AGRICULTURE AND RURAL DEVELOPMENT: LESSONS FOR CHRISTIAN GROUPS COMBATING PERSISTENT POVERTY

Persistent poverty is one of the core challenges faced by Christians and by development scholars and practitioners alike. There is no question that Jesus was concerned about the poor - both materially and spiritually. From his first public address in the Synagogue in Nazareth, His home town, where He concluded by saying that He had come to "preach good news to the poor" (Luke 4:18), Jesus lived the gospel in word and deed. We, as Christian men and women, whether researchers or practitioners, are called to do no less. When Jesus made His parting remarks to His disciples, He said (John 20:21) "As the Father has sent me, I am sending you." emphasizing that we are to do likewise. This concern permeates the Old and New Testament, another example being the words of the prophet Micah (6:8): "He has showed you, O man, what is good. And what does the LORD require of you? To act justly and to love mercy and to walk humbly with your God." We are here to think through together some of the implications of this mandate for ourselves as researchers and practitioners. More specifically, to consider how the work we do as researchers can inform our work in the field as practitioners in such a way as to more effectively help those who are materially poor.Community/Rural/Urban Development, O1, Q12, Q18,

Generalized Two-Dimensional QCD

We study two-dimensional gauge theories with fundamental fermions and a general first order gauge-field Lagrangian. For the case of U(1) we show how standard bosonization of the Schwinger model generalizes to give mesons interacting through a general Landau-Ginzburg potential. We then show how for a subclass of SU(N) theories, 't Hooft's solution of large N two-dimensional QCD can be generalized in a consistent and natural manner. We finally point out the possible relevance of studying these theories to the string formulation of two-dimensional QCD as well as to understanding QCD in higher dimensions.Comment: LPTENS-94/2, IASSNS-HEP-94/3, and RU-94-8. (harvmac with 4 figures, 23 pp.

NASTRAN general purpose interface requirements document

This NASTRAN (NASA STRuctural ANalysis) General Purpose Interface Requirements Document (IRD) defines standards for deliverables required of New Capability Contractors (NCCs) and relates these deliverables to the software development cycle. It also defines standards to be followed by NCCs for adding to and modifying the code in the NASTRAN software system and for adding to and modifying the four official NASTRAN manuals: The NASTRAN Theoretical Manual, the NASTRAN User's Manual, The NASTRAN Programmer's Manual, and The NASTRAN Demonstration Problem Manual. It is intended that this General Purpose IRD shall be incorporated by reference in all contracts for a new NASTRAN capability

Land snail diversity can reflect degrees of anthropogenic disturbance

Faunal indicators of old-growth forests in heavily-disturbed regions are virtually non-existent. However, land snails, in particular micro-snails, could reflect the impact of land-use on ecosystem integrity. Because of their size, limited mobility, and propensity to spend their entire lives at one locality due to lack of migratory behavior, micro-snails are susceptible to changes in land-use within forested ecosystems. Therefore, we proposed the hypothesis that micro-snails would reflect land-use in forested ecosystems. We sampled snail communities in paired old-growth and second-growth forests in three distinct ecoregions. Species diversity, richness, and abundance were greater in two of the three old-growth sites compared to paired second-growth sites. Across all of the ecoregions, 21 out of 70 species had an affinity for old-growth. Eighteen of which were statistically significant. These results suggest that anthropogenic disturbance plays a key role in shaping species diversity and community structure of land snail fauna. However, site specific factors also appear to be important moderators of the response, and the mechanisms of the process remain to be studied. Snails appear to be a promising group of organisms to use as indicators of historic forest disturbance. In order to maintain ecological integrity, forest managers should consider management strategies that are low impact and protect existing patches of old-growth forests

Livelihood strategies in the rural Kenyan highlands

The concept of a livelihood strategy has become central to development practice in recent years. Nonetheless, precise identification of livelihoods in quantitative data has remained methodologically elusive. This paper uses cluster analysis methods to operationalize the concept of livelihood strategies in household data and then uses the resulting strategy-specific income distributions to test whether the hypothesized outcome differences between livelihoods indeed exist. Using data from Kenya’s central and western highlands, we identify five distinct livelihood strategies that exhibit statistically significant differences in mean per capita incomes and stochastic dominance orderings that establish clear welfare rankings among livelihood strategies. Multinomial regression analysis identifies geographic, demographic and financial determinants of livelihood choice. The results should facilitate targeting of interventions designed to improve household livelihoods.Livelihood strategy, Kenya, Smallholder agriculture, Cluster analysis, Community/Rural/Urban Development,

Review of climate screening approaches and tools for agricultural investment: Areas for action and opportunities to add value

The CGIAR Research Program on Climate Change, Agriculture and Food Security (CCAFS) Climate Risk Management Flagship aims to enable the transition towards more climate-smart agricultural systems and climate-resilient rural livelihoods in high-risk environments. It does this in part by supporting the availability and effective use of relevant climate information by farmers and by the institutions that support them. As an initial step towards assessing whether and how CCAFS and its partners might contribute to improvements in the ways these funds are screened and used, CCAFS commissioned this selective review of current climate screening approaches and tools that several major development investors have put in place in recent years, focusing on their approach to screening investments in agriculture and food security. This selective review of donor agencies was undertaken in order to understand their various approaches to climate screening, identify current issues that they are facing, look for common threads and themes among them and suggest ways in which CCAFS might add value to their screening processes and that of other donors. In general, climate screening tools and approaches appear to be fairly well-developed and integrated in donor strategy and proposal development processes. Donors recognize their limitations and are seeking to modify them accordingly. There is certainly room for improvement, whether that be in facilitating the incorporation of relevant climate data into screening tools (to reduce the human effort required), ensuring that users are well-trained and oriented into climate screening for agriculture in order to reduce the impact of subjectivity on screening outcomes, and so on. That being said, informants were clear that there is not a need for more tools – but guidance and resources to support users in making more effective use of what exists. There is a need to generate additional evidence for the synergies to be derived from doing adaptation, mitigation and development together as well as to proactively communicate the importance of the paradigm shift embodied by this approach to agriculture. Additionally, there is an opportunity to assist donors through the development of guidance resources related to agriculture, to the appropriate and realistic use of climate information as well as more general information about no-regrets approaches to rehabilitating degraded lands and working with farmers in the context of climate variability and change when information is limited and the future is uncertain

Homozygous in-frame deletion in CATSPERE in a man producing spermatozoa with loss of CatSper function and compromised fertilizing capacity

STUDY QUESTIONDoes a man (patient 1) with a previously described deficiency in principle cation channel of sperm (CatSper) function have a mutation in the CatSper-epsilon (CATSPERE) and/or CatSper-zeta (CATSPERZ) gene?SUMMARY ANSWERPatient 1 has a homozygous in-frame 6-bp deletion in exon 18 (c.2393_2398delCTATGG, rs761237686) of CATSPERE.WHAT IS KNOWN ALREADYCatSper is the principal calcium channel of mammalian spermatozoa. Spermatozoa from patient 1 had a specific loss of CatSper function and were unable to fertilize at IVF. Loss of CatSper function could not be attributed to genetic abnormalities in coding regions of seven CatSper subunits. Two additional subunits (CatSper-epsilon (CATPSERE) and CatSper-zeta (CATSPERZ)) were recently identified, and are now proposed to contribute to the formation of the mature channel complex.STUDY DESIGN, SIZE, DURATIONThis was a basic medical research study analysing genomic data from a single patient (patient 1) for defects in CATSPERE and CATSPERZ.PARTICIPANTS/MATERIALS, SETTING, METHODSThe original exome sequencing data for patient 1 were analysed for mutations in CATSPERE and CATSPERZ. Sanger sequencing was conducted to confirm the presence of a rare variant.MAIN RESULTS AND THE ROLE OF CHANCEPatient 1 is homozygous for an in-frame 6-bp deletion in exon 18 (c.2393_2398delCTATGG, rs761237686) of CATSPERE that is predicted to be highly deleterious.LIMITATIONS, REASONS FOR CAUTIONThe nature of the molecular deficit caused by the rs761237686 variant and whether it is exclusively responsible for the loss of CatSper function remain to be elucidated.WIDER IMPLICATIONS OF THE FINDINGSPopulation genetics are available for a significant number of predicted deleterious variants of CatSper subunits. The consequence of homozygous and compound heterozygous forms on sperm fertilization potential could be significant. Selective targeting of CatSper subunit expression maybe a feasible strategy for the development of novel contraceptives.STUDY FUNDING/COMPETING INTEREST(S)This study was funded by project grants from the MRC (MR/K013343/1 and MR/012492/1), Chief Scientist Office/NHS research Scotland. This work was also supported by NIH R01GM111802, Pew Biomedical Scholars Award 00028642 and Packer Wentz Endowment Will to P.V.L. C.L.R.B is the editor-in-chief of Molecular Human Reproduction, has received lecturing fees from Merck and Ferring, and is on the Scientific Advisory Panel for Ohana BioSciences. C.L.R.B was chair of the World Health Organization Expert Synthesis Group on Diagnosis of Male infertility (2012–2016)

Blocking a wave: Frequency band gaps in ice shelves with periodic crevasses

We assess how the propagation of high-frequency elastic-flexural waves through an ice shelf is modified by the presence of spatially periodic crevasses. Analysis of the normal modes supported by the ice shelf with and without crevasses reveals that a periodic crevasse distribution qualitatively changes the mechanical response. The normal modes of an ice shelf free of crevasses are evenly distributed as a function of frequency. In contrast, the normal modes of a crevasse-ridden ice shelf are distributed unevenly. There are "band gaps", frequency ranges over which no eigenmodes exist. A model ice shelf that is 50 km in lateral extent and 300 m thick with crevasses spaced 500 m apart has a band gap from 0.2 to 0.38 Hz. This is a frequency range relevant for ocean wave/ice-shelf interactions. When the outermost edge of the crevassed ice shelf is oscillated at a frequency within the band gap, the ice shelf responds very differently from a crevasse-free ice shelf. The flexural motion of the crevassed ice shelf is confined to a small region near the outermost edge of the ice shelf and effectively "blocked" from reaching the interior.Comment: 6 pages, 4 figures, accepted to Annals of Glaciolog

The role of Isocitrate Lyase (ICL1) in the metabolic adaptation of Candida albicans biofilms

Background A major characteristic of Candida biofilm cells that differentiates them from free-floating cells is their high tolerance to antifungal drugs. This high resistance is attributed to particular biofilm properties, including the accumulation of extrapolymeric substances, morphogenetic switching, and metabolic flexibility. Objectives This study evaluated the roles of metabolic processes (in particular the glyoxylate cycle) on biofilm formation, antifungal drug resistance, morphology, and cell wall components. Methods Growth, adhesion, biofilm formation, and cell wall carbohydrate composition were quantified for isogenic Candida albicans ICL1/ICL1, ICL1/icl1, and icl1/icl1 strains. The morphology and topography of these strains were compared by light microscopy and scanning electron microscopy. FKS1 (glucan synthase), ERG11 (14-α-demethylase), and CDR2 (efflux pump) mRNA levels were quantified using qRT-PCR. Results The ICL1/icl1 and icl1/icl1 strains formed similar biofilms and exhibited analogous drug-tolerance levels to the control ICL1/ICL1 strains. Furthermore, the drug sequestration ability of β-1, 3-glucan, a major carbohydrate component of the extracellular matrix, was not impaired. However, the inactivation of ICL1 did impair morphogenesis. ICL1 deletion also had a considerable effect on the expression of the FKS1, ERG11, and CDR2 genes. FKS1 and ERG11 were upregulated in ICL1/icl1 and icl1/icl1 cells throughout the biofilm developmental stages, and CDR2 was upregulated at the early phase. However, their expression was downregulated compared to the control ICL1/ICL1 strain. Conclusions We conclude that the glyoxylate cycle is not a specific determinant of biofilm drug resistance

What Brown saw and you can too

A discussion is given of Robert Brown's original observations of particles ejected by pollen of the plant \textit{Clarkia pulchella} undergoing what is now called Brownian motion. We consider the nature of those particles, and how he misinterpreted the Airy disc of the smallest particles to be universal organic building blocks. Relevant qualitative and quantitative investigations with a modern microscope and with a "homemade" single lens microscope similar to Brown's, are presented.Comment: 14.1 pages, 11 figures, to be published in the American Journal of Physics. This differs from the previous version only in the web site referred to in reference 3. Today, this Brownian motion web site was launched, and http://physerver.hamilton.edu/Research/Brownian/index.html, is now correc