384 research outputs found
Lextale-Esp: a test to rapidly and efficiently assess the Spanish vocabulary size
The methods to measure vocabulary size vary across disciplines. This heterogeneity hinders direct comparisons between studies and slows down the understanding of research findings. A quick, free and efficient test of English language proficiency, LexTALE, was recently developed to remedy this problem. LexTALE has been validated and shown to be an effective tool for distinguishing between different levels of proficiency in English. The test has also been made available in Dutch, German, and French. The present study discusses the development of a Spanish version of the test: Lextale-Esp. The test discriminated well at the high and the low end of Spanish proficiency and returned a big difference between the vocabulary size of Spanish native and non-native speakers
How strongly do word reading times and lexical decision times correlate? Combining data from eye movement corpora and megastudies
We assess the amount of shared variance between three measures of visual word recognition latencies: eye movement latencies, lexical decision times and naming times. After partialling out the effects of word frequency and word length, two well-documented predictors of word recognition latencies, we see that 7-44% of the variance is uniquely shared between lexical decision times and naming times, depending on the frequency range of the words used. A similar analysis of eye movement latencies shows that the percentage of variance they uniquely share either with lexical decision times or with naming times is much lower. It is 5 – 17% for gaze durations and lexical decision times in studies with target words presented in neutral sentences, but drops to .2% for corpus studies in which eye movements to all words are analysed. Correlations between gaze durations and naming latencies are lower still. These findings suggest that processing times in isolated word processing and continuous text reading are affected by specific task demands and presentation format, and that lexical decision times and naming times are not very informative in predicting eye movement latencies in text reading once the effect of word frequency and word length are taken into account. The difference between controlled experiments and natural reading suggests that reading strategies and stimulus materials may determine the degree to which the immediacy-of-processing assumption and the eye-mind assumption apply. Fixation times are more likely to exclusively reflect the lexical processing of the currently fixated word in controlled studies with unpredictable target words rather than in natural reading of sentences or texts
FDTD Simulation of Thermal Noise in Open Cavities
A numerical model based on the finite-difference time-domain (FDTD) method is
developed to simulate thermal noise in open cavities owing to output coupling.
The absorbing boundary of the FDTD grid is treated as a blackbody, whose
thermal radiation penetrates the cavity in the grid. The calculated amount of
thermal noise in a one-dimensional dielectric cavity recovers the standard
result of the quantum Langevin equation in the Markovian regime. Our FDTD
simulation also demonstrates that in the non-Markovian regime the buildup of
the intracavity noise field depends on the ratio of the cavity photon lifetime
to the coherence time of thermal radiation. The advantage of our numerical
method is that the thermal noise is introduced in the time domain without prior
knowledge of cavity modes.Comment: 8 pages, 7 figure
Structure and dynamics of a human myelin protein P2 portal region mutant indicate opening of the β barrel in fatty acid binding proteins
Abstract
Background
Myelin is a multilayered proteolipid sheath wrapped around selected axons in the nervous system. Its constituent proteins play major roles in forming of the highly regular membrane structure. P2 is a myelin-specific protein of the fatty acid binding protein (FABP) superfamily, which is able to stack lipid bilayers together, and it is a target for mutations in the human inherited neuropathy Charcot-Marie-Tooth disease. A conserved residue that has been proposed to participate in membrane and fatty acid binding and conformational changes in FABPs is Phe57. This residue is thought to be a gatekeeper for the opening of the portal region upon ligand entry and egress.
Results
We performed a structural characterization of the F57A mutant of human P2. The mutant protein was crystallized in three crystal forms, all of which showed changes in the portal region and helix α2. In addition, the behaviour of the mutant protein upon lipid bilayer binding suggested more unfolding than previously observed for wild-type P2. On the other hand, membrane binding rendered F57A heat-stable, similarly to wild-type P2. Atomistic molecular dynamics simulations showed opening of the side of the discontinuous β barrel, giving important indications on the mechanism of portal region opening and ligand entry into FABPs. The results suggest a central role for Phe57 in regulating the opening of the portal region in human P2 and other FABPs, and the F57A mutation disturbs dynamic cross-correlation networks in the portal region of P2.
Conclusions
Overall, the F57A variant presents similar properties to the P2 patient mutations recently linked to Charcot-Marie-Tooth disease. Our results identify Phe57 as a residue regulating conformational changes that may accompany membrane surface binding and ligand exchange in P2 and other FABPs
Evidence for the association of the S100beta gene with low cognitive performance and dementia in the elderly
SentiBench - a benchmark comparison of state-of-the-practice sentiment analysis methods
In the last few years thousands of scientific papers have investigated
sentiment analysis, several startups that measure opinions on real data have
emerged and a number of innovative products related to this theme have been
developed. There are multiple methods for measuring sentiments, including
lexical-based and supervised machine learning methods. Despite the vast
interest on the theme and wide popularity of some methods, it is unclear which
one is better for identifying the polarity (i.e., positive or negative) of a
message. Accordingly, there is a strong need to conduct a thorough
apple-to-apple comparison of sentiment analysis methods, \textit{as they are
used in practice}, across multiple datasets originated from different data
sources. Such a comparison is key for understanding the potential limitations,
advantages, and disadvantages of popular methods. This article aims at filling
this gap by presenting a benchmark comparison of twenty-four popular sentiment
analysis methods (which we call the state-of-the-practice methods). Our
evaluation is based on a benchmark of eighteen labeled datasets, covering
messages posted on social networks, movie and product reviews, as well as
opinions and comments in news articles. Our results highlight the extent to
which the prediction performance of these methods varies considerably across
datasets. Aiming at boosting the development of this research area, we open the
methods' codes and datasets used in this article, deploying them in a benchmark
system, which provides an open API for accessing and comparing sentence-level
sentiment analysis methods
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SEIS: Insight's Seismic Experiment for Internal Structure of Mars.
By the end of 2018, 42 years after the landing of the two Viking seismometers on Mars, InSight will deploy onto Mars' surface the SEIS (Seismic Experiment for Internal Structure) instrument; a six-axes seismometer equipped with both a long-period three-axes Very Broad Band (VBB) instrument and a three-axes short-period (SP) instrument. These six sensors will cover a broad range of the seismic bandwidth, from 0.01 Hz to 50 Hz, with possible extension to longer periods. Data will be transmitted in the form of three continuous VBB components at 2 sample per second (sps), an estimation of the short period energy content from the SP at 1 sps and a continuous compound VBB/SP vertical axis at 10 sps. The continuous streams will be augmented by requested event data with sample rates from 20 to 100 sps. SEIS will improve upon the existing resolution of Viking's Mars seismic monitoring by a factor of ∼ 2500 at 1 Hz and ∼ 200 000 at 0.1 Hz. An additional major improvement is that, contrary to Viking, the seismometers will be deployed via a robotic arm directly onto Mars' surface and will be protected against temperature and wind by highly efficient thermal and wind shielding. Based on existing knowledge of Mars, it is reasonable to infer a moment magnitude detection threshold of M w ∼ 3 at 40 ∘ epicentral distance and a potential to detect several tens of quakes and about five impacts per year. In this paper, we first describe the science goals of the experiment and the rationale used to define its requirements. We then provide a detailed description of the hardware, from the sensors to the deployment system and associated performance, including transfer functions of the seismic sensors and temperature sensors. We conclude by describing the experiment ground segment, including data processing services, outreach and education networks and provide a description of the format to be used for future data distribution.Electronic supplementary materialThe online version of this article (10.1007/s11214-018-0574-6) contains supplementary material, which is available to authorized users
Spelling-to-sound correspondences affect acronym recognition processes
A large body of research has examined the factors which affect the speed with which words are recognised in lexical decision tasks. Nothing has yet been reported concerning the important factors in differentiating acronyms (e.g. BBC, HIV, NASA) from non-words. It appears that this task poses little problem for skilled readers, in spite of the fact that acronyms have uncommon, even illegal, spellings in English. We used regression techniques to examine the role of a number of lexical and non-lexical variables known to be important in word processing in relation to lexical decision for acronym targets. Findings indicated that acronym recognition is affected by age of acquisition and imageability. In a departure from findings in word recognition,acronym recognition was not affected by frequency. Lexical decision responses for acronyms were also affected by the relationship between spelling and sound - a pattern not usually observed in word recognition. We argue that the complexity of acronym recognition means that the process draws phonological information in addition to
semantics
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