Socio community practices’ analyses at a public superior education institution: Social commitment and transformational potential

La presente investigación pretende indag ar los aspectos transformadores de las prácticas socio comunitarias (PSC) realizadas por estudiantes avanzados de una institución pública de educación superior . Se trata de una investigación exploratoria descriptiva y cualitativa en la que se utilizaron diferentes instrumentos: observación no participante del dispositivo de tutorías a lo largo del dictado de las prácticas; observación no participante de los coloquios finales expuestos por los grupos de estudiantes; entrevistas de incidentes críticos a docen tes tutores; y análisis de los informes escritos finales realizados por los estudiantes. La muestra fue intencional compuesta por estudiantes (N=65) y docentes tutores (N=6) de las PSC de una institución pública de educación superior . Se calcularon descrip tivos básicos y se realizó análisis de contenido de los incidentes críticos y de los informes escritos presentados. Los resultados muestran que la realización de las PSC, a través de la metodología de Aprendizaje Servicio (APS), promueve la transformación de los estudiantes en las dimensiones epistemológica, social, pedagógica y ética. Estas transformaciones promueven la aparición de conductas prosociales favoreciendo el desarrollo ciudadano, un posicionamiento ético en la actividad profesional, la reflexió n crítica y el compromiso con la comunidad

Socio community practices’ analyses at a public superior education institution: Social commitment and transformational potential

La presente investigación pretende indagar los aspectos transformadores de las prácticas socio comunitarias (PSC) realizadas por estudiantes avanzados de una institución pública de educación superior. Se trata de una investigación exploratoria descriptiva y cualitativa en la que se utilizaron diferentes instrumentos: observación no participante del dispositivo de tutorías a lo largo del dictado de las prácticas, observación no participante de los coloquios finales expuestos por los grupos de estudiantes; entrevistas de incidentes críticos a docentes tutores y análisis de los informes escritos finales realizados por los estudiantes. La muestra fue intencional compuesta por estudiantes (N=65) y docentes tutores (N=6) de las prácticas socio comunitarias de una institución pública de educación superior. Se calcularon descriptivos básicos y se realizó análisis de contenido de los incidentes críticos y de los informes escritos presentados. Los resultados muestran que la realización de las PSC, a través de la metodología de Aprendizaje Servicio (APS), promueve la transformación de los estudiantes en las dimensiones epistemológica, social, pedagógica y ética. Estas transformaciones promueven la aparición de conductas prosociales favoreciendo el desarrollo ciudadano, un posicionamiento ético en la actividad profesional, la reflexión crítica y el compromiso con la comunidad.The present research pretends to know about socio community practices’ transformational aspects done by advanced students from a superior education public institution. It’s an exploratory descriptive and qualitative research in which there were used different instruments: tutorials non participant observation during the practices; final students’ colloquies non participant observation; teachers’ critical incidents interviews and students’ final written reports. The sample was intentional composed by students (N=65) and teachers (N=6) from a superior education public institution socio community practices. Basics descriptive statistics were calculated and critical incidents’ and final written reports’ content analyses were done. Results show that socio community practices following the social learning technique promote students transformation in epistemology, social, pedagogic and ethic dimensions. These transformations promote pro social and citizenship Prácticas universitarias y compromiso social.Fil: Tiritilli, Romina. Universidad Nacional de Mar del Plata. Facultad de Psicología; ArgentinaFil: Giometti, Paola. Universidad Nacional de Mar del Plata. Facultad de Psicología; ArgentinaFil: Bosch, Wanda. Universidad Nacional de Mar del Plata. Facultad de Psicología; ArgentinaFil: Silva Peralta, Yamila Fernanda. Universidad Nacional de Mar del Plata. Facultad de Psicología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata; Argentin

Inhibition of histone deacetylase 6 (HDAC6) protects against vincristine-induced peripheral neuropathies and inhibits tumor growth

As cancer is becoming more and more a chronic disease, a large proportion of patients is confronted with devastating side effects of certain anti-cancer drugs. The most common neurological complications are painful peripheral neuropathies. Chemotherapeutics that interfere with microtubules, including plant-derived vinca-alkaloids such as vincristine, can cause these chemotherapy-induced peripheral neuropathies (CIPN). Available treatments focus on symptom alleviation and pain reduction rather than prevention of the neuropathy. The aim of this study was to investigate the potential of specific histone deacetylase 6 (HDAC6) inhibitors as a preventive therapy for CIPN using multiple rodent models for vincristine-induced peripheral neuropathies (VIPN). HDAC6 inhibition increased the level of acetylated α-tubulin in tissues of rodents undergoing vincristine-based chemotherapy, which correlates to a reduced severity of the neurological symptoms, both at the electrophysiological and the behavioral level. Mechanistically, disturbances in axonal transport of mitochondria is considered as an important contributing factor in the pathophysiology of VIPN. As vincristine interferes with the polymerization of microtubules, we investigated whether disturbances in axonal transport could contribute to VIPN. We observed that increasing α-tubulin acetylation through HDAC6 inhibition restores vincristine-induced defects of axonal transport in cultured dorsal root ganglion neurons. Finally, we assured that HDAC6-inhibition offers neuroprotection without interfering with the anti-cancer efficacy of vincristine using a mouse model for acute lymphoblastic leukemia. Taken together, our results emphasize the therapeutic potential of HDAC6 inhibitors with beneficial effects both on vincristine-induced neurotoxicity, as well as on tumor proliferation. ispartof: Neurobiology of Disease vol:111 pages:59-69 ispartof: location:United States status: publishe

The Changing Landscape for Stroke\ua0Prevention in AF: Findings From the GLORIA-AF Registry Phase 2

Background GLORIA-AF (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients with Atrial Fibrillation) is a prospective, global registry program describing antithrombotic treatment patterns in patients with newly diagnosed nonvalvular atrial fibrillation at risk of stroke. Phase 2 began when dabigatran, the first non\u2013vitamin K antagonist oral anticoagulant (NOAC), became available. Objectives This study sought to describe phase 2 baseline data and compare these with the pre-NOAC era collected during phase 1. Methods During phase 2, 15,641 consenting patients were enrolled (November 2011 to December 2014); 15,092 were eligible. This pre-specified cross-sectional analysis describes eligible patients\u2019 baseline characteristics. Atrial fibrillation disease characteristics, medical outcomes, and concomitant diseases and medications were collected. Data were analyzed using descriptive statistics. Results Of the total patients, 45.5% were female; median age was 71 (interquartile range: 64, 78) years. Patients were from Europe (47.1%), North America (22.5%), Asia (20.3%), Latin America (6.0%), and the Middle East/Africa (4.0%). Most had high stroke risk (CHA2DS2-VASc [Congestive heart failure, Hypertension, Age  6575 years, Diabetes mellitus, previous Stroke, Vascular disease, Age 65 to 74 years, Sex category] score  652; 86.1%); 13.9% had moderate risk (CHA2DS2-VASc = 1). Overall, 79.9% received oral anticoagulants, of whom 47.6% received NOAC and 32.3% vitamin K antagonists (VKA); 12.1% received antiplatelet agents; 7.8% received no antithrombotic treatment. For comparison, the proportion of phase 1 patients (of N = 1,063 all eligible) prescribed VKA was 32.8%, acetylsalicylic acid 41.7%, and no therapy 20.2%. In Europe in phase 2, treatment with NOAC was more common than VKA (52.3% and 37.8%, respectively); 6.0% of patients received antiplatelet treatment; and 3.8% received no antithrombotic treatment. In North America, 52.1%, 26.2%, and 14.0% of patients received NOAC, VKA, and antiplatelet drugs, respectively; 7.5% received no antithrombotic treatment. NOAC use was less common in Asia (27.7%), where 27.5% of patients received VKA, 25.0% antiplatelet drugs, and 19.8% no antithrombotic treatment. Conclusions The baseline data from GLORIA-AF phase 2 demonstrate that in newly diagnosed nonvalvular atrial fibrillation patients, NOAC have been highly adopted into practice, becoming more frequently prescribed than VKA in Europe and North America. Worldwide, however, a large proportion of patients remain undertreated, particularly in Asia and North America. (Global Registry on Long-Term Oral Antithrombotic Treatment in Patients With Atrial Fibrillation [GLORIA-AF]; NCT01468701

Análisis de las Prácticas Socio Comunitarias en el marco de la FCEyS-UNMdP: Compromiso social y potencialidad transformadora

La presente investigación tiene por objetivo indagar los aspectos transformadores del Seminario de Prácticas Socio Comunitarias realizado por estudiantes avanzados de la Facultad de ciencias económicas y Sociales de la Universidad Nacional de Mar del Plata. La hipótesis que guía este estudio sostiene que la propuesta pedagógica de Aprendizaje Servicio promueve la capacidad transformadora del Seminario de Prácticas Socio Comunitarias en diferentes dimensiones: académica, profesional, comunitaria y personal. Se trata de una investigación exploratoria descriptiva cuali y cuantitativa. Se realizará observación no participante del dispositivo de tutorias a lo largo del dictado del Seminario así como de los coloquios finales expuestos por los grupos de estudiantes. Así mismo se administrarán entrevistas de incidentes críticos a docentes y se analizarán los informes escritos finales realizados por los estudiantes del Seminario. La muestra será intencional, compuesta por estudiantes y docentes del seminario de Prácticas socio Comunitarias de la Facultad de Ciencias Económicas y Sociales de la Universidad Nacional de Mar del Plata. Serán calculados descriptivos básicos, se realizará análisis de contenido de los incidentes críticos y de los informes escritos presentados

Análisis de las prácticas socio comunitarias en el marco de una institución pública de educación superior: Compromiso social y potencialidad transformadora

The present research pretends to know about socio community practices’ transformational aspects done by advanced students from a superior education public institution. It’s an exploratory descriptive and qualitative research in which there were used different instruments: tutorials non participant observation during the practices; final students’ colloquies non participant observation; teachers’ critical incidents interviews and students’ final written reports. The sample was intentional composed by students (N=65) and teachers (N=6) from a superior education public institution socio community practices. Basics descriptive statistics were calculated and critical incidents’ and final written reports’ content analyses were done. Results show that socio community practices following the social learning technique promote students transformation in epistemology, social, pedagogic and ethic dimensions. These transformations promote pro social and citizenship Prácticas universitarias y compromiso social © Psy, Soc, & Educ, 2016, Vol. 8(3) 202 behaviors, an ethic position related to professional activity, a critical reflection and community commitment.Keywords: University social commitment; service-learning, university.La presente investigación pretende indagar los aspectos transformadores de las prácticas socio comunitarias (PSC) realizadas por estudiantes avanzados de una institución pública de educación superior. Se trata de una investigación exploratoria descriptiva y cualitativa en la que se utilizaron diferentes instrumentos: observación no participante del dispositivo de tutorías a lo largo del dictado de las prácticas; observación no participante de los coloquios finales expuestos por los grupos de estudiantes; entrevistas de incidentes críticos a docentes tutores; y análisis de los informes escritos finales realizados por los estudiantes. La muestra fue intencional compuesta por estudiantes (N=65) y docentes tutores (N=6) de las PSC de una institución pública de educación superior. Se calcularon descriptivos básicos y se realizó análisis de contenido de los incidentes críticos y de los informes escritos presentados. Los resultados muestran que la realización de las PSC, a través de la metodología de Aprendizaje Servicio (APS), promueve la transformación de los estudiantes en las dimensiones epistemológica, social, pedagógica y ética. Estas transformaciones promueven la aparición de conductas prosociales favoreciendo el desarrollo ciudadano, un posicionamiento ético en la actividad profesional, la reflexión crítica y el compromiso con la comunidad

Electrophilic derivatives antagonise pheromone attraction in cydia pomonella

Pheromone antagonists are good disruptants of the pheromone communication in insects as such, have been used in mating disruption experiments. In this study, new non-fluorinated electrophilic keto derivatives structurally related to the pheromone of Cydia pomonella (codlemone) have been synthesised and tested as putative pheromone antagonists. RESULTS: Codlemone (1) was prepared in excellent stereoselectivity in a new, iterative approach involving two Horner-Wadsworth-Emmons reactions. Methyl ketone (2), keto ester (3) and diketone (4) were obtained from codlemone in straightforward approaches in good overall yields and excellent stereochemical purity (≥98% E,E). In electrophysiology, only compound 2 displayed inhibition of the antennal response to the pheromone after presaturation of the antennal receptors. Compounds 2 to 4 did not inhibit the pheromone-degrading enzyme responsible for codlemone metabolism, but mixtures of ketone 2 and diketone 4 with codlemone elicited erratic flights on males in a wind tunnel. In the field, blends of either compound (2 or 4) with the pheromone caught significantly fewer males than codlemone alone. CONCLUSION: Codlemone and the potential antagonists 2 to 4 have been synthesised in good yields and excellent stereoselectivity. These chemicals behave as pheromone antagonists of the codling moth both in the laboratory and in the field.University of Lleida, Centre UdL-IRTA, Lleida, Spain Department of Biological Chemistry and Molecular Modelling, IQAC (CSIC), Barcelona, Spain Crop Protection Department, Centre UdL-IRTA for RandD, Lleida, SpainPeer reviewe

Synthesis and SAR assessment of novel Tubathian analogs in the pursuit of potent and selective HDAC6 inhibitors

The synthesis of novel isoform-selective HDAC inhibitors is considered to be an important, emerging field in medicinal chemistry. In this paper, the preparation and assessment of thirteen selective HDAC6 inhibitors is disclosed, elaborating on a previously developed thiaheterocyclic Tubathian series. All compounds were evaluated in vitro for their ability to inhibit HDAC6, and a selection of five potent compounds was further screened toward all HDAC isoforms (HDAC1-11). The capability of these Tubathian analogs to inhibit alpha-tubulin deacetylation was assessed as well, and ADME/Tox data were collected. This thorough SAR evaluation revealed that the oxidized, para-substituted hydroxamic acids can be recognized as valuable lead structures in the pursuit of novel potent and selective HDAC6 inhibitors

Bicyclic-Capped Histone Deacetylase 6 Inhibitors with Improved Activity in a Model of Axonal Charcot-Marie-Tooth Disease

Charcot-Marie-Tooth (CMT) disease is a disorder of the peripheral nervous system where progressive degeneration of motor and sensory nerves leads to motor problems and sensory loss and for which no pharmacological treatment is available. Recently, it has been shown in a model for the axonal form of CMT that histone deacetylase 6 (HDAC6) can serve as a target for the development of a pharmacological therapy. Therefore, we aimed at developing new selective and activity-specific HDAC6 inhibitors with improved biochemical properties. By utilizing a bicyclic cap as the structural scaffold from which to build upon, we developed several analogues that showed improved potency compared to tubastatin A while maintaining excellent selectivity compared to HDAC1. Further screening in N2a cells examining both the acetylation of α-tubulin and histones narrowed down the library of compounds to three potent and selective HDAC6 inhibitors. In mutant HSPB1-expressing DRG neurons, serving as an in vitro model for CMT2, these inhibitors were able to restore the mitochondrial axonal transport deficits. Combining structure-based development of HDAC6 inhibitors, screening in N2a cells and in a neuronal model for CMT2F, and preliminary ADMET and pharmacokinetic profiles, resulted in the selection of compound 23d that possesses improved biochemical, functional, and druglike properties compared to tubastatin A.status: publishe

Synthesis of benzothiophene-based hydroxamic acids as potent and selective HDAC6 inhibitors

A small library of 3-[(4-hydroxycarbamoylphenyl)aminomethyl]benzothiophenes was prepared and assessed as a novel class of HDAC6 inhibitors, leading to the identification of three representatives as potent and selective HDAC6 inhibitors. Further tests with regard to inflammatory responses indicated that HDAC6 inhibition can be uncoupled from transcriptional inhibition at the level of activated NF-κB, AP-1, and GR.crosscheck: This document is CrossCheck deposited related_data: Supplementary Information copyright_licence: The Royal Society of Chemistry has an exclusive publication licence for this journal history: Received 23 April 2015; Accepted 11 May 2015; Accepted Manuscript published 11 May 2015; Advance Article published 21 May 2015; Version of Record published 2 June 2015status: publishe