Cardio-and Neuroprotective Effects of Corvitin and 2-Oxoglutarate in Rats with Pituitrin-Isoproterenol-Induced Myocardial Damage

Heart diseases, especially acute coronary syndrome (ACS), are among the most severe illnesses that often lead to death. Despitesignificant advances in the prevention and treatment of ACS, the incidence of the disease and its complications are very serious. +eimbalance between pro- and antioxidant systems, the formation of active carbonyl compounds, and the end products of glycation inthe blood and tissues are the key moments in the development of heart and neurological disorders leading to a change of behavioralresponses. So, the search for antioxidants with cardio- and neuroprotective effects is an urgent task. +is study was aimed atevaluating the effects of Corvitin and 2-oxoglutarate on physiological parameters, heart histology, and markers of carbonyl/oxidativestress of rats with pituitrin-isoproterenol-induced myocardial damage (PIMD). Increased sweating, tachycardia, significantly decreasedlocomotor and exploratory activity, changes of ECG, heart histology, and biochemical changes were observed in the PIMDgroup.+e administration of Corvitin or 2-OG led to the recovery of locomotor and cognitive activities of the rats, improvement inheart histology, a decrease in the levels of thiobarbituric acid reactive substances, advanced glycated end products, and variouschanges in the activity of the antioxidant enzymes, 6 days after PIMD. So, Corvitin and exogenous 2-OG show cardio- andneuroprotective effects through the decrease of carbonyl/oxidative stress and regulation of the activity of the antioxidant system

Wave-vortex interaction

We present an experimental study on the effect of a electromagneticaly generated vortex flow on parametrically amplified waves at the surface of a fluid. The underlying vortex flow, generated by a periodic Lorentz force, creates spatio-temporal fluctuations that interact nonlinearly with the standing surface waves. We characterize the bifurcation diagram and measure the power spectrum density (PSD) of the local surface wave amplitude. We show that the parametric instability threshold increases with increasing intensity of the vortex flow.Comment: 8 pages, 10 figures, submitted to Phys. Rev.

Specific features of state regulation of operations with cryptocurrencies in the conditions of digitalization

Purpose: The article investigates specific features of state regulation of operations with cryptocurrencies in the conditions of the world economy digitalization. Design/Methodology/Approach: In order to form the state regulation of operations with cryptocurrencies, which create additional risks for the national currencies functioning in international financial and credit relations, it is necessary to consider this phenomenon first, from the position of a complete ban on the use of cryptocurrencies as a means of payment, second, in combination of a ban on the use of cryptocurrencies as means of payment, third, from the possibility of expanding the range of cryptocurrency users by including legal entities into it and fourth, the full legalization of the cryptocurrency. Findings: The authors developed and proposed a set of measures aimed at the formation of common standards and norms of state regulation of operations with cryptocurrencies in international financial relations. Practical Implications: The results of the study can be applied in the development of legal regulation of virtual currencies not only at the national level, but also at the international level. Originality/Value: The main contribution of the study is to identify possible risks in the sphere of state regulation of cryptocurrencies based on the experience of some countries: from formal permission (including recommendations on possible risks) or the application of general principles of regulation in the field of payments to the complete ban of such activities.peer-reviewe

Solvent-free synthesis of cyclic carbonates from CO2 and epoxides catalyzed by reusable alumina-supported zinc dichloride

There is an ongoing interest to advance in the production of cyclic carbonates from carbon dioxide and epoxides under sustainable conditions. The ZnCl2/Al2O3-TBAI system has evinced to be a cheap, simple, readily accessible and reusable catalyst for the reaction of carbon dioxide with aromatic, aliphatic, cyclic and fluorinated epoxides with a low metal loading under solvent-free and mild conditions. This system has been also shown to be adequate for the reaction of epoxides with carbon disulfide to form the sulfur-containing cyclic carbonate analogs.This study was generously supported by the Russian Science Foundation [project no. 14-23-00186 P], the M. V. Lomonosov Moscow State University Program of Development, the Spanish Ministerio de Ciencia, Innovación y Universidades [MICIU; grant no. CTQ2017-88171-P] and the Generalitat Valenciana [GV; grant no. AICO/2017/007]

Improving the efficiency of university management : teacher’s performance monitoring as a tool to promote the quality of education

This study aims to examine the essence of education monitoring, its place in the higher education management system and the practical implementation of teacher’s performance monitoring as a tool to promote the quality of education. The article considers theoretical aspects of monitoring as a tool to promote the quality of education, assesses the performance of the university departments, research and teaching staff and discusses the results and suggestions on how to improve monitoring activities in higher education. Based on their research and findings, the authors claimed that the monitoring of the performance of the university research and teaching staff on the base of an indicator system in terms of education, methodology, research, organization and counselling services would lead to valid conclusions as to the effective performance of both individual researchers and teachers and university departments, in general.peer-reviewe

Estimation of running capacity can likely be removed from questionnaires estimating walking impairment in patients with claudication

OBJECTIVE: The Estimating Ambulation Capacity by History-Questionnaire (EACH-Q) and the Walking Impairment Questionnaire (WIQ) are used to estimate maximal walking distance (MWD). The EACH-Q and WIQ included 4 and 14 items respectively, among which one item dealing with running capacity. We hypothesised that this item was of little interest in patients with claudication. DESIGN: The WIQ and EACH-Q were self-completed and corrected before a constant load (3.2 km h(-1); 10% slope) treadmill tests, maximised to 15 min. PATIENTS: 371 patients (298 males/73 females, 62.9 +/- 11.2 years). METHODS: The number of errors (duplicate, absent or paradoxical answers to one item) and correlation of questionnaire scores with MWD on treadmill were calculated, before and after skipping the answer to the running item. RESULTS: The proportion of questionnaires with errors was 27% with the EACH-Q and 48% with the WIQ. Two-hundred and twenty-one (59.6%) and 245 (66%) out of 371 patients reported to be unable to run, for the EACH-Q and WIQ, respectively. The rate of errors was reduced by 15% for the EACH-Q (p < 0.05) when skipping the running item for scoring. The correlation coefficients between the MWD and the questionnaire scores were 0.449 and 0.485 for the EACH-Q and were 0.571 and 0.572 for the WIQ, before and after skipping the running item, respectively. CONCLUSION: Most of our patients reported to be unable to run and skipping the running item reduce the rate of errors in self-completing the questionnaires without impairing the correlation of questionnaire scores with treadmill results. It is likely that the running item could be removed from the WIQ and EACH-Q questionnaires

Formação de competência social do futuro especialista

Modern society is in dire need of socially competent professionals who can quickly adapt to the changing life situations, are ready to solve new problems, interested in improving the efficiency of professional activities, planning the future and ready to take responsibility for the decisions. The problem of development of social competency of the individual is interdisciplinary and in contrast to the problem of development of competency in general and professional competency in particular. In the scientific literature the approaches by which it is possible to give the essential characteristic of this phenomenon and to construct a model are designated: a) set of social knowledge, abilities, awareness of the person of social processes; b) social interaction, the ability and willingness of a person to it, the ability to build their relationships with other people and social organizations in real life; c) the integral quality of the individual, formed in the process of training and education; d) the purpose and result of the implementation of special development and educational programs of educational organizations. Comparative analysis allowed us to determine the components of social competency: personal component, social component, cognitive component, value-semantic component. In the social competency formation of students active teaching methods are the most popular. We consider the method of training “Educational firm” approved in the process of research at different educational levels as a systematized set of simulation methods. Effective socialization of a person should be considered in the context of competence-based approach, including the essential characteristics of competency, professionalism, qualification, personality.La sociedad moderna está en extrema necesidad de profesionales socialmente competentes que puedan adaptarse rápidamente a las situaciones cambiantes de la vida, estén listos para resolver nuevos problemas, interesados en mejorar la eficiencia de las actividades profesionales, planificar el futuro y listos para asumir la responsabilidad de las decisiones. El problema del desarrollo de la competencia social del individuo es interdisciplinario y en contraste con el problema del desarrollo de la competencia en general y la competencia profesional en particular. En la literatura científica se designan los enfoques mediante los cuales es posible dar la característica esencial de este fenómeno y construir un modelo: a) conjunto de conocimientos sociales, habilidades, conciencia de la persona de los procesos sociales; b) la interacción social, la capacidad y la disposición de una persona para ello, la capacidad de construir sus relaciones con otras personas y organizaciones sociales en la vida real; c) la calidad integral del individuo, formada en el proceso de formación y educación; d) El propósito y el resultado de la implementación de programas especiales de desarrollo y educación de organizaciones educativas. El análisis comparativo nos permitió determinar los componentes de la competencia social: componente personal, componente social, componente cognitivo, componente semántico de valor. En la formación de competencias sociales de los estudiantes, los métodos de enseñanza activos son los más populares. Consideramos el método de capacitación “firma educativa” aprobado en el proceso de investigación en diferentes niveles educativos como un conjunto sistematizado de métodos de simulación. La socialización efectiva de una persona debe considerarse en el contexto del enfoque basado en la competencia, incluidas las características esenciales de la competencia, el profesionalismo, la calificación, la personalidad.A sociedade moderna está em extrema necessidade de profissionais socialmente competentes que possam se adaptar rapidamente às situações de mudança da vida, prontos para resolver novos problemas, interessados em melhorar a eficiência das atividades profissionais, planejando o futuro e prontos para assumir a responsabilidade pelas decisões. O problema do desenvolvimento da competência social do indivíduo é interdisciplinar e em contraste com o problema do desenvolvimento da competência em geral e da competência profissional em particular. Na literatura científica as abordagens pelas quais é possível dar a característica essencial deste fenômeno e construir um modelo são designadas: a) conjunto de conhecimentos sociais, habilidades, consciência da pessoa de processos sociais; b) interação social, a capacidade e a disposição de uma pessoa para com ela, a capacidade de construir relacionamentos com outras pessoas e organizações sociais na vida real; c) a qualidade integral do indivíduo, formada no processo de formação e educação; d) o propósito e resultado da implementação de programas especiais de desenvolvimento e educação de organizações educacionais. A análise comparativa permitiu determinar os componentes da competência social: componente pessoal, componente social, componente cognitivo, componente valor-semântico. Na formação de competências sociais dos alunos, os métodos de ensino ativos são os mais populares. Consideramos o método de treinamento “Empresa Educacional” aprovado no processo de pesquisa em diferentes níveis educacionais como um conjunto sistematizado de métodos de simulação. A socialização efetiva de uma pessoa deve ser considerada no contexto da abordagem baseada em competência, incluindo as características essenciais de competência, profissionalismo, qualificação, personalidade

Realization of a classical counterpart of a scalable design for adiabatic quantum computation

We implement a classical counterpart of a scalable design for adiabatic quantum computation. The key element of this design is a coupler providing controllable coupling between two bistable elements (in our case superconducting rings with a single Josephson junction playing the role of a classical counterpart of superconducting flux qubits) The coupler is also a superconducting ring with a single Josephson junction that operates in the non-hysteretic mode. The flux coupling between two bistable rings can be controlled by changing the magnetic flux through the coupler. Thereby, the coupling can be tuned from ferromagnetic trough zero to to anti-ferromagnetic.Comment: 3 pages, 3 figures v2: extended discussion experimental result