Diagnosis and treatment of urticaria and angioedema: a worldwide perspective

Urticaria and angioedema are common clinical conditions representing a major concern for physicians and patients alike. The World Allergy Organization (WAO), recognizing the importance of these diseases, has contributed to previous guidelines for the diagnosis and management of urticaria. The Scientific and Clinical Issues Council of WAO proposed the development of this global Position Paper to further enhance the clinical management of these disorders through the participation of renowned experts from all WAO regions of the world. Sections on definition and classification, prevalence, etiology and pathogenesis, diagnosis, treatment, and prognosis are based on the best scientific evidence presently available. Additional sections devoted to urticaria and angioedema in children and pregnant women, quality of life and patient-reported outcomes, and physical urticarias have been incorporated into this document. It is expected that this article will supplement recent international guidelines with the contribution of an expert panel designated by the WAO, increasing awareness of the importance of urticaria and angioedema in medical practice and will become a useful source of information for optimum patient management worldwide

Seedtime and Harvest Today

Excerpts from the report: Seedtime and harvest have always been the peak seasons for farm labor, whether done by men and horses or by men and machines; and the approximate dates of these activities are of vital concern to many. But now, with war pressing hard upon our whole economic life, they become of even more critical immediate import. The plans of farmers, farm laborers, employment agencies, transportation systems, markets, and commercial concerns that buy and sell in farm areas are often drawn with the harvest seasons particularly in mind. Now, more than ever before, we need to take account of such circumstances if we are to attain that full production which is our goal. A marked present departure from past conditions during these seasons has to do with farm laborers and their families. Here, again, war, with its drain on manpower for all purposes, adds emphasis to a peacetime trend. Several circumstances, even before this country entered the war, had reduced the need for laborers in farm planting and harvesting work in which vast numbers were formerly employed. This publication takes special note of these changed conditions

Therapeutic strategies and potential implications of silver nanoparticles in the management of skin cancer

Skin cancer (SC) is the most common carcinoma affecting 3 million people annually in the United States and millions of people worldwide. It is classified as melanoma SC (MSC) and non-melanoma SC (NMSC). NMSC represents approximately 80% of SC and includes squamous cell carcinoma and basal cell carcinoma. MSC, however, has a higher mortality rate than SC because of its ability to metastasize. SC is a major health problem in the United States with significant morbidity and mortality in the Caucasian population. Treatment options for SC include cryotherapy, excisional surgery, Mohs surgery, curettage and electrodessication, radiation therapy, photodynamic therapy, immunotherapy, and chemotherapy. Treatment is chosen based on the type of SC and the potential for side effects. Novel targeted therapies are being used with increased frequency for large tumors and for metastatic disease. A scoping literature search on PubMed, Google Scholar, and Cancer Registry websites revealed that traditional chemotherapeutic drugs have little effect against SC after the cancer has metastasized. Following an overview of SC biology, epidemiology, and treatment options, this review focuses on the mechanisms of advanced technologies that use silver nanoparticles in SC treatment regimens