Understanding Ohio Soils

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Long duration thermal hard X-ray sources observed in two eruptive flares

We present observations of two eruptive flares on 17 of December 2006 (C1.9) and 19 of May 2007 (B9.7) which had good coverage with both Hinode and RHESSI. In these flares we see a long lived, gradual thermal hard X-ray source of low emission measure and, relative to the loops observed with GOES and XRT, high temperature. The lack of a non-thermal hard X-ray component and impulsive behaviour is inconsistent with electron beam driven chromospheric evaporation

Head to head tests of the hydrodynamic support for Saturn V

Head to head tests on Saturn V hydrodynamic support to determine performance compared with mathematical model predictio

Connexin32 and X-Linked Charcot-Marie-Tooth Disease

This paper deals with the genetic defect responsible for the X-linked form of Charcot-Marie-Tooth disease.Mutations in the gap junction geneconnexin32(Cx32) cause the X-linked form of Charcot–Marie–Tooth disease, an inherited demyelinating neuropathy

Applicability of the finite element method to analyze the stresses produced in concrete slabs over ground by tire loads of agricultural tractors

There are several methods to dimension concrete slabs due to vehicle loads, most of them based on Westergaard theory. These methods have been developed for industrial vehicles (cars, trucks and forklifts). Considering agricultural buildings one of the most used vehicles is the agricultural tractor whose characteristics (tires of great dimensions but with a reduced contact surface) are different to those of the industrial vehicles. The goal of this research was to analyze the applicability of the finite element method (FEM) to estimate the stresses generated on the concrete slabs considering the loads transmitted by agricultural tractors. To achieve this objective, the effect of the loads transmitted by the rear axle tires of three agricultural tractors has been considered. In parallel, the same study has been carried out using the Westergaard theory. As a preliminary step, to validate the FEM, a numerical analysis has been made to obtain the stresses generated on a concrete slab considering three forklifts. The numerical analysis results have been compared with those obtained by mean of validated methods (Portland Cement Association) and the classical theory of Westergaard. For each agricultural tractor, the actual geometry of the contact surface of tires has been measured on a concrete slab and discretized by the FEM. As a result of the research process developed, it is possible to conclude that the FEM is a valid tool to analyze the tensions generated by the loads transmitted by the tires of agricultural tractors on concrete floors supported on the ground

Human osteoblast growth and maturation in response to metformin and the thienopyridone, A769662

Metformin (Met) is a biguanide drug widely used in the treatment and management of non insulin-dependent diabetes mellitus. In recent years it has emerged that Met, by stimulating adenosine monophosphate-activated protein kinase (AMPK), can promote the maturation of osteoblasts, albeit cells sourced from rodent and murine calvaria. Finding novel uses for existing drugs is especially appealing, primarily from the fiscal and time constraints posed in developing new products. Identifying agents capable of supporting human osteoblast growth and differentiation are attractive in a bone regenerative context. Since studies using Met are invariably restricted to rodent and murine osteoblasts we sought to investigate whether this biguanide might have a positive influence upon human osteoblast growth and maturation. To this end we examined the effect of Met on two osteoblast-like cell lines, MG63 and Saos-2, and compared the responses to primary human osteoblasts and their bone marrow-derived stem cell progeny. Furthermore we examined the effect of a cell permeable Met surrogate, A769662, which is a potent and far more selective activator of AMPK. Herein we report that Met is without influence on cell growth. Furthermore the application of Met, albeit in the millimolar range, actually inhibited osteoblast maturation. Conversely A769662 was toxic to the osteosarcoma-derived cell lines, MG63 and Saos-2, but without effect on the growth of primary cells or their stem cell progenitors. Since the cell lines are known to be p53 deficient we propose that activation of AMPK by A769662 could form part of the arsenal in the fight against osteosarcoma

Stable isotope values in modern bryozoan carbonate from New Zealand and implications for paleoenvironmental interpretation

Bryozoan carbonate contains useful geochemical evidence of temperate shelf paleoenvironments. Stable isotope values were determined for 103 modern marine bryozoan skeletons representing 30 species from New Zealand. δ18O values range from -1.4 to 2.8 VPDB, while δ13C range from -4.5 to 2.8 VPDB (values uncorrected for mineralogical variation). These values are distinct from those of both tropical marine skeletons and New Zealand Tertiary fossils. Most bryozoans secrete carbonate in or near isotopic equilibrium with sea water, except for Celleporina and Steginoporella. The complex and variable mineralogies of the bryozoans reported here make correction for mineralogical effects problematic. Nevertheless, mainly aragonitic forms display higher isotope values, as anticipated. Both temperature and salinity constrain δ18O and δ13C values, and vary with latitude and water depth. Ten samples from a single branch of Cinctipora elegans from the Otago shelf cover a narrow range, although the striking difference in carbon isotope values between the endozone and exozone probably reflects different mineralisation histories. Our stable isotope results from three different laboratories on a single population from a single location are encouragingly consistent. Monomineralic bryozoans, when carefully chosen to avoid species suspected of vital fractionation, have considerable potential as geochemical paleoenvironmental indicators, particularly in temperate marine environments where bryozoans are dominant sediment producers