Cavity-enhanced optical frequency comb spectroscopy in the mid-infrared - application to trace detection of H2O2

We demonstrate the first cavity-enhanced optical frequency comb spectroscopy in the mid-infrared wavelength region and report the sensitive real-time trace detection of hydrogen peroxide in the presence of a large amount of water. The experimental apparatus is based on a mid-infrared optical parametric oscillator synchronously pumped by a high power Yb:fiber laser, a high finesse broadband cavity, and a fast-scanning Fourier transform spectrometer with autobalancing detection. The comb spectrum with a bandwidth of 200 nm centered around 3.75 {\mu}m is simultaneously coupled to the cavity and both degrees of freedom of the comb, i.e., the repetition rate and carrier envelope offset frequency, are locked to the cavity to ensure stable transmission. The autobalancing detection scheme reduces the intensity noise by a factor of 300, and a sensitivity of 5.4 {\times} 10^-9 cm^-1 Hz^-1/2 with a resolution of 800 MHz is achieved (corresponding to 6.9 {\times} 10^-11 cm^-1 Hz^-1/2 per spectral element for 6000 resolved elements). This yields a noise equivalent detection limit for hydrogen peroxide of 8 parts-per-billion (ppb); in the presence of 2.8% of water the detection limit is 130 ppb. Spectra of acetylene, methane and nitrous oxide at atmospheric pressure are also presented, and a line shape model is developed to simulate the experimental data.Comment: submitted to special FLAIR 2011 issue of Appl. Phys.

The Exchange

For this proposal, we assumed the position of respondents to the RFP that PSU will be releasing for the subject property. This proposal begins with an overview of the context of the site historically, spatially. We analyze the neighborhood and features that will help make the development fit within the broader context. Then, we analyze the outlook for each property type and make assumptions about achievable rents, occupancies, etc. Then, we determine what the vision of the development will be based on the foregoing analysis. Finally, we apply that vision to create a development program and determine financial feasibility. We gladly present The Exchange, a vibrant community in the heart of Portland

The challenges of achieving high training coverage for IMCI: case studies from Kenya and Tanzania

Health worker training is a key component of the integrated management of childhood illness (IMCI). However, training coverage remains low in many countries. We conducted in-depth case studies in two East African countries to examine the factors underlying low training coverage 10 years after IMCI had been adopted as policy. A document review and in-depth semi-structured interviews with stakeholders at facility, district, regional/provincial and national levels in two districts in Kenya (Homa Bay and Malindi) and Tanzania (Bunda and Tarime) were carried out in 2007–08

Mid-Infrared Time-Resolved Frequency Comb Spectroscopy of Transient Free Radicals

We demonstrate time-resolved frequency comb spectroscopy (TRFCS), a new broadband absorption spectroscopy technique for the study of trace free radicals on the microsecond timescale. We apply TRFCS to study the time-resolved, mid-infrared absorption of the deuterated hydroxyformyl radical trans-DOCO, an important short-lived intermediate along the OD + CO reaction path. Directly after photolysis of the chemical precursor acrylic acid-d_1, we measure absolute trans-DOCO product concentrations with a sensitivity of 5 × 10^(10) cm^(–3) and observe its subsequent loss with a time resolution of 25 μs. The multiplexed nature of TRFCS allows us to detect simultaneously the time-dependent concentration of several other photoproducts and thus unravel primary and secondary chemical reaction pathways

Atenção integrada às doenças prevalentes da infância: eficiência na atenção primária de saúde no Nordeste

OBJECTIVE: The Integrated Management of Childhood Illness is a strategy designed to address major causes of child mortality. The aim of this study was to assess the impact of the strategy on the quality of child health care provided at primary facilities. METHODS: Child health quality of care and costs were compared in four states in Northeastern Brazil, in 2001. There were studied 48 health facilities considered to have had stable strategy implementation at least two years before the start of study, with 48 matched comparison facilities in the same states. A single measure of correct management of sick children was used to assess care provided to all sick children. Costs included all resources at the national, state, local and facility levels associated with child health care. RESULTS: Facilities providing strategy-based care had significantly better management of sick children at no additional cost to municipalities relative to the comparison municipalities. At strategy facilities 72% of children were correctly managed compared with 56% in comparison facilities (p=0.001). The cost per child managed correctly was US$13.20 versus US$21.05 in the strategy and comparison municipalities, respectively, after standardization for population size. CONCLUSIONS: The strategy improves the efficiency of primary facilities in Northeastern Brazil. It leads to better health outcomes at no extra cost.OBJETIVO: A atenção integrada às doenças prevalentes da infância é uma estratégia desenvolvida para contribuir na redução das principais causas de mortalidade infantil. O objetivo do estudo foi avaliar o impacto da estratégia sobre a saúde infantil. MÉTODOS: Compararam-se a qualidade do atendimento à saúde infantil e os custos associados em quatro estados da região Nordeste do Brasil, em 2001. Foram estudadas 48 unidades de saúde onde havia implementação estável da estratégia por pelo menos dois anos antes do início do estudo e 48 unidades sem (controle) nos mesmos estados. O percentual de crianças doentes atendidas corretamente foi utilizado para avaliar a qualidade da atenção oferecida a crianças doentes. O custo total da atenção à saúde infantil foi avaliado a partir de dados coletados nos níveis nacional, estadual, municipal e de unidade de saúde. RESULTADOS: As unidades que adotam a estratégia obtiveram desempenho significantemente melhor no atendimento de crianças doentes, sem custos adicionais em relação aos municípios sem. Nas unidades com a estratégia, 72% das crianças avaliadas foram atendidas corretamente, comparado com 56% nas unidades controle. O custo por criança atendida corretamente foi de US$13.20 versus US$21.05 nos municípios com e sem a estratégia respectivamente, após os ajustes para o tamanho das populações municipais. CONCLUSÕES: A estratégia melhorou a eficiência das unidades de atenção primária de saúde da região estudada. Em unidades de atenção primária com a estratégia, a qualidade do tratamento foi melhor, sem aumento de custos

Influence of Invasive Hybrid Cattails on Habitat Use by Common Loons

An invasive hybrid cattail species, Typha x glauca (T. x glauca), is rapidly expanding across the United States and Canada. Dense clonal stands of T. x glauca outcompete native wetland plants, reduce open-water habitats, and negatively affect native wetland plant diversity; however, effects of hybrid cattail expansions on native wildlife are still unclear. We used multiple surveys and single-season occupancy models to examine how the relative coverage of T. x glauca affected habitat use by common loons (Gavia immer) at 71 wetland sites in Voyageurs National Park, Minnesota, USA, during summer 2016. Delineated wetland sites (2 ha) were considered potential resource patches for common loons and positioned along a gradient of relative T. x glauca coverage. Detection of common loons was influenced negatively by the time of day surveys were conducted. Occupancy probabilities were greater at sites with deeper water levels, possibly indicating selection for areas with adequate water depths for pursuit-based foraging for fish. Contrary to our hypothesis, common loons appeared insensitive to the relative coverage of T. x glauca at wetland sites. Future research should focus on elucidating potential threshold-effects of T. x glauca expansions on additional loon demographic rates

The Relationship between Age and Suicidal Thoughts and Attempted Suicide among Prisoners

Background Suicide is a major problem across the lifespan, yet rates are highest among middle-aged and older adults; a trend which remains relatively stable across varying sociological settings, including prisons. Despite this understanding, there is limited knowledge on the nature of suicidal thoughts and attempts among older prisoners, especially with respect to how they compare to younger counterparts. The present study aimed to increase insight into the relationship between age and suicidal thoughts and attempted suicide among prisoners, with particular focus on factors that may explain age-based variability. Results Cross-sectional data were drawn from a nationally representative sample of 18,185 prisoners housed within 326 prisons across the United States. In general, analyses revealed that: (a) attempted suicide was more commonly reported among younger prisoners, while suicidal ideation was more commonly reported among older prisoners; (b) the relationship between age and probability of reporting suicidal thoughts and behavior is curvilinear; (c) younger and older prisoners exhibit somewhat differing predictive patterns of suicidal thoughts and behavior (e.g., physical illness is directly associated with suicidal history for younger prisoners, whereas the effect of physical illness on suicidal history for older prisoners is mediated by depression). Conclusions There is evidence to suggest that suicidal thoughts and behavior may manifest differently for younger and older prisoners, with differing patterns of risk. More research is needed on age-based variability in suicidal thoughts and attempted suicide among prisoners, as well as those factors that might explain this variability. Importantly, future research must continue to investigate the nature of suicidal thoughts and behavior among older prisoners

The Extent of Medical Student Stigma in Healthcare Delivery to Populations Experiencing Homelessness or with Substance Use Disorders

Evaluating the significance of medical student bias towards people experiencing homelessness (PEH) and people who use drugs (PWUD) in Detroit, Michigan. Of the estimated 30,000 Michiganders experiencing homelessness, 5,000+ of PEH in Michigan reside in Detroit1,2. PEH suffered from a quadrupled rate of hospital readmission demonstrating the stark disparity in health outcomes among this population3. Additionally, 6% of the PEH in the state of Michigan engage in substance use1. PWUD have been historically stigmatized and subject to bias both within the healthcare system and otherwise, contributing to adverse health outcomes. Based on current literature, PWUD experiencing stigma and discrimination in healthcare settings have drastically negatively impacted recovery outcomes5. This “provider-based stigma” that PEH/PWUD experience is associated with internalization of biases leading to poorer health outcomes, increasing health comorbidities, reduction in treatment frequency, and lower quality of care4,5,6 This is an IRB-approved study (n=47) with medical student volunteers from a street medicine clinic in Detroit, Michigan. The survey recorded anonymized information about volunteers’ demographics, experiences, and attitudes toward providing care to PEH or PWUD on a 5-point and 7-point Likert scale. Subjects were stratified into two groups, individuals who volunteered 1-3 times and more than 3 times. Students who volunteered more than 3 times were significantly more likely to agree with the statement “Individuals who are experiencing homelessness and/or housing instability retain autonomy in their decision-making that should be respected”. This study was conducted at an urban medical campus where students are more likely to interact with PEH or PWUD compared to other medical schools. Survey responses of students from both categories did not indicate significant evidence of stigma towards PEH and PWUD. However, respondents’ volunteer status may indicate increased exposure and thus increased empathy and support toward PEH and PWUD