A model based safety architecture framework for Dutch high speed train lines

This paper presents a model-based safety architecture framework (MBSAF) for capturing and sharing architectural knowledge of safety cases of safetycritical systems of systems (SoS). Whilst architecture frameworks in the systems engineering domain consider safety often as dependent attribute, this study focusses specifically on sharing architectural knowledge of safety cases between stakeholders and managing safety in systems development. For this purpose, we adapt the A3 architecture overview (A3AO) tool. The application is shown though the case study of Dutch high speed train lines and shows how to derive requirements from various stakeholders by carrying out iterative validations of the A3AOs. The implemented technique consists of systems modeling language-based (SysML) diagrams. Outcomes of the assessment lead to guidelines for two A3AOs. This results in increasing and effective interaction between stakeholders, more overview for managing safety complexity, more insight into finding required safety information, and therefore; an increasing efficiency in safety engineerin

Incidence and survival trends of head and neck squamous cell carcinoma in the Netherlands between 1989 and 2011

SummaryBackgroundIncidence and survival trends of head and neck squamous cell carcinoma (HNSCC) are essential knowledge for guiding policy making and research.MethodsThe total population of the Netherlands was studied covering 1989–2011. Two-and five-year survival and age-standardized incidence rates of HNSCC were assessed in relation to site, gender and age (15years-of-age categories).ResultsWe recorded a statistically significant increase of oral, oropharyngeal and hypopharyngeal carcinoma for males and females of all ages, varying from 0.6% (hypopharynx in males) to 2.7% (oropharynx in females) per year. The incidence of laryngeal carcinoma significantly decreased for males with 2.3% per year; for females the situation was stable. In young adults (below 45years of age) the incidence figures were different: significant decreasing incidence trends were seen for both genders for carcinomas of the oropharynx, hypopharynx and larynx. Regarding oral carcinoma, no change was observed for the young patient group, but for subsites trends were divergent. Carcinoma of the floor or mouth decreased for both genders, but carcinoma of the tongue rose by a significant 2.8% per year for young males. Five-year survival trends for all ages showed no change for laryngeal carcinoma, a small improvement for oral and hypopharyngeal carcinoma, and a substantial and significant improvement of survival from 36% to 47% survival over the total period for oropharyngeal carcinoma.ConclusionIn the Netherlands for the last two decades, the incidence of oral, oropharyngeal and hypopharyngeal squamous cell carcinoma has increased and survival has improved. The incidence of laryngeal carcinoma has decreased in males, and remained unchanged in females; survival from laryngeal carcinoma has not changed

Polyphenols for Cancer Treatment or Prevention

Polyphenols are commonly found in fruits and vegetables, and have been suggested to have protective effects against chronic diseases, such as cancers. They are a diverse group of molecules, many of which possess antioxidant, anti-inflammatory, epigenetic, drug sensitization, and/or modulation of xenobiotic metabolizing enzyme properties. However, there is mixed evidence regarding their protective effects with respect to various cancers. Some of this controversy may be due to the combination of polyphenols administered, synergistic effects of accompanying compounds, bio-accessibility, bioavailability, effect of gut microbiota, and the type of cancer investigated. The purpose of this Special Issue is to present the recent evidence for the effect of polyphenol intake on cancer, as well as mechanisms of action. This Special Issue, entitled "Polyphenols for Cancer Treatment or Prevention", welcomes manuscript submissions of original research, meta-analyses, or reviews of the scientific literature. Authors should focus their manuscripts on polyphenol bioactives or dietary patterns naturally rich in polyphenols that have been identified and used for the prevention and or treatment of cancer

Differences in landing impulses between the traditional and swing blocking style in volleyball

Blocking is an important part in the game of volleyball. Previous research has shown that the swing blocking style leads to a greater jump height, penetration over the net and effective blocking area compared to the traditional blocking method. No available research has been found investigating the differences in landing. The purpose of this study was to examine the differences in landing impulses, landing time and vertical ground reaction forces (vGRF) between the traditional and swing blocking style in volleyball. Therefore, eight female collegiate volleyball players were filmed in high definition at 60Hz performing successful trials of both blocking styles. The videos were digitized and analyzed regarding the following variables: landing time, landing impulse, point of lowest COM, peak vGRF and average vGRF during the landing phase. Statistical analysis revealed that the landing impulse is bigger when subjects performed the swing blocking style compared to the traditional blocking style (

Impact of Solvent on the Thermal Stability of Amines

Water-lean solvents have been proposed as a possible alternative to aqueous amine systems in postcombustion carbon capture. There is however little data available on how amine degradation is affected by different solvents. This study presents new insights on the effect of solvent on thermal degradation of alkanolamines from laboratory-scale degradation experiments. Replacing the water in aqueous monoethanolamine (MEA) solutions with organic diluents resulted in varying thermal degradation rates. Overall, all tested organic diluents (triethylene glycol, diethylene glycol, mono ethylene glycol, tetrahydrofurfuryl alcohol, N-formyl morpholine/water, and N-methyl-2-pyrrolidone) resulted in higher thermal degradation rates for loaded MEA. None of the proposed parameters, such as acid–base behavior, polarity, or relative permittivities, stood out as single contributing factors for the variation in degradation rates. The typical degradation compounds observed for an aqueous MEA solvent were also observed for MEA in various concentrations and with various organic diluents.publishedVersio