Procedura di verifica del rispetto dei livelli di riferimento dell\u27induzione magnetica in presenza di forme d\u27onda complesse con frequenze fino a 100 kHz. PARTE I: ASPETTI GENERALI

.Le Linee Guida ICNIRP del 1998 (1) e lo Statement ICNIRP del 2003 (2) propongono nel complesso quattro approcci distinti per la verifica del rispetto dei livelli di riferimento ICNIRP in presenza di forme d\u27onda "complesse" a bassa frequenza, intendendosi con questo termine le forme d\u27onda pulsate o, in generale, non sinusoidali, aventi componenti spettrali di frequenza fino a 100 kHz. Tutti questi approcci conducono a definire un indice che rappresenta l\u27intensit? dell\u27esposizione ed a proporre un metodo per calcolarne il valore. I livelli di riferimento ICNIRP sono rispettati se tale valore risulta minore o uguale ad 1. In ogni caso gli indici sono calcolati separatamente per ogni componente cartesiana X,Y,Z del campo; l\u27indice complessivo ? dato dalla somma vettoriale degli indici delle tre componenti. In questo documento descriveremo questi metodi con riferimento alle esposizioni al campo magnetico in ambito occupazionale, ma quanto esporremo pu? essere sia facilmente esteso alle esposizioni della popolazione sia adattato al caso del campo elettrico

Analisis Finansial USAha Perikanan Jaring Klitik (Gill Net Dasar) Dan Jaring Nilon (Gill Net Permukaan) Di Pangkalan Pendaratan Ikan (Ppi) Tanjungsari Kabupaten Pemalang, Jawa Tengah

Dari beberapa jenis alat tangkap yang ada di PPI Tanjungsari, alat tangkap yang mendominasi adalah alat tangkap jaring klitik (Gill net dasar) dan jaring nilon (Gill net permukaan). Terdapat perbedaan antara kedua alat tangkap tersebut terkait dengan aspek teknis terutama aspek finansial. Oleh karena itu, perlu dianalisis tentang finansial USAha perikanan dari kedua alat tangkap tersebut. Metode penelitian yang digunakan adalah metode deskriptif dan studi kasus. Metode pengambilan sampel menggunakan metode purposive sampling dengan jumlah masing-masing responden per alat tangkap 15 orang. Metode analisis yang digunakan adalah metode analisis finansial yaitu; NPV, B/C ratio, IRR, dan Payback Periode (PP). Hasil menunjukan bahwa USAha perikanan tangkap Gill net dasar adalah sebagai berikut; NPV dengan nilai Rp. 111.986.427,-, B/C ratio adalah 1,44, IRR dengan nilai 47% , dan PP adalah 3,45 tahun yang berarti USAha perikanan Gill net dasar dikategorikan layak. Sedangkan, USAha perikanan tangkap Gill net permukaan adalah sebagai berikut; NPV dengan nilai Rp. 158.869.200,-, B/C ratio adalah 1,66, IRR dengan nilai 36%, dan PP adalah 4,19 tahun yang berarti USAha perikanan Gill net permukaan dikategorikan layak. Oleh karena itu, kedua unit USAha perikanan Gill net dasar dan Gill net permukaan dapat terus dilanjutkan. Some types of fishing gear that is in PPI Tanjungsari, fishing gear is dominated klitik net fishing gear (bottom Gill net) and nylon net (surface Gill net). There are differences between the two gears are related to technical aspects, especially the financial aspects.Therefore, need to be analyzed on fishing effort financially from the second gear. The method used is descriptive and case studies. The sampling method using purposive sampling method with the number of respondents per each gear 15 people. The analytical method used is the financial method that NPV, B / C ratio, IRR, and Payback Period (PP). Results showed that the efforts of fisheries bottom Gill net is as follows; NPV value of Rp. 111 986 427, -, B / C ratio is 1.44, with a value of 47% IRR and PP was 3.45 years, which means Gill net fishing businesses categorized as feasible basis. Meanwhile, surface Gill net fishery business is as follows; NPV value of Rp. 158 869 200, -, B / C ratio is 1.66, with a value of 36% IRR and PP was 4.19 years, which means surface Gill net fishing businesses categorized decent. Therefore, both business units bottom Gill net and surface Gill net can be continued

Scoring system comparison to determine severity in non-variceal upper gastrointestinal bleeding

Determining scoring values in cases of UGIB is important to do so it can be used as a basis to determine the mortality rate of UGIB patients. Despite the dependency of most risk scoring systems for this disorder on endoscopic findings, the Glasgow-Blatchford Bleeding Score (GBS) and Incomplete Rockall Score (IRS) are based on simple variables. Our purpose to differentiate about sensitivity and spesificity between IRS and GBS to predict the severity of patient with non variceal upper GI bleeding without the endoscopic score. Our study was undertaken in emergency department Saiful Anwar hospital, Malang. The sample consist of 102 patients with non variceal upper GI bleeding from November 2012 to April 2013. With receiving-operator characteristics (ROC), we compare the significance between IRS and GBS in predicting the severity of patient with non variceal upper GI bleeding. In next step, we compare both of them with the diagnostic test. ROC curve shows that GBS is slightly better than IRS (0,955 vs 0,744, p<0,05). IRS has better specificity (79,55% vs 70,45%) than GBS. But, GBS has better sensitivity (96,55% vs 65,52%). The final results is GBS as an alternative diagnostic score has better results than IRS in understanding the severity of patient with non variceal upper GI bleeding in Saiful Anwar hospital. Therefore, it can be used as a simple predictor replacing the endoscopic score

PENGARUH ATRAKTOR RUMPON TERHADAP HASIL TANGKAPAN ALAT TANGKAP BAGAN (LIFT NET) DI PERAIRAN DEMAK

One  kind  of  fishing  gear  that  use  to  captured  phototaxis  positif  fish  is  Lift  Net.  Lamp  was  no longer  used  as  fish  aggregating  device  for  lift  net  because  it  was  uneffective  and  unefficient  to gathered  fish  target.  If  the  problem  still  continued  it  can  raised  fuels  consumption  for  lamp attractor. Another fish aggregating device “rumpon” was a solution for lift net operation. Research objectives were to increase effectivity, efficiency and fishing production, and hopefully it can raise fisheries income.  Keyword : Liftnet, Rumpon, Demak Seawater

Hydrodynamics of domain growth in nematic liquid crystals

We study the growth of aligned domains in nematic liquid crystals. Results are obtained solving the Beris-Edwards equations of motion using the lattice Boltzmann approach. Spatial anisotropy in the domain growth is shown to be a consequence of the flow induced by the changing order parameter field (backflow). The generalization of the results to the growth of a cylindrical domain, which involves the dynamics of a defect ring, is discussed.Comment: 12 revtex-style pages, including 12 figures; small changes before publicatio

Dominant Mutations in GRHL3 Cause Van der Woude Syndrome and Disrupt Oral Periderm Development

Mutations in interferon regulatory factor 6 (IRF6) account for ∼70% of cases of Van der Woude syndrome (VWS), the most common syndromic form of cleft lip and palate. In 8 of 45 VWS-affected families lacking a mutation in IRF6, we found coding mutations in grainyhead-like 3 (GRHL3). According to a zebrafish-based assay, the disease-associated GRHL3 mutations abrogated periderm development and were consistent with a dominant-negative effect, in contrast to haploinsufficiency seen in most VWS cases caused by IRF6 mutations. In mouse, all embryos lacking Grhl3 exhibited abnormal oral periderm and 17% developed a cleft palate. Analysis of the oral phenotype of double heterozygote (Irf6+/−;Grhl3+/−) murine embryos failed to detect epistasis between the two genes, suggesting that they function in separate but convergent pathways during palatogenesis. Taken together, our data demonstrated that mutations in two genes, IRF6 and GRHL3, can lead to nearly identical phenotypes of orofacial cleft. They supported the hypotheses that both genes are essential for the presence of a functional oral periderm and that failure of this process contributes to VWS

Dominant Mutations in GRHL3 Cause Van der Woude Syndrome and Disrupt Oral Periderm Development

Peer reviewe

Protein kinase C activation disrupts epithelial apical junctions via ROCK-II dependent stimulation of actomyosin contractility

<p>Abstract</p> <p>Background</p> <p>Disruption of epithelial cell-cell adhesions represents an early and important stage in tumor metastasis. This process can be modeled <it>in vitro </it>by exposing cells to chemical tumor promoters, phorbol esters and octylindolactam-V (OI-V), known to activate protein kinase C (PKC). However, molecular events mediating PKC-dependent disruption of epithelial cell-cell contact remain poorly understood. In the present study we investigate mechanisms by which PKC activation induces disassembly of tight junctions (TJs) and adherens junctions (AJs) in a model pancreatic epithelium.</p> <p>Results</p> <p>Exposure of HPAF-II human pancreatic adenocarcinoma cell monolayers to either OI-V or 12-O-tetradecanoylphorbol-13-acetate caused rapid disruption and internalization of AJs and TJs. Activity of classical PKC isoenzymes was responsible for the loss of cell-cell contacts which was accompanied by cell rounding, phosphorylation and relocalization of the F-actin motor nonmuscle myosin (NM) II. The OI-V-induced disruption of AJs and TJs was prevented by either pharmacological inhibition of NM II with blebbistatin or by siRNA-mediated downregulation of NM IIA. Furthermore, AJ/TJ disassembly was attenuated by inhibition of Rho-associated kinase (ROCK) II, but was insensitive to blockage of MLCK, calmodulin, ERK1/2, caspases and RhoA GTPase.</p> <p>Conclusion</p> <p>Our data suggest that stimulation of PKC disrupts epithelial apical junctions via ROCK-II dependent activation of NM II, which increases contractility of perijunctional actin filaments. This mechanism is likely to be important for cancer cell dissociation and tumor metastasis.</p