Evolution inhabituelle d’un adénofibrome mammaire A propos d'un cas et revue de la littérature

Le fibroadénome est une lésion bénigne fréquente rencontrées chez l’adolescente et la jeunefemme jeune. L’adénofibrome est une lésion épithéliale bénigne sans risque carcinologique. Lefibroadénome contenant des foyers de carcinome canalaire in situ (CCIS) sont de diagnosticdifficile. Nous illustrons un cas clinique du service, d’une patiente suivie pour mastopathiesfibrokystique, chez qui, à la suite de l’apparition d’une induration mammaire gauche, sagynécologue lui préconise de faire une mammographie et une échographie mammaire.L’imagerie standard met en évidence une masse suspecte intra mammaire gauche et une autremasse du prolongement axillaire homolatérale, connue et étiquetée adénofibrome contenantactuellement des microcalcifications.La microbiopsies des deux masses est revenue en faveur d’ un carcinome canalaire infiltrant etd’un adénofibrome avec hyperplasie canalaire avec atypie. La patiente est opérée. L’étudeanatomopathologique de la pièce opératoire retrouve un carcinome infiltrant type non spécifiquepour la masse du QSE et un fibroadénome axillaire avec un contingent épithélial colonisé pardes lésions de carcinome canalaire in situ

Two deciduous human molars from the early Pleistocene deposits of Barranco León (Orce, Spain)

Recently Toro-Moyano et al. (2013) reported a deciduous tooth from Barranco Leo´n (Spain; BL02-J54-100) and claimed it to be the oldest human fossil in Europe. In that paper, the authors suggest that a previously reported human molar fragment from the same site (BL5-0) was not human but a deciduous molar of Hippopotamus found out of stratigraphic context. Here, we show the stratigraphic and spatial position of BL5-0, and we separate it from deciduous teeth of Hippopotamus. We conclude that two human deciduous molars have been discovered at the Barranco Leo´n site. Both teeth were found 9 meters apart, have a similar size, are heavily worn on the occlusal surface, have a nearly identical interstitial contact facet, and in both cases the roots are practically missing due to resorption. These similarities and the proximity of the finds suggest that both molars probably belonged to the same individua

Early onset lactating adenoma and the role of breast MRI: a case report

<p>Abstract</p> <p>Introduction</p> <p>Lactating adenoma is a benign condition, representing the most prevalent breast lesion in pregnant women and during puerperium; in this paper, a case of a woman with lactating adenoma occurring during the first trimester of pregnancy is reported. There have been no reports in the literature, according to our search, focusing on magnetic resonance imaging findings in cases of lactating adenomas. Also the early onset of the lesion during the first trimester of pregnancy is quite unusual and possibly unique.</p> <p>Case presentation</p> <p>We report the case of a primiparous 30-year-old Caucasian woman, who noted an asymptomatic lump within her left breast during the 9^thweek of gestation, slightly increasing in size over the next few weeks. Ultrasound demonstrated a hypoecoic solid mass, hypervascularized and measuring 4 cm. On magnetic resonance imaging, performed in the first month after delivery, the lesion appeared as an ovoidal homogeneous mass, with regular margins and a significant contrast enhancement indicative of a giant adenoma.</p> <p>Conclusion</p> <p>Magnetic resonance imaging could play an important role in the differential diagnosis of pregnancy-related breast lumps, particularly during puerperium, thus avoiding unnecessary surgical biopsies.</p

Ecoulement mamelonnaire sanglant unilateral et cancer du sein a Libreville, Gabon: Analyse rétrospective sur 10 ans.

Il s’agit d’une étude rétrospective menée dans deux centres hospitaliers de Libreville sur une période de dix ans, du 1er janvier 1998 au 31 décembre 2007. Les objectifs étaient de déterminer la proportion des étiologies malignes à l’origine de l’écoulement mamelonnaire sanglant unilatéral à Libreville et d’analyser le pronostic de ces patientes. A partir des dossiers médicaux, nous avons étudié les caractéristiques épidémiologiques, les résultats histologiques et le pronostic. 78 cas d’écoulement mamelonnaire ont été diagnostiqués durant cette période, soit un taux d’incidence de 0,7% de l’ensemble de la pathologie mammaire opérée durant cette période. L’âge moyen des patientes était de 44±3,7 ans. La pyramidectomie centrée sur le galactophore a été la chirurgie diagnostique la plus fréquente (73%). Il y a eu 11 cas de cancer (14,1%). Le carcinome canalaire invasif (45,45%) était la forme histologique la plus fréquente. En seconde intention, la mastectomie radicale associée au curage ganglionnaire axillaire a été le traitement majeur des cas de malignité. La survie était de 62,5% à cinq ans et de 54,5% à dix ans. A Libreville, l’écoulement mamelonnaire sanglant apparait chez des femmes d’âge moyen de 44±3,7 ans et son étiologie est généralement bénigne. Cependant des formes malignes peuvent être individualisées et leur pronostic à court terme est très réservé.MOTS CLES: Ecoulements mamelonnaires sanglants - Cancer du sein - Pronostic - Afrique

Giant phyllodes tumour – Case report, oncoplastic treatment and literature controversies

Phyllodes tumour corresponds to 1% of breast primary tumours. Its primary treatment is presently surgical and, for several reasons, it usually requires breast reconstruction. First of all, an important breast volume is often removed, not only because it can easily achieve great dimensions, thanks to it fast growing potential, but also because wide excision is recommended to avoid its frequent but unpredictable local recurrence (meaning that ideal tumour resection margins are unknown). Second, it frequently affects young woman with more aesthetic concerns. We present a case of phyllodes tumour recurrence where oncoplastic surgery was necessary at both episodes and discuss the literature controversies on this subject, mainly related to treatment and prognosis prediction factors.El tumor phyllodes representa el 1% de los tumores primarios de mama. Actualmente, su tratamiento primario es la cirugía y, por muchas razones, requiere normalmente reconstrucción de mama. Primeramente, porque a menudo es extirpado un importante volumen de mama, no sólo porque el tumor puede adquirir grandes dimensiones gracias a su alto potencial de crecimiento, sino también porque es recomendado una amplia excisión para evitar su frecuente pero impredecible recidiva local (los márgenes quirúrgicos ideales no son conocidos). Segundo, porque afecta frecuentemente a mujeres jóvenes con más preocupaciones estéticas. Presentamos un caso de recidiva de tumor phyllodes donde la cirugía oncoplástica fue necesaria en ambos episodios y discutimos las controversias en la literatura sobre este tema, principalmente dirigidos al tratamiento y a los factores pronósticos.info:eu-repo/semantics/publishedVersio

FEASIBILITY STUDY FOR PRODUCTION OF IODINE-131 USING DIOXIDE OF TELLURIUM-130

Objective: Currently, nuclear medicine is becoming increasingly important, through the discovery of several medical radioisotopes, which are used in diagnosis, treatment, and medical imaging. Among the most important radionuclide which is commonly used is iodine-131, with a half-life of 8.02 d. Iodine-131 is one of the mainly essential elements in nuclear medicine. Since their first use, several studies have been conducted to meet the world need of hospital specialists in nuclear medicine. The purpose of this study was to participate in a lawsuit about the feasibility of producing 131I.Methods: using neutron activation of the dioxide of tellurium (TeO2) under a neutron flux which varies between 5 1011 and 1013 n/cm²s for 4, 6 and 8 hours** per irradiation cycle during 5 d, and used the Fortron90 Code to calculate the activity of iodine-131.Results: The result of the activity of iodine-131 found about 4,634 Curie with an irradiation of 4 hours** per day and 9.381 Curie with an activation of 8 hours** per day.Conclusion: Production of iodine-131 can be very effective if an acceptable capsule is used for different masses of tellurium and a neutron flux in a nuclear reactor

Classification of Luminal Subtypes in Full Mammogram Images Using Transfer Learning

Automatic identification of patients with luminal and non-luminal subtypes during a routine mammography screening can support clinicians in streamlining breast cancer therapy planning. Recent machine learning techniques have shown promising results in molecular subtype classification in mammography; however, they are highly dependent on pixel-level annotations, handcrafted, and radiomic features. In this work, we provide initial insights into the luminal subtype classification in full mammogram images trained using only image-level labels. Transfer learning is applied from a breast abnormality classification task, to finetune a ResNet-18-based luminal versus non-luminal subtype classification task. We present and compare our results on the publicly available CMMD dataset and show that our approach significantly outperforms the baseline classifier by achieving a mean AUC score of 0.6688 and a mean F1 score of 0.6693 on the test dataset. The improvement over baseline is statistically significant, with a p-value of p<0.0001.Comment: Submitted to IEEE ISBI 202

Lucia Ráčková, François Schmitt, Les interférences linguistiques du français sur le slovaque. Lʼexemple du système verbal

COMPTES RENDUS: LUCIA RÁČKOVÁ, FRANÇOIS SCHMITT, LES INTERFÉRENCES LINGUISTIQUES DU FRANÇAIS SUR LE SLOVAQUE. LʼEXEMPLE DU SYSTÈME VERBAL. COLL. LANGUE ET PAROLE. PARIS : LʼHARMATTAN, 2019, PP. 139COMPTES RENDUS: LUCIA RÁČKOVÁ, FRANÇOIS SCHMITT, LES INTERFÉRENCES LINGUISTIQUES DU FRANÇAIS SUR LE SLOVAQUE. LʼEXEMPLE DU SYSTÈME VERBAL. COLL. LANGUE ET PAROLE. PARIS : LʼHARMATTAN, 2019, PP. 13