478 research outputs found
Phase II study of paclitaxel combined with capecitabine as second-line treatment for advanced gastric carcinoma after failure of cisplatin-based regimens
Purpose To determine the safety and the efficacy of paclitaxel and capecitabine as second-line combination chemotherapy after failure of platinum regimens in advanced gastric cancer. Methods Patients with histologically proven gastric cancer and measurable metastatic disease received capecitabine 825 mg/m2 twice daily (1,650 mg/m2 per day) on days 1â14 and paclitaxel 175 mg/m2 by intravenous infusion on day 1 every 3 weeks until disease progression or unacceptable toxicities. Results Between June 2003 and October 2005, 26 patients, of median age 59 years (range 41â84 years) were included in the study and were treated by paclitaxel/capecitabine combination. Overall response rate was 34.6% (95%CI = 17.2â55.7%) with one complete response and 42.3% (95%CI = 17.2â55.7%) of patients achieved a stable disease. Median progression-free survival was 4.5 months (95%CI = 4â4.5 months). Median overall survival was 7.5 months (95%CI = 6â10 months). Cumulated overall survival including cisplatin regimens was 15.5 months (95%CI = 11â18 months). Grade 3/4 adverse events included alopecia (30.8%), neutropenia (11.5%), hand foot skin reaction (11.5%), neuropathy (11.5%), arthralgias (7.5%), and anemia (3.8%). Conclusions Paclitaxel and capecitabine combination was safe and effective in advanced gastric cancer after failure of cisplatin regimens. The cumulated overall survival of 15.5 months suggests a particular interest of taxanes in second-line treatment after failure of platinum salts
SAPERI PER INSEGNARE. Formare insegnanti di italiano per stranieri. Un'esperienza di collaborazione fra UniversitĂ e scuola
Sources of resistance to foliar diseases of groundnut and their stability in West Africa
Three foliar pathogens, early (Cercospora arachidicola [Mycosphaerella arachidis]) and late (Cercosporidium personatum [M. berkeleyi]) leaf spots and rust (Puccinia arachidis) are a major constraint to groundnut production in West Africa, although their severities vary from location to location. A total of 424 germplasm lines was screened for resistance to these pathogens in Niger and Burkina Faso and resistant lines were identified. Some sources of resistance to early leaf spot reported in India showed variable reactions in West Africa. Differential reactions to early leaf spot at different locations indicated that there may be physiological races of the pathogen. Sources of resistance to late leaf spot and rust selected at the ICRISAT Centre (India) were also resistant in West Africa. Multiple disease resistance was evident in lines ICG 1707, ICG 6330 and USA 63
Bipolar querying of valid-time intervals subject to uncertainty
Databases model parts of reality by containing data representing properties of real-world objects or concepts. Often, some of these properties are time-related. Thus, databases often contain data representing time-related information. However, as they may be produced by humans, such data or information may contain imperfections like uncertainties. An important purpose of databases is to allow their data to be queried, to allow access to the information these data represent. Users may do this using queries, in which they describe their preferences concerning the data they are (not) interested in. Because users may have both positive and negative such preferences, they may want to query databases in a bipolar way. Such preferences may also have a temporal nature, but, traditionally, temporal query conditions are handled specifically. In this paper, a novel technique is presented to query a valid-time relation containing uncertain valid-time data in a bipolar way, which allows the query to have a single bipolar temporal query condition
Physical and Optical Properties of Poly(3-AlkylThiophene) with a View to the Fabrication of a Highly Nonlinear Waveguide
Publisher: Bentham (ISSN: 1874-088X)International audienceIn order to take advantage of the very high nonlinear susceptibility of conjugated polymer materials, Poly(3-AlkylThiophene)s, P3AT, were synthesized in the laboratory. The physical, thermomechanical and linear optical propertiesof synthesized P3AT have been investigated and the first experimental attempts at creating nonlinear optical waveguides and determining their characteristics are presented. After synthesizing P3AT, the relationships between polymer chain characteristics and mechanical properties are investigated to see if the polymer is suitable for optical waveguide process technology. We also examine the optical attenuation of the synthesized material, a crucial factor in anticipating the relative opacity of the future component. For the first time we present the absorption spectrum of 3-Octylthiophenemolecules in the Near Infra-Red (NIR) region that suggests optical losses for the material are about 0.6 dB.cm-1 at 1550 nm. Next we examined several waveguide structures such as ridge, buried and Strip Loaded WaveGuides (SLWG) based on P3AT material. For the buried waveguides, we have observed the signal transmission and in our opinion the low optical transmission of P3AT ridge and SLWG could be attributed to extrinsic losses (mainly scattering) due to both the remaining insoluble products in the polymer and to the poor adhesion between optical layers
Interactions among predators and plant specificity protect herbivores from top predators
The worldwide loss of top predators from natural and agricultural systems has heightened the need to understand how important they are in controlling herbivore abundance. The effect of top predators on herbivore species is likely to depend on (1) the importance of the consumption of intermediate predators by top predators (intra-guild predation; IGP), but also on (2) plant specificity by herbivores, because specialists may defend themselves better (enemy-free space; EFS). Insectivorous birds, as top predators, are generally known to effectively control herbivorous insects, despite also consuming intermediate predators such as spiders, but how this effect varies among herbivore species in relation to the cascading effects of IGP and EFS is not known. To explore this, we excluded birds from natural fynbos vegetation in South Africa using large netted cages and recorded changes in abundance relative to control plots for 199 plant-dwelling intermediate predator and 341 herbivore morpho-species that varied in their estimated plant specificity. We found a strong negative effect of birds on the total abundance of all intermediate predators, with especially clear effects on spiders (strong IGP). In contrast with previous studies, which document a negative effect of birds on herbivores, we found an overall neutral effect of birds on herbivore abundance, but the effect varied among species: some species were negatively affected by birds, suggesting that they were mainly consumed by birds, whereas others, likely released from spiders by IGP, were positively affected. Some species were also effectively neutrally affected by birds. These tended to be more specialized to plants compared to the other species, which may imply that some plant specialists benefited from protection provided by EFS from both birds and spiders. These results suggest that the response of herbivore species to top predators may depend on cascading effects of interactions among predators and on their degree of plant specificity
Importance of biotic niches versus drift in a plant-inhabiting arthropod community depends on rarity and trophic group
Communities are mostly composed of rare species; yet, the factors that determine their patterns of occurrence remain obscure. Theory predicts that, in contrast with common species, the occurrence of rare species will be poorly correlated with environmental variables (niches) and more affected by stochasticity (ecological drift), but how this pattern varies across different trophic groups is still poorly understood. Here, we compared the ability of environmental variables (bottom-up biotic niches) to predict the occurrence of plant-dwelling arthropods across different abundance classes in the Cape Floristic Region of South Africa. We compared three trophic groups, including 104 herbivorous hemipteran, 171 parasitoid wasp and 84 spider species, totalling 4511 individuals in 48 quadrats. To quantify bottom-up biotic niches, we studied the influences of species composition of plants on hemipterans, and of plants and hemipterans on spiders and wasps. We compared the observed strength of the correlation between rare species and their niches with expectations that were generated by repeatedly rarefying abundant species. A large proportion of arthropod species were very rare, i.e. with only one or two individuals (49-55%). Although rarefying abundant species greatly decreased the correlation with bottom-up biotic niches, bottom-up biotic niches generally better predicted the occurrence of rarefied abundant species than very rare ones, suggesting a greater influence of drift on very rare arthropods. That is, (very) rare arthropods are distributed more randomly than rarefied abundant species. Nevertheless, trophic groups differed in the details of their response to bottom-up biotic niches. Plant species composition was a better predictor of rarefied abundant than truly rare hemipterans. In contrast, the importance of bottom-up biotic niches among abundance classes varied less visibly in spiders and wasps. Our study thus suggests that the importance of niches in structuring arthropod communities depends on species rarity and trophic group
Exploiting Anti-monotonicity of Multi-label Evaluation Measures for Inducing Multi-label Rules
Exploiting dependencies between labels is considered to be crucial for
multi-label classification. Rules are able to expose label dependencies such as
implications, subsumptions or exclusions in a human-comprehensible and
interpretable manner. However, the induction of rules with multiple labels in
the head is particularly challenging, as the number of label combinations which
must be taken into account for each rule grows exponentially with the number of
available labels. To overcome this limitation, algorithms for exhaustive rule
mining typically use properties such as anti-monotonicity or decomposability in
order to prune the search space. In the present paper, we examine whether
commonly used multi-label evaluation metrics satisfy these properties and
therefore are suited to prune the search space for multi-label heads.Comment: Preprint version. To appear in: Proceedings of the Pacific-Asia
Conference on Knowledge Discovery and Data Mining (PAKDD) 2018. See
http://www.ke.tu-darmstadt.de/bibtex/publications/show/3074 for further
information. arXiv admin note: text overlap with arXiv:1812.0005
An investigation of the close environment of beta Cep with the VEGA/CHARA interferometer
High-precision interferometric measurements of pulsating stars help to
characterize their close environment. In 1974, a close companion was discovered
around the pulsating star beta Cep using the speckle interferometry technique
and features at the limit of resolution (20 milli-arcsecond or mas) of the
instrument were mentioned that may be due to circumstellar material. Beta Cep
has a magnetic field that might be responsible for a spherical shell or
ring-like structure around the star as described by the MHD models. Using the
visible recombiner VEGA installed on the CHARA long-baseline interferometer at
Mt. Wilson, we aim to determine the angular diameter of beta Cep and resolve
its close environment with a spatial resolution up to 1 mas level. Medium
spectral resolution (R=6000) observations of beta Cep were secured with the
VEGA instrument over the years 2008 and 2009. These observations were performed
with the S1S2 (30m) and W1W2 (100m) baselines of the array. We investigated
several models to reproduce our observations. A large-scale structure of a few
mas is clearly detected around the star with a typical flux relative
contribution of 0.23 +- 0.02. Our best model is a co-rotational geometrical
thin ring around the star as predicted by magnetically-confined wind shock
models. The ring inner diameter is 8.2 +- 0.8 mas and the width is 0.6 +- 0.7
mas. The orientation of the rotation axis on the plane of the sky is PA = 60 +-
1 deg, while the best fit of the mean angular diameter of beta Cep gives UD[V]
= 0.22 +- 0.05 mas. Our data are compatible with the predicted position of the
close companion of beta Cep. These results bring additional constraints on the
fundamental parameters and on the future MHD and asteroseismological models of
the star.Comment: Paper accepted for publication in A&A (in press
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