Asperger\u27s Syndrome/Autism Spectrum Disorder and Marital Satisfaction: A Quantitative Study

Few empirical studies exist that examine adult Asperger-affected relationships. The purpose of this study was to determine whether the marital satisfaction of individuals in relationships in which at least one partner has Asperger’s Syndrome (AS) or Autism Spectrum Disorder (ASD), differs in some significant way from the marital satisfaction of individuals in relationships in which neither partner has AS/ASD. Participants were 126 adults in relationships in which at least one partner had a diagnosis of AS or ASD, recruited from Asperger- and autism-related websites, social media, and organizations from English-speaking countries. Couples consisted of heterosexual and same-sex couples, couples with and without children, and couples in which either the male and/or the female partner had an AS/ASD diagnosis. Members of each couple responded independently. Using an online version of the Marital Satisfaction Inventory, Revised (MSI R), the mean scores of individuals in AS/ASD-affected relationships were compared with the normative data of the MSI R for males and females on each of 10 dimensions of marital satisfaction, resulting in 20 comparisons. The dimensions of martial satisfaction included global distress, affective communication, problem solving communication, time together, aggression, sexual dissatisfaction, disagreement about finances, family history of distress, dissatisfaction with children, and conflict over child rearing. Comparisons were made using independent samples t-tests. Because of the highly significant results, step-down procedures were not needed to correct for possible inflation of Type 1 errors. Of the 20 comparisons, 15 demonstrated significantly more dissatisfaction among individuals in AS/ASD-affected relationships than those from the normative data sample, at p \u3c .001. In all cases, individuals in AS/ASD-affected partnerships were more dissatisfied than their normative sample counterparts. Separate analyses revealed that NT individuals were less satisfied than their AS/ASD partners. Women reported higher levels of sexual dissatisfaction than men. Findings of lower marital satisfaction for AS/ASD-affected relationships replicate those of a similar, prior study, but differ from two other studies that found no difference in marital satisfaction related to partner AS/ASD status. Future research, clinical implications, and alternatives to traditional couples counseling are discussed

ATP precursor depletion and postischemic myocardial recovery

Although cardioplegia reduces myocardial metabolism during ischemia, adenosine triphosphate (ATP) depletion occurs, which may contribute to poor functional recovery after reperfusion. Augmenting myocardial adenosine during ischemia is successful in improving ATP repletion and myocardial recovery following ischemia. If adenosine is an important determinant of ischemic tolerance, then depletion or elimination of myocardial adenosine should lead to poor functional and metabolic recovery after ischemia. To test this hypothesis, isolated, perfused rabbit hearts were subjected to 120 min of 34[deg]C ischemia. Hearts received St. Thomas cardioplegia alone or cardioplegia containing 200 [mu]M adenosine, or cardioplegia containing 15, 5, 2.5, or 0.025 [mu]g/ml adenosine deaminase (ADA), which catalyzes the breakdown of adenosine to inosine, making adenosine unavailable as an ATP precursor. Functional recovery was determined and myocardial nucleotide levels were measured before, during, and after ischemia. Following ischemia and reperfusion, control hearts recovered to 51 +/- 3% of preischemic developed pressure (DP). There was significantly better recovery in adenosine-augmented hearts (68 +/- 7%), while ADA hearts had significantly worse recovery. Hearts treated with 0.025 [mu]g/ml ADA recovered to only 29 +/- 5% of DP and higher dose ADA hearts failed to demonstrate any recovery of systolic function. Furthermore, adenosine enhanced metabolic recovery, whereas ADA resulted in greatly depleted ATP and precursor reserves. Postischemic developed pressure closely paralleled the availability of myocardial adenosine, consistent with the hypothesis that myocardial adenosine levels at end ischemia and early reperfusion are important determinants of functional recovery after global ischemia.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/29313/1/0000378.pd

Xanthine oxidase inhibition attenuates ischemic-reperfusion lung injury

Ischemic-reperfusion lung injury is a factor potentially limiting the usefulness of distant organ procurement for heart-lung transplantation. Toxic oxygen metabolites are considered a major etiologic factor in reperfusion injury. Although oxygen-free radicals may be generated by many mechanisms, we investigated the role of xanthine oxidase in this injury process by using lodoxamide, a xanthine oxidase inhibitor, to inhibit ischemic-reperfusion injury in an isolated rat lung model. Isolated rat lungs were perfused with physiologic salt solution (PSS) osmotically stabilized with Ficoll until circulating blood elements were nondetectable in the pulmonary venous effluent. Lungs were rendered ischemic by interrupting ventilation and perfusion for 2 hr at 37[deg]C. After the ischemic interval, the lungs were reperfused with whole blood and lung injury was determined by measuring the accumulation of 125I-bovine serum albumin in lung parenchyma and alveolar lavage fluid as well as by gravimetric measurements. Lung effluent was collected immediately pre- and postischemia for analysis of uric acid by high-pressure liquid chromatography. Lodoxamide (1 mM) caused significant attenuation of postischemic lung injury. Uric acid levels in the lung effluent confirmed inhibition of xanthine oxidase. Protection from injury was not complete, however, implying that additional mechanisms may contribute to ischemic-reperfusion injury in the lung.Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/27322/1/0000345.pd