeV. The high angular segmentation of our hodoscope combined with a suitable target to control possible contaminants, allowed to unambiguously disentangle the contribution of various states in 33Cl, in particular the 2.352 MeV state lying just few tens of keV above the proton separation energy

Study of the 32S(3He,d)33Cl one-proton transfer reaction with a new generation hodoscope

Abstract The 32S(3He,d)33Cl one-proton transfer reaction is a powerful tool to investigate the spectroscopy of low-lying states in the proton-rich 33Cl nucleus. However, the extraction of firm differential cross-section data at various angles, against which benchmarking theoretical models to correctly constrain the spectroscopy of 33Cl, is made challenging by the presence of competitive reaction products contaminating the detected energy spectra. We have recently measured the 32S(3He,d)33Cl reaction at 9.8 MeV incident energy by using a new generation hodoscope of silicon detectors, capable to detect and identify emitted deuterons down to energies of the order of 2 MeV. The high angular segmentation of our hodoscope allowed to unambiguously disentangle the contribution of one-proton transfer reactions in the ground state of 33Cl and in its 0.810 MeV, 2.352 MeV, 2.685 MeV, 2.846 MeV excited states from contaminant deuteron-emitting reactions. These data will be crucial to help to constrain Jπ and spectroscopic factor C 2 Sp values of low-lying 33Cl states, still ambiguous in the literature. The present status of the analysis is discussed in the paper

A Rare Functional Noncoding Variant at the GWAS-Implicated MIR137/MIR2682 Locus Might Confer Risk to Schizophrenia and Bipolar Disorder

Schizophrenia (SZ) genome-wide association studies (GWASs) have identified common risk variants in >100 susceptibility loci; however, the contribution of rare variants at these loci remains largely unexplored. One of the strongly associated loci spans MIR137 (miR137) and MIR2682 (miR2682), two microRNA genes important for neuronal function. We sequenced ∼6.9 kb MIR137/MIR2682 and upstream regulatory sequences in 2,610 SZ cases and 2,611 controls of European ancestry. We identified 133 rare variants with minor allele frequency (MAF) <0.5%. The rare variant burden in promoters and enhancers, but not insulators, was associated with SZ (p = 0.021 for MAF < 0.5%, p = 0.003 for MAF < 0.1%). A rare enhancer SNP, 1:g.98515539A>T, presented exclusively in 11 SZ cases (nominal p = 4.8 × 10−4). We further identified its risk allele T in 2 of 2,434 additional SZ cases, 11 of 4,339 bipolar (BP) cases, and 3 of 3,572 SZ/BP study controls and 1,688 population controls; yielding combined p values of 0.0007, 0.0013, and 0.0001 for SZ, BP, and SZ/BP, respectively. The risk allele T of 1:g.98515539A>T reduced enhancer activity of its flanking sequence by >50% in human neuroblastoma cells, predicting lower expression of MIR137/MIR2682. Both empirical and computational analyses showed weaker transcription factor (YY1) binding by the risk allele. Chromatin conformation capture (3C) assay further indicated that 1:g.98515539A>T influenced MIR137/MIR2682, but not the nearby DPYD or LOC729987. Our results suggest that rare noncoding risk variants are associated with SZ and BP at MIR137/MIR2682 locus, with risk alleles decreasing MIR137/MIR2682 expression

Variability in Working Memory Performance Explained by Epistasis vs Polygenic Scores in the ZNF804A Pathway

Importance: We investigated the variation in neuropsychological function explained by risk alleles at the psychosis susceptibility gene ZNF804A and its interacting partners using single nucleotide polymorphisms (SNPs), polygenic scores, and epistatic analyses. Of particular importance was the relative contribution of the polygenic score vs epistasis in variation explained. Objectives To (1) assess the association between SNPs in ZNF804A and the ZNF804A polygenic score with measures of cognition in cases with psychosis and (2) assess whether epistasis within the ZNF804A pathway could explain additional variation above and beyond that explained by the polygenic score. Design, Setting, and Participants: Patients with psychosis (n = 424) were assessed in areas of cognitive ability impaired in schizophrenia including IQ, memory, attention, and social cognition. We used the Psychiatric GWAS Consortium 1 schizophrenia genome-wide association study to calculate a polygenic score based on identified risk variants within this genetic pathway. Cognitive measures significantly associated with the polygenic score were tested for an epistatic component using a training set (n = 170), which was used to develop linear regression models containing the polygenic score and 2-SNP interactions. The best-fitting models were tested for replication in 2 independent test sets of cases: (1) 170 individuals with schizophrenia or schizoaffective disorder and (2) 84 patients with broad psychosis (including bipolar disorder, major depressive disorder, and other psychosis). Main Outcomes and Measures: Participants completed a neuropsychological assessment battery designed to target the cognitive deficits of schizophrenia including general cognitive function, episodic memory, working memory, attentional control, and social cognition. Results: Higher polygenic scores were associated with poorer performance among patients on IQ, memory, and social cognition, explaining 1% to 3% of variation on these scores (range, P = .01 to .03). Using a narrow psychosis training set and independent test sets of narrow phenotype psychosis (schizophrenia and schizoaffective disorder), broad psychosis, and control participants (n = 89), the addition of 2 interaction terms containing 2 SNPs each increased the R2 for spatial working memory strategy in the independent psychosis test sets from 1.2% using the polygenic score only to 4.8% (P = .11 and .001, respectively) but did not explain additional variation in control participants. Conclusions and Relevance: These data support a role for the ZNF804A pathway in IQ, memory, and social cognition in cases. Furthermore, we showed that epistasis increases the variation explained above the contribution of the polygenic score