An investigation of exoskeleton robotic systems in assisting construction tasks

Whilst industrial robots have been widely used in many industrial sectors, they are predominantly used in a structured factory environment. In recent years, off-site robotics have been investigated extensively and there are some promising candidates emerging. One such category of robots is exoskeleton robots and this paper provides an in-depth assessment of their suitability in assisting human operators in undertaking manual operations typically found in the construction industry. This work aims to objectively assess the advantages and disadvantages of these two suits and provide recommendations for further improvements of similar system designs. The paper focuses on the passive exoskeleton robotic suits which are commercially available. Three types of activities are designed and a mechatronic methodology has been designed and implemented to capture visual data in order to assess these systems in comparison with normal human operations. The study suggests that these passive suits do reduce the effort required by human operators to undertake the same construction tasks as evidenced by the results from one focused study, though a number of improvements could be made to improve their performance for wider adoption

Biomolecular Condensates in Cell Biology and Virology: Phase-Separated Membraneless Organelles (MLOs)

Membraneless organelles (MLOs) in the cytoplasm and nucleus in the form of 2D and 3D phase-separated biomolecular condensates are increasingly viewed as critical in regulating diverse cellular functions. These functions include cell signaling, immune synapse function, nuclear transcription, RNA splicing and processing, mRNA storage and translation, virus replication and maturation, antiviral mechanisms, DNA sensing, synaptic transmission, protein turnover and mitosis. Components comprising MLOs often associate with low affinity; thus cell integrity can be critical to the maintenance of the full complement of respective MLO components. Phase-separated condensates are typically metastable (shape-changing) and can undergo dramatic, rapid and reversible assembly and disassembly in response to cell signaling events, cell stress, during mitosis, and after changes in cytoplasmic crowding (as observed with condensates of the human myxovirus resistance protein MxA). Increasing evidence suggests that neuron-specific aberrations in phase-separation properties of RNA-binding proteins (e.g. FUS and TDP-43) and others (such as the microtubule-binding protein tau) contribute to the development of degenerative neurological diseases (e.g. amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer\u27s disease). Thus, studies of liquid-like phase separation (LLPS) and the formation, structure and function of MLOs are of considerable importance in understanding basic cell biology and the pathogenesis of human diseases

Biomolecular condensates in cell biology and virology: Phase-separated membraneless organelles (MLOs)

Membraneless organelles (MLOs) in the cytoplasm and nucleus in the form of 2D and 3D phase-separated biomolecular condensates are increasingly viewed as critical in regulating diverse cellular functions. These functions include cell signaling, immune synapse function, nuclear transcription, RNA splicing and processing, mRNA storage and translation, virus replication and maturation, antiviral mechanisms, DNA sensing, synaptic transmission, protein turnover and mitosis. Components comprising MLOs often associate with low affinity; thus cell integrity can be critical to the maintenance of the full complement of respective MLO components. Phase-separated condensates are typically metastable (shape-changing) and can undergo dramatic, rapid and reversible assembly and disassembly in response to cell signaling events, cell stress, during mitosis, and after changes in cytoplasmic crowding (as observed with condensates of the human myxovirus resistance protein MxA). Increasing evidence suggests that neuron-specific aberrations in phase-separation properties of RNA-binding proteins (e.g. FUS and TDP-43) and others (such as the microtubule-binding protein tau) contribute to the development of degenerative neurological diseases (e.g. amyotrophic lateral sclerosis, frontotemporal lobar degeneration, and Alzheimer\u27s disease). Thus, studies of liquid-like phase separation (LLPS) and the formation, structure and function of MLOs are of considerable importance in understanding basic cell biology and the pathogenesis of human diseases

Additional file 1: of Everybody needs a cheerleader to get a kidney transplant: a qualitative study of the patient barriers and facilitators to kidney transplantation in the Southeastern United States

Focus Group Interview Guide. This is the interview guide used for all of the focus groups in this study. (DOCX 14 kb

Spatial and Temporal Patterns of Stranded Intertidal Marine Debris: Is There a Picture of Global Change?

Floating and stranded marine debris is widespread. Increasing sea levels and altered rainfall, solar radiation, wind speed, waves, and oceanic currents associated with climatic change are likely to transfer more debris from coastal cities into marine and coastal habitats. Marine debris causes economic and ecological impacts, but understanding the scope of these requires quantitative information on spatial patterns and trends in the amounts and types of debris at a global scale. There are very few large-scale programs to measure debris, but many peer-reviewed and published scientific studies of marine debris describe local patterns. Unfortunately, methods of defining debris, sampling, and interpreting patterns in space or time vary considerably among studies, yet if data could be synthesized across studies, a global picture of the problem may be avaliable. We analyzed 104 published scientific papers on marine debris in order to determine how to evaluate this. Although many studies were well designed to answer specific questions, definitions of what constitutes marine debris, the methods used to measure, and the scale of the scope of the studies means that no general picture can emerge from this wealth of data. These problems are detailed to guide future studies and guidelines provided to enable the collection of more comparable data to better manage this growing problem

Additional file 1: of Process evaluation of the RaDIANT community study: a dialysis facility-level intervention to increase referral for kidney transplantation

ESRD Network 6 RaDIANT Process Evaluation Questionnaire. 20- item questionnaire designed by the Southeastern Kidney Transplant (SEKTx) Coalition to measure fidelity, reach, sustainability, and context of the RaDIANT intervention (DOCX 25 kb