1,882 research outputs found
Relativistic models of magnetars: the twisted-torus magnetic field configuration
We find general relativistic solutions of equilibrium magnetic field
configurations in magnetars, extending previous results of Colaiuda et al.
(2008). Our method is based on the solution of the relativistic Grad-Shafranov
equation, to which Maxwell's equations can be reduced in some limit. We obtain
equilibrium solutions with the toroidal magnetic field component confined into
a finite region inside the star, and the poloidal component extending to the
exterior. These so-called twisted-torus configurations have been found to be
the final outcome of dynamical simulations in the framework of Newtonian
gravity, and appear to be more stable than other configurations. The solutions
include higher order multipoles, which are coupled to the dominant dipolar
field. We use arguments of minimal energy to constrain the ratio of the
toroidal to the poloidal field.Comment: 13 pages, 12 figures. Minor changes to match the version published on
MNRA
Intact fibroblast growth factor 23 and fragments in plasma from Gambian children
SUMMARY: Fibroblast growth factor 23 (FGF23) is grossly elevated in Gambian children with rickets and, at a lower prevalence, in those without bone deformities. We used western blotting to mimic the detection capabilities of the C-terminal FGF23 enzyme-linked immunosorbent assay (ELISA). Only intact FGF23 hormone was present in Gambian plasma samples from children with and without rickets. INTRODUCTION: Elevated circulating FGF23 concentrations have been detected in plasma samples from Gambian children using the C-terminal Immutopics ELISA. The Immutopics ELISA detects both the intact FGF23 hormone and the C-terminal fragment. The aim of this study was to determine whether the elevated FGF23 concentrations as detected by the ELISA were predominantly due to a high proportion of intact FGF23 hormone and/or C-terminal FGF23 fragments. METHODS: Stored, frozen plasma samples from previous studies of Gambian children with known concentrations of FGF23 as determined by C-terminal Immutopics ELISA assay, were selected for western blotting analysis: from children with rickets-like bone deformities (n = 4) and local controls (n = 4), with elevated >900 RU/ml (n = 2) and normal <30 RU/ml (n = 2; from each group). The anti-FGF23 polyclonal antibody that recognizes the C-terminal of FGF23 (as used in the Immutopics kit) was used as the primary antibody and the anti-IgG polyclonal antibody conjugated to horseradish peroxidase (HRP) was used as the secondary antibody. RESULTS: Firstly, C-terminal FGF23 fragments, although detectable in standards from the Immutopics ELISA kit, were not in the Gambian plasma samples. Secondly, there was no difference in the size of FGF23 molecules present in plasma from children with rickets-like bone deformities and children from the local community. CONCLUSIONS: Western blotting has provided evidence that elevated FGF23 concentrations, as determined by the C-terminal Immutopics ELISA, measured in Gambian children with and without rickets-like bone deformities was not caused by an increased proportion of circulating inactive C-terminal fragments
The MiMeS Project: Magnetism in Massive Stars
The Magnetism in Massive Stars (MiMeS) Project is a consensus collaboration
among the foremost international researchers of the physics of hot, massive
stars, with the basic aim of understanding the origin, evolution and impact of
magnetic fields in these objects. The cornerstone of the project is the MiMeS
Large Program at the Canada-France-Hawaii Telescope, which represents a
dedication of 640 hours of telescope time from 2008-2012. The MiMeS Large
Program will exploit the unique capabilities of the ESPaDOnS spectropolarimeter
to obtain critical missing information about the poorly-studied magnetic
properties of these important stars, to confront current models and to guide
theory.Comment: 6 pages, 3 figures, proceedings of IAUS 259: Cosmic Magnetic Field
Valence Instability of YbCuSi through its quantum critical point
We report Resonant inelastic x-ray scattering measurements (RIXS) in
YbCuSi at the Yb L edge under high pressure (up to 22 GPa) and at
low temperatures (down to 7 K) with emphasis on the vicinity of the transition
to a magnetic ordered state. We find a continuous valence change towards the
trivalent state with increasing pressure but with a pronounced change of slope
close to the critical pressure. Even at 22 GPa the Yb state is not fully
achieved. The pressure where this feature is observed decreases as the
temperature is reduced to 9 GPa at 7K, a value close to the critical pressure
(\itshape{p\normalfont{}}\normalfont 7.5 GPa) where magnetic
order occurs. The decrease in the valence with decreasing temperature
previously reported at ambient pressure is confirmed and is found to be
enhanced at higher pressures. We also compare the f electron occupancy between
YbCuSi and its Ce-counterpart, CeCuSi
The aetiology of rickets-like lower limb deformities in Malawian children
Summary: Debilitating rickets-like lower limb deformities are common in children throughout the world, particularly in Malawi, Africa where the causes are unknown. We have identified that Blount disease and calcium deficiency rickets are the likely causes of these deformities and propose calcium supplementation as a potential treatment of Malawian rickets.
Introduction: Surgical correction of rickets-like lower limb deformities is the most common paediatric operation performed at Beit Cure Orthopaedic Hospital, Malawi. The aim of this study was to investigate the aetiology of these deformities.
Methods: Children with a tibio-femoral angle of deformity >20° were enrolled (n = 42, 3.0–15.0 years). Anthropometric and early life and well-being data were collected. Early morning serum and urine samples were collected on the morning of the operation for markers of calcium and phosphate homeostasis. Knee radiographs were obtained, and the children were diagnosed with either Blount (BD, n = 22) or evidence of rickets disease (RD, n = 20). As BD is a mechanical rather than metabolic disease, BD were assumed to be biochemically representative of the local population and thus used as a local reference for RD.
Results: There were no differences in anthropometry or early life experiences between BD and RD. Parathyroid hormone (PTH), 1,25-dihydroxyvitamin D, total alkaline phosphatase and urinary phosphate were significantly higher and serum phosphate, 25-hydroxyvitamin D (25OHD) and tubular maximal reabsorption of phosphate significantly lower in RD than BD. There was no difference in serum calcium, fibroblast growth factor 23 or markers of iron status between groups. All children had 25OHD > 25 nmol/L.
Conclusions: Vitamin D deficiency is not implicated in the aetiology of RD or BD in Malawian children. The cause of RD in Malawi is likely to be dietary calcium deficiency leading to elevated PTH resulting in increased losses of phosphate from the bone and glomerular filtrate. The causes of BD remain unclear; there was no evidence in support of previously suggested risk factors such as being overweight or starting to walk early. Prior to surgical intervention, supplementation with calcium should be considered for children with RD
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Associations between maternal prenatal cortisol and fetal growth are specific to infant sex: findings from the Wirral Child Health and Development Study
Recent findings highlight that there are prenatal risks for affective disorders that are mediated by glucocorticoid mechanisms, and may be specific to females. There is also evidence of sex differences in prenatal programming mechanisms and developmental psychopathology, whereby effects are in opposite directions in males and females. As birth weight is a risk for affective disorders, we sought to investigate whether maternal prenatal cortisol may have sex-specific effects on fetal growth. Participants were 241 mothers selected from the Wirral Child Health and Development Study (WCHADS) cohort (n=1233) using a psychosocial risk stratifier, so that responses could be weighted back to the general population. Mothers provided saliva samples, which were assayed for cortisol, at home over 2 days at 32 weeks gestation (on waking, 30-min post-waking and during the evening). Measures of infant birth weight (corrected for gestational age) were taken from hospital records. General population estimates of associations between variables were obtained using inverse probability weights. Maternal log of the area under the curve cortisol predicted infant birth weight in a sex-dependent manner (interaction term P=0.029). There was a positive and statistically significant association between prenatal cortisol in males, and a negative association in females that was not statistically significant. A sex interaction in the same direction was evident when using the waking (P=0.015), and 30-min post-waking (P=0.013) cortisol, but not the evening measure. There was no interaction between prenatal cortisol and sex to predict gestational age. Our findings add to an emerging literature that suggests that there may be sex-specific mechanisms that underpin fetal programming
CP and related phenomena in the context of Stellar Evolution
We review the interaction in intermediate and high mass stars between their
evolution and magnetic and chemical properties. We describe the theory of
Ap-star `fossil' fields, before touching on the expected secular diffusive
processes which give rise to evolution of the field. We then present recent
results from a spectropolarimetric survey of Herbig Ae/Be stars, showing that
magnetic fields of the kind seen on the main-sequence already exist during the
pre-main sequence phase, in agreement with fossil field theory, and that the
origin of the slow rotation of Ap/Bp stars also lies early in the pre-main
sequence evolution; we also present results confirming a lack of stars with
fields below a few hundred gauss. We then seek which macroscopic motions
compete with atomic diffusion in determining the surface abundances of AmFm
stars. While turbulent transport and mass loss, in competition with atomic
diffusion, are both able to explain observed surface abundances, the interior
abundance distribution is different enough to potentially lead to a test using
asterosismology. Finally we review progress on the turbulence-driving and
mixing processes in stellar radiative zones.Comment: Proceedings of IAU GA in Rio, JD4 on Ap stars; 10 pages, 7 figure
Double superconducting transition in the filled skutterudite PrOs4Sb12 and sample characterizations
A thorough characterization of many samples of the filled skutterudite
compound PrOs4Sb12 is provided. We find that the double superconducting
transition in the specific heat Tc1~1.89K and Tc2~1.72K tends to appear in
samples with a large residual resistivity ratio, large specific heat jump at
the superconducting transition and with the highest absolute value of the
specific heat above Tc1. However, we present evidence which casts doubt on the
intrinsic nature of the double superconducting transition. The ratio of the two
specific heat jumps \Delta C(Tc1)/\Delta C(Tc2) shows a wide range of values on
crystals from different batches but also within the same batch. This ratio was
strongly reduced by polishing a sample down to 120um. Remarkably, three samples
exhibit a single sharp transition of ~15mK in width at Tc~1.7K. The normalized
specific heat jump (C-Cnormal)/Cnormal at Tc of two of them is higher than ~32%
so larger than the sum of the two specific heat jumps when a double transition
exists. As an evidence of better quality, the slope in the transition is at
least two time steeper.
We discuss the origins of the double transition; in particular we consider,
based on X-ray diffraction results, a scenario involving Pr-vacancies. The
superconducting phase diagram under magnetic field of a sample with a single
transition is fitted with a two-band model taking into account the good values
for the gap as deduced from thermal conductivity measurements.Comment: 10 pages, 9 figures, 2 tables, submitted to Physical review
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