LMDA Review, volume 9, issue 2

Contents include: Literary Managers and Dramaturgs of the Americas Annual Conference 1999 Setting the Table: A Working Retreat, The State of the Profession Round One, Call for Nominations LMDA President-Elect, On Elliot Hayes and the LMDA Prize, Early Career Dramaturg Program, Report on Canadian Caucus Meeting, Introducing Celise Kalke, Research at the Theater Center, Script Exchange, LMDA Online, Education in the Arts, A Team Approach to Dramaturgy at Cornish College of the Arts, Process Translation: Translator/Dramaturg Meets Actor/Translator, Jobs, Disruption in Job Line Service, Dramaturgy Focus Group Association for Theater in Higher Education Toronto Conference, Report on the Dramaturgy Focus Group ATHE 1999, Recent Publications by Members, and Literary Managers and Dramaturgs of the Americas Bibliography 1999https://soundideas.pugetsound.edu/lmdareview/1019/thumbnail.jp

Baseline findings and safety of infrequent vs. frequent screening of human papillomavirus vaccinated women

Less frequent cervical cancer screening in human papillomavirus (HPV) vaccinated birth cohorts could produce considerable savings without increasing cervical cancer incidence and loss of life-years. We report here the baseline findings and interim results of safety and accuracy of infrequent screening among HPV16/18 vaccinated females. The entire 1992-1994 birth-cohorts (30,139 females) were invited to a community-randomized HPV16/18-vaccination trial. A total of 9,482 female trial participants received HPV16/18-vaccination in 2007-2009 at age of 13-15. At age 22, 4,273 (45%) of these females consented to attend a randomized trial on frequent (ages 22/25/28; Arm 1: 2,073 females) vs. infrequent screening (age 28; Arm 2: 2,200 females) in 2014-2017. Females (1,329), who had got HPV16/18 vaccination at age 18 comprised the safety Arm 3. Baseline prevalence and incidence of HPV16/18 and other high-risk HPV types were: 0.5% (53/1,000 follow-up years, 10(4)) and 25% (2,530/10(4)) in the frequently screened Arm 1; 0.2% (23/10(4)) and 24% (2,413/10(4)) in the infrequently screened Arm 2; and 3.1% (304/10(4)) and 23% (2,284/10(4)) in the safety Arm 3. Corresponding prevalence of HSIL/ASC-H and of any abnormal cytological findings were: 0.3 and 4.2% (Arm 1), 0.4 and 5.3% (Arm 2) and 0.3 and 4.7% (Arm 3). Equally rare HSIL/CIN3 findings in the infrequently screened safety Arm A3 (0.4%) and in the frequently screened Arm 1 (0.4%) indicate no safety concerns on infrequent screening despite the up to 10 times higher HPV16/18 baseline prevalence and incidence in the former.Peer reviewe

Human papillomavirus vaccine efficacy against invasive, HPV-positive cancers : population-based follow-up of a cluster-randomised trial

Background Human papillomavirus (HPV) vaccination protects against HPV, a necessary risk factor for cervical cancer. We now report results from population-based follow-up of randomised cohorts that vaccination provides HPV-type-specific protection against invasive cancer. Methods Individually and/or cluster randomised cohorts of HPV-vaccinated and non-vaccinated women were enrolled in 2002-2005. HPV vaccine cohorts comprised originally 16-17 year-old HPV 16/18-vaccinated PATRICIA (NCT00122681) and 012 trial (NCT00169494) participants (2465) and HPV6/11/16/18-vaccinated FUTURE II (NCT00092534) participants (866). Altogether, 3341 vaccines were followed by the Finnish Cancer Registry in the same way as 16 526 non-HPV-vaccinated controls. The control cohort stemmed from 15 665 originally 18-19 years-old women enrolled in 2003 (6499) or 2005 (9166) and 861 placebo recipients of the FUTURE II trial. The follow-up started 6 months after the clinical trials in 2007 and 2009 and ended in 2019. It was age aligned for the cohorts. Findings During a follow-up time of up to 11 years, we identified 17 HPV-positive invasive cancer cases (14 cervical cancers, 1 vaginal cancer, 1 vulvar cancer and 1 tongue cancer) in the non-HPV-vaccinated cohorts and no cases in the HPV-vaccinated cohorts. HPV typing of diagnostic tumour blocks found HPV16 in nine cervical cancer cases, HPV18, HPV33 and HPV52 each in two cases and HPV45 in one cervical cancer case. The vaginal, vulvar and tongue cancer cases were, respectively, positive for HPV16, HPV52/66 and HPV213. Intention-to-treat vaccine efficacy against all HPV-positive cancers was 100% (95% CI 2 to 100, p Interpretation Vaccination is effective against invasive HPV-positive cancer.Peer reviewe

The quality of life of frequently vs. infrequently screened HPV vaccinated women

Purpose: Cervical lesions caused by human papillomavirus (HPV) are related to decreased quality of life (QoL) of women. Also, cervical cancer (CC) screening can cause psychological adverse effects. It has been assumed that by decreasing the HPV-related disease burden, HPV vaccinations would increase the QoL. This study compares the effect of CC screening on QoL of HPV vaccinated women in two different screening protocols. Methods: A total of 753 HPV16/18 vaccinated women were randomized to frequent (22/25/28 years of age) and infrequent (28 years of age) CC screening arms. QoL questionnaires (EQ VAS, RAND 36, amended CECA 10) were sent at the age of 28. Results: Median EQ VAS scores were 80 (Q1–Q3 75–90) in both screening arms. Mean RAND 36 scores of frequently and infrequently screened women were 78.13/81.64 in Physical role functioning domain and, respectively, 77.93/80.18 in Pain, 69.10/69.12 in General Health, 54.67/53.61 in Energy, 83.72/85.11 in Social functioning, 69.53/69.68 in Emotional role functioning, and 68.16/69.29 in Emotional well-being domain. Among women with a self-reported history of Pap cytology abnormalities, overall mean scores of amended CECA 10 were 69.52/72.07, and among women with a self-reported history of genital warts, 60.09/66.73, respectively. Conclusion: There was no significant difference in the QoL of HPV vaccinated women between the two CC screening arms. Women were mostly satisfied with the screening experience despite the screening frequency. This information is important for the future screening program planning as we need to reach the best possible balance with screening benefits and harms. Trial registration number: NCT02149030, date of registration 29/5/2014.Peer reviewe

LMDA New & Noteworthy, May 2020

Contents include: #LMDA2020 // Conference Countdown; Managing Life and Work in the Time of COVID-19: Thoughts from the LMDA Executive Committee; The Kennedy Center Dramaturgy Intensive: Learn from the best. Work with the best; Regional Events; Your Dramaturgy Ad Here; Pandemic Response: Resources for Artists in the U.S. and Canada (link).https://soundideas.pugetsound.edu/lmdanewsletter/1033/thumbnail.jp

Suomalaisten keskimääräinen efektiivinen annos vuonna 2018

Tässä raportissa päivitetään tiedot suomalaisten vuosittain saamasta keskimääräisestä efektiivisestä annoksesta. Suomalaiset altistuvat niin luonnollisista kuin keinotekoisista lähteistä peräisin olevalle ionisoivalle säteilylle. Vuonna 2018 suomalaisten saama keskimääräinen efektiivinen annos oli 5,9 millisievertiä (mSv). Kaksi kolmasosaa tästä säteilyannoksesta, 4 mSv, on peräisin sisäilman radonista. Noin 1,1 mSv suomalaisten vuotuisesta efektiivisestä annoksesta aiheutuu luonnon taustasäteilystä (muu kuin sisäilman radon). Säteilyn lääketieteellinen käyttö aiheuttaa suomalaiselle keskimäärin 0,76 mSv vuotuisen efektiivisen annoksen

Den genomsnittliga effektiva dosen hos finländarna 2018

I den här rapporten uppdateras uppgifterna om den genomsnittliga effektiva dosen finländarna får årligen. Finländare exponeras för joniserande strålning från både naturliga och konstgjorda källor. År 2018 uppgick finländarnas genomsnittliga effektiva till 5,9 millisievert. Två tredjedelar av den här stråldosen, 4 mSv, härstammar från radon i inomhusluften. Cirka 1,1 mSv av finländarnas årliga effektiva dos beror på naturens bakgrundsstrålning (annat än radon i inomhusluften). Medicinsk användning av strålning orsakar finländare i genomsnitt en årlig effektiv dos på 0,76 mSv