140 research outputs found
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Psycho-markers of weight loss. The roles of TFEQ Disinhibition and Restraint in exercise-induced weight loss
yesEating behaviour traits, namely Disinhibition and Restraint, have the potential to exert an effect on food
intake and energy balance. The effectiveness of exercise as a method of weight management could be
influenced by these traits. Fifty eight overweight and obese participants completed 12-weeks of supervised
exercise. Each participant was prescribed supervised exercise based on an expenditure of
500 kcal/session, 5 d/week for 12-weeks. Following 12-weeks of exercise there was a significant reduction
in mean body weight ( 3.26 ± 3.63 kg), fat mass (FM: 3.26 ± 2.64 kg), BMI ( 1.16 ± 1.17 kg/m2)
and waist circumference (WC: 5.0 ± 3.23 cm). Regression analyses revealed a higher baseline Disinhibition
score was associated with a greater reduction in BMI and WC, while Internal Disinhibition was associated
with a larger decrease in weight, %FM and WC. Neither baseline Restraint or Hunger were
associated with any of the anthropometric markers at baseline or after 12-weeks. Furthermore, after
12-weeks of exercise, a decrease in Disinhibition and increase in Restraint were associated with a greater
reduction in WC, whereas only Restraint was associated with a decrease in weight. Post-hoc analysis of
the sub-factors revealed a decrease in External Disinhibition and increase in Flexible Restraint were associated
with weight loss. However, an increase in Rigid Restraint was associated with a reduction in %FM
and WC. These findings suggest that exercise-induced weight loss is more marked in individuals with a high level of Disinhibition. These data demonstrate the important roles that Disinhibition and Restraint
play in the relationship between exercise and energy balance.BBSR
The biology of appetite control: Do resting metabolic rate and fat-free mass drive energy intake?
The prevailing model of homeostatic appetite control envisages two major inputs; signals from adipose tissue and from peptide hormones in the gastrointestinal tract. This model is based on the presumed major influence of adipose tissue on food intake. However, recent studies have indicated that in obese people fat-free mass (FFM) is strongly positively associated with daily energy intake and with meal size. This effect has been replicated in several independent groups varying in cultural and ethnic backgrounds, and appears to be a robust phenomenon. In contrast fat mass (FM) is weakly, or mildly negatively associated with food intake in obese people. In addition resting metabolic rate (RMR), a major component of total daily energy expenditure, is also associated with food intake. This effect has been replicated in different groups and is robust. This action is consistent with the proposal that energy requirements â reflected in RMR (and other aspects of energy expenditure) constitute a biological drive to eat. Consistent with its storage function, FM has a strong inhibitory effect on food intake in lean subjects, but this effect appears to weaken dramatically as adipose tissue increases. This formulation can account for several features of the development and maintenance of obesity and provides an alternative, and transparent, approach to the biology of appetite control
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Relationships among tonic and episodic aspects of motivation to eat, gut peptides, and weight before and after bariatric surgery.
yesBackground The interaction between motivation to eat, eating behaviour traits and gut peptides following gastric bypass (GBP) surgery are not fully understood.
Setting Danderyd Hospital, Karolinska Institutet, Stockholm, Sweden.
Method Appetite and hormone responses to a fixed liquid pre-load were assessed in 12 obese (BMI 45 ± 1.9 kg/m2) participants immediately before, 3 days, 2 months, and 1 year following gastric by-pass (GBP) surgery. Subjective appetite and plasma levels of ghrelin, leptin, insulin and GLP-1 were measured for a 3-hour postprandial period. Eating behaviour traits were also measured using the TFEQR18.
Results There was a decrease in TFEQ Emotional Eating (EE) and Uncontrolled Eating (UE) from pre to 1-year post-surgery, but no significant change in Restraint. In addition, there was a reduction in subjective appetite ratings, and alterations in appetite peptides favouring an anorectic response. Pre-surgery EE was significantly related to fasting and AUC ghrelin; UE was associated with AUC desire to eat while there was a significant association between fasting desire to eat and ghrelin (fasting and AUC). 1 year post-surgery, UE was positively related to fasting insulin and Restraint was negatively associated with GLP-1. UE and subjective hunger were positively correlated, while the relationship between desire to eat and ghrelin remained.
Conclusion The relationships amongst subjective appetite ratings, eating behaviour traits and appetite peptides in obese patients both before and at one-year post GBP surgery contribute to the reduction in a propensity to over-eat and weight loss
Calculations of parity nonconserving s-d transitions in Cs, Fr, Ba II, and Ra II
We have performed ab initio mixed-states and sum-over-states calculations of
parity nonconserving (PNC) electric dipole (E1) transition amplitudes between
s-d electron states of Cs, Fr, Ba II, and Ra II. For the lower states of these
atoms we have also calculated energies, E1 transition amplitudes, and
lifetimes. We have shown that PNC E1 transition amplitudes between s-d states
can be calculated to high accuracy. Contrary to the Cs 6s-7s transition, in
these transitions there are no strong cancelations between different terms in
the sum-over-states approach. In fact, there is one dominating term which
deviates from the sum by less than 20%. This term corresponds to an s-p_{1/2}
weak matrix element, which can be calculated to better than 1%, and a
p_{1/2}-d_{3/2} E1 transition amplitude, which can be measured. Also, the s-d
amplitudes are about four times larger than the corresponding s-s transitions.
We have shown that by using a hybrid mixed-states/sum-over-states approach the
accuracy of the calculations of PNC s-d amplitudes could compete with that of
Cs 6s-7s if p_{1/2}-d_{3/2} E1 amplitudes are measured to high accuracy.Comment: 15 pages, 8 figures, submitted to Phys. Rev.
Adaptation of plasminogen activator sequences to known protease structures
AbstractThe sequences of urokinase (UK) and tissue-type plasminogen activator (TPA) were aligned with those of chymotrypsin, trypsin, and elastase according to their âstructurally conserved regionsâ. In spite of its trypsin-like specificity UK was model-built on the basis of the chymotrypsin structure because of a corresponding disulfide pattern. The extra disulfide bond falls to cysteines 50 and 111d. Insertions can easily be accommodated at the surface. As they occur similarly in both, UK and TPA, a role in plasminogen recognition may be possible. Of the functional positions known to be involved in substrate or inhibitor binding, Asp 97, Lys 143 and Arg 217 (Leu in TPA) may contribute to plasminogen activating specificity. PTI binding may in part be impaired by structural differences at the edge of the binding pocket
Observation of a 1750 MeV/c^2 Enhancement in the Diffractive Photoproduction of K^+K^-
Using the FOCUS spectrometer with photon beam energies between 20 and 160
\gev, we confirm the existence of a diffractively photoproduced enhancement in
at 1750 \mevcc with nearly 100 times the statistics of previous
experiments. Assuming this enhancement to be a single resonance with a
Breit-Wigner mass shape, we determine its mass to be
\mevcc and its width to be \mevcc. We find no
corresponding enhancement at 1750 \mevcc in , and again neglecting any
possible interference effects we place limits on the ratio . Our results are consistent with previous
photoproduction experiments, but, because of the much greater statistics,
challenge the common interpretation of this enhancement as the
seen in annihilation experiments.Comment: 10 pages, 5 figure
Strong Decays of Strange Quarkonia
In this paper we evaluate strong decay amplitudes and partial widths of
strange mesons (strangeonia and kaonia) in the 3P0 decay model. We give
numerical results for all energetically allowed open-flavor two-body decay
modes of all nsbar and ssbar strange mesons in the 1S, 2S, 3S, 1P, 2P, 1D and
1F multiplets, comprising strong decays of a total of 43 resonances into 525
two-body modes, with 891 numerically evaluated amplitudes. This set of
resonances includes all strange qqbar states with allowed strong decays
expected in the quark model up to ca. 2.2 GeV. We use standard nonrelativistic
quark model SHO wavefunctions to evaluate these amplitudes, and quote numerical
results for all amplitudes present in each decay mode. We also discuss the
status of the associated experimental candidates, and note which states and
decay modes would be especially interesting for future experimental study at
hadronic, e+e- and photoproduction facilities. These results should also be
useful in distinguishing conventional quark model mesons from exotica such as
glueballs and hybrids through their strong decays.Comment: 69 pages, 5 figures, 39 table
Novel Approach to Confront Electroweak Data and Theory
A novel approach to study electroweak physics at one-loop level in generic
theories is introduced. It separates the 1-loop
corrections into two pieces: process specific ones from vertex and box
contributions, and universal ones from contributions to the gauge boson
propagators. The latter are parametrized in terms of four effective form
factors , , and corresponding to the , , and
propagators. Under the assumption that only the Standard Model contributes to
the process specific corrections, the magnitudes of the four form factors are
determined at and at q^2=\mmz by fitting to all available precision
experiments. These values are then compared systematically with predictions of
theories. In all fits \alpha_s(\mz) and
\bar{\alpha}(\mmz) are treated as external parameters in order to keep the
interpretation as flexible as possible. The treatment of the electroweak data
is presented in detail together with the relevant theoretical formulae used to
interpret the data. No deviation from the Standard Model has been identified.
Ranges of the top quark and Higgs boson masses are derived as functions of
\alpha_s(\mz) and \bar{\alpha}(\mmz). Also discussed are consequences of
the recent precision measurement of the left-right asymmetry at SLC as well as
the impact of a top quark mass and an improved mass measurement.Comment: 123 pages, LaTeX (33 figures available via anonymous ftp),
KEK-TH-375, KEK preprint 93-159, KANAZAWA-94-19, DESY 94-002, YUMS 94-22,
SNUTP 94-82, to be published in Z.Phys.
Radio emission and jets from microquasars
To some extent, all Galactic binary systems hosting a compact object are
potential `microquasars', so much as all galactic nuclei may have been quasars,
once upon a time. The necessary ingredients for a compact object of stellar
mass to qualify as a microquasar seem to be: accretion, rotation and magnetic
field. The presence of a black hole may help, but is not strictly required,
since neutron star X-ray binaries and dwarf novae can be powerful jet sources
as well. The above issues are broadly discussed throughout this Chapter, with a
a rather trivial question in mind: why do we care? In other words: are jets a
negligible phenomenon in terms of accretion power, or do they contribute
significantly to dissipating gravitational potential energy? How do they
influence their surroundings? The latter point is especially relevant in a
broader context, as there is mounting evidence that outflows powered by
super-massive black holes in external galaxies may play a crucial role in
regulating the evolution of cosmic structures. Microquasars can also be thought
of as a form of quasars for the impatient: what makes them appealing, despite
their low number statistics with respect to quasars, are the fast variability
time-scales. In the first approximation, the physics of the jet-accretion
coupling in the innermost regions should be set by the mass/size of the
accretor: stellar mass objects vary on 10^5-10^8 times shorter time-scales,
making it possible to study variable accretion modes and related ejection
phenomena over average Ph.D. time-scales. [Abridged]Comment: 28 pages, 13 figures, To appear in Belloni, T. (ed.): The Jet
Paradigm - From Microquasars to Quasars, Lect. Notes Phys. 794 (2009
Efeitos agudos de diferentes intensidades de exercĂcio sobre a ingestĂŁo alimentar pĂłs-exercĂcio
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