Radiation-induced phase development in AISI 316

During irradiation at temperatures between 460 and 650/sup 0/C, the alloy AISI 316 decomposes into an austenite matrix of altered composition and some mixture of six possible precipitate phases. These phases are ..gamma..', G, eta-silicide, M/sub 23/C/sub 6/, M/sub 6/C, and Laves. The balance of phases developed is exceptionally sensitive to a large number of material and environmental variables and frequently varies within a single grain. All of these phases are found to be either naturally rich in nickel and silicon or to become progressively enriched in these elements as the irradiation proceeds. The precipitates can be considered to be classified as thermally stable but modified, irradiation-enhanced, irradiation-induced, and irradiation-transformed

The London Workshop on the Biogeography and Connectivity of the Clarion-Clipperton Zone

Recent years have seen a rapid increase in survey and sampling expeditions to the Clarion-Clipperton Zone (CCZ) abyssal plain, a vast area of the central Pacific that is currently being actively explored for deep-sea minerals (ISA, 2016). Critical to the development of evidence-based environmental policy in the CCZ are data on the biogeography and connectivity of species at a CCZ-regional level. The London Workshop on the Biogeography and Connectivity of the CCZ was convened to support the integration and synthesis of data from European Union (EU) CCZ projects, supported by the EU Managing Impacts of Deep-Sea Resource Exploitation (MIDAS) and EU Joint Programming Initiative Healthy and Productive Seas and Oceans (JPI Oceans) projects. The London Workshop had three clear goals: (1) To explore, review and synthesise the latest molecular biogeography and connectivity data from across recent CCZ cruises from both contractor and academia-funded projects; (2) To develop complementary and collaborative institutional and program-based academic publication plans to avoid duplication of effort and ensure maximum collaborative impact; (3) To plan a joint synthetic data publication highlighting key results from a range of planned molecular biogeography/connectivity publications. 32 participants attended the workshop at the Natural History Museum in London from 10-12 May 2016. Presentations and discussions are summarised in this report covering (1) overviews of current CCZ environmental projects, (2) policy and industry perspectives, (3) synthesis of DNA taxonomy and biogeography studies, (4) summaries of the latest population genetic studies, (5) summaries of the latest broader morphological context, (6) an overview of publication and proposal plans to maximise collaborative opportunities and finally a series of workshop recommendations

Know Your Current Ih: Interaction with a Shunting Current Explains the Puzzling Effects of Its Pharmacological or Pathological Modulations

The non-specific, hyperpolarization activated, Ih current is particularly involved in epilepsy and it exhibits an excitatory or inhibitory action on synaptic integration in an apparently inconsistent way. It has been suggested that most of the inconsistencies could be reconciled invoking an indirect interaction with the M-type K+ current, another current involved in epilepsy. However, here we show that the original experiments, and the simplified model used to explain and support them, cannot explain in a conclusive way the puzzling Ih actions observed in different experimental preparations. Using a realistic model, we show instead how and why a shunting current, such as that carried by TASK-like channels, and dependent on Ih channel is able to explain virtually all experimental findings on Ih up- or down-regulation by modulators or pathological conditions. The model results suggest several experimentally testable predictions to characterize in more details this elusive and peculiar interaction, which may be of fundamental importance in the development of new treatments for all those pathological and cognitive dysfunctions caused, mediated, or affected by Ih

Potencial de economia de energia elétrica através do uso da luz natural e da ventilação híbrida em edifícios comerciais em Florianópolis

O objetivo deste estudo é estimar o potencial de economia de energia elétrica com o uso da luz natural integrada ao sistema de iluminação artificial e a utilização da ventilação híbrida em edifícios comerciais localizados em Florianópolis, SC. O trabalho foi baseado em simulações computacionais nos programas EnergyPlus e Daysim. Foram simulados modelos de ambientes de edificações comerciais, com três geometrias, três dimensões de sala por geometria, dez áreas de janela por modelo e quatro orientações. Os modelos foram examinados por meio de quatro estudos de caso. No Caso 1 (referência), a edificação opera com sistemas de iluminação e de condicionamento artificiais; no Caso 2, ocorre a integração da iluminação natural com a artificial, com condicionamento artificial; já no Caso 3, utilizam-se a ventilação híbrida e a iluminação artificial; no Caso 4, adotam-se a iluminação natural integrada com a artificial e a ventilação híbrida. Os consumos de eletricidade do Caso 1 foram comparados com os demais casos. Assim, foi estimado o potencial de economia de energia elétrica gerado pelo uso da luz natural e ventilação híbrida. Conclui-se que a utilização da iluminação natural e da ventilação híbrida em edificações comerciais localizadas em Florianópolis apresenta potencial de economia de energia elétrica de até 64,9% e que essas estratégias podem ser utilizadas para aumentar a eficiência energética desse tipo de edificação

Human factors in the design of sustainable built environments

Scientific research provides convincing evidence that climate change is having significant impacts on many aspects of life. In the built-environment domain, regulatory requirements are pushing the challenges of environmental, economic, and social sustainability at the core of the professional agenda, although the aims of carbon reduction and energy conservation are frequently given a priority over occupants' comfort, well-being, and satisfaction. While most practitioners declare to embrace sustainability as a driver of their professional approach, a general lack of integrated creative and technical skills hinders the design of buildings centred on articulate and comprehensive sustainability goals, encompassing, other than energy criteria, also human-centred and ethical values founded on competent and informed consideration of the requirements of the site, the programme, and the occupants. Built environments are designed by humans to host a range of human activities. In response, this article aims to endorse a sustainable approach to design founded on the knowledge arising from scholarly and evidence-based research, exploring principles and criteria for the creation and operation of human habitats that can respond to energy and legislative demands, mitigate their environmental impacts, and adapt to new climate scenarios, while elevating the quality of experience and delight to those occupying them

Leveraging ubiquitous computing as a platform for collecting real-time occupant feedback in buildings

Building occupants represent a rich source of information for evaluating environmental design practices and building operations.  This paper presents a scalable diagnostic technology for collecting real-time Indoor Environmental Quality (IEQ) feedback from building occupants: an interactive desktop polling station. The device demonstrates the potential of ubiquitous computing, a model of human-computer interaction in which information processing is integrated into everyday objects, to engage occupants in providing IEQ feedback in real work environments.  Example data from a field study of a high-performance office building are presented demonstrating the applicability of multiple devices to acquire detailed feedback over daily and seasonal variations in climatic conditions.  Sample results show how polling station data can help identify the frequency and magnitude of discomfort with the spatial and temporal granularity needed to assess, validate, and improve the performance of environmentally responsive building technologies, controls, and design strategies. Analysis of repeated-measures subjective assessments paired with concurrent physical measurements is performed to demonstrate how existing standards and assumptions for occupant comfort could be evaluated and refined using detailed occupant feedback from buildings in use.  Results are discussed regarding implications for improving decision-making for the design, certification, and operation of environmentally responsive buildings

A biophysical model of endocannabinoid-mediated short term depression in hippocampal inhibition

Memories are believed to be represented in the synaptic pathways of vastly interconnected networks of neurons. The plasticity of synapses, that is, their strengthening and weakening depending on neuronal activity, is believed to be the basis of learning and establishing memories. An increasing number of studies indicate that endocannabinoids have a widespread action on brain function through modulation of synap–tic transmission and plasticity. Recent experimental studies have characterised the role of endocannabinoids in mediating both short- and long-term synaptic plasticity in various brain regions including the hippocampus, a brain region strongly associated with cognitive functions, such as learning and memory. Here, we present a biophysically plausible model of cannabinoid retrograde signalling at the synaptic level and investigate how this signalling mediates depolarisation induced suppression of inhibition (DSI), a prominent form of shortterm synaptic depression in inhibitory transmission in hippocampus. The model successfully captures many of the key characteristics of DSI in the hippocampus, as observed experimentally, with a minimal yet sufficient mathematical description of the major signalling molecules and cascades involved. More specifically, this model serves as a framework to test hypotheses on the factors determining the variability of DSI and investigate under which conditions it can be evoked. The model reveals the frequency and duration bands in which the post-synaptic cell can be sufficiently stimulated to elicit DSI. Moreover, the model provides key insights on how the state of the inhibitory cell modulates DSI according to its firing rate and relative timing to the post-synaptic activation. Thus, it provides concrete suggestions to further investigate experimentally how DSI modulates and is modulated by neuronal activity in the brain. Importantly, this model serves as a stepping stone for future deciphering of the role of endocannabinoids in synaptic transmission as a feedback mechanism both at synaptic and network level

The role of peptides in bone healing and regeneration: A systematic review

Background: Bone tissue engineering and the research surrounding peptides has expanded significantly over the last few decades. Several peptides have been shown to support and stimulate the bone healing response and have been proposed as therapeutic vehicles for clinical use. The aim of this comprehensive review is to present the clinical and experimental studies analysing the potential role of peptides for bone healing and bone regeneration. Methods: A systematic review according to PRISMA guidelines was conducted. Articles presenting peptides capable of exerting an upregulatory effect on osteoprogenitor cells and bone healing were included in the study. Results: Based on the available literature, a significant amount of experimental in vitro and in vivo evidence exists. Several peptides were found to upregulate the bone healing response in experimental models and could act as potential candidates for future clinical applications. However, from the available peptides that reached the level of clinical trials, the presented results are limited. Conclusion: Further research is desirable to shed more light into the processes governing the osteoprogenitor cellular responses. With further advances in the field of biomimetic materials and scaffolds, new treatment modalities for bone repair will emerge