An Oxalate-Bridged Copper(II) Complex Combining Monodentate Benzoate, 2,2'-bipyridine and Aqua Ligands:Synthesis, Crystal Structure and Investigation of Magnetic Properties

A dinuclear copper(II) complex of formula [{Cu(bipy)(bzt)(OH2)}2(μ-ox)] (1) (where bipy = 2,2'-bipyridine, bzt = benzoate and ox = oxalate) was synthesised and characterised by diffractometric (powder and single-crystal XRD) and thermogravimetric (TG/DTG) analyses, spectroscopic techniques (IR, Raman, electron paramagnetic resonance spectroscopy (EPR) and electronic spectroscopy), magnetic measurements and density functional theory (DFT) calculations. The analysis of the crystal structure revealed that the oxalate ligand is in bis(bidentate) coordination mode between two copper(II) centres. The other four positions of the coordination environment of the copper(II) ion are occupied by one water molecule, a bidentate bipy and a monodentate bzt ligand. An inversion centre located on the ox ligand generates the other half of the dinuclear complex. Intermolecular hydrogen bonds and π-π interactions are responsible for the organisation of the molecules in the solid state. Molar magnetic susceptibility and field dependence magnetisation studies evidenced a weak intramolecular-ferromagnetic interaction (J = +2.9 cm-1) between the metal ions. The sign and magnitude of the calculated J value by density functional theory (DFT) are in agreement with the experimental data

Covalency and magnetic anisotropy in lanthanide single molecule magnets: the DyDOTA archetype

International audienc

Does prostate acinar adenocarcinoma with Gleason Score 3 + 3 = 6 have the potential to metastasize?

Background: There is a worldwide debate involving clinicians, uropathologists as well as patients and their families on whether Gleason score 6 adenocarcinoma should be labelled as cancer. Case description: We report a case of man diagnosed with biopsy Gleason score 6 acinar adenocarcinoma and classified as low risk (based on a PSA of 5 ng/mL and stage cT2a) whose radical prostatectomy specimen initially showed organ confined Gleason score 3 + 3 = 6, WHO nuclear grade 3, acinar adenocarcinoma with lymphovascular invasion and secondary deposit in a periprostatic lymph node. When deeper sections were cut to the point that almost all the slice present in the paraffin block was sectioned, a small tumor area (<5% of the whole tumor) of Gleason pattern 4 (poorly formed glands) was found in an extraprostatic position. Conclusion: The epilogue was that the additional finding changed the final Gleason score to 3 + 3 = 6 with tertiary pattern 4 and the stage to pT3a. Virtual Slides: The virtual slide(s) for this article can be found here: http://www.diagnosticpathology.diagnomx.eu/ vs/13000_2014_19

Relaxation Dynamics and Magnetic Anisotropy in a Low-Symmetry DyIII Complex

The magnetic behaviour of a Dy(LH)3 complex (LH(-) is the anion of 2-hydroxy-N'-[(E)-(2-hydroxy-3-methoxyphenyl)methylidene]benzhydrazide) was analysed in depth from both theoretical and experimental points of view. Cantilever torque magnetometry indicated that the complex has Ising-type anisotropy, and provided two possible directions for the easy axis of anisotropy due to the presence of two magnetically non-equivalent molecules in the crystal. Ab initio calculations confirmed the strong Ising-type anisotropy and disentangled the two possible orientations. The computed results obtained by using ab initio calculations were then used to rationalise the composite dynamic behaviour observed for both pure Dy(III) phase and Y(III) diluted phase, which showed two different relaxation channels in zero and non-zero static magnetic fields. In particular, we showed that the relaxation behaviour at the higher temperature range can be correctly reproduced by using a master matrix approach, which suggests that Orbach relaxation is occurring through a second excited doublet

Bimodal CD40/Fas-Dependent Crosstalk between iNKT Cells and Tumor-Associated Macrophages Impairs Prostate Cancer Progression

Heterotypic cellular and molecular interactions in the tumor microenvironment (TME) control cancer progression. Here, we show that CD1d-restricted invariant natural killer (iNKT) cells control prostate cancer (PCa) progression by sculpting the TME. In a mouse PCa model, iNKT cells restrained the proangiogenic and immunosuppressive capabilities of tumor-infiltrating immune cells by reducing proangiogenic TIE2+, M2-like macrophages (TEMs), and sustaining pro-inflammatory M1-like macrophages. iNKT cells directly contacted macrophages in the PCa stroma, and iNKT cell transfer into tumorbearing mice abated TEMs, delaying tumor progression. iNKT cells modulated macrophages through the cooperative engagement of CD1d, Fas, and CD40, which promoted selective killing of M2-like and survival of M1-like macrophages. Human PCa aggressiveness associate with reduced intra-tumoral iNKT cells, increased TEMs, and expression of pro-angiogenic genes, underscoring the clinical significance of this crosstalk. Therefore, iNKT cells may control PCa through mechanisms involving differential macrophage modulation, which may be harnessed for therapeutically reprogramming the TME

Using a scale model room to assess the contribution of building material of volcanic origin to indoor radon

AbstractIn the frame of Radon rEal time monitoring System and Proactive Indoor Remediation (RESPIRE), a LIFE 2016 project funded by the European Commission, the contribution of building materials of volcanic origin to indoor radon concentration was investigated. First, total gamma radiation and related outdoor dose rates of geological materials in the Caprarola area (Central Italy) were measured to define main sources of radiation. Second, 222Rn and 220Rn exhalation rates of these rocks used as building materials were measured using an accumulation chamber connected in a closed loop with a RAD7 radon monitor. Among others, the very porous "Tufo di Gallese" ignimbrite provided the highest values. This material was then used to construct a scale model room of 62 cm × 50 cm × 35 cm (inner length × width × height, respectively) to assess experimental radon and thoron activity concentration at equilibrium and study the effects of climatic conditions and different coatings on radon levels. A first test was carried out at ambient temperature to determine experimental 222Rn and 220Rn equilibrium activities in the model room, not covered with plaster or other coating materials. Experimental 222Rn equilibrium was recorded in just two days demonstrating that the room "breaths", exchanging air with the outdoor environment. This determines a dilution of indoor radon concentration. Other experiments showed that inner covers (such as plasterboard and different kinds of paints) partially influence 222Rn but entirely cut the short-lived 220Rn. Finally, decreases in ambient temperature reduce radon exhalation from building material and, in turn, indoor activity concentration