Orbital Observations of Dust Lofted by Daytime Convective Turbulence

Over the past several decades, orbital observations of lofted dust have revealed the importance of mineral aerosols as a climate forcing mechanism on both Earth and Mars. Increasingly detailed and diverse data sets have provided an ever-improving understanding of dust sources, transport pathways, and sinks on both planets, but the role of dust in modulating atmospheric processes is complex and not always well understood. We present a review of orbital observations of entrained dust on Earth and Mars, particularly that produced by the dust-laden structures produced by daytime convective turbulence called “dust devils”. On Earth, dust devils are thought to contribute only a small fraction of the atmospheric dust budget; accordingly, there are not yet any published accounts of their occurrence from orbit. In contrast, dust devils on Mars are thought to account for several tens of percent of the planet’s atmospheric dust budget; the literature regarding martian dust devils is quite rich. Because terrestrial dust devils may temporarily contribute significantly to local dust loading and lowered air quality, we suggest that martian dust devil studies may inform future studies of convectively-lofted dust on Earth

The SIB Swiss Institute of Bioinformatics' resources: focus on curated databases

The SIB Swiss Institute of Bioinformatics (www.isb-sib.ch) provides world-class bioinformatics databases, software tools, services and training to the international life science community in academia and industry. These solutions allow life scientists to turn the exponentially growing amount of data into knowledge. Here, we provide an overview of SIB's resources and competence areas, with a strong focus on curated databases and SIB's most popular and widely used resources. In particular, SIB's Bioinformatics resource portal ExPASy features over 150 resources, including UniProtKB/Swiss-Prot, ENZYME, PROSITE, neXtProt, STRING, UniCarbKB, SugarBindDB, SwissRegulon, EPD, arrayMap, Bgee, SWISS-MODEL Repository, OMA, OrthoDB and other databases, which are briefly described in this article

Lung Microbiota and Bacterial Abundance in Patients with Bronchiectasis when Clinically Stable and during Exacerbation

Rationale: Characterization of bacterial populations in infectious respiratory diseases will provide improved understanding of the relationship between the lung microbiota, disease pathogenesis, and treatment outcomes. Objectives: To comprehensively define lung microbiota composition during stable disease and exacerbation in patients with bronchiectasis. Methods: Sputum was collected from patients when clinically stable and before and after completion of antibiotic treatment of exacerbations. Bacterial abundance and community composition were analyzed using anaerobic culture and 16S rDNA pyrosequencing. Measurements and Main Results: In clinically stable patients, aerobic and anaerobic bacteria were detected in 40 of 40 (100%) and 33 of 40 (83%) sputum samples, respectively. The dominant organisms cultured were Pseudomonas aeruginosa (n = 10 patients), Haemophilus influenzae (n = 12), Prevotella (n = 18), and Veillonella (n = 13). Pyrosequencing generated more than 150,000 sequences, representing 113 distinct microbial taxa; the majority of observed community richness resulted from taxa present in low abundance with similar patterns of phyla distribution in clinically stable patients and patients at the onset of exacerbation. After treatment of exacerbation, there was no change in total (P = 0.925), aerobic (P = 0.917), or anaerobic (P = 0.683) load and only a limited shift in community composition. Agreement for detection of bacteria by culture and pyrosequencing was good for aerobic bacteria such as P. aeruginosa (κ = 0.84) but poorer for other genera including anaerobes. Lack of agreement was largely due to bacteria being detected by pyrosequencing but not by culture. Conclusions: A complex microbiota is present in the lungs of patients with bronchiectasis and remains stable through treatment of exacerbations, suggesting that changes in microbiota composition do not account for exacerbations

Treatment of advanced thyroid cancer with axitinib: Phase 2 study with pharmacokinetic/pharmacodynamic and quality-of-life assessments

BACKGROUND: In a previous phase 2 trial, axitinib was active and well tolerated in patients with advanced thyroid cancer. In this second phase 2 trial, the efficacy and safety of axitinib were evaluated further in this population, and pharmacokinetic/pharmacodynamic relationships and patient-reported outcomes were assessed. METHODS: Patients (N = 52) with metastatic or unresectable, locally advanced medullary or differentiated thyroid cancer that was refractory or not amenable to iodine-131 received a starting dose of axitinib 5 mg twice daily. The primary endpoint was the objective response rate (ORR). Secondary endpoints included progression-free survival (PFS), overall survival (OS), safety, pharmacokinetic parameters, and patient-reported outcomes assessed with the MD Anderson Symptom Inventory questionnaire. RESULTS: The overall ORR was 35% (18 partial responses), and 18 patients had stable disease for ≥16 weeks. The median PFS was 16.1 months, and the median OS was 27.2 months. All-causality, grade ≥3 adverse events (>5%) were fatigue, dyspnea, diarrhea, decreased weight, pain in extremity, hypertension, decreased appetite, palmar-plantar erythrodysesthesia, hypocalcemia, and myalgia. Patients who had greater axitinib exposure had a longer median PFS. Quality of life was maintained during treatment with axitinib, and no significant deterioration in symptoms or interference in daily life caused by symptoms, assessed on MD Anderson Symptom Inventory subscales, were observed. CONCLUSIONS: Axitinib has activity and a manageable safety profile while maintaining quality of life, and it represents an additional treatment option for patients with advanced thyroid cancer

Improved Representation of Clouds in the Atmospheric Component LMDZ6A of the IPSL‐CM6A Earth System Model

International audienc

Improved Representation of Clouds in the Atmospheric Component LMDZ6A of the IPSL-CM6A Earth System Model

The cloud parameterizations of the LMDZ6A climate model (the atmospheric component of the IPSL-CM6 Earth system model) are entirely described, and the global cloud distribution and cloud radiative effects are evaluated against the CALIPSO-CloudSat and CERES observations. The cloud parameterizations in recent versions of LMDZ favor an object-oriented approach for convection, with two distinct parameterizations for shallow and deep convection and a coupling between convection and cloud description through the specification of the subgrid-scale distribution of water. Compared to the previous version of the model (LMDZ5A), LMDZ6A better represents the low-level cloud distribution in the tropical belt, and low-level cloud reflectance and cover are closer to the PARASOL and CALIPSO-GOCCP observations. Mid-level clouds, which were mostly missing in LMDZ5A, are now better represented globally. The distribution of cloud liquid and ice in mixed-phase clouds is also in better agreement with the observations. Among identified deficiencies, low-level cloud covers are too high in mid-latitude to high-latitude regions, and high-level cloud covers are biased low globally. However, the cloud global distribution is significantly improved, and progress has been made in the tuning of the model, resulting in a radiative balance in close agreement with the CERES observations. Improved tuning also revealed structural biases in LMDZ6A, which are currently being addressed through a series of new physical and radiative parameterizations for the next version of LMDZ. ©2020. The Authors

LMDZ6A: The Atmospheric Component of the IPSL Climate Model With Improved and Better Tuned Physics

International audienceThis study presents the version of the LMDZ global atmospheric model used as the atmospheric component of the Institut Pierre Simon Laplace coupled model (IPSL-CM6A-LR) to contribute to the 6th phase of the international Coupled Model Intercomparison Project (CMIP6). This LMDZ6A version includes original convective parameterizations that define the LMDZ "New Physics": a mass flux parameterization of the organized structures of the convective boundary layer, the "thermal plume model," and a parameterization of the cold pools created by reevaporation of convective rainfall. The vertical velocity associated with thermal plumes and gust fronts of cold pools are used to control the triggering and intensity of deep convection. Because of several shortcomings, the early version 5B of this New Physics was worse than the previous "Standard Physics" version 5A regarding several classical climate metrics. To overcome these deficiencies, version 6A includes new developments: a stochastic triggering of deep convection, a modification of the thermal plume model that allows the representation of stratocumulus and cumulus clouds in a unified framework, an improved parameterization of very stable boundary layers, and the modification of the gravity waves scheme targeting the quasi-biennal oscillation in the stratosphere. These improvements to the physical content and a more well-defined tuning strategy led to major improvements in the LMDZ6A version model climatology. Beyond the presentation of this particular model version and documentation of its climatology, the present paper underlines possible methodological pathways toward model improvement that can be shared across modeling groups. Plain Language Summary The improvement of global numerical models is essential for the anticipation of future climate changes. We present significant advances in the physical content of a particular atmospheric model which contributes to the simulations of the Coupled Model Intercomparison project CMIP that feed reports from the IPCC. We document in particular the improvements of the representation through "parameterizations" of convective and cloudy processes. The article emphasizes the importance of strengthening the formalization of the methodology of development and tuning of models, so that new physical ideas can be translated into effective improvement of the climate representation

Henri III et son temps

Le présent recueil présente l’apport de la recherche récente sur le règne de Henri III dont l’historiographie a été totalement renouvelée depuis une dizaine d’années. On est sorti de la « légende noire » pour atteindre une meilleure compréhension de l’homme, de ses convictions religieuses, de son intelligence politique. Au-delà de la personnalité et de l’action du dernier souverain Valois, les actes du colloque international tenu à Tours présentent des mises au point politiques, économiques et sociales sur la France à la fin du xvie siècle. Cinq communications d’historiens polonais éclairent le règne de « Henryk Walezy » à Cracovie et les relations politiques et culturelles entre la France et la Pologne