European organization of telecom regulators and the impact on the pace of telecom innovations, Is EU modesty hampering innovation in telecom? Think global, act local…

In a recent political discussion about the optimal division of power and competence between national and European regulatory bodies for telecommunication markets, the European Commission, the Parliament and the Council fundamentally disagreed about the necessity and most suitable arrangement (if any) for a newly established regulatory body. In the end, a body of European Regulators for Electronic Communications (BEREC) resulted as a compromise. This paper initially describes the decision making process from which BEREC resulted and subsequently critically assesses the expected contribution of BEREC to the innovativeness of the internal telecommunication markets by confronting BEREC with innovation theory and general principles for effective market authority. One result of this analysis is that a more centralized model of market authority (as initially considered by the Commission) might contribute more to the innovative potential of the internal telecommunication markets than BEREC is expected to

Structure of the Cytoplasmic Loop between Putative Helices II and III of the Mannitol Permease of Escherichia coli: A Tryptophan and 5-Fluorotryptophan Spectroscopy Study

In this work, four single tryptophan (Trp) mutants of the dimeric mannitol transporter of Escherichia coli, EIImtl, are characterized using Trp and 5-fluoroTrp (5-FTrp) fluorescence spectroscopy. The four positions, 97, 114, 126, and 133, are located in a region shown by recent studies to be involved in the mannitol translocation process. To spectroscopically distinguish between the Trp positions in each subunit of dimeric EIImtl, 5-FTrp was biosynthetically incorporated because of its much simpler photophysics compared to those of Trp. The steady-state and time-resolved fluorescence methodologies used point out that all four positions are in structured environments, both in the absence and in the presence of a saturating concentration of mannitol. The fluorescence decay of all 5-FTrp-containing mutants was highly homogeneous, suggesting similar microenvironments for both probes per dimer. However, Stern-Volmer quenching experiments using potassium iodide indicate different solvent accessibilities for the two probes at positions 97 and 133. A 5 Å two-dimensional (2D) projection map of the membrane-embedded IICmtl dimer showing 2-fold symmetry is available. The results of this work are in better agreement with a 7 Å projection map from a single 2D crystal on which no symmetry was imposed.

The Elephant Trunk Nebula and the Trumpler 37 cluster: Contribution of triggered star formation to the total population of an HII region

Rich young stellar clusters produce HII regions whose expansion into the nearby molecular cloud is thought to trigger the formation of new stars. However, the importance of this mode of star formation is uncertain. This investigation seeks to quantify triggered star formation (TSF) in IC 1396A (a.k.a., the Elephant Trunk Nebula), a bright rimmed cloud (BRC) on the periphery of the nearby giant HII region IC 1396 produced by the Trumpler 37 cluster. X-ray selection of young stars from Chandra X-ray Observatory data is combined with existing optical and infrared surveys to give a more complete census of the TSF population. Over 250 young stars in and around IC 1396A are identified; this doubles the previously known population. A spatio-temporal gradient of stars from the IC 1396A cloud toward the primary ionizing star HD 206267 is found. We argue that the TSF mechanism in IC 1396A is the radiation-driven implosion process persisting over several million years. Analysis of the X-ray luminosity and initial mass functions indicates that >140 stars down to 0.1 Msun were formed by TSF. Considering other BRCs in the IC 1396 HII region, we estimate the TSF contribution for the entire HII region exceeds 14-25% today, and may be higher over the lifetime of the HII region. Such triggering on the periphery of HII regions may be a significant mode of star formation in the Galaxy.Comment: Accepted for publication in MNRAS; 28 pages, 18 figure

HIF-1α-independent hypoxia-induced rapid PTK6 stabilization is associated with increased motility and invasion

This article has been made available through the Brunel Open Access Publishing Fund.PTK6/Brk is a non-receptor tyrosine kinase overexpressed in cancer. Here we demonstrate that cytosolic PTK6 is rapidly and robustly induced in response to hypoxic conditions in a HIF-1-independent manner. Furthermore, a proportion of hypoxic PTK6 subsequently re-localized to the cell membrane. We observed that the rapid stabilization of PTK6 is associated with a decrease in PTK6 ubiquitylation and we have identified c-Cbl as a putative PTK6 E3 ligase in normoxia. The consequences of hypoxia-induced PTK6 stabilization and subcellular re-localization to the plasma membrane include increased cell motility and invasion, suggesting PTK6 targeting as a therapeutic approach to reduce hypoxia-regulated metastatic potential. This could have particular significance for breast cancer patients with triple negative disease.A Breast Cancer Campaign pilot grant awarded to E.M.H. supported this study. I.M.P. is supported by University of Hull HEFCE funding, and Royal Society and Breast Cancer Campaign pilot grants. S.A.E. is supported by ICR HEFCE funding and Cancer Research UK program grant C309/A11566. A.H. is supported by Brunel University HEFCE funding. E.M.H. is supported by a Cancer Research UK grant

Membership of the Orion Nebula Population from the Chandra Orion Ultradeep Project

The Chandra Orion Ultradeep project (COUP) observation described in a companion paper by Getman et al. provides an exceptionally deep X-ray survey of the Orion Nebula Cluster and associated embedded young stellar objects. Membership of the region is important for studies of the stellar IMF, cluster dynamics, and star formation. The COUP study detected 1616 X-ray sources. In this study we confirm cloud membership for 1315 stars, identify 16 probable foreground field stars having optical counterparts with discrepant proper motions, and classify the remaining 285 X-ray sources, of which 51 are lightly and 234 heavily obscured. The 51 lightly obscured sources without known counterparts fall into three groups. (i) Sixteen are likely new members of the Orion Nebula Cluster. (ii) Two with unusually soft and non-flaring X-ray emission appear to be associated with nebular shocks, and may be new examples of X-rays produced at the bow shocks of Herbig-Haro outflows. (iii) The remaining thirty three are very weak uncertain sources, possibly spurious. Out of 234 heavily absorbed sources without optical or near-infrared counterparts 75 COUP sources are likely new embedded cloud members (with membership for 42 confirmed by powerful X-ray flares), and the remaining 159 are likely extragalactic AGN seen through the molecular cloud, as argued by a careful simulation of the extragalactic background population. Finally, a few new binary companions to Orion stars may have been found, but most cases of proximate COUP sources can be attributed to chance superpositions in this crowded field.Comment: 49 pages, 6 figures, 5 tables. Accepted for publication in ApJS, special issue dedicated to Chandra Orion Ultradeep Project. A version with high quality figures can be found at http://www.astro.psu.edu/users/gkosta/COUP_Membership.pd

Rapid Circumstellar Disk Evolution and an Accelerating Star Formation Rate in the Infrared Dark Cloud M17 SWex

We present a catalog of 840 X-ray sources and first results from a 100 ks Chandra X-ray Observatory imaging study of the filamentary infrared dark cloud G014.225$-$00.506, which forms the central regions of a larger cloud complex known as the M17 southwest extension (M17 SWex). In addition to the rich population of protostars and young stellar objects with dusty circumstellar disks revealed by Spitzer Space Telescope archival data, we discover a population of X-ray-emitting, intermediate-mass pre--main-sequence stars (IMPS) that lack infrared excess emission from circumstellar disks. We model the infrared spectral energy distributions of this source population to measure its mass function and place new constraints on the inner dust disk destruction timescales for 2-8 $M_{\odot}$ stars. We also place a lower limit on the star formation rate (SFR) and find that it is quite high ($\dot{M}\ge 0.007~M_{\odot}$ yr$^{-1}$), equivalent to several Orion Nebula Clusters in G14.225$-$0.506 alone, and likely accelerating. The cloud complex has not produced a population of massive, O-type stars commensurate with its SFR. This absence of very massive (${\ge}20~M_{\odot}$) stars suggests that either (1) M17 SWex is an example of a distributed mode of star formation that will produce a large OB association dominated by intermediate-mass stars but relatively few massive clusters, or (2) the massive cores are still in the process of accreting sufficient mass to form massive clusters hosting O stars.Comment: 29 pages, 9 figures, accepted to Ap