167 research outputs found
Logarithmic Corrections in the 2D XY Model
Using two sets of high-precision Monte Carlo data for the two-dimensional XY
model in the Villain formulation on square lattices, the scaling
behavior of the susceptibility and correlation length at the
Kosterlitz-Thouless phase transition is analyzed with emphasis on
multiplicative logarithmic corrections in the finite-size
scaling region and in the high-temperature phase near
criticality, respectively. By analyzing the susceptibility at criticality on
lattices of size up to we obtain , in agreement with
recent work of Kenna and Irving on the the finite-size scaling of Lee-Yang
zeros in the cosine formulation of the XY model. By studying susceptibilities
and correlation lengths up to in the high-temperature phase,
however, we arrive at quite a different estimate of , which is
in good agreement with recent analyses of thermodynamic Monte Carlo data and
high-temperature series expansions of the cosine formulation.Comment: 13 pages, LaTeX + 8 postscript figures. See also
http://www.cond-mat.physik.uni-mainz.de/~janke/doc/home_janke.htm
Citizen Science 2.0 : Data Management Principles to Harness the Power of the Crowd
Citizen science refers to voluntary participation by the general public in scientific endeavors. Although citizen science has a long tradition, the rise of online communities and user-generated web content has the potential to greatly expand its scope and contributions. Citizens spread across a large area will collect more information than an individual researcher can. Because citizen scientists tend to make observations about areas they know well, data are likely to be very detailed. Although the potential for engaging citizen scientists is extensive, there are challenges as well. In this paper we consider one such challenge – creating an environment in which non-experts in a scientific domain can provide appropriate and accurate data regarding their observations. We describe the problem in the context of a research project that includes the development of a website to collect citizen-generated data on the distribution of plants and animals in a geographic region. We propose an approach that can improve the quantity and quality of data collected in such projects by organizing data using instance-based data structures. Potential implications of this approach are discussed and plans for future research to validate the design are described
The Crystallography of Color Superconductivity
We develop the Ginzburg-Landau approach to comparing different possible
crystal structures for the crystalline color superconducting phase of QCD, the
QCD incarnation of the Larkin-Ovchinnikov-Fulde-Ferrell phase. In this phase,
quarks of different flavor with differing Fermi momenta form Cooper pairs with
nonzero total momentum, yielding a condensate that varies in space like a sum
of plane waves. We work at zero temperature, as is relevant for compact star
physics. The Ginzburg-Landau approach predicts a strong first-order phase
transition (as a function of the chemical potential difference between quarks)
and for this reason is not under quantitative control. Nevertheless, by
organizing the comparison between different possible arrangements of plane
waves (i.e. different crystal structures) it provides considerable qualitative
insight into what makes a crystal structure favorable. Together, the
qualitative insights and the quantitative, but not controlled, calculations
make a compelling case that the favored pairing pattern yields a condensate
which is a sum of eight plane waves forming a face-centered cubic structure.
They also predict that the phase is quite robust, with gaps comparable in
magnitude to the BCS gap that would form if the Fermi momenta were degenerate.
These predictions may be tested in ultracold gases made of fermionic atoms. In
a QCD context, our results lay the foundation for a calculation of vortex
pinning in a crystalline color superconductor, and thus for the analysis of
pulsar glitches that may originate within the core of a compact star.Comment: 41 pages, 13 figures, 1 tabl
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Junior staffing changes and the temporal ecology of adverse incidents in acute psychiatric wards
Aim. This paper reports an examination of the relationship between adverse incident rates, the arrival of new junior staff on wards, and days of the week on acute psychiatric wards.
Background. Incidents of violence, absconding and self-harm in acute inpatient services pose risks to patients and staff. Previous research suggests that the arrival of inexperienced new staff may trigger more adverse incidents. Findings on the relationship between incidents and the weekly routine are inconsistent.
Method. A retrospective analysis was conducted of formally reported incident rates, records of nursing student allocations and junior doctor rotation patterns, using Poisson Regression. Variance between days of the week was explored using contingency table analysis. The data covered 30 months on 17 psychiatric wards, and were collected in 2002–2004.
Findings. The arrival of new and inexperienced staff on the wards was not associated with increases in adverse incident rates. Most types of incidents were less frequent at weekends and midweek. Incident rates were unchanged on ward-round days, but increased rates were found on the days before and after ward rounds.
Conclusion. Increased patient tension is associated with raised incident rates. It may be possible to reduce incident rates by moderating stimulation in the environment and by mobilizing support for patients during critical periods
On the role of the upper part of words in lexical access : evidence with masked priming
More than 100 years ago, Huey (1908) indicated that the upper part of words was more relevant for perception than the lower part. Here we examined whether mutilated words, in their upper/lower portions (e.g., , , , ), can automatically access their word units in the mental lexicon. To that end, we conducted four masked repetition priming experiments with the lexical decision task. Results showed that mutilated primes produced a sizeable masked repetition priming effect. Furthermore, the magnitude of the masked repetition priming effect was greater when the upper part of the primes was preserved than when the lower portion was preserved –this was the case not only when the mutilated words were presented in lowercase but also when the mutilated words were presented in uppercase. Taken together, these findings suggest that the front-end of computational models of visual-word recognition should be modified to provide a more realistic account at the level of letter features.The research reported in this article has been partially supported by Grant PSI2008-04069/PSIC and CONSOLIDER-INGENIO2010 CSD2008-00048 from the Spanish Ministry of Science and Innovation and by Grant PTDC/PSI-PCO/104671/2008 from the Portuguese Foundation for Science and Technology
Discovery and Characterization of Peptide Inhibitors for Calcium and Integrin Binding Protein 1
Calcium and integrin binding protein 1 (CIB1) is an EF-hand-containing, small intracellular protein that has recently been implicated in cancer cell survival and proliferation. In particular, CIB1 depletion significantly impairs tumor growth in triple-negative breast cancer (TNBC). Thus, CIB1 is a potentially attractive target for cancer chemotherapy that has yet to be validated by a chemical probe. To produce a probe molecule to the CIB1 helix 10 (H10) pocket and demonstrate that it is a viable target for molecular intervention, we employed random peptide phage display to screen and select CIB1-binding peptides. The top peptide sequence selected, UNC10245092, was produced synthetically, and binding to CIB1 was confirmed by isothermal titration calorimetry (ITC) and a time-resolved fluorescence resonance energy transfer (TR-FRET) assay. Both assays showed that the peptide bound to CIB1 with low nanomolar affinity. CIB1 was cocrystallized with UNC10245092, and the 2.1 Å resolution structure revealed that the peptide binds as an α-helix in the H10 pocket, displacing the CIB1 C-terminal H10 helix and causing conformational changes in H7 and H8. UNC10245092 was further derivatized with a C-terminal Tat-derived cell penetrating peptide (CPP) to demonstrate its effects on TNBC cells in culture, which are consistent with results of CIB1 depletion. These studies provide a first-in-class chemical tool for CIB1 inhibition in cell culture and validate the CIB1 H10 pocket for future probe and drug discovery efforts
Novel word integration in the mental lexicon: Evidence from unmasked and masked semantic priming
The PHENIX Experiment at RHIC
The physics emphases of the PHENIX collaboration and the design and current
status of the PHENIX detector are discussed. The plan of the collaboration for
making the most effective use of the available luminosity in the first years of
RHIC operation is also presented.Comment: 5 pages, 1 figure. Further details of the PHENIX physics program
available at http://www.rhic.bnl.gov/phenix
Recommendations for reporting ion mobility Mass Spectrometry measurements
Here we present a guide to ion mobility mass spectrometry experiments, which covers both linear and nonlinear methods: what is measured, how the measurements are done, and how to report the results, including the uncertainties of mobility and collision cross section values. The guide aims to clarify some possibly confusing concepts, and the reporting recommendations should help researchers, authors and reviewers to contribute comprehensive reports, so that the ion mobility data can be reused more confidently. Starting from the concept of the definition of the measurand, we emphasize that (i) mobility values (K0) depend intrinsically on ion structure, the nature of the bath gas, temperature, and E/N; (ii) ion mobility does not measure molecular surfaces directly, but collision cross section (CCS) values are derived from mobility values using a physical model; (iii) methods relying on calibration are empirical (and thus may provide method‐dependent results) only if the gas nature, temperature or E/N cannot match those of the primary method. Our analysis highlights the urgency of a community effort toward establishing primary standards and reference materials for ion mobility, and provides recommendations to do so. © 2019 The Authors. Mass Spectrometry Reviews Published by Wiley Periodicals, Inc
New insights into the genetic etiology of Alzheimer's disease and related dementias
Characterization of the genetic landscape of Alzheimer's disease (AD) and related dementias (ADD) provides a unique opportunity for a better understanding of the associated pathophysiological processes. We performed a two-stage genome-wide association study totaling 111,326 clinically diagnosed/'proxy' AD cases and 677,663 controls. We found 75 risk loci, of which 42 were new at the time of analysis. Pathway enrichment analyses confirmed the involvement of amyloid/tau pathways and highlighted microglia implication. Gene prioritization in the new loci identified 31 genes that were suggestive of new genetically associated processes, including the tumor necrosis factor alpha pathway through the linear ubiquitin chain assembly complex. We also built a new genetic risk score associated with the risk of future AD/dementia or progression from mild cognitive impairment to AD/dementia. The improvement in prediction led to a 1.6- to 1.9-fold increase in AD risk from the lowest to the highest decile, in addition to effects of age and the APOE ε4 allele
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