1,377 research outputs found

    Writing Beyond Campus: Writing Centers in Service-Learning and Community-Engaged Scholarship

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    This roundtable discussion serves as a forum for writing center professionals to discuss past experiences with and future opportunities for community-engaged work in our field. The lessons learned from this discussion will be used to both (1) identify strategic opportunities for engagement between writing labs and their respective communities and (2) inform the ongoing development of online resources for instructors and students who wish to integrate writing into current and future university-community work

    Navigating the Political Waters of Open Access Publishing in Libraries

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    In recent years, many libraries have forayed into the world of open access (OA) publishing. While it marks a major shift in the mission of libraries to move from providing access to content to generating and creating content ourselves, it still involves the same basic values regarding access to information. The environment has changed, and libraries are adapting with new approaches and new staff skills to promote these fundamental values. The authors selected nineteen libraries and conducted phone interviews with a specific list of questions, encouraging discussion about how each library approached being a publisher. This chapter examines the politics and issues involved, and makes recommendations for defining our roles in this new territory. The authors highlight the approaches various libraries have taken—and the challenges faced—in selecting a platform, writing a business plan, planning for preservation, educating researchers about OA publishing, working with a university press, marketing, and navigating staff training issues. The chapter concludes with recommendations for areas of focus and future research

    Towards a Better Understanding of Online Influence: Differences in Twitter Communication Between Companies and Influencers

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    In the last decade, Social Media platforms such as Twitter have gained importance in the various marketing strategies of companies. This work aims to examine the presence of influential content on a textual level, by investigating characteristics of tweets in the context of social impact theory, and its dimension immediacy. To this end, we analysed influential Twitter communication data during Black Friday 2018 with methods from social media analytics such as sentiment analysis and degree centrality. Results show significant differences in communication style between companies and influencers. Companies published longer textual content and created more tweets with a positive sentiment and more first-person pronouns than influencers. These findings shall serve as a basis for a future experimental study to examine the impact of text presence on consumer cognition and the willingness to purchase

    Cryogenic 9Be+ Penning trap for precision measurements with (anti-)protons

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    Cooling and detection schemes using laser cooling and methods of quantum logic can contribute to high precision CPT symmetry tests in the baryonic sector. This work introduces an experiment to sympathetically cool protons and antiprotons using the Coulomb interaction with a 9Be+ ion trapped in a nearby but separate potential well. We have designed and set up an apparatus to show such coupling between two identical ions for the first time in a Penning trap. In this paper, we present evidence for successful loading and Doppler cooling of clouds and single ions. Our coupling scheme has applications in a range of high-precision measurements in Penning traps and has the potential to substantially improve motional control in these experiments

    Mechanistic Studies on Diamine Oxidase

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    To investigate the enzyme pea seedling diamine oxidase our studies concentrated on three main areas: 1. mechanistic studies of the oxidative deamination of primary diamines catalysed by diamine oxidase; 2. oxidation of aromatic compounds with amine side chains by pea seedling diamine oxidase; and 3. inhibition of pea seedling diamine oxidase. To make use of diamines synthesised within the research group a fourth area was studied: 4. synthesis of cisplatin analogues. Mechanistic Studies of the Diamine Oxidase-Catalysed Deamination of Diamines Diamine oxidase catalyses the oxidative deamination of diamines to their corresponding aminoaldehydes (Scheme A). To test the hypothesis that the diamine oxidase-catalysed oxidation proceeds via an enamine intermediate (i) we prepared a number of alpha,o-diamines labelled with deuterium at the beta-positions. The [2H4]-labelled diamines and the corresponding unlabelled diamines were incubated with pea seedling diamine oxidase and the products were trapped with benzoylacetic acid in situ. (Scheme B). This gave substituted acetophenone products (ii) which were analysed by NMR and mass spectrometry. From a comparison of the spectroscopic data we were able to show that the enamine intermediate (i) is not involved in the enzymatic process. 2. Oxidation of Aromatic Compounds with Amine Side Chains by Pea Seedling Diamine Oxidase A range of quinoline, pyridine, thiophene and pyrrole derivatives with amine side chains were synthesised and tested as substrates of pea seedling diamine oxidase using a spectrophotometric assay which measures the hydrogen peroxide by-product of the enzymatic reaction. From this assay Vmax and Km values were obtained for the oxidation of each substrate using diamine oxidase. The Vmax is the maximal rate of oxidation and gives an indication of the oxidation rate for the various substrates. The KM is a measure of the strength of the enzyme-substrate complex and determines the binding efficiency of the substrate to the enzyme. Analysis of this kinetic data provided information on the enzymatic process and the nature of the pea enzyme's active site. Comparison of the kinetic data obtained from the various aromatic substrates enabled us to study the effect on the binding affinity and rate of oxidation from changes to the ring size of the substrates. The role of the second amine group was also explored using nitrogen heterocycles with amine side chains. 3. Inhibition of Pea Seedling Diamine Oxidase Polyamines are known to be essential in the growth and replication of cells, and diamine oxidase plays a key role in the polyamine metabolism with the oxidative deamination of diamines. Inhibitors of diamine oxidase should therefore have a considerable effect on the polyamine metabolism and hence cell growth. With this in mind inhibitors of diamine oxidase may possess important biological activity. Compounds which were shown to be poor substrates but efficient binders of the pea seedling diamine oxidase from our initial studies were tested as inhibitors. These tests were carried out using the same spectrophotometric assay as before, but which had been modified to include the inhibitor. Most of the compounds tested were found to inhibit the diamine oxidase-catalysed deamination of putrescine and were shown to be competitive inhibitors. 4. The Synthesis of Cisplatin Analogues Cisplatin (iii) is a widely used anticancer drug, but its therapeutic value is limited by the number of toxic side effects which it exhibits. To make use of the diamines available from other studies, we attempted to make cisplatin analogues with various diamines used as bidentate ligands. As there were no examples of unsaturated diamines being used in cisplatin analogues we used cis-1.4-diaminobut-2-ene (iv) which had previously shown antibiotic activity. We made our target compound cis-1,4-diamino(dichloro)-platinum (II) (v), but were unable to make our second target cis-1,4-diaminobut-2-ene(1,1-cyclobutanedicarboxylato)platinum (II) (vi)

    Sixfold improved single particle measurement of the magnetic moment of the antiproton

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    Our current understanding of the Universe comes, among others, from particle physics and cosmology. In particle physics an almost perfect symmetry between matter and antimatter exists. On cosmological scales, however, a striking matter/antimatter imbalance is observed. This contradiction inspires comparisons of the fundamental properties of particles and antiparticles with high precision. Here we report on a measurement of the g-factor of the antiproton with a fractional precision of 0.8 parts per million at 95% confidence level. Our value /2=2.7928465(23) outperforms the previous best measurement by a factor of 6. The result is consistent with our proton g-factor measurement gp/2=2.792847350(9), and therefore agrees with the fundamental charge, parity, time (CPT) invariance of the Standard Model of particle physics. Additionally, our result improves coefficients of the standard model extension which discusses the sensitivity of experiments with respect to CPT violation by up to a factor of 20.EU/ERC/290870-MEFUCOMax-Planck SocietyHelmholtz-GemeinschaftRIKEN Initiative Research Unit ProgramRIKEN President FundingRIKEN Pioneering Project FundingRIKEN FPR FundingRIKEN JRA ProgramMEXT/24000008Max-Planck SocietyEU/ERC Advanced Grant/290870-MEFUCOHelmholtz-GemeinschaftCERN-fellowship program
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