877 research outputs found

    Indications, complications, and outcomes of cardiac surgery after heart transplantation: results from the cash study

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    [Abstract] Background: Allograft pathologies, such as valvular, coronary artery, or aortic disease, may occur early and late after cardiac transplantation. Cardiac surgery after heart transplantation (CASH) may be an option to improve quality of life and allograft function and prolong survival. Experience with CASH, however, has been limited to single-center reports. Methods: We performed a retrospective, multicenter study of heart transplant recipients with CASH between January 1984 and December 2020. In this study, 60 high-volume cardiac transplant centers were invited to participate. Results: Data were available from 19 centers in North America (n = 7), South America (n = 1), and Europe (n = 11), with a total of 110 patients. A median of 3 (IQR 2-8.5) operations was reported by each center; five centers included ≥ 10 patients. Indications for CASH were valvular disease (n = 62), coronary artery disease (CAD) (n = 16), constrictive pericarditis (n = 17), aortic pathology (n = 13), and myxoma (n = 2). The median age at CASH was 57.7 (47.8-63.1) years, with a median time from transplant to CASH of 4.4 (1-9.6) years. Reoperation within the first year after transplantation was performed in 24.5%. In-hospital mortality was 9.1% (n = 10). 1-year survival was 86.2% and median follow-up was 8.2 (3.8-14.6) years. The most frequent perioperative complications were acute kidney injury and bleeding revision in 18 and 9.1%, respectively. Conclusion: Cardiac surgery after heart transplantation has low in-hospital mortality and postoperative complications in carefully selected patients. The incidence and type of CASH vary between international centers. Risk factors for the worse outcome are higher European System for Cardiac Operative Risk Evaluation (EuroSCORE II) and postoperative renal failure

    Observation of an Excited Bc+ State

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    Using pp collision data corresponding to an integrated luminosity of 8.5 fb-1 recorded by the LHCb experiment at center-of-mass energies of s=7, 8, and 13 TeV, the observation of an excited Bc+ state in the Bc+π+π- invariant-mass spectrum is reported. The observed peak has a mass of 6841.2±0.6(stat)±0.1(syst)±0.8(Bc+) MeV/c2, where the last uncertainty is due to the limited knowledge of the Bc+ mass. It is consistent with expectations of the Bc∗(2S31)+ state reconstructed without the low-energy photon from the Bc∗(1S31)+→Bc+γ decay following Bc∗(2S31)+→Bc∗(1S31)+π+π-. A second state is seen with a global (local) statistical significance of 2.2σ (3.2σ) and a mass of 6872.1±1.3(stat)±0.1(syst)±0.8(Bc+) MeV/c2, and is consistent with the Bc(2S10)+ state. These mass measurements are the most precise to date

    Impacts of chemical gradients on microbial community structure

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    Succession of redox processes is sometimes assumed to define a basic microbial community structure for ecosystems with oxygen gradients. In this paradigm, aerobic respiration, denitrification, fermentation and sulfate reduction proceed in a thermodynamically determined order, known as the ‘redox tower’. Here, we investigated whether redox sorting of microbial processes explains microbial community structure at low-oxygen concentrations. We subjected a diverse microbial community sampled from a coastal marine sediment to 100 days of tidal cycling in a laboratory chemostat. Oxygen gradients (both in space and time) led to the assembly of a microbial community dominated by populations that each performed aerobic and anaerobic metabolism in parallel. This was shown by metagenomics, transcriptomics, proteomics and stable isotope incubations. Effective oxygen consumption combined with the formation of microaggregates sustained the activity of oxygen-sensitive anaerobic enzymes, leading to braiding of unsorted redox processes, within and between populations. Analyses of available metagenomic data sets indicated that the same ecological strategies might also be successful in some natural ecosystems

    Measurement of the Bs0 →μ+μ- decay properties and search for the B0 →μ+μ- and Bs0 →μ+μ-γ decays

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    An improved measurement of the decay B0s→μ+μ− and searches for the decays B0→μ+μ− and B0s→μ+μ−γ are performed at the LHCb experiment using data collected in proton-proton collisions at √s=7, 8 and 13 TeV, corresponding to integrated luminosities of 1, 2 and 6  fb−1, respectively. The B0s→μ+μ− branching fraction and effective lifetime are measured to be B(B0s→μ+μ−)=(3.09+0.46+0.15−0.43−0.11)×10−9 and τ(B0s→μ+μ−)=(2.07±0.29±0.03)  ps, respectively, where the uncertainties include both statistical and systematic contributions. No significant signal for B0→μ+μ− and B0s→μ+μ−γ decays is found and the upper limits B(B0→μ+μ−)4.9  GeV/c2. Additionally, the ratio between the B0→μ+μ− and B0s→μ+μ− branching fractions is measured to be Rμ+μ−<0.095 at 95% confidence level. The results are in agreement with the Standard Model predictions

    Measurement of χc1(3872) production in proton-proton collisions at √s = 8 and 13 TeV

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    The production cross-section of the χc1(3872) state relative to the ψ(2S) meson is measured using proton-proton collision data collected with the LHCb experiment at centre-of-mass energies of s√s = 8 and 13 TeV, corresponding to integrated luminosities of 2.0 and 5.4 fb−1, respectively. The two mesons are reconstructed in the J/ψπ+π− final state. The ratios of the prompt and nonprompt χc1(3872) to ψ(2S) production cross-sections are measured as a function of transverse momentum, pT, and rapidity, y, of the χc1(3872) and ψ(2S) states, in the kinematic range 4 < pT < 20 GeV/c and 2.0 < y < 4.5. The prompt ratio is found to increase with pT, independently of y. For the prompt component, the double ratio of the χc1(3872) and ψ(2S) production cross-sections between 13 and 8 TeV is observed to be consistent with unity, independent of pT and centre-of-mass energy

    Observation of Λ0b → D+pπ−π− and Λ0b → D*+pπ−π− decays

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    The multihadron decays Λ0b → D+pπ−π− and Λ0b → D*+pπ−π− are observed in data corresponding to an integrated luminosity of 3 fb−1, collected in proton-proton collisions at centre-of-mass energies of 7 and 8 TeV by the LHCb detector. Using the decay Λ0b → Λ+cπ+π−π− as a normalisation channel, the ratio of branching fractions is measured to be B(Λ0b→D+pπ−π−)B(Λ0b→Λ0cπ+π−π−)×B(D+→K−π+π+)B(Λ0c→pK−π−)=(5.35±0.21±0.16)%, where the first uncertainty is statistical and the second systematic. The ratio of branching fractions for the Λ0b → D*+pπ−π− and Λ0b → D+pπ−π− decays is found to be B(Λ0b→D∗+pπ−π−)B(Λ0b→D+pπ−π−)×(B(D∗+→D+π0)+B(D∗+→D+γ))=(61.3±4.3±4.0)%

    Observation of the B0→D*0K+π− and B0s→D*0K−π+ decays

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    The first observations of B 0 → ¯ D ∗ ( 2007 ) 0 K + π − and B 0 s → ¯ D ∗ ( 2007 ) 0 K − π + decays are presented, and their branching fractions relative to that of the B 0 → ¯ D ∗ ( 2007 ) 0 π + π − decay are reported. These modes can potentially be used to investigate the spectroscopy of charm and charm-strange resonances and to determine the angle γ of the Cabibbo-Kobayashi-Maskawa unitarity triangle. It is also important to understand them as a source of potential background in determinations of γ from B + → D K + and B 0 → D K + π − decays. The analysis is based on a sample corresponding to an integrated luminosity of 5.4     fb − 1 of proton-proton collision data at 13 TeV center-of-mass energy recorded with the LHCb detector. The ¯ D ∗ ( 2007 ) 0 mesons are fully reconstructed in the ¯ D 0 π 0 and ¯ D 0 γ channels with the ¯ D 0 → K + π − decay. A novel weighting method is used to subtract background while simultaneously applying an event-by-event efficiency correction to account for resonant structures in the decays
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