Combination of molecular similarity measures using data fusion

Many different measures of structural similarity have been suggested for matching chemical structures, each such measure focusing upon some particular type of molecular characteristic. The multi-faceted nature of biological activity suggests that an appropriate similarity measure should encompass many different types of characteristic, and this article discusses the use of data fusion methods to combine the results of searches based on multiple similarity measures. Experiments with several different types of dataset and activity suggest that data fusion provides a simple, but effective, approach to the combination of individual similarity measures. The best results were generally obtained with a fusion rule that sums the rank positions achieved by each molecule in searches using individual measures

Can Big Media do "Big Society"?: A Critical Case Study of Commercial, Convergent Hyperlocal News

The UK Government is committed to helping ‘nurture a new generation of local media companies’. Changes to local media ownership rules allowing companies to follow their customers from platform to platform are supposed to assist in this by encouraging economies of scale. This paper provides a timely case study examining a UK-based commercial local news network owned by Daily Mail & General Trust that leverages economies of scale: Northcliffe Media’s network of 154 Local People websites. The study evaluates the level of audience engagement with the Local People sites through a user survey, and by looking at the numbers of active users, their contributions and their connections with other users. Interviews with ten of the ‘community publishers’ who oversee each site on the ground were conducted, along with a content survey. Although the study reveals a demand for community content, particularly of a practical nature, the results question the extent to which this type of ‘big media’ local news website can succeed as a local social network, reinvigorate political engagement, or encourage citizen reporting. The Government hopes that communities, especially rural ones, will increasingly use the Internet to access local news and information, thereby supporting new, profitable local media companies, who will nurture a sense of local identity and hold locally-elected politicians to account. This case study highlights the difficulties inherent in achieving such outcomes, even using the Government’s preferred convergent, commercial model

Assessment of closure coefficients for compressible-flow turbulence models

A critical assessment is made of the closure coefficients used for turbulence length scale in existing models of the transport equation, with reference to the extension of these models to compressible flow. It is shown that to satisfy the compressible 'law of the wall', the model coefficients must actually be functions of density gradients. The magnitude of the errors that result from neglecting this dependence on density varies with the variable used to specify the length scale. Among the models investigated, the k-omega model yields the best performance, although it is not completely free from errors associated with density terms. Models designed to reduce the density-gradient effect to an insignificant level are proposed

Emergence of Kinetic Behavior in Streaming Ultracold Neutral Plasmas

We create streaming ultracold neutral plasmas by tailoring the photoionizing laser beam that creates the plasma. By varying the electron temperature, we control the relative velocity of the streaming populations, and, in conjunction with variation of the plasma density, this controls the ion collisionality of the colliding streams. Laser-induced fluorescence is used to map the spatially resolved density and velocity distribution function for the ions. We identify the lack of local thermal equilibrium and distinct populations of interpenetrating, counter-streaming ions as signatures of kinetic behavior. Experimental data is compared with results from a one-dimensional, two-fluid numerical simulation.Comment: 8 pages, 6 figure

A Systematic Review of Behaviour-Related Outcome Assessments for Children on the Autism Spectrum with Intellectual Disabilities in Education Settings

A systematic review was completed to identify assessments used with children with intellectual disabilities to assess adaptive behaviour, challenging behaviour and autism-related behaviour and consider their appropriateness for use by special education teachers with autistic pupils. The findings of this review led to the recommendation that the Pervasive Development Disorder Behavior Inventory, Aberrant Behavior Checklist, Autism Treatment Evaluation Checklist and the Teacher Autism Progress Scale are currently the most appropriate assessments for these purposes, although some limitations of these assessments exist. Additional recommendations included teacher input during the development of robust assessments to show progress for autistic children with intellectual disabilities and further evaluation of commonly used assessments with an appropriate sample in a relevant education setting

Inference of heating properties from "hot" non-flaring plasmas in active region cores. I. Single nanoflares

The properties that are expected of “hot” non-flaring plasmas due to nanoflare heating in active regions are investigated using hydrodynamic modeling tools, including a two-fluid development of the Enthalpy Based Thermal Evolution of Loops code. Here we study a single nanoflare and show that while simple models predict an emission measure distribution extending well above 10 MK, which is consistent with cooling by thermal conduction, many other effects are likely to limit the existence and detectability of such plasmas. These include: differential heating between electrons and ions, ionization non-equilibrium, and for short nanoflares, the time taken for the coronal density to increase. The most useful temperature range to look for this plasma, often called the “smoking gun” of nanoflare heating, lies between 10 6.6 and 10 7 K. Signatures of the actual heating may be detectable in some instances.Publisher PDFPeer reviewe

Enthalpy-Based Thermal Evolution of Loops: III. Comparison of Zero-Dimensional Models

Zero dimensional (0D) hydrodynamic models, provide a simple and quick way to study the thermal evolution of coronal loops subjected to time-dependent heating. This paper presents a comparison of a number of 0D models that have been published in the past and is intended to provide a guide for those interested in either using the old models or developing new ones. The principal difference between the models is the way the exchange of mass and energy between corona, transition region and chromosphere is treated, as plasma cycles into and out of a loop during a heating-cooling cycle. It is shown that models based on the principles of mass and energy conservation can give satisfactory results at some, or, in the case of the Enthalpy Based Thermal Evolution of Loops (EBTEL) model, all stages of the loop evolution. Empirical models can lead to low coronal densities, spurious delays between the peak density and temperature, and, for short heating pulses, overly short loop lifetimes

Design of a low-noise aeroacoustic wind tunnel facility at Brunel University

This paper represents the design principle of a quiet, low turbulence and moderately high speed aeroacoustic wind tunnel which was recently commissioned at Brunel University. A new hemi-anechoic chamber was purposely built to facilitate aeroacoustic measurements. The wind tunnel can achieve a maximum speed of about 80 ms-1. The turbulence intensity of the free jet in the potential core is between 0.1–0.2%. The noise characteristic of the aeroacoustic wind tunnel was validated by three case studies. All of which can demonstrate a very low background noise produced by the bare jet in comparison to the noise radiated from the cylinder rod/flat plate/airfoil in the air stream.The constructions of the aeroacoustic wind tunnel and the hemi-anechoic chamber are financially supported by the School of Engineering and Design at Brunel University