Giant cell arteritis exclusively detected by 18F-fluorodeoxyglucose positron emission tomography: a case report

INTRODUCTION: This case of giant cell arteritis is noteworthy because it evaded standard diagnostic criteria and only emerged as fever of unknown origin. In this regard, we present (18)F-fluorodeoxyglucose positron emission tomography as a valid diagnostic method. CASE PRESENTATION: This case report describes a 58-year-old Caucasian woman who is a cigarette smoker with a 10-week history of fever of unknown origin, night sweats and weight loss of 12kg. Initially, clinical presentation was suspicious of malignant disease. Laboratory findings detected significantly elevated inflammatory blood parameters including C-reactive protein and elevated erythrocyte sedimentation rate (110mm/hour). Extensive diagnostic workup including microbiological and rheumatological assessment, ultrasonography, endoscopy and computed tomography of abdomen and thorax did not indicate any septic or malignant focus. Eventually, (18)F-fluorodeoxyglucose positron emission tomography was able to reveal arteritis of her aortic arch and supraaortic branches. Subsequently, she commenced steroid and methotrexate therapy that led to sustained remission. CONCLUSIONS: This case of giant cell arteritis may promote discussion regarding a more specific classification for this disease entity. Furthermore, it confirms that (18)F-fluorodeoxyglucose positron emission tomography might serve as a valuable tool for diagnosis of giant cell arteritis, because it could facilitate an accurate and non-invasive detection of lesions of large vessels

Testing the accuracy of feldspar single grains to date late Holocene cyclone and tsunami deposits

Quartz is the preferred dosimeter for luminescence dating of Holocene sediments as optically stimulated luminescence (OSL) signals reset rapidly upon light exposure, and are stable over time. However, feldspar is required where quartz luminescence properties are inappropriate for dating, as is often the case in geologically young mountain ranges and areas with young volcanism. Here we aim to evaluate the potential of single grain feldspar luminescence dating applied to late Holocene cyclone and tsunami deposits, for which complete signal resetting can a priori not be guaranteed. To address potential problems of feldspar dating of such deposits associated with heterogeneous bleaching, remnant doses and anomalous fading, we use a low-temperature post infrared infrared stimulated luminescence protocol (pIRIR150) on single grains. For most samples, good agreement between fading corrected IR50 and non-fading corrected pIRIR150 ages is observed. Both feldspar ages generally also show good agreement with age control provided by historical data and quartz luminescence ages. pIRIR150 remnant ages in modern analogue samples are shown to be 150, IR50 and quartz ages, indicates that a significant number of grains must have experienced relatively complete signal resetting during or immediately prior to transport, as the three signals are known to bleach at different rates. Since light exposure during the event is expected to be limited, we deduce that a significant portion of the grains in the cyclone and tsunami deposits was already bleached prior to the event of interest. These well-bleached grains were likely eroded at the beach, while other grains with larger remnant ages probably originate from the shallow subtidal, coastal barriers or even further inland sources. Additional signal resetting during storm and tsunami transport is indicated by slightly younger quartz than feldspar ages for grains with incomplete pre-transport resetting that were eroded at the Holocene coastal barrier.</p

“ESPAÑOLES”

La fundación de las colonias extranjeras en México fue el resultado de un proceso de colonización por el cual atravesó el mundo y nuestro país no fue la excepción, Sin embargo, con gran diferencia se distinguió por un sistema heterogéneo constituido por una amplio mosaico étnico de más de 600 grupos indígenas en diferentes estadios de desarrollo determinado por un conjunto de factores en los que intervinieron procesos de aculturación, transculturación y sincretismo cultural para integrar al indígena al mundo novohispano mediante; sometimiento, catástrofe demográfica, explotación, enajenación y violencia la sociedad indígena se mantuvo en pie con significativas pérdidas humanas

The environs of Elaia (NW Turkey) – Sea-level fluctuations, vegetation history and microfaunal record

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Quantitative Stain-free and Continuous Multimodal Monitoring of Wound Healing in vitro with Digital Holographic Microscopy

Impaired epithelial wound healing has significant pathophysiological implications in several conditions including gastrointestinal ulcers, anastomotic leakage and venous or diabetic skin ulcers. Promising drug candidates for accelerating wound closure are commonly evaluated in in vitro wound assays. However, staining procedures and discontinuous monitoring are major drawbacks hampering accurate assessment of wound assays. We therefore investigated digital holographic microscopy (DHM) to appropriately monitor wound healing in vitro and secondly, to provide multimodal quantitative information on morphological and functional cell alterations as well as on motility changes upon cytokine stimulation. Wound closure as reflected by proliferation and migration of Caco-2 cells in wound healing assays was studied and assessed in time-lapse series for 40 h in the presence of stimulating epidermal growth factor (EGF) and inhibiting mitomycin c. Therefore, digital holograms were recorded continuously every thirty minutes. Morphological changes including cell thickness, dry mass and tissue density were analyzed by data from quantitative digital holographic phase microscopy. Stimulation of Caco-2 cells with EGF or mitomycin c resulted in significant morphological changes during wound healing compared to control cells. In conclusion, DHM allows accurate, stain-free and continuous multimodal quantitative monitoring of wound healing in vitro and could be a promising new technique for assessment of wound healing

Lexikographische Arbeitsprozesse – am Beispiel des Deutschen Fremdwörterbuchs

Das Deutsche Fremdw&ouml;rterbuch des Mannheimer Instituts f&uuml;r deutsche Sprache ist mit seiner nunmehr &uuml;ber 100 Jahre andauernden Geschichte27 einer der prominentesten Vertreter der deutschen Fremdwortlexikographie. Nach einem kurzen &Uuml;berblick &uuml;ber die Geschichte des Deutschen Fremdw&ouml;rterbuchs gew&auml;hrt der Text einen Einblick in die gegenw&auml;rtigen Methoden der fremdwortlexikographischen Arbeit und zeigt anhand einiger ausgew&auml;hlter Aspekte der W&ouml;rterbucherstellung, welche M&ouml;glichkeiten, aber auch welche Notwendigkeiten die t&auml;gliche W&ouml;rterbucharbeit bestimmen. In den Blick genommen werden neben der W&ouml;rterbuchbasis und der Lemmaauswahl vor allem die konkrete Artikelarbeit sowie die Organisationsstruktur der Redaktion.Lexicographic work based on the example of the Deutsches Fremdw&ouml;rterbuchDue to its century-spanning history, the Deutsches Fremdw&ouml;rterbuch, currently developed at the Institut f&uuml;r deutsche Sprache in Mannheim, is one of the most prominent exponents of German loan word lexicography. After a short overview of the dictionary&rsquo;s history, the text provides insight into the methods applied in current loan word lexicography. By examining selected aspects of dictionary making, it shows the possibilities and limitations that determine day-to-day lexicographic work. Besides the dictionary basis and the selection of entries, the text focuses on the daily routines and the organisational structure of the editorial department.Das Deutsche Fremdw&ouml;rterbuch des Mannheimer Instituts f&uuml;r deutsche Sprache ist mit seiner nunmehr &uuml;ber 100 Jahre andauernden Geschichte27 einer der prominentesten Vertreter der deutschen Fremdwortlexikographie. Nach einem kurzen &Uuml;berblick &uuml;ber die Geschichte des Deutschen Fremdw&ouml;rterbuchs gew&auml;hrt der Text einen Einblick in die gegenw&auml;rtigen Methoden der fremdwortlexikographischen Arbeit und zeigt anhand einiger ausgew&auml;hlter Aspekte der W&ouml;rterbucherstellung, welche M&ouml;glichkeiten, aber auch welche Notwendigkeiten die t&auml;gliche W&ouml;rterbucharbeit bestimmen. In den Blick genommen werden neben der W&ouml;rterbuchbasis und der Lemmaauswahl vor allem die konkrete Artikelarbeit sowie die Organisationsstruktur der Redaktion.Lexicographic work based on the example of the Deutsches Fremdw&ouml;rterbuchDue to its century-spanning history, the Deutsches Fremdw&ouml;rterbuch, currently developed at the Institut f&uuml;r deutsche Sprache in Mannheim, is one of the most prominent exponents of German loan word lexicography. After a short overview of the dictionary&rsquo;s history, the text provides insight into the methods applied in current loan word lexicography. By examining selected aspects of dictionary making, it shows the possibilities and limitations that determine day-to-day lexicographic work. Besides the dictionary basis and the selection of entries, the text focuses on the daily routines and the organisational structure of the editorial department