Spatial Price Differences in China: Estimates and Implications

Prices differ across space: from province to province, from rural (or urban) areas in one province to rural (or urban) areas in another province, and from rural to urban areas within one province. Systematic differences in prices across a range of goods and services in different localities imply regional differences in the costs of living. If high- income provinces also have high costs of living, and low-income provinces have low costs of living, the use of nominal income measures in explaining such economic outcomes as inequality can lead to misinterpretations. Income should be adjusted for costs of living. We are interested in the sign and magnitude of the adjustments needed, their changes over time, and their impact on economic outcomes in China. In this article, we construct a set of (rural, urban, total) provincial- level spatial price deflators for the years 1984-2002 that can be used to obtain provincial-level income measures adjusted for purchasing power. We provide illustrations of the significant effect of ignoring spatial price differences in the analysis of China's economy.

Aluminum-26 Enrichment in the Surface of Protostellar Disks Due to Protostellar Cosmic Rays

The radioactive decay of aluminum-26 ($^{26}$Al) is an important heating source in early planet formation. Since its discovery, there have been several mechanisms proposed to introduce $^{26}$Al into protoplanetary disks, primarily through contamination by external sources. We propose a local mechanism to enrich protostellar disks with $^{26}$Al through irradiation of the protostellar disk surface by cosmic rays accelerated in the protostellar accretion shock. We calculate the $^{26}$Al enrichment, [$^{26}$Al/$^{27}$Al], at the surface of the protostellar disk in the inner AU throughout the evolution of low-mass stars, from M-dwarfs to proto-Suns. Assuming constant mass accretion rates, $\dot{m}$, we find that irradiation by MeV cosmic rays can provide significant enrichment on the disk surface if the cosmic rays are not completely coupled to the gas in the accretion flow. Importantly, we find that low accretion rates, $\dot{m} < 10^{-7}$ M$_{\odot}$ yr$^{-1}$, are able to produce canonical amounts of $^{26}$Al, $[^{26}{\rm Al}/^{27}{\rm Al}] \approx 5\times10^{-5}$. These accretion rates are experienced at the transition from Class I- to Class II-type protostars, when it is assumed that calcium-aluminum-rich inclusions condense in the inner disk. We conclude that irradiation of the inner disk surface by cosmic ray protons accelerated in accretion shocks at the protostellar surface may be an important mechanism to produce $^{26}$Al. Our models show protostellar cosmic rays may be a viable model to explain the enrichment of $^{26}$Al found in the Solar System.Comment: Accepted to ApJ, in pres

Two- and three-body color flux tubes in the Chromo Dielectric Model

Using the framework of the Chromo Dielectric Model we perform an analysis of color electric flux tubes in meson-like $q\bar{q}$ and baryon-like $qqq$ quark configurations. We discuss the Abelian color structure of the model and point out a symmetry in color space as a remnant of the SU(3) symmetry of QCD. The generic features of the model are discussed by varying the model parameters. We fix these parameters by reproducing the string tension $\tau=980$MeV/fm and the transverse width $\rho=0.35$fm of the $q\bar{q}$ flux tube obtained in lattice calculations. We use a bag constant $B^{1/4}=(240-260)$MeV, a glueball mass $m_g = (1000-1700)$MeV and a strong coupling constant $C_F \alpha_s = 0.2-0.3$. We show that the asymptotic string profile of an infinitely long flux tube is already reached for $q\bar{q}$ separations $R\ge1.0$fm. A connection to the Dual Color Superconductor is made by extracting a magnetic current from the model equations and a qualitative agreement between the two descriptions of confinement is shown. In the study of the $qqq$ system we observe a $\mathsf{\Delta}$-like geometry for the color electric fields and a \textsf{Y}-like geometry in the scalar fields both in the energy density distribution and in the corresponding potentials. The resulting total $qqq$ potential is described neither by the $\mathsf{\Delta}$-picture nor by the \textsf{Y}-picture alone.Comment: 32 pages, 35 eps-figures, revised version, some references + 1 eps-file added, to be published in Phys.Rev.

Interactions of multi-quark states in the chromodielectric model

We investigate 4-quark ($qq\bar{q}\bar{q}$) systems as well as multi-quark states with a large number of quarks and anti-quarks using the chromodielectric model. In the former type of systems the flux distribution and the corresponding energy of such systems for planar and non-planar geometries are studied. From the comparison to the case of two independent $q\bar{q}$-strings we deduce the interaction potential between two strings. We find an attraction between strings and a characteristic string flip if there are two degenerate string combinations between the four particles. The interaction shows no strong Van-der-Waals forces and the long range behavior of the potential is well described by a Yukawa potential, which might be confirmed in future lattice calculations. The multi-quark states develop an inhomogeneous porous structure even for particle densities large compared to nuclear matter constituent quark densities. We present first results of the dependence of the system on the particle density pointing towards a percolation type of transition from a hadronic matter phase to a quark matter phase. The critical energy density is found at $\epsilon_c = 1.2 GeV/fm^3$.Comment: 19 pages, 40 eps-figures, RevTex 4, v2: typos correcte

Non-disjunction of chromosome 13

We performed a molecular study with 21 microsatellites on a sample of 82 trisomy 13 conceptuses, the largest number of cases studied to date. The parental origin was determined in every case and in 89% the extra chromosome 13 was of maternal origin with an almost equal number of maternal MI and MII errors. The latter finding is unique among human autosomal trisomies, where maternal MI (trisomies 15, 16, 21, 22) or MII (trisomy 18) errors dominate. Of the nine paternally derived cases five were of MII origin but none arose from MI errors. There was some evidence for elevated maternal age in cases with maternal meiotic origin for liveborn infants. Maternal and paternal ages were elevated in cases with paternal meiotic origin. This is in contrast to results from a similar study of non-disjunction of trisomy 21 where paternal but not maternal age was elevated. We find clear evidence for reduced recombination in both maternal MI and MII errors and the former is associated with a significant number of tetrads (33%) that are nullichiasmate, which do not appear to be a feature of normal chromosome 13 meiosis. This study supports the evidence for subtle chromosome-specific influences on the mechanisms that determine non-disjunction of human chromosomes, consistent with the diversity of findings for other trisomie

Polarized recombination of acoustically transported carriers in GaAs nanowires

The oscillating piezoelectric field of a surface acoustic wave (SAW) is employed to transport photoexcited electrons and holes in GaAs nanowires deposited on a SAW delay line on a LiNbO3 crystal. The carriers generated in the nanowire by a focused light spot are acoustically transferred to a second location where they recombine. We show that the recombination of the transported carriers occurs in a zinc blende section on top of the predominant wurtzite nanowire. This allows contactless control of the linear polarized emission by SAWs which is governed by the crystal structure. Additional polarization-resolved photoluminescence measurements were performed to investigate spin conservation during transport

Mechanochemical control of epidermal stem cell divisions by B-plexins

The precise spatiotemporal control of cell proliferation is key to the morphogenesis of epithelial tissues. Epithelial cell divisions lead to tissue crowding and local changes in force distribution, which in turn suppress the rate of cell divisions. However, the molecular mechanisms underlying this mechanical feedback are largely unclear. Here, we identify a critical requirement of B-plexin transmembrane receptors in the response to crowding-induced mechanical forces during embryonic skin development. Epidermal stem cells lacking B-plexins fail to sense mechanical compression, resulting in disinhibition of the transcriptional coactivator YAP, hyperproliferation, and tissue overgrowth. Mechanistically, we show that B-plexins mediate mechanoresponses to crowding through stabilization of adhesive cell junctions and lowering of cortical stiffness. Finally, we provide evidence that the B-plexin-dependent mechanochemical feedback is also pathophysiologically relevant to limit tumor growth in basal cell carcinoma, the most common type of skin cancer. Our data define a central role of B-plexins in mechanosensation to couple cell density and cell division in development and disease.Peer reviewe

Cationic Liposomes Formulated with Synthetic Mycobacterial Cordfactor (CAF01): A Versatile Adjuvant for Vaccines with Different Immunological Requirements

It is now emerging that for vaccines against a range of diseases including influenza, malaria and HIV, the induction of a humoral response is insufficient and a substantial complementary cell-mediated immune response is necessary for adequate protection. Furthermore, for some diseases such as tuberculosis, a cellular response seems to be the sole effector mechanism required for protection. The development of new adjuvants capable of inducing highly complex immune responses with strong antigen-specific T-cell responses in addition to antibodies is therefore urgently needed. (cell-mediated/humoral) and malaria (humoral) immunization with CAF01-based vaccines elicited significant protective immunity against challenge.CAF01 is potentially a suitable adjuvant for a wide range of diseases including targets requiring both CMI and humoral immune responses for protection

Modulation of NKp30- and NKp46-Mediated Natural Killer Cell Responses by Poxviral Hemagglutinin

Natural killer (NK) cells are an important element in the immune defense against the orthopox family members vaccinia virus (VV) and ectromelia virus (ECTV). NK cells are regulated through inhibitory and activating signaling receptors, the latter involving NKG2D and the natural cytotoxicity receptors (NCR), NKp46, NKp44 and NKp30. Here we report that VV infection results in an upregulation of ligand structures for NKp30 and NKp46 on infected cells, whereas the binding of NKp44 and NKG2D was not significantly affected. Likewise, infection with ectromelia virus (ECTV), the mousepox agent, enhanced binding of NKp30 and, to a lesser extent, NKp46. The hemagglutinin (HA) molecules from VV and ECTV, which are known virulence factors, were identified as novel ligands for NKp30 and NKp46. Using NK cells with selectively silenced NCR expression and NCR-CD3ζ reporter cells, we observed that HA present on the surface of VV-infected cells, or in the form of recombinant soluble protein, was able to block NKp30-triggered activation, whereas it stimulated the activation through NKp46. The net effect of this complex influence on NK cell activity resulted in a decreased NK lysis susceptibility of infected cells at late time points of VV infection when HA was expression was pronounced. We conclude that poxviral HA represents a conserved ligand of NCR, exerting a novel immune escape mechanism through its blocking effect on NKp30-mediated activation at a late stage of infection