Do Entry Conditions Vary across Markets?

macroeconomics, entry conditions

Common Carrier Regulation of Telecommunications Contracts and the Private Carrier Alternative

The Communications Act of 1934 requires, among other things, that telephone companies as common carriers make their services available to the general public at affordable rates. The Federal Communications Commission (FCC) has the authority to classify telephone services as common carriers as well as the ability to remove common carrier regulation to promote competition, satisfy consumer demand for individually tailored offerings, and avoid unnecessary regulatory costs. The Authors of this Article believe that the FCC should remove the common carrier regulation from certain long-distance service contracts and that such regulation is consistent with the deregulatory aims of the recent Telecommunications Act of 1996. The Article first reviews the judicial development of the common carrier definition which finds that a communications service is acting as a carrier if it either (1) actually holds out its service indiscriminately to the public or (2) is required to hold itself out because the public interest requires it. The Authors discuss the relatively broad application of this definition to new and existing telephone services in a series of cases. Part I concludes with an examination of recent instances where the FCC has used this definition to reclassify various telecommunications services as private or noncommon carriers/carriage. These instances fall into five categories: (1) satellite transponders, (2) broadcast-related services, (3) private land mobile services, (4) private microwave services, and (5) certain communications services, such as enhanced services and inside wiring. In Part II the Authors describe the growth and importance of individually negotiated telecommunications service contracts to the business operations of many customers. The Article then discusses the application of the private carrier alternative to these contracts. The Authors argue that there is nothing inherent in these contracts which requires that they be designated as common carrier services. The Authors offer several reasons why the FCC should no longer require that the contract services indiscriminately be held out to the public, including some of the potential benefits of removing this regulation. The Authors feel that classifying the service contracts as private would promote competition and innovation, as well as reduce regulatory costs

Common Carrier Regulation of Telecommunications Contracts and the Private Carrier Alternative

The Communications Act of 1934 requires, among other things, that telephone companies as common carriers make their services available to the general public at affordable rates. The Federal Communications Commission (FCC) has the authority to classify telephone services as common carriers as well as the ability to remove common carrier regulation to promote competition, satisfy consumer demand for individually tailored offerings, and avoid unnecessary regulatory costs. The Authors of this Article believe that the FCC should remove the common carrier regulation from certain long-distance service contracts and that such regulation is consistent with the deregulatory aims of the recent Telecommunications Act of 1996. The Article first reviews the judicial development of the common carrier definition which finds that a communications service is acting as a carrier if it either (1) actually holds out its service indiscriminately to the public or (2) is required to hold itself out because the public interest requires it. The Authors discuss the relatively broad application of this definition to new and existing telephone services in a series of cases. Part I concludes with an examination of recent instances where the FCC has used this definition to reclassify various telecommunications services as private or noncommon carriers/carriage. These instances fall into five categories: (1) satellite transponders, (2) broadcast-related services, (3) private land mobile services, (4) private microwave services, and (5) certain communications services, such as enhanced services and inside wiring. In Part II the Authors describe the growth and importance of individually negotiated telecommunications service contracts to the business operations of many customers. The Article then discusses the application of the private carrier alternative to these contracts. The Authors argue that there is nothing inherent in these contracts which requires that they be designated as common carrier services. The Authors offer several reasons why the FCC should no longer require that the contract services indiscriminately be held out to the public, including some of the potential benefits of removing this regulation. The Authors feel that classifying the service contracts as private would promote competition and innovation, as well as reduce regulatory costs

Preferences of children in grades two through eight in social studies subject areas

Thesis (Ed.M.)--Boston Universit

APOBECs and Herpesviruses

The apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like (APOBEC) family of DNA cytosine deaminases provides a broad and overlapping defense against viral infections. Successful viral pathogens, by definition, have evolved strategies to escape restriction by the APOBEC enzymes of their hosts. HIV-1 and related retroviruses are thought to be the predominant natural substrates of APOBEC enzymes due to obligate single-stranded (ss)DNA replication intermediates, abundant evidence for cDNA strand C-to-U editing (genomic strand G-to-A hypermutation), and a potent APOBEC degradation mechanism. In contrast, much lower mutation rates are observed in double-stranded DNA herpesviruses and the evidence for APOBEC mutation has been less compelling. However, recent work has revealed that Epstein-Barr virus (EBV), Kaposi's sarcoma-associated herpesvirus (KSHV), and herpes simplex virus-1 (HSV-1) are potential substrates for cellular APOBEC enzymes. To prevent APOBEC-mediated restriction these viruses have repurposed their ribonucleotide reductase (RNR) large subunits to directly bind, inhibit, and relocalize at least two distinct APOBEC enzymes-APOBEC3B and APOBEC3A. The importance of this interaction is evidenced by genetic inactivation of the EBV RNR (BORF2), which results in lower viral infectivity and higher levels of C/G-to-T/A hypermutation. This RNR-mediated mechanism therefore likely functions to protect lytic phase viral DNA replication intermediates from APOBEC-catalyzed DNA C-to-U deamination. The RNR-APOBEC interaction defines a new pathogen-host conflict that the virus must win in real-time for transmission and pathogenesis. However, partial losses over evolutionary time may also benefit the virus by providing mutational fuel for adaptation

Ultra-High Temperature Distributed Wireless Sensors

Research was conducted towards the development of a passive wireless sensor for measurement of temperature in coal gasifiers and coal-fired boiler plants. Approaches investigated included metamaterial sensors based on guided mode resonance filters, and temperature-sensitive antennas that modulate the frequency of incident radio waves as they are re-radiated by the antenna. In the guided mode resonant filter metamaterial approach, temperature is encoded as changes in the sharpness of the filter response, which changes with temperature because the dielectric loss of the guided mode resonance filter is temperature-dependent. In the mechanically modulated antenna approach, the resonant frequency of a vibrating cantilever beam attached to the antenna changes with temperature. The vibration of the beam perturbs the electrical impedance of the antenna, so that incident radio waves are phase modulated at a frequency equal to the resonant frequency of the vibrating beam. Since the beam resonant frequency depends on temperature, a Doppler radar can be used to remotely measure the temperature of the antenna. Laboratory testing of the guided mode resonance filter failed to produce the spectral response predicted by simulations. It was concluded that the spectral response was dominated by spectral reflections of radio waves incident on the filter. Laboratory testing of the mechanically modulated antenna demonstrated that the device frequency shifted incident radio waves, and that the frequency of the re-radiated waves varied linearly with temperature. Radio wave propagation tests in the convection pass of a small research boiler plant identified a spectral window between 10 and 13 GHz for low loss propagation of radio waves in the interior of the boiler

Evaluating operational AVHRR sea surface temperature data at the coastline using surfers

Sea surface temperature (SST) is an essential climate variable that can be measured routinely from Earth Observation (EO) with high temporal and spatial coverage. To evaluate its suitability for an application, it is critical to know the accuracy and precision (performance) of the EO SST data. This requires comparisons with co-located and concomitant in situ data. Owing to a relatively large network of in situ platforms there is a good understanding of the performance of EO SST data in the open ocean. However, at the coastline this performance is not well known, impeded by a lack of in situ data. Here, we used in situ SST measurements collected by a group of surfers over a three year period in the coastal waters of the UK and Ireland, to improve our understanding of the performance of EO SST data at the coastline. At two beaches near the city of Plymouth, UK, the in situ SST measurements collected by the surfers were compared with in situ SST collected from two autonomous buoys located ∼7 km and ∼33 km from the coastline, and showed good agreement, with discrepancies consistent with the spatial separation of the sites. The in situ SST measurements collected by the surfers around the coastline, and those collected offshore by the two autonomous buoys, were used to evaluate the performance of operational Advanced Very High Resolution Radiometer (AVHRR) EO SST data. Results indicate: (i) a significant reduction in the performance of AVHRR at retrieving SST at the coastline, with root mean square errors in the range of 1.0 to 2.0 °C depending on the temporal difference between match-ups, significantly higher than those at the two offshore stations (0.4 to 0.6 °C); (ii) a systematic negative bias in the AVHRR retrievals of approximately 1 °C at the coastline, not observed at the two offshore stations; and (iii) an increase in the root mean square error at the coastline when the temporal difference between match-ups exceeded three hours. Harnessing new solutions to improve in situ sampling coverage at the coastline, such as tagging surfers with sensors, can improve our understanding of the performance of EO SST data in coastal regions, helping inform users interested in EO SST products for coastal applications. Yet, validating EO SST products using in situ SST data at the coastline is challenged by difficulties reconciling the two measurements, which are provided at different spatial scales in a dynamic and complex environment

Viral Mimicry of Cdc2/Cyclin-Dependent Kinase 1 Mediates Disruption of Nuclear Lamina during Human Cytomegalovirus Nuclear Egress

The nuclear lamina is a major obstacle encountered by herpesvirus nucleocapsids in their passage from the nucleus to the cytoplasm (nuclear egress). We found that the human cytomegalovirus (HCMV)-encoded protein kinase UL97, which is required for efficient nuclear egress, phosphorylates the nuclear lamina component lamin A/C in vitro on sites targeted by Cdc2/cyclin-dependent kinase 1, the enzyme that is responsible for breaking down the nuclear lamina during mitosis. Quantitative mass spectrometry analyses, comparing lamin A/C isolated from cells infected with viruses either expressing or lacking UL97 activity, revealed UL97-dependent phosphorylation of lamin A/C on the serine at residue 22 (Ser22). Transient treatment of HCMV-infected cells with maribavir, an inhibitor of UL97 kinase activity, reduced lamin A/C phosphorylation by approximately 50%, consistent with UL97 directly phosphorylating lamin A/C during HCMV replication. Phosphorylation of lamin A/C during viral replication was accompanied by changes in the shape of the nucleus, as well as thinning, invaginations, and discrete breaks in the nuclear lamina, all of which required UL97 activity. As Ser22 is a phosphorylation site of particularly strong relevance for lamin A/C disassembly, our data support a model wherein viral mimicry of a mitotic host cell kinase activity promotes nuclear egress while accommodating viral arrest of the cell cycle