403 research outputs found

    Identifying Extension Information Delivery Methods For Environmental Issues

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    The primary purpose of this study was to identify the types of information sources that farmers find useful, and the human resource organizations they depend upon when confronted with environmental issues

    Cluster Analysis and Topoclimate Modeling to Examine Bristlecone Pine Tree-ring Growth Signals in the Great Basin, USA

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    Tree rings have long been used to make inferences about the environmental factors that influence tree growth. Great Basin bristlecone pine is a long-lived species and valuable dendroclimatic resource, but often with mixed growth signals; in many cases, not all trees at one location are limited by the same environmental variable. Past work has identified an elevational threshold below the upper treeline above which trees are limited by temperature, and below which trees tend to be moisture limited. This study identifies a similar threshold in terms of temperature instead of elevation through fine-scale topoclimatic modeling, which uses a suite of topographic and temperature-sensor data to predict temperatures across landscapes. We sampled trees near the upper limit of growth at four high-elevation locations in the Great Basin region, USA, and used cluster analysis to find dual-signal patterns in radial growth. We observed dual-signal patterns in ring widths at two of those sites, with the signals mimicking temperature and precipitation patterns. Trees in temperature-sensitive clusters grew in colder areas, while moisture-sensitive cluster trees grew in warmer areas. We found thresholds between temperatureand moisture-sensitivity ranging from 7.4 °C to 8°C growing season mean temperature. Our findings allow for a better physiological understanding of bristlecone pine growth, and seek to improve the accuracy of climate reconstructions

    Development and Validation of Makeup and Sexualized Clothing Questionnaires

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    Background: Body acceptance programs on college campuses indicated that collegiate women often report feeling pressure to dress in a sexualized manner, and use makeup to enhance beauty. Currently, no quantitative measures exist to assess attitudes and daily behaviors that may arise in response to perceived pressure to wear makeup or dress in a provocative manner. The goal of the current studies was to develop brief self-report questionnaires aimed at assessing makeup and sexualized clothing use and attitudes in young women. Methods: An exploratory factor analysis in a sample of 403 undergraduate women was used in Study 1 to create items to measure the pressure women feel to wear makeup and sexualized clothing. A confirmatory factor analysis (N = 153) was used in Study 2 to confirm the factor structure found in Study 1. An incremental validity analysis was also conducted in Study 2. Across both studies, participants completed online questionnaires. Results: In Study 1, items were developed for two questionnaires to assess perceived pressure to wear makeup and discomfort when not wearing makeup, and perceived pressure to wear sexualized clothing, and body image concerns with regards to sexualized clothing. The exploratory factor analyses revealed Unconfident and Unease scales for the Makeup Questionnaire (MUQ) and Body Dissatisfaction and Pressure scales for the Sexualized Clothing Questionnaire (SCQ). In Study 2, the confirmatory factor analyses confirmed the factor structure for the MUQ and SCQ. The incremental validity analysis revealed that these measures can be used to predict self-objectification and shape and weight concern in women. Conclusion: These studies provide preliminary support for the factor structure of two novel questionnaires aimed at assessing perceived pressure to wear makeup and sexualized clothing

    Single copy shRNA configuration for ubiquitous gene knockdown in mice

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    RNA interference through the expression of small hairpin RNA (shRNA) molecules has become a very promising tool in reverse mouse genetics as it may allow inexpensive and rapid gene function analysis in vivo. However, the prerequisites for ubiquitous and reproducible shRNA expression are not well defined. Here we show that a single copy shRNA-transgene can mediate body-wide gene silencing in mice when inserted in a defined locus of the genome. The most commonly used promoters for shRNA expression, H1 and U6, showed a comparably broad activity in this configuration. Taken together, the results define a novel approach for efficient interference with expression of defined genes in vivo. Moreover, we provide a rapid strategy for the production of gene knockdown mice combining recombinase mediated cassette exchange and tetraploid blastocyst complementation approaches

    Efficient Code Generation in a Region-based Dynamic Binary Translator

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    Region-based JIT compilation operates on translation units comprising multiple basic blocks and, possibly cyclic or conditional, control flow between these. It promises to reconcile aggressive code optimisation and low compilation latency in performance-critical dynamic binary translators. Whilst various region selection schemes and isolated code optimisation techniques have been investigated it remains unclear how to best exploit such regions for efficient code generation. Complex interactions with indirect branch tables and translation caches can have adverse effects on performance if not considered carefully. In this paper we present a complete code generation strategy for a region-based dynamic binary translator, which exploits branch type and control flow profiling information to improve code quality for the common case. We demonstrate that using our code generation strategy a competitive region-based dynamic compiler can be built on top of the LLVM JIT compilation framework. For the ARM-V5T target ISA and SPEC CPU 2006 benchmarks we achieve execution rates of, on average, 867 MIPS and up to 1323 MIPS on a standard X86 host machine, outperforming state-of-the-art QEMU-ARM by delivering a speedup of 264%

    Fine-scale Modeling of Bristlecone Pine Treeline Position in the Great Basin, USA

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    Great Basin bristlecone pine (Pinus longaeva) and foxtail pine (Pinus balfouriana) are valuable paleoclimate resources due to their longevity and climatic sensitivity of their annually-resolved rings. Treeline research has shown that growing season temperatures limit tree growth at and just below the upper treeline. In the Great Basin, the presence of precisely dated remnant wood above modern treeline shows that the treeline ecotone shifts at centennial timescales tracking long-term changes in climate; in some areas during the Holocene climatic optimum treeline was 100 meters higher than at present. Regional treeline position models built exclusively from climate data may identify characteristics specific to Great Basin treelines and inform future physiological studies, providing a measure of climate sensitivity specific to bristlecone and foxtail pine treelines. This study implements a topoclimatic analysis—using topographic variables to explain patterns in surface temperatures across diverse mountainous terrain—to model the treeline position of three semi-arid bristlecone and/or foxtail pine treelines in the Great Basin as a function of growing season length and mean temperature calculated from in situ measurements. Results indicate: (1) the treeline sites used in this study are similar to other treelines globally, and require a growing season length of between 147–153 days and average temperature ranging from 5.5°C–7.2°C, (2) site-specific treeline position models may be improved through topoclimatic analysis and (3) treeline position in the Great Basin is likely out of equilibrium with the current climate, indicating a possible future upslope shift in treeline position

    FGF receptor genes and breast cancer susceptibility: results from the Breast Cancer Association Consortium

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    Background:Breast cancer is one of the most common malignancies in women. Genome-wide association studies have identified FGFR2 as a breast cancer susceptibility gene. Common variation in other fibroblast growth factor (FGF) receptors might also modify risk. We tested this hypothesis by studying genotyped single-nucleotide polymorphisms (SNPs) and imputed SNPs in FGFR1, FGFR3, FGFR4 and FGFRL1 in the Breast Cancer Association Consortium. Methods:Data were combined from 49 studies, including 53 835 cases and 50 156 controls, of which 89 050 (46 450 cases and 42 600 controls) were of European ancestry, 12 893 (6269 cases and 6624 controls) of Asian and 2048 (1116 cases and 932 controls) of African ancestry. Associations with risk of breast cancer, overall and by disease sub-type, were assessed using unconditional logistic regression. Results:Little evidence of association with breast cancer risk was observed for SNPs in the FGF receptor genes. The strongest evidence in European women was for rs743682 in FGFR3; the estimated per-allele odds ratio was 1.05 (95 confidence interval=1.02-1.09, P=0.0020), which is substantially lower than that observed for SNPs in FGFR2. Conclusion:Our results suggest that common variants in the other FGF receptors are not associated with risk of breast cancer to the degree observed for FGFR2. © 2014 Cancer Research UK
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