2,007 research outputs found
Geochemistry and clay Mineral assemblages of pre- to post-orogenic coarse clastics of the eastern Afghan-Tajik Depression (Central Asia)
Abstract HKT-ISTP 2013
A
Monitoring of Cell Layer Integrity with a Current-Driven Organic Electrochemical Transistor
The integrity of CaCo-2 cell barriers is investigated by organic electrochemical transistors (OECTs) in a current-driven configuration. Ion transport through cellular barriers via the paracellular pathway is modulated by tight junctions between adjacent cells. Rupturing its integrity by H2O2 is monitored by the change of the output voltage in the transfer characteristics. It is demonstrated that by operating the OECT in a current-driven configuration, the sensitive and temporal resolution for monitoring the cell barrier integrity is strongly enhanced as compared to the OECT transient response measurement. As a result, current-driven OECTs are useful tools to assess dynamic and critical changes in tight junctions, relevant for clinical applications as drug targeting and screening
Self-energy of Lambda in finite nuclei
The self--energy of the strange baryon in O is calculated
using a microscopic many--body approach which accounts for correlations beyond
the mean--field or Hartree--Fock approximation. The non-locality and
energy-dependence of the self--energy is discussed and the effects on
the bound and scattering states are investigated. For the nucleon--hyperon
interaction, we use the potential models of the J\"{u}lich and Nijmegen groups.Comment: 17 pages, Revtex Latex style, 7 figs include
State scaling of continuous-time sigma-delta modulators
In this paper, the common method of scaling the feedback coefficients of
continuous time sigma delta modulators in order to stabilize the system is
enhanced. The presented approach scales the different states of the system
instead of the coefficients. The new corresponding coefficients are then
calculated from the solution of the state space description. Therewith, it is
possible to tune the maximum out-of-band gain directly in continuous time. In
addition, the input amplitude distribution between each quantization level of
multi bit sigma-delta modulator can be adapted
Rheology Dependent on the Distance to the Propagating Thrust Tip—(Ultra‐)Mylonites and Pseudotachylytes of the Silvretta Basal Thrust
To evaluate how the presence of pseudotachylytes affects the strength of crustal rocks, deformed pseudotachylytes and their relationship with pristine pseudotachylytes at the base of the Silvretta nappe are analyzed. Pseudotachylytes formed associated with high-stress crystal plasticity (σd > 400 MPa), as indicated by twinned amphiboles in gneisses. Mylonitic quartz clasts enclosed within deformed pseudotachylytes and mylonitic vein-quartz, hosting folded pseudotachylyte injection veins, reflect creep at lower stresses (ca. 100 MPa) after seismic rupturing. Deformed pseudotachylytes can be crosscut by pristine pseudotachylytes, indicating a second, independent stage of coseismic rupturing after creep. The evidence of dynamic dislocation creep of quartz and the presence of stilpnomelane and epidote associated with all fault rocks indicate similar ambient greenschist facies conditions during all deformation stages. Whereas the intermediate stage of creep is interpreted to represent deformation at large distance to the propagating thrust tip, the pristine pseudotachylytes represent the last stage of rupturing eventually leading to nappe decoupling from its basement. Gneiss clasts in an ultramylonitic matrix (i.e., deformed pseudotachylyte) reveal that pseudotachylytes have a lower strength during creep in relation to the hosting gneisses. In contrast, during coseismic high-stress crystal plasticity, the coarse gneisses accumulate a higher amount of strain. This strength-relationship explains that only those rocks rupture, which have not been previously deformed before. The study demonstrates the importance of different strengths of crustal rocks at specific stress- and strain-rate conditions in dependence on the distance to the propagating fault tip
IslamiCity Creating an Islamic Cybersociety
Since the mid-1990s, Islamic webcontent has grown considerably. The distribution of fatwas, one of the most booming components of Islamic webcontent, is becoming a must for any Islamic website. In 1999 at least 10,000 fatwas were to be found online. In the year 2000 the number rose to at least 14,000 fatwas, and this year thousands more are sure to be added to the score. Since the time of the Prophet Muhammad, the provision of fatwas has been an important social barometer. The interactive component of the internet has made online fatwa services not only possible, but easy and accessible as well. Such virtual services, however, impact certain Islamic beliefs and practices
Monitoring Reversible Tight Junction Modulation with a Current‐Driven Organic Electrochemical Transistor
AbstractThe barrier functionality of a cell layer regulates the passage of nutrients into the blood. Modulating the barrier functionality by external chemical agents like poly‐l‐lysine (PLL) is crucial for drug delivery. The ability of a cell layer to impede the passage of ions through it and therefore to act as a barrier, can be assessed electrically by measuring the resistance across the cell layer. Here, an organic electrochemical transistor (OECT) is used in a current‐driven configuration for the evaluation of reversible modulation of tight junctions in Caco‐2 cells over time. Exposure to low and medium concentrations of PLL initiates reversible modulation, whereas a too high concentration induces an irreversible barrier disruption due to nonfunctional tight junction proteins. The results demonstrate the suitability of OECTs to in situ monitor temporal barrier modulation and recovery, which can offer valuable information for drug delivery applications
The high-intensity hyperon beam at CERN
A high-intensity hyperon beam was constructed at CERN to deliver Sigma- to
experiment WA89 at the Omega facility and operated from 1989 to 1994. The setup
allowed rapid changeover between hyperon and conventional hadron beam
configurations. The beam provided a Sigma-flux of 1.4 x 10^5 per burst at mean
momenta between 330 and 345 Gev/c, produced by about 3 x 10^10 protons of 450
GeV/c . At the experiment target the beam had a Sigma-/pi- ratio close to 0.4
and a size of 1.6 x 3.7 cm^2. The beam particle trajectories and their momenta
were measured with a scintillating fibre hodoscope in the beam channel and a
silicon microstrip detector at the exit of the channel. A fast transition
radiation detector was used to identify the pion component of the beam.Comment: 20 pages, 13 figures. Submitted to Nucl. Instr. Meth.
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