Federal Terrorism Risk Insurance

The terrorist attacks of September 11, 2001 represented a loss for commercial property & casualty insurers that was both unprecedented and unanticipated. After sustaining this record capital loss, the availability of adequate private insurance coverage against future terrorist attacks came into question. Concern over the potential adverse consequences of the lack of availability of insurance against terrorist incidents led to calls for federal intervention in insurance markets. This paper discusses the economic rationale for and against federal intervention in the market, and concludes that the benefits from establishing a temporary transition program, during which the private sector can build capacity and adapt to a dramatically changed environment for terrorism risk, may provide benefits to the economy that exceed the direct and indirect costs.

Just how hot are the ω\omega Centauri extreme horizontal branch pulsators?

Past studies based on optical spectroscopy suggest that the five $\omega$ Cen pulsators form a rather homogeneous group of hydrogen-rich subdwarf O stars with effective temperatures of around 50 000 K. This places the stars below the red edge of the theoretical instability strip in the log $g$ $-$ Teff diagram, where no pulsation modes are predicted to be excited. Our goal is to determine whether this temperature discrepancy is real, or whether the stars' effective temperatures were simply underestimated. We present a spectral analysis of two rapidly pulsating extreme horizontal branch (EHB) stars found in $\omega$ Cen. We obtained Hubble Space Telescope/COS UV spectra of two $\omega$ Cen pulsators, V1 and V5, and used the ionisation equilibrium of UV metallic lines to better constrain their effective temperatures. As a by-product we also obtained FUV lightcurves of the two pulsators. Using the relative strength of the N IV and N V lines as a temperature indicator yields Teff values close to 60 000 K, significantly hotter than the temperatures previously derived. From the FUV light curves we were able to confirm the main pulsation periods known from optical data. With the UV spectra indicating higher effective temperatures than previously assumed, the sdO stars would now be found within the predicted instability strip. Such higher temperatures also provide consistent spectroscopic masses for both the cool and hot EHB stars of our previously studied sample.Comment: 9 pages, accepted for publication in Astronomy and Astrophysic

MLB Statcast Pitch Analysis: the Association between Active Spin and Opponent’s Batting Average

Baseball has often been described as a game of statistics and strategy, and current technology allows detailed examination of the game. One statistic measured concerning the movement of the ball is spin rate, the rotations per minute created by the pitcher when the ball is released from the hand. However, recent research has not examined the inclusion of pitchers’ spin rate in batter strategy. PURPOSE: The purpose of this study is to see if there is an association between the movement of breaking balls with the batting average of Major League Baseball batters. METHODS: A sample including 76 elite Major League Baseball pitchers, all male (age = 30.12 ± 3.68, mean ± sd), were taken from the 2019 MLB regular season using Statcast, Pitch F/x, and Trackman cameras. Statcast is used in Major League Baseball and collects the pitcher’s data revolving around their pitches (e.g., active spin, speed, whiff). Pitchers who had thrown a minimum of 2,500 pitches were included. The outcome was batting average, an aggregate number based on the number of players who faced an individual pitcher during the season. We performed multivariable linear regression models to regress batting average on curveballs and sliders separately. Covariates for assessment included pitcher demographics, active movement of the pitch, spin rate of the pitch, hits, at bats, percent of breaking balls thrown, pitch velocity, and number thrown versus right- and left-handed batters. RESULTS: After regression assumptions and steps were satisfied, 43.7% of the variation in batting average could be accounted for by the active spin of the slider, the number of sliders thrown, pitching hand, and the pitcher’s height. For every one-unit increase in active spin of the slider, batting average significantly decreased by 0.0013. Concerning curveballs, regression steps yielded a single-variable model, where 13.1% of the variation in batting average could be explained by the number of curveballs thrown. For every one-unit increase in the number of curveballs thrown, batting average significantly decreased by 0.00013. CONCLUSION: Variables significantly associated with batting average varied by whether a slider or a curveball was thrown; an increase in spin rate was significantly associated with a decrease in batting average for sliders thrown, but not for curveballs. The results of this study can be used by coaches as they prepare for games to enable the most favorable matchup between batter and pitcher. Future research should expand the timeline to include multiple MLB seasons to further corroborate these findings

Locality in Theory Space

Locality is a guiding principle for constructing realistic quantum field theories. Compactified theories offer an interesting context in which to think about locality, since interactions can be nonlocal in the compact directions while still being local in the extended ones. In this paper, we study locality in "theory space", four-dimensional Lagrangians which are dimensional deconstructions of five-dimensional Yang-Mills. In explicit ultraviolet (UV) completions, one can understand the origin of theory space locality by the irrelevance of nonlocal operators. From an infrared (IR) point of view, though, theory space locality does not appear to be a special property, since the lowest-lying Kaluza-Klein (KK) modes are simply described by a gauged nonlinear sigma model, and locality imposes seemingly arbitrary constraints on the KK spectrum and interactions. We argue that these constraints are nevertheless important from an IR perspective, since they affect the four-dimensional cutoff of the theory where high energy scattering hits strong coupling. Intriguingly, we find that maximizing this cutoff scale implies five-dimensional locality. In this way, theory space locality is correlated with weak coupling in the IR, independent of UV considerations. We briefly comment on other scenarios where maximizing the cutoff scale yields interesting physics, including theory space descriptions of QCD and deconstructions of anti-de Sitter space.Comment: 40 pages, 11 figures; v2: references and clarifications added; v3: version accepted by JHE

Altered functional brain network connectivity and glutamate system function in transgenic mice expressing truncated Disrupted-in-Schizophrenia 1

Considerable evidence implicates DISC1 as a susceptibility gene for multiple psychiatric diseases. DISC1 has been intensively studied at the molecular, cellular and behavioral level, but its role in regulating brain connectivity and brain network function remains unknown. Here, we utilize a set of complementary approaches to assess the functional brain network abnormalities present in mice expressing a truncated Disc1 gene (Disc1tr Hemi mice). Disc1tr Hemi mice exhibited hypometabolism in the prefrontal cortex (PFC) and reticular thalamus along with a reorganization of functional brain network connectivity that included compromised hippocampal–PFC connectivity. Altered hippocampal–PFC connectivity in Disc1tr Hemi mice was confirmed by electrophysiological analysis, with Disc1tr Hemi mice showing a reduced probability of presynaptic neurotransmitter release in the monosynaptic glutamatergic hippocampal CA1–PFC projection. Glutamate system dysfunction in Disc1tr Hemi mice was further supported by the attenuated cerebral metabolic response to the NMDA receptor (NMDAR) antagonist ketamine and decreased hippocampal expression of NMDAR subunits 2A and 2B in these animals. These data show that the Disc1 truncation in Disc1tr Hemi mice induces a range of translationally relevant endophenotypes underpinned by glutamate system dysfunction and altered brain connectivity

Discovery of macrocyclic inhibitors of apurinic/apyrimidinic endonuclease 1

Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential base excision repair enzyme that is upregulated in a number of cancers, contributes to resistance of tumors treated with DNA-alkylating or -oxidizing agents, and has recently been identified as an important therapeutic target. In this work, we identified hot spots for binding of small organic molecules experimentally in high resolution crystal structures of APE1 and computationally through the use of FTMAP analysis (http://ftmap.bu.edu/). Guided by these hot spots, a library of drug-like macrocycles was docked and then screened for inhibition of APE1 endonuclease activity. In an iterative process, hot-spot-guided docking, characterization of inhibition of APE1 endonuclease, and cytotoxicity of cancer cells were used to design next generation macrocycles. To assess target selectivity in cells, selected macrocycles were analyzed for modulation of DNA damage. Taken together, our studies suggest that macrocycles represent a promising class of compounds for inhibition of APE1 in cancer cells.This work was supported by grants from the National Institutes of Health (Grant R01CA205166 to M.R.K. and M.M.G. and Grant R01CA167291 to M.R.K.) and by the Earl and Betty Herr Professor in Pediatric Oncology Research, Jeff Gordon Children's Foundation, and the Riley Children's Foundation (M.R.K.). Work at the BU-CMD (J.A.P., L.E.B., R.T.) is supported by the National Institutes of Health, Grant R24 GM111625. D.B. and S.V. were supported by the National Institutes of Health, Grant R35 GM118078. (R35 GM118078 - National Institutes of Health; R01CA205166 - National Institutes of Health; R01CA167291 - National Institutes of Health; R24 GM111625 - National Institutes of Health; Earl and Betty Herr Professor in Pediatric Oncology Research; Jeff Gordon Children's Foundation; Riley Children's Foundation)Accepted manuscriptSupporting documentatio

Brane Universes with Gauss-Bonnet-Induced-Gravity

The DGP brane world model allows us to get the observed late time acceleration via modified gravity, without the need for a ``dark energy'' field. This can then be generalised by the inclusion of high energy terms, in the form of a Gauss-Bonnet bulk. This is the basis of the Gauss-Bonnet-Induced-Gravity (GBIG) model explored here with both early and late time modifications to the cosmological evolution. Recently the simplest GBIG models (Minkowski bulk and no brane tension) have been analysed. Two of the three possible branches in these models start with a finite density ``Big-Bang'' and with late time acceleration. Here we present a comprehensive analysis of more general models where we include a bulk cosmological constant and brane tension. We show that by including these factors it is possible to have late time phantom behaviour.Comment: 12 pages, 19 figures. Minor modifications to text, comments on phantom behaviour added. References added. As submitted to JCA

Testing the forward modeling approach in asteroseismology. I. Seismic solutions for the hot B subdwarf Balloon 090100001 with and without a priori mode identification

Context: Balloon 090100001, the brightest of the known pulsating hot B subdwarfs, exhibits simultaneoulsy both short- and long-period pulsation modes, and shows relatively large amplitudes for its dominant modes. For these reasons, it has been studied extensively over the past few years, including a successful experiment carried out at the Canada-France-Hawaii Telescope to pin down or constrain the value of the degree index ℓ of several pulsation modes through multicolor photometry. Aims: The primary goal of this paper is to take advantage of such partial mode identification to test the robustness of our standard approach to the asteroseismology of pulsating subdwarf B stars. The latter is based on the forward approach whereby a model that best matches the observed periods is searched for in parameter space with no a priori assumption about mode identification. When successful, this method leads to the determination of the global structural parameters of the pulsator. As a bonus, it also leads, after the fact, to complete mode identification. For the first time, with the availability of partial mode identification for Balloon 090100001, we are able to evaluate the sensitivity of the inferred seismic model to possible uncertainty in mode identification. Methods: We carry out a number of exercises based on the double optimization technique that we developed within the framework of the forward modeling approach in asteroseismology. We use the set of ten periods corresponding to the independent pulsation modes for which values of ℓ have been either formally identified or constrained through multicolor photometry in Balloon 090100001. These exercises differ in that they assume different a priori mode identification. Results: Our primary result is that the asteroseismic solution stands very robust, whether or not external constraints on the values of the degree ℓ are used. Although this may come as a small surprise, the test proves to be conclusive, and small differences in mode identification among the ten modes do not affect in any significant way, at the typical accuracy presently achieved, the final emergent seismic model. This is due to the structure of the p-mode pulsation spectra in sdB stars. In all cases, the inferred structural parameters of Balloon 090100001 remain practically unchanged. They correspond, and this constitutes our second important result, to a star beyond the TAEHB with T_eff = 28 000 ± 1 200 K, log g = 5.383 ± 0.004, M⋆/Msun = 0.432 ± 0.015, and log{M_env/M⋆} = -4.89 ± 0.14. Other structural parameters are also derived.Peer reviewe

Statistical Entropy of Schwarzschild Black Strings and Black Holes

The statistical entropy of a Schwarzschild black string in five dimensions is obtained by counting the black string states which form a representation of the near-horizon conformal symmetry with a central charge. The statistical entropy of the string agrees with its Bekenstein-Hawking entropy as well as that of the Schwarzschild black hole in four dimensions. The choice of the string length which gives the Virasoro algebra also reproduces the precise value of the Bekenstein-Hawking entropy and lies inside the stability bound of the string.Comment: 8 pages, Late