1,141 research outputs found

    Liquidity Externalities of Convertible Bond Issuance in Canada

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    The paper examines the impact of convertible bond issuance and arbitrage activity on Canadian equity market liquidity. We use convertible bond issuance event dates for the period of November 2001 to April 2010 to analyze the change in short interest, a proxy for convertible arbitrage activity, and stock liquidity during a one-year event window. Liquidity measures include Amihud, turnover, dollar volume and spread to price ratio. We find that there are significant increases in short interest, but minimal improvements in liquidity following the convertible bond issuances. However, statistical tests support that the change in liquidity is positively related to the change in short interest

    Th17 Cells in Immunity and Autoimmunity

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    Th17 and IL-17 play important roles in the clearance of extracellular bacterial and fungal infections. However, strong evidence also implicates the Th17 lineage in several autoimmune disorders including multiple sclerosis, psoriasis, rheumatoid arthritis, inflammatory bowel disease, systemic lupus erythematosus, and asthma. The Th17 subset has also been connected with type I diabetes, although whether it plays a role in the pathogenicity of or protection from the disease remains a controversial issue. In this review we have provided a comprehensive overview of Th17 pathogenicity and function, including novel evidence for a protective role of Th17 cells in conjunction with the microbiota gut flora in T1D onset and progression

    Yamato: Bringing the Moon to the Earth ... Again

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    The Yamato mission to the lunar South Pole-Aitken Basin returns samples that enable dating of lunar formation and the lunar bombardment period. The design of the Yamato mission is based on a systems engineering process which takes an advanced consideration of cost and mission risk to give the mission a high probability of success

    Fun versus Practical: Physiological Responses and Preference of Exercise Equipment

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    The elliptical cross trainer has become a popular a mode of exercise, but can only be used indoors. The StreetStrider was designed as an outdoor elliptical-bike. PURPOSE: The purpose of this study is to determine whether the elliptical or the StreetStrider was more enjoyable, and to compare the physiological variables for energy expenditure, heart rate (HR), VO2, and Rate of Perceived Exertion (RPE). METHODS: Thirty participants (15 male, 15 female, mean age=22±2) from Cleveland State University exercised for 20 minutes at 75% of their age predicted maximal heart rate on the StreetStrider and elliptical. Energy expenditure was measured with a COSMED K4b metabolic system. Participants’ RPE was recorded every five minutes using the Borg Scale for Rate of Perceived Exertion. Data was analyzed using SPSS version 18. A paired sample t-test compared physiological responses. A one-way ANOVA analyzed gender differences. A significance level of .05 was used to determine significance. RESULTS: No significant differences were shown in energy expenditure (p=.930), HR (p=.098), or in average RPE (p=.529) between the exercise trials. A preference survey concluded that most subjects found the StreetStrider more enjoyable than the elliptical. CONCLUSION: The StreetStrider is more enjoyable than the elliptical and as effective in energy expenditure, and could serve as a substitute for the elliptical.https://engagedscholarship.csuohio.edu/u_poster_2014/1034/thumbnail.jp

    Comparison of Electronic and Mechanical Handgrip Devices in Lowering Blood Pressure

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    Hypertension causes billions of deaths per year (Millar et al., 2013). The Zona PlusTM is an expensive tool designed to lower blood pressure (BP) using isometric exercise. This exercise may be achieved using a less expensive Handgrip Dynamometer. PURPOSE: The purpose of this research is to determine if the Zona or Handgrip Dynamometer is more efficient at lowering BP and most cost effective for patients. METHODS: Twenty subjects used the Zona and twenty subjects used the dynamometer three times per week for six weeks. BP was taken once per week prior to the treatment. A maximum voluntary contraction (MVC) was recorded for each hand before every treatment. Participants were required to hold the handgrip at 30% of their MVC for four two-minute contractions. A paired samples T test was used to analyze changes in participants’ BP. A one-way ANOVA was used to compare the BP changes between the Zona and the Handgrip. RESULTS: The results indicated no significant changes in participants’ pre- and post- treatment after training when using the Zona for either stolic (p=0.225) or diastolic BP (p=1.000). There was also no significant difference in participants’ post treatment systolic BP (p=0.199), however, the post treatment for diastolic increased significantly (p=0.027 BP between those that used the Zona PlusTM and Handgrip Dynamometer. CONCLUSION: Though the Dynamometer is more cost efficient, neither the Zona nor the Dynamometer resulted in lowered BP.https://engagedscholarship.csuohio.edu/u_poster_2014/1037/thumbnail.jp

    Diffusion of Cardiopulmonary Resuscitation Training to Chinese Immigrants with Limited English Proficiency

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    Cardiopulmonary resuscitation (CPR) is an effective intervention for prehospital cardiac arrest. Despite all available training opportunities for CPR, disparities exist in participation in CPR training, CPR knowledge, and receipt of bystander CPR for certain ethnic groups. We conducted five focus groups with Chinese immigrants who self-reported limited English proficiency (LEP). A bilingual facilitator conducted all the sessions. All discussions were taped, recorded, translated, and transcribed. Transcripts were analyzed by content analysis guided by the theory of diffusion. The majority of participants did not know of CPR and did not know where to get trained. Complexity of CPR procedure, advantages of calling 9-1-1, lack of confidence, and possible liability discourage LEP individuals to learn CPR. LEP individuals welcome simplified Hands-Only CPR and are willing to perform CPR with instruction from 9-1-1 operators. Expanding the current training to include Hands-Only CPR and dispatcher-assisted CPR may motivate Chinese LEP individuals to get trained for CPR

    Perioperative Vision Loss in Cervical Spinal Surgery.

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    STUDY DESIGN: Retrospective multicenter case series. OBJECTIVE: To assess the rate of perioperative vision loss following cervical spinal surgery. METHODS: Medical records for 17 625 patients from 21 high-volume surgical centers from the AOSpine North America Clinical Research Network who received cervical spine surgery (levels from C2 to C7) between January 1, 2005, and December 31, 2011, inclusive, were reviewed to identify occurrences of vision loss following surgery. RESULTS: Of the 17 625 patients in the registry, there were 13 946 patients assessed for the complication of blindness. There were 9591 cases that involved only anterior surgical approaches; the remaining 4355 cases were posterior and/or circumferential fusions. There were no cases of blindness or vision loss in the postoperative period reported during the sampling period. CONCLUSIONS: Perioperative vision loss following cervical spinal surgery is exceedingly rare

    Trigeminal schwannoma presenting with malocclusion: A case report and review of the literature

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    Background: Trigeminal schwannomas are rare tumors of the trigeminal nerve. Depending on the location, from which they arise along the trigeminal nerve, these tumors can present with a variety of symptoms that include, but are not limited to, changes in facial sensation, weakness of the masticatory muscles, and facial pain. Case Description: We present a case of a 16-year-old boy with an atypical presentation of a large trigeminal schwannoma: painless malocclusion and unilateral masticatory weakness. This case is the first documented instance; to the best of our knowledge, in which a trigeminal schwannoma has led to underbite malocclusion; it is the 19th documented case of unilateral trigeminal motor neuropathy of any etiology. We discuss this case as a unique presentation of this pathology, and the relevant anatomy implicated in clinical examination aid in further understanding trigeminal nerve pathology. Conclusion: We believe our patient’s underbite malocclusion occurred secondary to his trigeminal schwannoma, resulting in associated atrophy and weakness of the muscles innervated by the mandibular branch of the trigeminal nerve. Furthermore, understanding the trigeminal nerve anatomy is crucial in localizing lesions of the trigeminal nerve
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