Applied group theory applications in the engineering (physical, chemical, and medical), biological, social, and behavioral sciences and in the fine arts

A generalized applied group theory is developed, and it is shown that phenomena from a number of diverse disciplines may be included under the umbrella of a single theoretical formulation based upon the concept of a group consistent with the usual definition of this term

Mean first passage time analysis reveals rate-limiting steps, parallel pathways and dead ends in a simple model of protein folding

We have analyzed dynamics on the complex free energy landscape of protein folding in the FOLD-X model, by calculating for each state of the system the mean first passage time to the folded state. The resulting kinetic map of the folding process shows that it proceeds in jumps between well-defined, local free energy minima. Closer analysis of the different local minima allows us to reveal secondary, parallel pathways as well as dead ends.Comment: 7 page

In search of phylogenetic congruence between molecular and morphological data in bryozoans with extreme adult skeletal heteromorphy

peerreview_statement: The publishing and review policy for this title is described in its Aims & Scope. aims_and_scope_url: http://www.tandfonline.com/action/journalInformation?show=aimsScope&journalCode=tsab20© Crown Copyright 2015. This document is the author's final accepted/submitted version of the journal article. You are advised to consult the publisher's version if you wish to cite from it

Interrelation of structural and electronic properties of InGaN/GaN quantum dots using an eight-band k.p model

We present an eight-band k.p model for the calculation of the electronic structure of wurtzite semiconductor quantum dots (QDs) and its application to indium gallium nitride (InGaN) QDs formed by composition fluctuations in InGaN layers. The eight-band k.p model accounts for strain effects, piezoelectric and pyroelectricity, spin-orbit and crystal field splitting. Exciton binding energies are calculated using the self-consistent Hartree method. Using this model, we studied the electronic properties of InGaN QDs and their dependence on structural properties, i.e., their chemical composition, height, and lateral diameter. We found a dominant influence of the built-in piezoelectric and pyroelectric fields, causing a spatial separation of the bound electron and hole states and a redshift of the exciton transition energies. The single-particle energies as well as the exciton energies depend heavily on the composition and geometry of the QDs

SEM-EDS analyses of small craters in stardust aluminium foils: implications for the Wild-2 dust distribution

Implications for the Wild-2 dust distribution of the statistical results obtained by SEM-EDS from nearly 300 impact craters on aluminium foils of the Stardust sample tray assembly

Retinal metric: a stimulus distance measure derived from population neural responses

The ability of the organism to distinguish between various stimuli is limited by the structure and noise in the population code of its sensory neurons. Here we infer a distance measure on the stimulus space directly from the recorded activity of 100 neurons in the salamander retina. In contrast to previously used measures of stimulus similarity, this "neural metric" tells us how distinguishable a pair of stimulus clips is to the retina, given the noise in the neural population response. We show that the retinal distance strongly deviates from Euclidean, or any static metric, yet has a simple structure: we identify the stimulus features that the neural population is jointly sensitive to, and show the SVM-like kernel function relating the stimulus and neural response spaces. We show that the non-Euclidean nature of the retinal distance has important consequences for neural decoding.Comment: 5 pages, 4 figures, to appear in Phys Rev Let

Stop-and-go kinetics in amyloid fibrillation

Many human diseases are associated with protein aggregation and fibrillation. Using glucagon as a model system for protein fibrillation we show that fibrils grow in an intermittent fashion, with periods of growth followed by long pauses. Remarkably, even if the intrinsic transition rates vary considerably in each experiment, the probability of being in the growing (stopping) state is very close to 1/4 (3/4), suggesting the presence of 4 independent conformations of the fibril tip. We discuss this possibility in terms of existing structural knowledge

Epigenetic aging signatures in mice livers are slowed by dwarfism, calorie restriction and rapamycin treatment

Background: Global but predictable changes impact the DNA methylome as we age, acting as a type of molecular clock. This clock can be hastened by conditions that decrease lifespan, raising the question of whether it can also be slowed, for example, by conditions that increase lifespan. Mice are particularly appealing organisms for studies of mammalian aging; however, epigenetic clocks have thus far been formulated only in humans. Results: We first examined whether mice and humans experience similar patterns of change in the methylome with age. We found moderate conservation of CpG sites for which methylation is altered with age, with both species showing an increase in methylome disorder during aging. Based on this analysis, we formulated an epigenetic-aging model in mice using the liver methylomes of 107 mice from 0.2 to 26.0 months old. To examine whether epigenetic aging signatures are slowed by longevity-promoting interventions, we analyzed 28 additional methylomes from mice subjected to lifespan-extending conditions, including Prop1df/df dwarfism, calorie restriction or dietary rapamycin. We found that mice treated with these lifespan-extending interventions were significantly younger in epigenetic age than their untreated, wild-type age-matched controls. Conclusions: This study shows that lifespan-extending conditions can slow molecular changes associated with an epigenetic clock in mice livers

Prevalence of meticillin-resistant Staphylococcus aureus colonisation amongst residents in Maltese nursing homes

Since the 1960’s, meticillin-resistant Staphylococcus aureus (MRSA) has become a major pathogen with everincreasing incidence rates of hospital-acquired and community-acquired infections. Malta has currently one of the highest rates of hospital-acquired and community-acquired infections in Europe. In addition, reports have estimated community carriage at more than 8%. MRSA carriage in homes for the elderly is very important because these residents are often hospitalized and therefore serve as a source of transmission. The aims of this study were to establish the prevalence of MRSA nasal carriage amongst residents in nursing homes in Malta, to determine their antibiotic susceptibility and to determine the significance of specific risk factors found in the literature. Nasal swabs were taken from 397 randomly chosen residents in 10 governmental nursing homes. A short questionnaire including possible risk factors reported to be associated with MRSA nasal carriage was also filled. MRSA carriage amongst nursing home residents was 19.4% (95% CI 17.6 – 21.2%) ranging from 0% to 25% amongst the nursing homes studied. Logistic regression analyses indicated that previous hospital admission was the only risk factor that was found to be significantly (OR: 1.956, p: 0.011; 95CI 1.163 - 3.290) associated with MRSA nasal colonization amongst nursing home residents.peer-reviewe

Measuring the proton spectrum in neutron decay - latest results with aSPECT

The retardation spectrometer aSPECT was built to measure the shape of the proton spectrum in free neutron decay with high precision. This allows us to determine the antineutrino electron angular correlation coefficient a. We aim for a precision more than one order of magnitude better than the present best value, which is Delta_a /a = 5%. In a recent beam time performed at the Institut Laue-Langevin during April / May 2008 we reached a statistical accuracy of about 2% per 24 hours measurement time. Several systematic effects were investigated experimentally. We expect the total relative uncertainty to be well below 5%.Comment: Accepted for publication in the Conference Proceedings of the International Workshop on Particle Physics with Slow Neutrons 2008 held at the ILL, France. To be published in Nuclear Instruments and Methods in Physics Research, Section