One-loop corrections to ALP couplings

The plethora of increasingly precise experiments which hunt for axion-like particles (ALPs), as well as their widely different energy reach, call for the theoretical understanding of ALP couplings at loop-level. We derive the one-loop contributions to ALP-SM effective couplings, including finite corrections. The complete leading-order — dimension five — effective linear Lagrangian is considered. The ALP is left off-shell, which is of particular impact on LHC and accelerator searches of ALP couplings to γγ, ZZ, Zγ, WW, gluons and fermions. All results are obtained in the covariant Rξ gauge. A few phenomenological consequences are also explored as illustration, with flavour diagonal channels in the case of fermions: in particular, we explore constraints on the coupling of the ALP to top quarks, that can be extracted from LHC data, from astrophysical sources and from Dark Matter direct detection experiments such as PandaX, LUX and XENON1T. Furthermore, we clarify the relation between alternative ALP bases, the role of gauge anomalous couplings and their interface with chirality-conserving and chirality-flip fermion interactions, and we briefly discuss renormalization group aspect

Guerra, franquismo y transición: los gobernadores civiles en Andalucía (1936-1979) [Informe]

El Centro de Estudios Andaluces acaba de colgar en su página web el informe Guerra, Franquismo y Transición. Los gobernadores civiles en Andalucía (1936-1979). Coordinado por el profesor de la Universidad de Sevilla (Julio Ponce Alberca), el informe, en el que han participado los investigadores Jesús García Bonilla y Diego Ramos Sánchez, está a disposición de todos los interesados que quieran consultarlo libremente, ya que se enmarca dentro del proyecto Factoría de Ideas, una ventana virtual abierta a todas las reflexiones, líneas de investigación y análisis de tendencias que se generen en consonancia con las áreas temáticas que aborda el Centro de Estudios Andaluces. El estudio se constituye en una aportación fundamental al estudio del Franquismo y la Guerra Civil en Andalucía, ya que hasta ahora no se había realizado una investigación en profundidad sobre el papel que jugaron estos importantes representantes del gobierno, tanto en el desarrollo de la contienda, como en la instauración y consolidación del régimen de Franco. Los investigadores recogen en este texto el dispar destino de los gobernadores civiles andaluces en los días que siguieron a la sublevación del 18 de julio de 1936. Asimismo, inciden en la difícil encrucijada que les tocó vivir, por un lado, al tener que enfrentarse a los militares insurrectos, y por otro, a los comités populares que se erigieron en verdaderos los organizadores de la resistencia. Los historiadores desentrañan las acciones de quienes fueron nombrados, bien por el Gobierno de la República bien por los insurrectos, como un arma más para combatir al otro bando en tiempo de lucha. En segundo lugar, la obra detalla el complejo papel desempeñado por estos mandos designados en provincias por la dictadura de Franco para que interrelacionasen con las élites locales, el partido único, y convirtiesen en hechos las políticas del nuevo gobierno franquista. Finalmente, el estudio se detiene en la importante contribución de los gobernadores civiles en la construcción de la reforma política sancionada por el referéndum constitucional de 1976.Centro de Estudios Andaluce

Nonresonant searches for axion-like particles in vector boson scattering processes at the LHC

We propose a new search for Axion-Like Particles (ALPs), targeting Vector Boson Scattering (VBS) processes at the LHC. We consider nonresonant ALP-mediated VBS, where the ALP participates as an off-shell mediator. This process occurs whenever the ALP is too light to be produced resonantly, and it takes advantage of the derivative nature of ALP interactions with the electroweak Standard Model bosons. We study the production of ZZ, Zγ, W±γ, W±Z and W±W± pairs with large diboson invariant masses in association with two jets. Working in a gauge-invariant framework, upper limits on ALP couplings to electroweak bosons are obtained from a reinterpretation of Run 2 public CMS VBS analyses. The constraints inferred on ALP couplings to ZZ, Zγ and W±W± pairs are very competitive for ALP masses up to 100 GeV. They have the advantage of being independent of the ALP coupling to gluons and of the ALP decay width. Simple projections for LHC Run 3 and HL-LHC are also calculated, demonstrating the power of future dedicated analyses at ATLAS and CMSThe work of J.B. was supported by the Spanish MICIU through the National Program FPU (grant number FPU18/03047). The work of J.M.R. was supported by the Spanish MICIU through the National Program FPI-Severo Ochoa (grant number PRE2019-089233). J.B. and J.M.R. acknowledge partial financial support by the Spanish MINECO through the Centro de excelencia Severo Ochoa Program under grant SEV-2016-0597, by the Spanish “Agencia Estatal de Investigacíon” (AEI) and the EU “Fondo Europeo de Desarrollo Regional” (FEDER) through the project PID2019-108892RB-I00/AEI/10.13039/501100011033. J.F.T. acknowledges support from the AEI and the EU FEDER through the project PID2020- 116262RB-C4

Concerns vs components for web development

The Web has been growing and evolving in the last couple of decades at a very high speed, causing web applications to be more and more complex. Aspect oriented programming gives us a way of reducing the complexity of software development process, in the sense that it is easier to reason about concepts separately. This paper wants to explore the way in which aspects are being applied during the development of web applications and, at the same time, compare the benefits of using aspects with the benefits of other emerging strategies for developing web applications, such as Cocoon, a component-oriented web framework publishing

Diseño del sistema de alcantarillado sanitario y planta de tratamiento para El Casco Urbano de la Concordia Ingeniero Civil

Presenta el diseño del sistema de alcantarillado sanitario del casco urbano del municipio de La Concordia-Jinotega en Nicaragua; contiene los cálculos hidráulicos y topográficos de dos alternativas de red de recolección de aguas residuales (una convencional y otra condominial) con su sistema de tratamiento y los planos respectivos

Una experiencia práctica reutilizando aspectos

Este art´ıculo cuenta nuestra experiencia obtenida tras haber realizado un proyecto utilizando la tecnolog´ıa de aspectos AspectJ, y plantearsenos el hecho de reutilizar los aspectos definidos en el mismo con un nuevo proyecto a desarrollar. En definitiva, comprobar de forma pr´actica el grado de reutilizaci´on que tienen los aspectos en distintas aplicaciones

Pancreatitis aguda en pediatría

Acute pancreatitis (AP) is an inflammation of the pancreas that can be severe in the pediatric population. The main cause of this disease is cholelithiasis and the main risk factor linked to BP is genetic mutations. Diagnosis is made based on clinical symptoms, laboratory tests, and diagnostic imaging. Initial treatment includes early nutrition, aggressive hydration with crystalloid solutions, and administration of analgesics, such as morphine. In some cases, endoscopic intervention may be necessary. Patients should be carefully monitored during the first 48 hours of hospitalization for any signs of complications. Patients should be carefully monitored during the first 48 hours of hospitalization for any signs of complications. After discharge, further evaluation is recommended to identify possible underlying causes and prevent future episodes of PA. After discharge, further evaluation is recommended to identify possible underlying causes and prevent future episodes of PA. In general, adequate and timely management can prevent serious complications and improve the prognosis of AP in the pediatric population, however, there are cases where pseudocysts, pancreatic necrosis and abscesses are observed as sequelae of this disease.La pancreatitis aguda (PA) es una inflamación del páncreas que puede ser grave en la población pediátrica. La principal causa de esta enfermedad es la colelitiasis, y el principal factor de riesgo vinculado con la PA son las mutaciones genéticas. El diagnóstico se realiza con base en los síntomas clínicos, los exámenes de laboratorio y las imágenes de diagnóstico. El tratamiento inicial incluye la nutrición temprana, hidratación agresiva con soluciones cristaloides y la administración de analgésicos, como la morfina. En algunos casos, puede ser necesaria la intervención endoscópica. Los pacientes deben ser monitoreados cuidadosamente durante las primeras 48 horas de hospitalización para detectar cualquier signo de complicaciones. Después del alta médica, se recomienda realizar una evaluación adicional para identificar posibles causas subyacentes y prevenir futuros episodios de PA. En general, un manejo adecuado y oportuno puede prevenir complicaciones graves y mejorar el pronóstico de la PA en la población pediátrica, sin embargo, hay casos donde se observan pseudoquistes, necrosis pancreática y abscesos como secuelas de esta enfermedad

Malformaciones anorrectales en pediatría

Anorectal malformations (MRA) are a set of congenital anomalies in which there is an alteration of the anorectal and urogenital region visible in boys and girls at birth. It is speculated that this pathology is the product of abnormal development of the cloacal membrane (CM) leading to disruption of the normal development of local muscles and nerves. Male infants are more likely to have MRA, with a male-to-female ratio of 4:1. There are multiple types of MRA, including perineal fistula, vestibular fistula, rectouretral fistula, imperforate anus, and other complex malformations. There is evidence that those mothers with diabetes, obesity, high exposure to nicotine and caffeine are more likely to conceive a son or daughter with some type of anorectal malformation. After performing a physical examination of the infant during the first 24 hours of life, it is possible to easily recognize the presence of MRA and begin an appropriate approach in order to prevent significant complications or death. As treatment, surgical techniques such as anoplasty, posterior sagittal anorrectoplasty (PSARP), colostomy and laparoscopy are used, which can present postoperative complications in the patient. Despite surgical correction, some patients may require second interventions, or suffer from disorders such as constipation and fecal incontinence that can affect their quality of life.Las malformaciones anorrectales (ARM) son un conjunto de anomalías congénitas en las que se produce una alteración de la región anorrectal y urogenital visible en niños y niñas al nacer. Se especula que esta patología es el producto de un desarrollo anormal de la membrana cloacal (MC) que conduce a la interrupción del desarrollo normal de los músculos y nervios locales. Los neonatos de sexo masculino son más propensos a padecer de una ARM, con una proporción de sexo hombre-mujer de 4:1. Hay múltiples tipos de ARM, entre los cuales se destacan la fístula perineal, fístula vestibular, fístula rectouretral, el ano imperforado y otras malformaciones complejas. Existe evidencia de que aquellas madres con diabetes, obesidad, alta exposición a la nicotina y a la cafeína son más propensas a concebir un hijo o hija con algún tipo de malformación anorrectal. Tras llevar a cabo un examen físico del infante durante las primeras 24 horas de vida, es posible reconocer fácilmente la presencia de una ARM y comenzar un adecuado abordaje, con el fin de prevenir complicaciones significativas o la muerte. Como tratamiento se utilizan técnicas quirúrgicas como la anoplastia, anorrectoplastia sagital posterior (PSARP), colostomía y laparoscopia, las cuales pueden presentar complicaciones postoperatorias en el paciente. A pesar de la corrección quirúrgica, algunos pacientes pueden requerir segundas intervenciones, o bien, sufrir trastornos como estreñimiento e incontinencia fecal, que puede llegar a afectar su calidad de vida

Protumorigenic effects of Snail-expression fibroblasts on colon cancer cells

et al.Snail1 is a transcriptional factor that plays an important role in epithelial–mesenchymal transition and in the acquisition of invasive properties by epithelial cells. In colon tumors, Snail1 expression in the stroma correlates with lower specific survival of cancer patients. However, the role(s) of Snail1 expression in stroma and its association with patients' survival have not been determined. We used human primary carcinoma-associated fibroblasts (CAFs) or normal fibroblasts (NFs) and fibroblast cell lines to analyze the effects of Snail1 expression on the protumorigenic capabilities in colon cancer cells. Snail1 expression was higher in CAFs than in NFs and, as well as α-SMA, a classic marker of activated CAFs. Moreover, in tumor samples from 50 colon cancer patients, SNAI1 expression was associated with expression of other CAF markers, such as α-SMA and fibroblast activation protein. Interestingly, coculture of CAFs with colon cells induced a significant increase in epithelial cell migration and proliferation, which was associated with endogenous SNAI1 expression levels. Ectopic manipulation of Snail1 in fibroblasts demonstrated that Snail1 expression controlled migration as well as proliferation of cocultured colon cancer cells in a paracrine manner. Furthermore, expression of Snail1 in fibroblasts was required for the coadjuvant effect of these cells on colon cancer cell growth and invasion when coxenografted in nude mice. Finally, cytokine profile changes, particularly MCP-3 expression, in fibroblasts are put forward as mediators of Snail1-derived effects on colon tumor cell migration. In summary, these studies demonstrate that Snail1 is necessary for the protumorigenic effects of fibroblasts on colon cancer cells.This research was supported by the PI12/02037, Fundación Científica AECC, SAF2010-20750, S2010/BMD-2344, RTICC-RD12/0036/0041 and by the Fundación Banco Santander. Antonio García de Herreros’ laboratory was supported by RTICC-RD12/0036/0005 and SAF 2010-16089. Ma Jesús Larriba’s laboratory was supported by RD12/0036/0021. Cristina Peña and José Miguel García are recipients of Miguel Servet Contracts from the Instituto de Salud Carlos III.Peer reviewe