Lymphome t/nk primitif du larynx : localisation inhabituelle de lymphome extranodal

Nous rapportons un cas de lymphome extranodal T/Nk primitif du larynx. il s’agit d’un patient âgé de 22 ans qui s’était présenté pour une dysphonie chronique associée à une dyspnée inspiratoire. une chimiothérapie protocole SMiLE avec radiothérapie ont été institués avec obtention d’une rémission complète. Huit mois plus tard, le patient présentait une récidive de la tumeur avec un oedème palpébral et une obstruction du canal lacrymonasal. L’évolution a été fatale suite à une aspergillose invasive en cours de chimiothérapie.Mots clés : lymphome, larynx.A rare case of primary laryngeal T/Nk- cell lymphoma, nasal type is reported. The patient was 22-year old male who presented with dysphonia, dyspnea. Chemotherapy protocol SMiLE and radiotherapy were instituted with complete remission of the tumor. Eight months afterward, he presented with tumor recurrence, palpebral edema, obstruction of the lacrymonasal duct. He died within few days with invasive aspergillosis while he was receiving chemotherapy SMiLE regimen.Keyswords : lymphoma, larynx

Regularized multiframe super-resolution image reconstruction using linear and nonlinear filters

The primary goal of the multiframe super-resolution image reconstruction is to produce an image with a higher resolution by integrating information extracted from a set of corresponding images with low resolution, which is used in various fields. However, super-resolution image reconstruction approaches are typically affected by annoying restorative artifacts, including blurring, noise, and staircasing effect. Accordingly, it is always difficult to balance between smoothness and edge preservation. In this paper, we intend to enhance the efficiency of multiframe super-resolution image reconstruction in order to optimize both analysis and human interpretation processes by improving the pictorial information and enhancing the automatic machine perception. As a result, we propose new approaches that firstly rely on estimating the initial high-resolution image through preprocessing of the reference low-resolution image based on median, mean, Lucy-Richardson, and Wiener filters. )is preprocessing stage is used to overcome the degradation present in the reference low-resolution image, which is a suitable kernel for producing the initial high-resolution image to be used in the reconstruction phase of the final image. then, L2 norm is employed for the data-fidelity term to minimize the residual among the predicted high-resolution image and the observed low-resolution images. Finally, bilateral total variation prior model is utilized to restrict the minimization function to a stable state of the generated HR image. )e experimental results of the synthetic data indicate that the proposed approaches have enhanced efficiency visually and quantitatively compared to other existing approaches

High Prevalence of Extended-Spectrum Beta Lactamases among Salmonella enterica Typhimurium Isolates from Pediatric Patients with Diarrhea in China

We investigated the extended-spectrum beta lactamases among 62 Salmonella enterica Typhimurium isolates recovered from children with diarrhea in a Chinese pediatric hospital. A large proportion of S. enterica Typhimurium isolates were resistant to multiple antimicrobial agents, including ampicillin (90.3%), tetracycline (80.6%), trimethoprim/sulfamethoxazole (74.2%), chloramphenicol (66.1%), cefotaxime (27.4%). Forty-nine (79.0%) of S. enterica Typhimurium isolates were positive for blaTEM-1b and resistant to ampicillin. Thirteen S. enterica Typhimurium isolates (21.0%) were positive for blaCTX-M-1-group and blaCTX-M-9-group, and all isolates harboring blaCTX-M genes were positive for ISEcp1. Two main clones (PFGE type A and D) accounted for nearly 70% of S. enterica Typhimurium isolates, and 7 CTX-M-producing isolates belonged to PFGE type D. Collectively, our data reveal multi-drug resistance and a high prevalence of extended spectrum beta lactamases among S. enterica Typhimurium isolates from children in China. In addition, we report the first identification of blaCTX-M-55 within Salmonella spp. Our data also suggest that clonal spread is responsible for the dissemination of S. enterica Typhimurium isolates

The Making of the NEAM Tsunami Hazard Model 2018 (NEAMTHM18)

The NEAM Tsunami Hazard Model 2018 (NEAMTHM18) is a probabilistic hazard model for tsunamis generated by earthquakes. It covers the coastlines of the North-eastern Atlantic, the Mediterranean, and connected seas (NEAM). NEAMTHM18 was designed as a three-phase project. The first two phases were dedicated to the model development and hazard calculations, following a formalized decision-making process based on a multiple-expert protocol. The third phase was dedicated to documentation and dissemination. The hazard assessment workflow was structured in Steps and Levels. There are four Steps: Step-1) probabilistic earthquake model; Step-2) tsunami generation and modeling in deep water; Step-3) shoaling and inundation; Step-4) hazard aggregation and uncertainty quantification. Each Step includes a different number of Levels. Level-0 always describes the input data; the other Levels describe the intermediate results needed to proceed from one Step to another. Alternative datasets and models were considered in the implementation. The epistemic hazard uncertainty was quantified through an ensemble modeling technique accounting for alternative models’ weights and yielding a distribution of hazard curves represented by the mean and various percentiles. Hazard curves were calculated at 2,343 Points of Interest (POI) distributed at an average spacing of ∼20 km. Precalculated probability maps for five maximum inundation heights (MIH) and hazard intensity maps for five average return periods (ARP) were produced from hazard curves. In the entire NEAM Region, MIHs of several meters are rare but not impossible. Considering a 2% probability of exceedance in 50 years (ARP≈2,475 years), the POIs with MIH >5 m are fewer than 1% and are all in the Mediterranean on Libya, Egypt, Cyprus, and Greece coasts. In the North-East Atlantic, POIs with MIH >3 m are on the coasts of Mauritania and Gulf of Cadiz. Overall, 30% of the POIs have MIH >1 m. NEAMTHM18 results and documentation are available through the TSUMAPS-NEAM project website (http://www.tsumaps-neam.eu/), featuring an interactive web mapper. Although the NEAMTHM18 cannot substitute in-depth analyses at local scales, it represents the first action to start local and more detailed hazard and risk assessments and contributes to designing evacuation maps for tsunami early warning.publishedVersio

Collateral circulation: Past and present

Following an arterial occlusion outward remodeling of pre-existent inter-connecting arterioles occurs by proliferation of vascular smooth muscle and endothelial cells. This is initiated by deformation of the endothelial cells through increased pulsatile fluid shear stress (FSS) caused by the steep pressure gradient between the high pre-occlusive and the very low post-occlusive pressure regions that are interconnected by collateral vessels. Shear stress leads to the activation and expression of all NOS isoforms and NO production, followed by endothelial VEGF secretion, which induces MCP-1 synthesis in endothelium and in the smooth muscle of the media. This leads to attraction and activation of monocytes and T-cells into the adventitial space (peripheral collateral vessels) or attachment of these cells to the endothelium (coronary collaterals). Mononuclear cells produce proteases and growth factors to digest the extra-cellular scaffold and allow motility and provide space for the new cells. They also produce NO from iNOS, which is essential for arteriogenesis. The bulk of new tissue production is carried by the smooth muscles of the media, which transform their phenotype from a contractile into a synthetic and proliferative one. Important roles are played by actin binding proteins like ABRA, cofilin, and thymosin beta 4 which determine actin polymerization and maturation. Integrins and connexins are markedly up-regulated. A key role in this concerted action which leads to a 2-to-20 fold increase in vascular diameter, depending on species size (mouse versus human) are the transcription factors AP-1, egr-1, carp, ets, by the Rho pathway and by the Mitogen Activated Kinases ERK-1 and -2. In spite of the enormous increase in tissue mass (up to 50-fold) the degree of functional restoration of blood flow capacity is incomplete and ends at 30% of maximal conductance (coronary) and 40% in the vascular periphery. The process of arteriogenesis can be drastically stimulated by increases in FSS (arterio-venous fistulas) and can be completely blocked by inhibition of NO production, by pharmacological blockade of VEGF-A and by the inhibition of the Rho-pathway. Pharmacological stimulation of arteriogenesis, important for the treatment of arterial occlusive diseases, seems feasible with NO donors

Effect of quantitative feed restriction on the performance of broiler chickens in Tunisia

The study was conducted to investigate the effect of a quantitative feed restriction phase on the live weight of broilers and assess their compensatory growth performance. Four hundred day-old chicks (Arbor Acres) were reared in four units of 100 chicks. These units were randomized into a control group (T) fed ad libitum and three restricted groups (A, B and C). Chickens of groups A, B and C were limited to 90, 80 and 70%, respectively, of the ad libitum feed intake between 16 and 23 days of age. After the 23rd day of age, all chickens were fed ad libitum until the end of the experiment (42 days of age). Results showed that during the restriction phase the body weight and average daily gain were significantly different (p < 0.01) between the four groups, and higher in chicks fed ad libitum than in those in the restricted groups. Delayed growth was more pronounced in chicks restricted at 70% of ad libitum consumption. After returning to ad libitum feeding, compensatory growth, characterized by rapid growth, was observed just after refeeding in chicks restricted at 70%, at 35 days of age in those assigned the least severe restriction (90%), and in the last week of rearing in the group assigned an intermediate level of restriction (80%). Feed efficiency improved in the restricted groups but the final body weights remained lower than those in the group fed ad libitum. Thus, with an intermediate reduction of the amount of feed consumed (20% for eight days), a final acceptable body weight was obtained

SVM Assisted Primary User-Detection for Non-Cooperative Cognitive Radio Networks

International audienceThis paper presents a new blind spectrum sensing (SS) algorithm based on a machine learning model: the radial basis function support-vector machines (RBF-SVM). As features, the introduced approach uses statistical tests that are based on the eigenvalues of the received signals covariance matrix. Since the decision on the frequency resource occupancy is in fact an issue of labeling binary data, SVM is intended as a potential technique for SS paradigm. The flexibility of SVM for linearly non-separable and high dimensional data makes it a good candidate for our issue, particularly that we consider low signal to noise ratios (SNR). Computer simulations shows that the proposal outperforms classical non-cooperative SS algorithms. © 2020 IEEE