Orthopedic Treatment of Skeletal Class III Malocclusions With Maxillary Deficiency

Objective:The purpose of this study was to compare the treatment effects of a double-plate appliance (DPA) and a double-plate appliance and facemask combination (DPA-FM) in correcting Class III malocclusions.Materials and Methods:The material consisted of lateral cephalometric radiographs of 40 children with skeletal and dental Class III malocclusion. In the first treatment group, 13 patients (mean age: 10 years 3 months) were treated with DPA. In the second treatment group, 15 patients (mean age: 10 years 9 months) were treated with DPA-FM. In the third group, 12 patients (mean age: 10 years 6 months) were observed without treatment for 9 months. Statistical evaluation was made by ANOVA, Duncan, and paired t tests.Results:The increases in SNA and ANB angles were significantly greater in the DPA-FM group than in the DPA group. The proclination of upper incisors (U1/NA) and retroclination of lower incisors (L1/NB) were significantly greater in the DPA group than in the DPA-FM group. The retroclination of lower incisors (L1/NB) in the DPA group showed a significant difference compared with the control group. The increase in ANS-Me length was significantly greater in the DPA-FM group than in the control group.Conclusion:The DPA-FM treatment was more effective in sagittal correction of the maxilla than the DPA treatment. The dental contribution to Class III treatment seemed to be greater in the DPA group, but in this group vertical skeletal changes were more satisfying

ONSET CHARACTERISTICS AND ACCOMPANYING AUTOIMMUNE DISEASES IN AUTOIMMUNE BULLOUS DERMATOSES

Amaç: Demografik ve klinik özellikleri açısından bazı farklılıklar gösteren otoimmünbüllöz dermatoz (OBD)'lara bazı otoimmün hastalıkların eşlik edebildiği bildirilmiştir.Bu çalışmada kliniğimizde yatan OBD olgularında demografik ve klinik başlangıçözellikleri ile eşlik eden otoimmün hastalıkların araştırılması amaçlanmıştır.Gereç ve yöntem: Bu çalışmada 2000-2009 tarihleri arasında kliniğimizde yatanOBD'lu 97 olgunun dosyası cinsiyet, başlangıç yaşı, dökülerin başlangıç yeri ve eşlikeden otoimmün hastalıklar açısından retrospektif olarak taranmıştır.Bulgular: Çalışmaya alınan 97 olgunun 50 (%51,5)'si pemfigus (37'si pemfigusvulgaris, 4'ü pemfigus vejetans, 9'u pemfigus foliaseus), 40 (%41,2)'ı pemfigoid (38'ibüllöz pemfigoid, 2'si sikatrisyel pemfigoid), 5'i (%5,1) dermatitis herpetiformis, 1(%1,1)'i lineer Ig A büllöz dermatozu ve 1 (%1,1)'i ise edinsel epidermolizis büllozaolarak saptanmıştır. Pemfigus vulgaris, pemfigus vejetans ve büllöz pemfigoidliolgularda hem deri hem mukozada başlayan dökülerin görüldüğü, pemfigus foliaseus,dermatitis herpetiformis, lineer IgA büllöz dermatozu ve edinsel epidermolizisbüllozalı olgularda sadece deri başlangıçlı dökülerin olduğu ve sikatrisyel pemfigoidliolgularda ise sadece mukozal başlangıçlı dökülerin görüldüğü belirlenmiştir. Ayrıca,genel olarak OBD'lu olguların %26,8'inde en sık diabetes mellitus (%17,5) olmak üzerepsoriyazis, liken planus, Hashimato tiroiditi, Graves hastalığı, romatoid artrit veülseratif kolit gibi eşlik eden otoimmün bir hastalık saptanmıştır.Sonuç: Farklı başlangıç özellikleri gösteren OBD'lara farklı oranlarda olmakla birliktebazı otoimmün hastalıkların eşlik edebildiği gösterilmiştir.SUMMARYObjectives: It has been reported that some autoimmune diseases may be accompaniedwith autoimmune bullous dermatoses (ABD) which may show some differences indemographic and clinical characteristics. In this study, we aimed to investigate thedemographic and clinical onset characteristics, and the accompanying autoimmunediseases in ABD patients previously hospitalized in our clinic.Material and method: In this study, the files of 97 ABD patients who had been hospi-talized between years 2000-2009 were retrospectively reviewed in terms of gender, ageat onset, onset localization of lesions, and the accompanying autoimmune diseases.Results: Between the 97 patients, 50 (51.5%) had pemphigus (pemphigus vulgaris in37 patients, pemphigus vegetans in 4 patients, pemphigus foliaceus in 9 patients), 40(41.2%) had pemphigoid (bullous pemphigoid in 37 patients, cicatricial pemphigoid in2 patients), 5 (5.1%) had dermatitis herpetiformis, 1 (1.1%) had linear IgA bullousdermatosis and 1 (1.1%) had epidermolysis bullosa acquisita. It is determined that thedisease began from both skin and mucosa in patients with pemphigus vulgaris,pemphigus vegetans and bullous pemphigoid, only skin in patients with pemphigusfoliaceus, dermatitis herpetiformis, linear IgA bullous dermatosis and epidermolysisbullosa acquisita, and only mucosa in patients with cicatricial pemphigoid.Furthermore, 26.8% of all ABD patients accompanied by autoimmune diseasesprimarily diabetes mellitus (17.5%), subsequently psoriasis, lichen planus, Hashimatothyroiditis, Graves disease, romatoid arthritis and ulcerative colitis.Conclusion: This study demonstrated that some autoimmune diseases in differentproportions may accompany ABD which show different onset characteristics

Assessment of Orbital-Optimized MP2.5 for Thermochemistry and Kinetics: Dramatic Failures of Standard Perturbation Theory Approaches for Aromatic Bond Dissociation Energies and Barrier Heights of Radical Reactions

An assessment of orbital-optimized MP2.5 (OMP2.5) [Bozkaya, U.; Sherrill, C. D. J. Chem. Phys. 2014, 141, 204105] for thermochemistry and kinetics is presented. The OMP2.5 method is applied to closed- and open-shell reaction energies, barrier heights, and aromatic bond dissociation energies. The performance of OMP2.5 is compared with that of the MP2, OMP2, MP2.5, MP3, OMP3, CCSD, and CCSD­(T) methods. For most of the test sets, the OMP2.5 method performs better than MP2.5 and CCSD, and provides accurate results. For barrier heights of radical reactions and aromatic bond dissociation energies OMP2.5–MP2.5, OMP2–MP2, and OMP3–MP3 differences become obvious. Especially, for aromatic bond dissociation energies, standard perturbation theory (MP) approaches dramatically fail, providing mean absolute errors (MAEs) of 22.5 (MP2), 17.7 (MP2.5), and 12.8 (MP3) kcal mol^–1, while the MAE values of the orbital-optimized counterparts are 2.7, 2.4, and 2.4 kcal mol^–1, respectively. Hence, there are 5–8-folds reductions in errors when optimized orbitals are employed. Our results demonstrate that standard MP approaches dramatically fail when the reference wave function suffers from the spin-contamination problem. On the other hand, the OMP2.5 method can reduce spin-contamination in the unrestricted Hartree–Fock (UHF) initial guess orbitals. For overall evaluation, we conclude that the OMP2.5 method is very helpful not only for challenging open-shell systems and transition-states but also for closed-shell molecules. Hence, one may prefer OMP2.5 over MP2.5 and CCSD as an <i>O</i>(<i>N</i>⁶) method, where <i>N</i> is the number of basis functions, for thermochemistry and kinetics. The cost of the OMP2.5 method is comparable with that of CCSD for energy computations. However, for analytic gradient computations, the OMP2.5 method is only half as expensive as CCSD

Assessment of Orbital-Optimized MP2.5 for Thermochemistry and Kinetics: Dramatic Failures of Standard Perturbation Theory Approaches for Aromatic Bond Dissociation Energies and Barrier Heights of Radical Reactions

An assessment of orbital-optimized MP2.5 (OMP2.5) [Bozkaya, U.; Sherrill, C. D. J. Chem. Phys. 2014, 141, 204105] for thermochemistry and kinetics is presented. The OMP2.5 method is applied to closed- and open-shell reaction energies, barrier heights, and aromatic bond dissociation energies. The performance of OMP2.5 is compared with that of the MP2, OMP2, MP2.5, MP3, OMP3, CCSD, and CCSD­(T) methods. For most of the test sets, the OMP2.5 method performs better than MP2.5 and CCSD, and provides accurate results. For barrier heights of radical reactions and aromatic bond dissociation energies OMP2.5–MP2.5, OMP2–MP2, and OMP3–MP3 differences become obvious. Especially, for aromatic bond dissociation energies, standard perturbation theory (MP) approaches dramatically fail, providing mean absolute errors (MAEs) of 22.5 (MP2), 17.7 (MP2.5), and 12.8 (MP3) kcal mol^–1, while the MAE values of the orbital-optimized counterparts are 2.7, 2.4, and 2.4 kcal mol^–1, respectively. Hence, there are 5–8-folds reductions in errors when optimized orbitals are employed. Our results demonstrate that standard MP approaches dramatically fail when the reference wave function suffers from the spin-contamination problem. On the other hand, the OMP2.5 method can reduce spin-contamination in the unrestricted Hartree–Fock (UHF) initial guess orbitals. For overall evaluation, we conclude that the OMP2.5 method is very helpful not only for challenging open-shell systems and transition-states but also for closed-shell molecules. Hence, one may prefer OMP2.5 over MP2.5 and CCSD as an <i>O</i>(<i>N</i>⁶) method, where <i>N</i> is the number of basis functions, for thermochemistry and kinetics. The cost of the OMP2.5 method is comparable with that of CCSD for energy computations. However, for analytic gradient computations, the OMP2.5 method is only half as expensive as CCSD

Long term results of double plate appliance and facemask combination in the treatment of Class III malocclusion: cephalometric analysis

Objective: The aim of this study was to evaluate the long term results of double plate appliance and facemask combination (DPA-FM) in treating Class III malocclusions when growth potential of the patients was close to cease or ceased. Materials and Method: The material consisted of the pretreatment (T1), posttreatment (T2), and long term (T3) lateral cephalometric and the hand-wrist radiographs of 13 patients (5 females, 8 males; mean chronological age: 11.1±1.40 years) with skeletal and dental Class III malocclusion treated with DPA-FM combination. The mean DPA-FM treatment time was 10.8±1.88 months. The hand-wrist growth and developmental stages were MP3u or Ru at T3. The mean follow-up period was 5.0±1.98 years. Friedman’s Two-Way ANOVA and Wilcoxon signed-rank tests were used to evaluate the treatment (T2-T1), follow-up (T3-T2) and overall (T3-T1) results. Results: With the DPA-FM therapy, SNA and ANB angles increased (p<0.001); however, no significant differences were found in these parameters during T3-T2 period [p=0.655 (SNA), p=0.805 (ANB)]. Significant increases were found in N┴FH-A distance during the treatment (p<0.01) and follow-up (p<0.05) periods. Molar relation showed significant increases with DPA-FM in both the treatment and overall period (p<0.001). Overjet increased significantly during the treatment (p<0.001), follow-up (p<0.05), and overall (p<0.001) periods. Significant protrusion of upper incisors (U1/NA) was observed during the treatment, follow-up, and overall periods (p<0.05). U6/PP and L6/MP angles did not change during the DPA-FM treatment; however, these parameters decreased significantly during the follow-up and overall periods (p<0.05). Conclusion: In the treatment of Class III malocclusion, the DPA-FM appliance was effective. The skeletal and dental sagittal changes achieved by orthopedic treatment were maintained in the long term

Evaluation of the effects of the hybrid Pendulum in comparison with the conventional Pendulum appliance

Objective: To evaluate the anchorage control and distalization of maxillary molars with the hybrid Pendulum appliance and to compare the results with a conventional Pendulum appliance. Materials and Methods: This study was carried out on the pre-(T0) and post-(T1) treatment lateral cephalograms and dental casts of 43 patients with Angle Class II molar relationships who were treated with conventional or hybrid Pendulum appliances. The hybrid Pendulum (HP) group consisted of 22 patients (14 females; eight males; mean age 14.3 +/- 2.43 years) and treatment results were compared with a conventional Pendulum appliance (CP) group, which consisted of 21 patients (15 females; six males; mean age 14.6 +/- 3.39 years). Intragroup comparisons were made with Wilcoxon test and intergroup comparisons were made with MannWhitney U- test (P <.05). Results: The mean distalization duration was 0.70 +/- 0.25 years in the HP group and 0.83 +/- 0.4 years in the CP group. Maxillary first molars showed significant distal movement and tipping of 4.25 mm and 9.09 degrees in the HP group, and 3.21 mm and 9.86 degrees in the CP group. Loss of anchorage at the first premolars was significantly smaller in the HP appliance group compared to CP group. The second premolars distalized spontaneously in the HP group while they mesialized significantly in the CP group. Proclination and protrusion of maxillary incisors were greater with the CP appliance compared to the HP appliance. Conclusions: Maxillary molar distalization was achieved with both appliances. Mesialization of the anchorage unit was controlled successfully with the hybrid Pendulum; however, the conventional Pendulum appliance caused anchorage loss

A Rare Gamma-Pyranopyrazole Skeleton: Design, One-Pot Synthesis and Computational Study

Drawing upon a consecutive amide coupling and intramolecular cyclisation pathway, a one-pot, straight-forward synthetic route has been developed for a range of pyrazole fused gamma-pyrone derivatives. The reaction mechanism proposed for the chemoselective formation of gamma-pyranopyrazole is furthermore fully supported by experimental and computational studies.WoSScopu