Renovatie Praktijkcentrum Sterksel: de vleesvarkensunit

In 2001 wordt deze unit met name ingezet voor het onderzoek naar 60% dichte vloer bij vleesvarkens. In dit artikel volgt een uitgebreidere beschrijving van de nieuwe vleesvarkensunit, die in 2000 gebouwd is

Renovatie praktijkcentrum Sterksel: de stal voor guste en drachtige zeugen

Speerpunten zijn onderzoek naar economisch duurzame implementaties van het Varkensbesluit 1998 in combinatie met emissie-arme huisvesting en optimale klimaatbeheersing

Energiezuinig ventileren met nieuwe luchtinlaatsystemen

Soms lijkt het er op dat 's zomers geldt: 'hoe meer ventileren, hoe beter'. Het Praktijkonderzoek is ervan overtuigd, dat de variant 'minder maar efficiënter' tot succes kan leiden

Artificial termite-fishing tasks as enrichment for sanctuary-housed chimpanzees: Behavioral effects and impact on welfare

The welfare of captive animals is nowadays a topic of major concern. In order to express their natural behavioral repertoires, however, animals require complex environments and stimuli which are difficult to reproduce in captivity. To overcome this, environmental enrichment is considered one of the most successful tools to increase behavioral opportunities and enhance animal welfare. In this study, we explored whether providing an artificial termite-fishing task, and whether participation in this task, predicted changes in the solitary and social behavior of sanctuary-housed chimpanzees (Pan troglodytes). We compared chimpanzee behavior when the enrichment was presented to different periods without enrichment. We found that the presence of the enrichment predicted an increase in tool use and feeding behavior and a decrease in inactivity, especially for those chimpanzees with higher participation. However, we did not detect significant changes in abnormal or self-directed behaviors. Furthermore, we found no variation in affiliation- or aggression-related behaviors, but social proximity increased in chimpanzees that participated more. Our results support previous studies demonstrating that artificial termite-fishing promotes species-typical behaviors in captive chimpanzees with no major effects on social activities

A Bayesian nonparametric approach to dynamic item-response modeling: An application to the GUSTO cohort study

Statistical analysis of questionnaire data is often performed employing techniques from item-response theory. In this framework, it is possible to differentiate respondent profiles and characterize the questions (items) included in the questionnaire via interpretable parameters. These models are often crosssectional and aim at evaluating the performance of the respondents. The motivating application of this work is the analysis of psychometric questionnaires taken by a group of mothers at different time points and by their children at one later time point. The data are available through the GUSTO cohort study. To this end, we propose a Bayesian semiparametric model and extend the current literature by: (i) introducing temporal dependence among questionnaires taken at different time points; (ii) jointly modeling the responses to questionnaires taken from different, but related, groups of subjects (in our case mothers and children), introducing a further dependency structure and therefore sharing of information; (iii) allowing clustering of subjects based on their latent response profile. The proposed model is able to identify three main groups of mother/child pairs characterized by their response profiles. Furthermore, we report an interesting maternal reporting bias effect strongly affecting the clustering structure of the mother/child dyads

End-of-life care for patients with advanced ovarian cancer in the Netherlands:A retrospective registry-based analysis

OBJECTIVE: Patients with advanced ovarian cancer have a poor prognosis and can experience debilitating symptoms in the last phase of life. Several analyses, mainly performed in the United States (US), show high rates of chemotherapy administration and hospital visits near the end-of-life in this patient category. No large European studies are available, while the organisation of palliative care differs between the US and Europe. We aimed to analyse the intensity of inpatient care near the end-of-life in the Netherlands and perform a cross-study comparison with previous reports. METHODS: All patients with ovarian cancer that died in 2016 and 2017 were identified from the Vektis database, a data warehouse including all insurance declarations in the Netherlands. For the last 6 months of life the following parameters of aggressive care were extracted: administration of chemotherapy, emergency room (ER) visits, surgical procedures, hospital and intensive care unit (ICU) admissions. The intensity of inpatient care was compared to previously reported European and US data. RESULTS: Data on medical care use was available for 1775 patients. During the last 6 months of life, half of the ovarian cancer patients were admitted to hospital. Chemotherapy administration near the end-of-life was infrequent: 12% in the last month of life. Surgery and ICU admissions in the final 6 months of life were rare (<10%). Our cohort showed the lowest percentages of all five indicators of aggressive care reported thus far. CONCLUSION: Aggressive medical care use in the final 6 months of life in this Dutch cohort of ovarian cancer patients was lower than in other previously reported cohorts

Visualization, navigation, augmentation. The ever-changing perspective of the neurosurgeon

Introduction: The evolution of neurosurgery coincides with the evolution of visualization and navigation. Augmented reality technologies, with their ability to bring digital information into the real environment, have the potential to provide a new, revolutionary perspective to the neurosurgeon. Research question: To provide an overview on the historical and technical aspects of visualization and navigation in neurosurgery, and to provide a systematic review on augmented reality (AR) applications in neurosurgery. Material and methods: We provided an overview on the main historical milestones and technical features of visualization and navigation tools in neurosurgery. We systematically searched PubMed and Scopus databases for AR applications in neurosurgery and specifically discussed their relationship with current visualization and navigation systems, as well as main limitations. Results: The evolution of visualization in neurosurgery is embodied by four magnification systems: surgical loupes, endoscope, surgical microscope and more recently the exoscope, each presenting independent features in terms of magnification capabilities, eye-hand coordination and the possibility to implement additional functions. In regard to navigation, two independent systems have been developed: the frame-based and the frame-less systems. The most frequent application setting for AR is brain surgery (71.6%), specifically neuro-oncology (36.2%) and microscope-based (29.2%), even though in the majority of cases AR applications presented their own visualization supports (66%). Discussion and conclusions: The evolution of visualization and navigation in neurosurgery allowed for the development of more precise instruments; the development and clinical validation of AR applications, have the potential to be the next breakthrough, making surgeries safer, as well as improving surgical experience and reducing costs

Clinical benefit of systemic therapies for recurrent ovarian cancer-ESMO-MCBS scores

BACKGROUND: Licensed systemic treatment options for platinum-sensitive recurrent ovarian cancer are platinum-based chemotherapy and maintenance treatment with bevacizumab and poly (ADP-ribose) polymerase inhibitors. For platinum-resistant disease, several non-platinum options are available. We aimed to assess the clinical benefit of these treatments according to the European Society of Medical Oncology (ESMO)-Magnitude of Clinical Benefit Scale (MCBS). MATERIALS AND METHODS: A PubMed search was carried out including all studies evaluating systemic treatment of recurrent epithelial ovarian cancer, from 1990 onwards. Randomised trials with an adequate comparator and design showing a statistically significant benefit of the study arm were independently scored by two blinded observers using the ESMO-MCBS. RESULTS: A total of 1127 papers were identified, out of which 61 reported results of randomised trials of sufficient quality. Nineteen trials showed statistically significant results and the studied treatments were graded according to ESMO-MCBS. Only three treatments showed substantial benefit (score of 4 on a scale of 1-5) according to the ESMO-MCBS: platinum-based chemotherapy with paclitaxel in the platinum-sensitive setting and the addition of bevacizumab to chemotherapy in the platinum-resistant setting. The WEE1 inhibitor adavosertib (not licensed) also scores a 4, based on a recent small phase II study. Assessment of quality-of-life data and toxicity using the ESMO-MCBS showed to be complex, which should be taken into account in using this score for clinical decision making. CONCLUSION: Only a few licensed systemic therapies for recurrent ovarian cancer show substantial clinical benefit based on ESMO-MCBS scores. Trials demonstrating overall survival benefit are sparse

Guiding cities under increased droughts: The limits to sustainable urban futures

Climate change is likely to increase droughts. The vulnerability of cities to droughts is increasing worldwide. Policy responses from cities to droughts lack consideration of long-term climatic and socio-economic scenarios, and focus on short-term emergency actions that disregard sustainability in the connected regional and river basin systems. We aim to explore the dynamics of the water-energy-land nexus in urban systems suffering increased climate change-related droughts, and their implications for sustainability. We complement a case study with a literature review providing cross-regional insights, and detail pervasive knowledge, policy and ambition gaps in the interaction between cities and droughts. We show that water availability with low emissions, without compromising ecosystems and with low costs to society, poses a local-scale limit to sustainable urban growth, a new concept delineating the limits to growth in cities. We conclude that urban and river basin planners need to institutionalize transparency and cross-sectoral integration in multi-sector partnerships, to consider long-term land use planning together with water and energy, and to apply integrated climate services to cities. Our study reveals the importance of including land, water and energy in long-term urban planning, and to connect them with the county, region, river basin and global scales. © 2021 The Author(s)The authors would like to express their gratitude for limited contributions, comments and discussions that helped to improve the manuscript to Muhamad Bahri, Jörg Cortekar, Mirabela Marin, Serban Octavian Davidescu, Iñaki Torres Cobián, and to two anonymous reviewers that helped to substantially improve the manuscript. Valuable feedback obtained in two conference sessions co‑lead by some of the authors (at Adaptation Futures 2018 in Cape Town, and at the 4th European Climate Change Adaptation conference, in Lisbon in 2019) is acknowledged. The authors acknowledge financial support from the project CLISWELN funded by ERA4CS. ERA4CS is an ERA-NET initiated by JPI Climate, and CLISWELN is funded by BMBF (DE), UEFISCDI (RO), BMBWF and FFG (AT), and MINECO (ES), with co-funding from the European Union (Grant 690462 ). This paper and the content included in it do not represent the opinion of the European Union, and the European Union is not responsible for any use that might be made of its content. Marta OlazabalThe authors would like to express their gratitude for limited contributions, comments and discussions that helped to improve the manuscript to Muhamad Bahri, Jörg Cortekar, Mirabela Marin, Serban Octavian Davidescu, Iñaki Torres Cobián, and to two anonymous reviewers that helped to substantially improve the manuscript. Valuable feedback obtained in two conference sessions co‑lead by some of the authors (at Adaptation Futures 2018 in Cape Town, and at the 4th European Climate Change Adaptation conference, in Lisbon in 2019) is acknowledged. The authors acknowledge financial support from the project CLISWELN funded by ERA4CS. ERA4CS is an ERA-NET initiated by JPI Climate, and CLISWELN is funded by BMBF (DE), UEFISCDI (RO), BMBWF and FFG (AT), and MINECO (ES), with co-funding from the European Union (Grant 690462 ). This paper and the content included in it do not represent the opinion of the European Union, and the European Union is not responsible for any use that might be made of its content. Marta Olazaba

Espacios de gobernanza para la adaptación al cambio global en ríos mediterráneos: el proyecto REDAPTA en las cuencas de los ríos Tordera y Serpis

[EN] The REDAPTA project, "Spaces of Governance for the Adaptation to Global Change in Mediterranean Rivers", developed its activities simultaneously in the Tordera (Catalonia) and Serpis (Valencia Region) river basins. The project worked in collaboration with two "spaces of governance" in the two basins: the "Taula del Delta i de la Baixa Tordera" and the "Plataforma Ciutadana per a la Defensa del Riu Serpis". The methodology used aimed at fostering knowledge exchange and deliberation, delivering an adaptation strategy for the basins including ten measures co-produced with stakeholders. The second result of the REDAPTA project is a handbook describing the concepts and approach used, the main methodological steps of the co-design process and the lessons learned during its implementation. To raise awareness and showcase the importance of public engagement in river monitoring, field visits were organised in the Tordera and the Serpis rivers, including capacity building activities. The participants were able to get to know a river stretch and, by using digital tools developed by the project teams, they could record some observations and indicators for a basic characterisation. Finally, aiming to promote this innovative approach, the project encouraged the exchange of experiences between different organisations in a specific seminar and explored their interest in creating an "Iberian Network of Spaces of Governance for Water Management".[ES] El proyecto REDAPTA, "Espacios de Gobernanza para la Adaptación al Cambio Global en Ríos Mediterráneos", desarrolló sus actividades de forma simultánea en las cuencas de los ríos Tordera (Cataluña) y Serpis (Comunidad Valenciana). El proyecto trabajó en colaboración con dos "espacios de gobernanza": la "Taula del Delta i de la Baixa Tordera" y la "Plataforma Ciutadana per a la Defensa del Riu Serpis". Se siguió una metodología para el proceso de co-diseño, con el objetivo de intercambiar conocimientos y fomentar la deliberación, y el resultado fue un documento estratégico de adaptación, para cada cuenca, que incluye diez medidas concretas de adaptación co-producidas con los actores. El segundo resultado del REDAPTA fue un manual que describe los conceptos y el enfoque aplicados, las principales etapas metodológicas del proceso de co-diseño y las lecciones aprendidas durante su aplicación. Con el objetivo de concienciar a la ciudadanía y visibilizar la importancia del seguimiento participativo de actuaciones de mejora fluvial, se realizó una actividad en campo en ambos ríos, con una primera parte de capacitación y una segunda de toma de información. Los participantes pudieron conocer un tramo del río y, utilizando las herramientas digitales desarrolladas por el proyecto, pudieron registrar diferentes observaciones e indicadores para su caracterización básica. Por último, con el fin de promover el enfoque innovador del proyecto, se llevó a cabo una jornada de intercambio de experiencias entre diferentes organizaciones, explorando su interés en crear una "Red Ibérica de Espacios de Gobernanza para la Gestión del Agua".Broekman, A.; Garófano-Gómez, V.; Martinez-Capel, F.; Sanchez-Plaza, A. (2021). Espacios de gobernanza para la adaptación al cambio global en ríos mediterráneos: el proyecto REDAPTA en las cuencas de los ríos Tordera y Serpis. RestauraRíos. 1:1-16. https://doi.org/10.51443/RestauraRios.2021.01S116