Differences in the Timing of Implausibility Detection for Recipient and Instrument Prepositional Phrases

We conducted two word-by-word reading experiments to investigate the timing of implausibility detection for recipient and instrument prepositional phrases (PPs). These PPs differ in thematic role, relative frequency, and possibly in argument status. The results showed a difference in the timing of garden path effects such that the detection of implausible dative recipients (which are clearly arguments) was delayed relative to the detection of implausible instruments (which may not be arguments). They also demonstrated that commitments to syntactic structure were made at the preposition for both dative and instrument PPs. While these results refute delay models of parsing (e.g., Britt, 1994) and syntax-first accounts of PP-attachment (e.g., Frazier, 1978; Frazier & Clifton, 1996), they support constraint-based lexicalist models that enable verb bias and plausibility information to compete (Garnsey, Pearlmutter, Myers, & Lotocky, 1997).Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/45106/1/10936_2004_Article_477924.pd

Persistent structural priming during online second-language comprehension

We report 2 self-paced reading experiments investigating the longevity of structural priming effects in comprehending reduced relative clauses among adult Chinese-speaking learners of English. Experiment 1 showed that structural priming occurred both when prime and target sentences were immediately adjacent and when they were separated by 1 or 2 filler sentences of unrelated structures. Moreover, the magnitude of the priming effect held constant across different lag conditions. Experiment 2 replicated the persistent priming effect and ruled out the possibility that the effect was due to verb repetition priming. Taken together, the current results suggest that recent experience with a given structure can have relatively long-lived facilitation effect on the language-processing system in second-language learners. As such, structural priming may serve as a learning mechanism for second-language speakers

Out of the Box and Onto the Stage: Enacting Information Systems Research through Theatre

The quest for digital innovation leads to consideration of new ways to infuse creativity into research and practice. One approach is to import techniques from artistic disciplines such as theatre. This panel explores the benefits and pitfalls of importing theatrical techniques into IS research. The nonlinear and holistic approach of the artistic fields facilitates incorporation of the emotional, subtle and implicit aspects of IS research. Theatre can also serve as a generative research method that can facilitate the reframing of the way the world is seen and understood. But skeptics argue that the use of theatre might lead to the blurring of the lines between “fact and fiction” to the detriment of the scientific research tradition. This panel presents four different ways to increase IS research creativity by incorporating theatrical techniques into the process. The audience is invited to join the dialogue in search of productive creativity

Lexicalized structural priming in second language online sentence comprehension

Prior work has shown intriguing differences between L1 and L2 comprehension priming of relative clauses. We investigated English reduced relative clause priming in Chinese adult learners of English. Participants of different education levels read sentences in a self-paced, moving window paradigm. Critical sentences had a temporarily ambiguous reduced relative clause. Across lists, critical sentences were rotated, so that they occurred either as prime or as target, and had either the same or different verb as the critical sentence with which they were paired. Prime/target pairs were separated by several filler sentences, which never contained a relative clause. Mean reading times for the disambiguating region in the target sentences were faster than in the prime sentences, but only in the same-verb condition, not in the different-verb condition. This pattern of results is consistent with L1 comprehension priming research, suggesting that similar lexically specific mechanisms are involved in L1 and L2 comprehension priming of reduced relative clauses. These findings are in line with lexicalist accounts of sentence comprehension (e.g., MacDonald et al., 1994), according to which syntactic information is bound to specific words. In addition, these findings argue against theories that postulate fundamental differences in processing of L1 and L2 (e.g., Clahsen and Felser, 2006a, 2006b)

miRNA Expression in Colon Polyps Provides Evidence for a Multihit Model of Colon Cancer

Changes in miRNA expression are a common feature in colon cancer. Those changes occurring in the transition from normal to adenoma and from adenoma to carcinoma, however, have not been well defined. Additionally, miRNA changes among tumor subgroups of colon cancer have also not been adequately evaluated. In this study, we examined the global miRNA expression in 315 samples that included 52 normal colonic mucosa, 41 tubulovillous adenomas, 158 adenocarcinomas with proficient DNA mismatch repair (pMMR) selected for stage and age of onset, and 64 adenocarcinomas with defective DNA mismatch repair (dMMR) selected for sporadic (n = 53) and inherited colon cancer (n = 11). Sporadic dMMR tumors all had MLH1 inactivation due to promoter hypermethylation. Unsupervised PCA and cluster analysis demonstrated that normal colon tissue, adenomas, pMMR carcinomas and dMMR carcinomas were all clearly discernable. The majority of miRNAs that were differentially expressed between normal and polyp were also differentially expressed with a similar magnitude in the comparison of normal to both the pMMR and dMMR tumor groups, suggesting a stepwise progression for transformation from normal colon to carcinoma. Among the miRNAs demonstrating the largest fold up- or down-regulated changes (≥4), four novel (miR-31, miR-1, miR-9 and miR-99a) and two previously reported (miR-137 and miR-135b) miRNAs were identified in the normal/adenoma comparison. All but one of these (miR-99a) demonstrated similar expression differences in the two normal/carcinoma comparisons, suggesting that these early tumor changes are important in both the pMMR- and dMMR-derived cancers. The comparison between pMMR and dMMR tumors identified four miRNAs (miR-31, miR-552, miR-592 and miR-224) with statistically significant expression differences (≥2-fold change)

Clinical decision-making: midwifery students' recognition of, and response to, post partum haemorrhage in the simulation environment

<p>Abstract</p> <p>Background</p> <p>This paper reports the findings of a study of how midwifery students responded to a simulated post partum haemorrhage (PPH). Internationally, 25% of maternal deaths are attributed to severe haemorrhage. Although this figure is far higher in developing countries, the risk to maternal wellbeing and child health problem means that all midwives need to remain vigilant and respond appropriately to early signs of maternal deterioration.</p> <p>Methods</p> <p>Simulation using a patient actress enabled the research team to investigate the way in which 35 midwifery students made decisions in a dynamic high fidelity PPH scenario. The actress wore a birthing suit that simulated blood loss and a flaccid uterus on palpation. The scenario provided low levels of uncertainty and high levels of relevant information. The student's response to the scenario was videoed. Immediately after, they were invited to review the video, reflect on their performance and give a commentary as to what affected their decisions. The data were analysed using Dimensional Analysis.</p> <p>Results</p> <p>The students' clinical management of the situation varied considerably. Students struggled to prioritise their actions where more than one response was required to a clinical cue and did not necessarily use mnemonics as heuristic devices to guide their actions. Driven by a response to single cues they also showed a reluctance to formulate a diagnosis based on inductive and deductive reasoning cycles. This meant they did not necessarily introduce new hypothetical ideas against which they might refute or confirm a diagnosis and thereby eliminate fixation error.</p> <p>Conclusions</p> <p>The students response demonstrated that a number of clinical skills require updating on a regular basis including: fundal massage technique, the use of emergency standing order drugs, communication and delegation of tasks to others in an emergency and working independently until help arrives. Heuristic devices helped the students to evaluate their interventions to illuminate what else could be done whilst they awaited the emergency team. They did not necessarily serve to prompt the students' or help them plan care prospectively. The limitations of the study are critically explored along with the pedagogic implications for initial training and continuing professional development.</p

Human colon cancer profiles show differential microRNA expression depending on mismatch repair status and are characteristic of undifferentiated proliferative states

<p>Abstract</p> <p>Background</p> <p>Colon cancer arises from the accumulation of multiple genetic and epigenetic alterations to normal colonic tissue. microRNAs (miRNAs) are small, non-coding regulatory RNAs that post-transcriptionally regulate gene expression. Differential miRNA expression in cancer versus normal tissue is a common event and may be pivotal for tumor onset and progression.</p> <p>Methods</p> <p>To identify miRNAs that are differentially expressed in tumors and tumor subtypes, we carried out highly sensitive expression profiling of 735 miRNAs on samples obtained from a statistically powerful set of tumors (n = 80) and normal colon tissue (n = 28) and validated a subset of this data by qRT-PCR.</p> <p>Results</p> <p>Tumor specimens showed highly significant and large fold change differential expression of the levels of 39 miRNAs including miR-135b, miR-96, miR-182, miR-183, miR-1, and miR-133a, relative to normal colon tissue. Significant differences were also seen in 6 miRNAs including miR-31 and miR-592, in the direct comparison of tumors that were deficient or proficient for mismatch repair. Examination of the genomic regions containing differentially expressed miRNAs revealed that they were also differentially methylated in colon cancer at a far greater rate than would be expected by chance. A network of interactions between these miRNAs and genes associated with colon cancer provided evidence for the role of these miRNAs as oncogenes by attenuation of tumor suppressor genes.</p> <p>Conclusion</p> <p>Colon tumors show differential expression of miRNAs depending on mismatch repair status. miRNA expression in colon tumors has an epigenetic component and altered expression that may reflect a reversion to regulatory programs characteristic of undifferentiated proliferative developmental states.</p

Global chemical effects of the microbiome include new bile-acid conjugations

A mosaic of cross-phylum chemical interactions occurs between all metazoans and their microbiomes. A number of molecular families that are known to be produced by the microbiome have a marked effect on the balance between health and disease. Considering the diversity of the human microbiome (which numbers over 40,000 operational taxonomic units), the effect of the microbiome on the chemistry of an entire animal remains underexplored. Here we use mass spectrometry informatics and data visualization approaches to provide an assessment of the effects of the microbiome on the chemistry of an entire mammal by comparing metabolomics data from germ-free and specific-pathogen-free mice. We found that the microbiota affects the chemistry of all organs. This included the amino acid conjugations of host bile acids that were used to produce phenylalanocholic acid, tyrosocholic acid and leucocholic acid, which have not previously been characterized despite extensive research on bile-acid chemistry. These bile-acid conjugates were also found in humans, and were enriched in patients with inflammatory bowel disease or cystic fibrosis. These compounds agonized the farnesoid X receptor in vitro, and mice gavaged with the compounds showed reduced expression of bile-acid synthesis genes in vivo. Further studies are required to confirm whether these compounds have a physiological role in the host, and whether they contribute to gut diseases that are associated with microbiome dysbiosis