Citation Analysis of the Most Influential Publications in Travel Medicine

Introduction: Citation analysis reflects the extent to which published work has been recognized in the scientific community. The purpose of this study was to characterize the most cited publications in travel medicine.Methods: Travel medicine articles indexed on Scopus which had been published in the English language through 2016 were retrieved independently by two researchers using various search terms. Eligible articles with at least 50 citations were ranked according to citation count. Additional information was recorded, including authorship, year of publication, journal, journal impact factor, source country, institution of origin, category of article, level of evidence and principal article theme.Results: Among the 174 most cited articles, the greatest number of citations recorded was 1217 for an original research article published in 2013. The most productive decade for most cited articles was 2000-2010. Of the articles, 122 were original research, 47 were reviews, and 5 were of other article types. The top-ranked author published 15 articles among the most cited. The most prolific institution among the most influential papers was based in Munich, Germany. Nine broad themes emerged from the most cited publication list, with air travel (29), malaria (26), post-travel assessment (16), travelers’ diarrhea (14), and high altitude illness (13) being the most prominent subjects.Conclusion: Travel medicine research has proliferated since the founding of the discipline in the 1970s. This first citation analysis of travel medicine research provides an historical perspective and highlights sources of greatest influence on the travel medicine community

11 C-Metomidate PET/CT is a useful adjunct for lateralization of primary aldosteronism in routine clinical practice.

OBJECTIVE: To describe clinical practice experience of 11 C-Metomidate PET/CT as an adjunct to adrenal vein sampling (AVS) in the lateralization of aldosterone-producing adenomas (APA) in primary aldosteronism (PA). CONTEXT: Accurate lateralization of APA in the setting of PA offers the potential for surgical cure and improved long-term cardiovascular outcomes. Challenges associated with AVS, the current gold standard lateralization modality, mean that only a small proportion of potentially eligible patients currently make it through to surgery. This has prompted consideration of alternative strategies for lateralization, including the application of novel molecular PET tracers such as 11 C-Metomidate. DESIGN: Clinical Service Evaluation/Retrospective audit. PATIENTS: Fifteen individuals with a confirmed diagnosis of PA, undergoing lateralization with 11 C-Metomidate PET/CT prior to final clinical decision on surgical vs medical management. MEASUREMENTS: All patients underwent screening aldosterone renin ratio (ARR), followed by confirmatory testing with the seated saline infusion test, according to Endocrine Society Clinical Practice Guidelines. Adrenal glands were imaged using dedicated adrenal CT. 11 C-Metomidate PET/CT was undertaken due to equivocal or failed AVS. Management outcomes were assessed by longitudinal measurement of blood pressure, ARR, number of hypertensive medications following adrenalectomy or institution of medical therapy. RESULTS: We describe the individual lateralization and clinical outcomes for 15 patients with PA. CONCLUSION: 11 C-Metomidate PET/CT in conjunction with adrenal CT and AVS provided useful information which aided clinical decision-making for PA within a multidisciplinary hypertension clinic

Estimating the parameters of globular cluster M 30 (NGC 7099) from time-series photometry

Aims: We present the analysis of 26 nights of V and I time-series observations from 2011 and 2012 of the globular cluster M 30 (NGC 7099). We used our data to search for variable stars in this cluster and refine the periods of known variables; we then used our variable star light curves to derive values for the cluster's parameters. Methods: We used difference image analysis to reduce our data to obtain high-precision light curves of variable stars. We then estimated the cluster parameters by performing a Fourier decomposition of the light curves of RR Lyrae stars for which a good period estimate was possible. We also derived an estimate for the age of the cluster by fitting theoretical isochrones to our colour-magnitude diagram (CMD). Results: Out of 13 stars previously catalogued as variables, we find that only 4 are bona fide variables. We detect two new RR Lyrae variables, and confirm two additional RR Lyrae candidates from the literature. We also detect four other new variables, including an eclipsing blue straggler system, and an SX Phoenicis star. This amounts to a total number of confirmed variable stars in M 30 of 12. We perform Fourier decomposition of the light curves of the RR Lyrae stars to derive cluster parameters using empirical relations. We find a cluster metallicity [Fe/H][SUB]ZW[/SUB] = -2.01 ± 0.04, or [Fe/H][SUB]UVES[/SUB] = -2.11 ± 0.06, and a distance of 8.32 ± 0.20 kpc (using RR0 variables), 8.10 kpc (using one RR1 variable), and 8.35 ± 0.42 kpc (using our SX Phoenicis star detection in M 30). Fitting isochrones to the CMD, we estimate an age of 13.0 ± 1.0 Gyr for M 30. This work is based on data collected by MiNDSTEp with the Danish 1.54 m telescope at the ESO La Silla Observatory.The full light curves, an extract of which is shown in Table 2 are only available at the CDS via anonymous ftp to http://cdsarc.u-strasbg.fr (ftp://130.79.128.5) or via http://cdsarc.u-strasbg.fr/viz-bin/qcat?J/A+A/555/A36Tables 8-10, and Figs. 6 and 9 are available in electronic form at http://www.aanda.org</A

Dental patient reported outcome and oral health-related quality of life measures: protocol for a systematic evidence map of reviews.

This research synthesis protocol addresses the question: what is the evidence concerning measurement properties of dental patient reported outcome measures (dPROMs), and regarding the real-world value of dPROMs, and where are the gaps in this evidence? Evidence mapping will systematically examine reviews of quantitative dPROMs used to assess the impact of oral health on the quality of life of dental patients and research participants. Evidence gaps where future research or systematic reviews are required will be identified. Materials and methods: This protocol accords with the PRISMA-P guideline. Open Science Framework Registration https://doi.org/10.17605/OSF.IO/RZD3N. Biomedical and grey literature databases will be searched, adapting the same search strategy. Published or unpublished reviews evaluating any dPROM will be considered for inclusion. There will be no restriction by date, setting, or language. AMSTAR2 and ROBIS will evaluate risk of bias. Psychometric criteria will be adapted from COSMIN. Data will be summarised separately for specific populations and conditions. Discussion The findings will enable clinicians and researchers to identify methodologically robust dPROMs, appropriate for use with relevant populations and conditions. Implications for real-world practice and research will be discussed

Impact of reducing water fluoride on dental caries and fluorosis

Guidance intended to reduce fluoride toothpaste ingestion in early childhood was introduced in Ireland in 2002. In 2007, water fluoride concentration was adjusted from 0.8–1.0 to 0.6–0.8 ppm. The objective of this study was to determine the difference in caries and fluorosis levels following introduction of these 2 policy measures. A before-and-after study compared caries and fluorosis in random samples of 8-y-olds in Dublin (n = 707) and Cork-Kerry (n = 1148) in 2017 with 8-y-olds in Dublin (n = 679) and Cork-Kerry (n = 565) in 2002. Dentinal caries experience (primary teeth, d3vcmft(cde)) and fluorosis (permanent teeth, Dean’s index of very mild or higher) were clinically measured. Lifetime exposure to community water fluoridation (CWF) was classified as “full CWF”/“no CWF.” Effect of examination year on caries prevalence and severity and fluorosis prevalence was assessed using multivariate regression adjusting for other explanatory variables. There was little change in commencement of fluoride toothpaste use at ≤24 mo following introduction of toothbrushing guidance. Among children with full CWF, there was no statistically significant difference in caries prevalence or severity between 2017 and 2002. In 2017, caries prevalence was 55% in Dublin (full CWF) and 56% in Cork-Kerry (full CWF), and mean d3vcmft(cde) among children with caries was 3.4 and 3.7, respectively. Caries severity was less in 2017 (mean 4.2) than 2002 (mean 4.9) among children with no CWF (P = 0.039). The difference in caries severity between children with full CWF and no CWF was less in 2017 than in 2002 (interaction P = 0.013), suggesting a reduced benefit for CWF in 2017. In 2017, fluorosis prevalence was 18% in Dublin (full CWF) and 12% in Cork-Kerry (full CWF). Fluorosis was predominantly “very mild” with no statistically significant difference between 2017 and 2002. CWF at 0.6 to 0.8 ppm is an effective caries-preventive measure. Results suggested low uptake of toothbrushing guidance, a reduced caries-preventive effect for CWF in primary teeth, and no reduction in fluorosis following introduction of the policy measures

Barriers, Enablers and Referral Patterns of General Practitioners, Physiotherapists, and People with Osteoarthritis to Exercise Treatments

An online survey was circulated to people with osteoarthritis, physiotherapists, and general practitioners in Ireland from March-September 2021. Data collected from these surveys is presented in this dataset

JAK inhibitor improves type I interferon induced damage: proof of concept in dermatomyositis

International audienceDermatomyositis is an acquired auto-immune disease characterized by skin lesions and muscle-specific pathological features such as perifascicular muscle fibre atrophy and vasculopathy. Dermatomyositis patients display an upregulation of type I interferon-inducible genes in muscle fibres, endothelial cells, skin and peripheral blood. However, the effect of type I interferon on muscle tissue has not yet been determined. Our aim was to study the pathogenicity of type I interferon in vitro and to evaluate the efficacy of the type I interferon pathway blockade for therapeutic purposes. The activation of type I interferon in differentiating myoblasts abolished myotube formation with reduced myogenin expression while in differentiated myotubes, we observed a reduction in surface area and an upregulation of atrophy-associated genes. In vitro endothelial cells exposure to type I interferon disrupted vascular network organization. All the pathogenic effects observed in vitro were abolished by ruxolitinib. Finally, four refractory dermatomyositis patients were treated with ruxolitinib and improvement ensued in skin lesions, muscle weakness and a reduced serum type I interferon levels and interferon-inducbile genes scores. We propose JAK inhibition as a mechanism-based treatment for dermatomyositis, a finding that is relevant for the design of future clinical trials targeting dermatomyositis