Comparative Analytical study on management of Pauwel’s Type II and III Neck of Femur Fracture treated by Cancellous Screw Fixation Alone Versus Additional Valgus Osteotomy with Internal Fixation

INTRODUCTION: Fracture neck of femur is aptly called as “the unsolved fracture”. This is because even with so much of advances in orthopaedic field, there is no simple method of treatment which can give consistently successful results for this fracture. Management of fracture neck of femur (Pauwel’s type II and III) especially in younger patients is a really demanding and challenging task for any orthopaedic surgeon. AIM AND OBJECTIVES: To compare the outcome on the management of neck of femur fracture (Pauwel’s Type II and III) treated with cancellous screws fixation alone versus additionalvalgus osteotomy with internal Fixation. MATERIALS AND METHODS: Study conducted at the Institute of Orthopaedics and Traumatology, Madras Medical College, Chennai. Duration of study is from April 2016 - September 2016. It is both retrospective & prospective study. The total number of cases studied were 20. Cases selected based on our inclusion and exclusion criteria. 10 patients undergone fixation with cancellous screws alone and 10 patients undergone additional valgus osteotomy with internal fixation.Both groups undergo same postoperative protocol and are followed up with serial X rays. Radiological assessment done with the post-operative follow up X-rays and functional assessment withHarris hip score. RESULTS: We achieved union in 9 cases treated with additional valgus osteotomy and internal fixation. Union rate is 90% when compared to other group fixed with cancellous screw alone (60%). There is a statistically significant decrease in complication rate and increase in fracture union rate and functional outcome when fracture neck of femur treated with additional valgus osteotomy with internal fixation. CONCLUSION: For the patients under 60 years of age with fracture of the femoral neck of Pauwel’s type II and II, additional valgus osteotomy produces good results in terms of fracture union and very low possibility of avascular necrosis of femoral head, whereas internal fixation alone in type II and III fractures has more failure rate for fracture union

A Chemoenzymatic Approach toward the Rapid and Sensitive Detection of O-GlcNAc Posttranslational Modifications

We report a new chemoenzymatic strategy for the rapid and sensitive detection of O-GlcNAc posttranslational modifications. The approach exploits the ability of an engineered mutant of β-1,4-galactosyltransferase to selectively transfer an unnatural ketone functionality onto O-GlcNAc glycosylated proteins. Once transferred, the ketone moiety serves as a versatile handle for the attachment of biotin, thereby enabling chemiluminescent detection of the modified protein. Importantly, this approach permits the rapid visualization of proteins that are at the limits of detection using traditional methods. Moreover, it bypasses the need for radioactive precursors and captures the glycosylated species without perturbing metabolic pathways. We anticipate that this general chemoenzymatic strategy will have broad application to the study of posttranslational modifications

MICROWAVE-ASSISTED SYNTHESIS AND CHARACTERIZATION OF ZNO NANOPARTICLES

A spinel ZnO nanocatalyst was successfully synthesized via a direct microwave heating method. X-ray diffraction (XRD) analysis confirmed the formation of a single-phase cubic spinel gahnite structure (ZnAl₂O₄) with a calculated lattice parameter of 8.335 Å, indicating high phase purity. The average crystallite size, estimated using the Debye-Scherrer equation, was approximately 26.53 nm. Fourier-transform infrared (FT-IR) spectroscopy revealed characteristic metal–oxygen stretching vibrations, corroborating the spinel structure. High-resolution scanning electron microscopy (HR-SEM) images displayed well-defined, nano-sized grains with uniform morphology, suggesting effective control over particle formation. These findings demonstrate that microwave-assisted synthesis is a viable and efficient approach for producing high-purity spinel ZnO nanocatalysts with desirable structural and morphological properties

Integrating place-specific livelihood and equity outcomes into global assessments of bioenergy deployment

__Abstract__ Integrated assessment models suggest that the large-scale deployment of bioenergy could contribute to ambitious climate change mitigation efforts. However, such a shift would intensify the global competition for land, with possible consequences for 1.5 billion smallholder livelihoods that these models do not consider. Maintaining and enhancing robust livelihoods upon bioenergy deployment is an equally important sustainability goal that warrants greater attention. The social implications of biofuel production are complex, varied and place-specific, difficult to model, operationalize and quantify. However, a rapidly developing body of social science literature is advancing the understanding of these interactions. In this letter we link human geography research on the interaction between biofuel crops and livelihoods in developing countries to integrated assessments on biofuels. We review case-study research focused on first-generation biofuel crops to demonstrate that food, income, land and other assets such as health are key livelihood dimensions that can be impacted by such crops and we highlight how place-specific and global dynamics influence both aggregate and distributional outcomes across these livelihood dimensions. We argue that place-specific production models and land tenure regimes mediate livelihood outcomes, which are also in turn affected by global and regional markets and their resulting equilibrium dynamics. The place-specific perspective suggests that distributional consequences are a crucial complement to aggregate outcomes; this has not been given enough weight in comprehensive assessments to date. By narrowing the gap between place-specific case studies and global models, our discussion offers a route towards integrating livelihood and equity considerations into scenarios of future bioenergy deployment, thus contributing to a key challenge in sustainability sciences

Implementation of Vector Quantization for Image Compression - A Survey

This paper presents a survey on vector quantization for image compression. Moreover it provides a means of decomposition of the signal in an approach which takes the improvement of inter and intra band correlation as more lithe partition for higher dimension vector spaces. Thus, the image is compressed without information loss using artificial neural networks (ANN). Since 1988, a growing body of research has examined the use of VQ for the image compression. This paper discusses about vector quantization, its principle and examples, its various techniques and image compression its advantages and applications. Additionally this paper also provides a comparative table in the view of simplicity, storage space, robustness and transfer time of various vector quantization methods. In addition the proposed paper also presents a survey on different methods of vector quantization for image compression

Priority of Career Path Preferences among Veterinary Interns in Tamil Nadu, India

Aims: This study aims to identify the career preferences of veterinary interns at Tamil Nadu Veterinary and Animal Sciences University (TANUVAS) Study Design: The study uses a survey-based exploratory and descriptive research design. Place and Duration of Study: The research was conducted among final-year (Veterinary Interns) Bachelor of Veterinary Sciences and Animla Husbandry (B.V.Sc. & A.H.) students from four constituent colleges of TANUVAS: Madras Veterinary College at Chennai, Veterinary College and Research Institute (VCRI) at Namakkal, VCRI at Tirunelveli, and VCRI at Orathanadu, between the year 2022 and 2023. Methodology: A sample of 275 final-year veterinary interns was selected using simple random sampling. Data were collected using structured and pre-tested questionnaires. The Garrett Ranking Method was used to identify career preferences of veterinary interns. Respondents ranked various career options, which were converted into scores and then ranked based on the mean scores obtained. Results: The most preferred career path among veterinary graduates was Government Veterinary Services, followed by Faculty positions in Indian universities and Research Scientist roles within ICAR and other government sectors. Private practice, positions in private laboratories, and roles in the livestock industry and careers in civil services were moderately preferred, while, entrepreneurial ventures, and international opportunities were preferred by comparatively few numbers of veterinary interns. Conclusion: The study shows a strong preference for roles in the government and academic and research fields among veterinary interns. Understanding these preferences is important for improving educational awareness programs and career guidance, helping to better prepare graduates for their careers and ensuring effective use of veterinary manpower in Tamil Nadu

Microbial Enrichment of a Novel Growing Substrate and its Effect on Plant Growth

The quality of torrefied grass fibers (TGF) as a new potting soil ingredient was tested in a greenhouse experiment. TGF was colonized with previously selected microorganisms. Four colonization treatments were compared: (1) no inoculants, (2) the fungus Coniochaeta ligniaria F/TGF15 alone, (3) the fungus followed by inoculation with two selected bacteria, and (4) the fungus with seven selected bacteria. Cultivation-based and DNA-based methods, i.e., PCR-DGGE and BOX-PCR, were applied to assess the bacterial and fungal communities established in the TGF. Although colonization was not performed under sterile conditions, all inoculated strains were recovered from TGF up to 26 days incubation. Stable fungal and bacterial populations of 108 and 109 CFU/g TGF, respectively, were reached. As a side effect of the torrefaction process that aimed at the chemical stabilization of grass fibers, potentially phytotoxic compounds were generated. These phytotoxic compounds were cold-extracted from the fibers and analyzed by gas chromatography mass spectrometry. Four of 15 target compounds that had previously been found in the extract of TGF were encountered, namely phenol, 2-methoxyphenol, benzopyran-2-one, and tetrahydro-5,6,7,7a-benzofuranone. The concentration of these compounds decreased significantly during incubation. The colonized TGF was mixed with peat (P) in a range of 100%:0%, 50%:50%, 20%:80%, and 0%:100% TGF/P (w/w), respectively, to assess suitability for plant growth. Germination of tomato seeds was assessed three times, i.e., with inoculated TGF that had been incubated for 12, 21, and 26 days. In these tests, 90–100% of the seeds germinated in 50%:50% and 20%:80% TGF/P, whereas on average only 50% of the seeds germinated in pure TGF. Germination was not improved by the microbial inoculants. However, plant fresh weight as well as leaf area of 28-day-old tomato plants were significantly increased in all treatments where C. ligniaria F/TGF15 was inoculated compared to the control treatment without microbial inoculants. Colonization with C. ligniaria also protected the substrate from uncontrolled colonization by other fungi. The excellent colonization of TGF by the selected plant-health promoting bacteria in combination with the fungus C. ligniaria offers the possibility to create disease suppressive substrate, meanwhile replacing 20% to 50% of peat in potting soil by TGF

Microbial degradation of furanic compounds: biochemistry, genetics, and impact

Microbial metabolism of furanic compounds, especially furfural and 5-hydroxymethylfurfural (HMF), is rapidly gaining interest in the scientific community. This interest can largely be attributed to the occurrence of toxic furanic aldehydes in lignocellulosic hydrolysates. However, these compounds are also widespread in nature and in human processed foods, and are produced in industry. Although several microorganisms are known to degrade furanic compounds, the variety of species is limited mostly to Gram-negative aerobic bacteria, with a few notable exceptions. Furanic aldehydes are highly toxic to microorganisms, which have evolved a wide variety of defense mechanisms, such as the oxidation and/or reduction to the furanic alcohol and acid forms. These oxidation/reduction reactions constitute the initial steps of the biological pathways for furfural and HMF degradation. Furfural degradation proceeds via 2-furoic acid, which is metabolized to the primary intermediate 2-oxoglutarate. HMF is converted, via 2,5-furandicarboxylic acid, into 2-furoic acid. The enzymes in these HMF/furfural degradation pathways are encoded by eight hmf genes, organized in two distinct clusters in Cupriavidus basilensis HMF14. The organization of the five genes of the furfural degradation cluster is highly conserved among microorganisms capable of degrading furfural, while the three genes constituting the initial HMF degradation route are organized in a highly diverse manner. The genetic and biochemical characterization of the microbial metabolism of furanic compounds holds great promises for industrial applications such as the biodetoxifcation of lignocellulosic hydrolysates and the production of value-added compounds such as 2,5-furandicarboxylic acid

Applications of Site-Specific Labeling to Study HAMLET, a Tumoricidal Complex of α-Lactalbumin and Oleic Acid

umor cells), and its tumoricidal activity has been well established.-acetylgalactosaminyltransferase II (ppGalNAc-T2) and further conjugated with aminooxy-derivatives of fluoroprobe or biotin molecules.We found that the molten globule form of hLA and αD-hLA proteins, with or without C-terminal extension, and with and without the conjugated fluoroprobe or biotin molecule, readily form a complex with OA and exhibits tumoricidal activity similar to HAMLET made with full-length hLA protein. The confocal microscopy studies with fluoroprobe-labeled samples show that these proteins are internalized into the cells and found even in the nucleus only when they are complexed with OA. The HAMLET conjugated with a single biotin molecule will be a useful tool to identify the cellular components that are involved with it in the tumoricidal activity

Hybrid method for selection of the optimal process of leachate treatment in waste treatment and valorization plants or landfills

“The final publication is available at Springer via http://dx.doi.org/10.1007/s10098-014-0834-4”Leachate from waste landfill or treatment plants is a very complex and highly contaminated liquid effluent. In its composition, it is found dissolved organic matter, inorganic salts, heavy metals, and other xenobiotic organic compounds, so it can be toxic, carcinogenic, and capable of inducing a potential risk to biota and humans. European law does not allow such leachate to leave the premises without being depolluted. There are many procedures that enable debugging, always combining different techniques. Choosing the best method to use in each case is a complex decision, as it depends on many tangible and intangible factors that must be weighed to achieve a balance between technical, cost, and environmental sustainability. 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