NLTT5306B: an inflated, weakly irradiated brown dwarf

We present Spitzer observations at 3.6 and 4.5 µm and a near-infrared IRTF SpeX spectrum of the irradiated brown dwarf NLTT5306B. We determine that the brown dwarf has a spectral type of L5 and is likely inflated, despite the low effective temperature of the white dwarf primary star. We calculate brightness temperatures in the Spitzer wavebands for both the model radius, and Roche Lobe radius of the brown dwarf, and conclude that there is very little day–night side temperature difference. We discuss various mechanisms by which NLTT5306B may be inflated, and determine that while low-mass brown dwarfs (M < 35 M_(Jup)) are easily inflated by irradiation from their host star, very few higher mass brown dwarfs are inflated. The higher mass brown dwarfs that are inflated may be inflated by magnetic interactions or may have thicker clouds

Spectral Analysis of Binary Pre-white Dwarf Systems

Short period double degenerate white dwarf (WD) binaries with periodsof less than ∼1 day are considered to be one of the likely progenitors of type Ia super-novae. These binaries have undergone a period of common envelope evolution. If thecore ignites helium before the envelope is ejected, then a hot subdwarf remains priorto contracting into a WD. Here we present a comparison of two very rare systems thatcontain two hot subdwarfs in short period orbits. We provide a quantitative spectro-scopic analysis of the systems using synthetic spectra from state-of-the-art non-LTEmodels to constrain the atmospheric parameters of the stars. We also use these modelsto determine the radial velocities, and thus calculate dynamical masses for the stars ineach system.Fil: Finch, N. L.. University of Leicester; Reino UnidoFil: Braker, I. P.. University of Leicester; Reino UnidoFil: Reindl, N.. University of Leicester; Reino UnidoFil: Barstow, M. A.. University of Leicester; Reino UnidoFil: Casewell, S. L.. University of Leicester; Reino UnidoFil: Burleigh, M.. University of Leicester; Reino UnidoFil: Kupfer, T.. University of California; Estados UnidosFil: Kilkenny, D.. University of the Western Cape; SudáfricaFil: Geier, S.. Universitat Potsdam; AlemaniaFil: Schaffenroth, V.. Universitat Potsdam; AlemaniaFil: Schaffenroth, V.. Universitat Potsdam; AlemaniaFil: Miller Bertolami, Marcelo Miguel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Astrofísica La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Astronómicas y Geofísicas. Instituto de Astrofísica La Plata; ArgentinaFil: Taubenberger, S.. Gobierno de la República Federal de Alemania. Max Planck Institut für Astrophysik; AlemaniaFil: Freudenthal, J.. No especifíca;Radiative Signatures from the Cosmos: A Conference in Honor of Ivan HubenyParisFranciaUniversidad de Pari

Specialist nursing and community support for the carers of people with dementia living at home: an evidence synthesis.

Specialist nurses are one way of providing support for family carers of people with dementia, but relatively little is known about what these roles achieve, or if they are more effective than roles that do not require a clinical qualification. The aim of this review was to synthesise the literature on the scope and effectiveness of specialist nurses, known as Admiral Nurses, and set this evidence in the context of other community-based initiatives to support family carers of people with dementia. We undertook a systematic review of the literature relating to the scope and effectiveness of Admiral Nurses and a review of reviews of interventions to support the family carers of people with dementia. To identify studies, we searched electronic databases, undertook lateral searches and contacted experts. Searches were undertaken in November 2012. Results are reported narratively with key themes relating to Admiral Nurses identified using thematic synthesis. We included 33 items relating to Admiral Nurses (10 classified as research) and 11 reviews evaluating community-based support for carers of people with dementia. There has been little work to evaluate specific interventions provided by Admiral Nurses, but three overarching thematic categories were identified: (i) relational support, (ii) co-ordinating and personalising support and (iii) challenges and threats to the provision of services by Admiral Nurses. There was an absence of clearly articulated goals and service delivery was subject to needs of the host organisation and the local area. The reviews of community-based support for carers of people with dementia included 155 studies but, in general, evidence that interventions reduced caregiver depression or burden was weak, although psychosocial and educational interventions may reduce depression in carers. Community support for carers of people with dementia, such as that provided by Admiral Nurses, is valued by family carers, but the impact of such initiatives is not clearly established

The first sub-70 minute non-interacting WD-BD system: EPIC212235321

We present the discovery of the shortest-period, non-interacting, white dwarf-brown dwarf post-common-envelope binary known. The K2 light curve shows the system, EPIC 21223532 has a period of 68.2 min and is not eclipsing, but does show a large reflection effect due to the irradiation of the brown dwarf by the white dwarf primary. Spectra show hydrogen, magnesium and calcium emission features from the brown dwarf's irradiated hemisphere, and the mass indicates the spectral type is likely to be L3. Despite having a period substantially lower than the cataclysmic variable period minimum, this system is likely a pre-cataclysmic binary, recently emerged from the common-envelope. These systems are rare, but provide limits on the lowest mass object that can survive common envelope evolution, and information about the evolution of white dwarf progenitors, and post-common envelope evolution

Pediatric brain tumor cancer stem cells: cell cycle dynamics, DNA repair, and etoposide extrusion

Reliable model systems are needed to elucidate the role cancer stem cells (CSCs) play in pediatric brain tumor drug resistance. The majority of studies to date have focused on clinically distinct adult tumors and restricted tumor types. Here, the CSC component of 7 newly established primary pediatric cell lines (2 ependymomas, 2 medulloblastomas, 2 gliomas, and a CNS primitive neuroectodermal tumor) was thoroughly characterized. Comparison of DNA copy number with the original corresponding tumor demonstrated that genomic changes present in the original tumor, typical of that particular tumor type, were retained in culture. In each case, the CSC component was approximately 3–4-fold enriched in neurosphere culture compared with monolayer culture, and a higher capacity for multilineage differentiation was observed for neurosphere-derived cells. DNA content profiles of neurosphere-derived cells expressing the CSC marker nestin demonstrated the presence of cells in all phases of the cell cycle, indicating that not all CSCs are quiescent. Furthermore, neurosphere-derived cells demonstrated an increased resistance to etoposide compared with monolayer-derived cells, having lower initial DNA damage, potentially due to a combination of increased drug extrusion by ATP-binding cassette multidrug transporters and enhanced rates of DNA repair. Finally, orthotopic xenograft models reflecting the tumor of origin were established from these cell lines. In summary, these cell lines and the approach taken provide a robust model system that can be used to develop our understanding of the biology of CSCs in pediatric brain tumors and other cancer types and to preclinically test therapeutic agents

Two white dwarfs in ultrashort binaries with detached, eclipsing, likely substellar companions detected by K2

Using data from the extended Kepler mission in K2 Campaign 10, we identify two eclipsing binaries containing white dwarfs with cool companions that have extremely short orbital periods of only 71.2 min (SDSS J1205−0242, a.k.a. EPIC 201283111) and 72.5 min (SDSS J1231+0041, a.k.a. EPIC 248368963). Despite their short periods, both systems are detached with small, low-mass companions, in one case a brown dwarf and in the other case either a brown dwarf or a low-mass star. We present follow-up photometry and spectroscopy of both binaries, as well as phase-resolved spectroscopy of the brighter system, and use these data to place preliminary estimates on the physical and binary parameters. SDSS J1205−0242 is composed of a 0.39 ± 0.02 M⊙ helium-core white dwarf that is totally eclipsed by a 0.049 ± 0.006 M⊙ (51 ± 6MJ) brown-dwarf companion, while SDSS J1231+0041 is composed of a 0.56 ± 0.07 M⊙ white dwarf that is partially eclipsed by a companion of mass ≲0.095  M⊙. In the case of SDSS J1205−0242, we look at the combined constraints from common-envelope evolution and brown-dwarf models; the system is compatible with similar constraints from other post-common-envelope binaries, given the current parameter uncertainties, but has potential for future refinement